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1. 发明授权

US5770588A Non-antibacterial tetracycline compositions of the prevention and treatment of root caries 失效
标题翻译：非抗菌四环素组合物预防和治疗根龋
公开(公告)号：US5770588A
公开(公告)日：1998-06-23
申请号：US591949
申请日：1996-01-23
申请人： Thomas F. McNamara , Lorne M. Golub , Nangavarum S. Ramamurthy
发明人： Thomas F. McNamara , Lorne M. Golub , Nangavarum S. Ramamurthy
IPC分类号： A61K31/65
CPC分类号： A61Q11/00 , A61K31/65 , A61K8/42
摘要： Methods of inhibiting root caries formation on mammalian tooth surfaces are disclosed. The methods include topically contacting the tooth root surfaces with an effective amount of a non-antibacterial tetracycline which is not systemically absorbed into the blood stream. In preferred embodiments, the tetracyclines are included in various oral hygiene products such as dentifrices, lozenges, chewing gums and the like to contact the tooth root surfaces.
摘要翻译：公开了抑制哺乳动物牙齿表面的根龋形成的方法。所述方法包括将牙根表面与有效量的非全身吸收到血液中的非抗菌四环素进行局部接触。在优选的实施方案中，四环素包括在各种口腔卫生产品如洁牙剂，锭剂，口香糖等中以接触牙根表面。

2. 发明授权

US4666897A Inhibition of mammalian collagenolytic enzymes by tetracyclines 失效
标题翻译：通过四环素抑制哺乳动物胶原分解酶
公开(公告)号：US4666897A
公开(公告)日：1987-05-19
申请号：US566517
申请日：1983-12-29
申请人： Lorne M. Golub , Thomas F. McNamara , N. S. Ramamurthy
发明人： Lorne M. Golub , Thomas F. McNamara , N. S. Ramamurthy
IPC分类号： A61K31/65
CPC分类号： A61K31/65
摘要： A method of reducing pathologically excessive levels of activity of collagenolytic enzymes in mammals to substantially normal levels by administering 10-100% of the normal antibiotic therapeutic dose of a tetracycline is disclosed.
摘要翻译：公开了一种通过施用10-100％的正常抗生素治疗剂量的四环素来将哺乳动物中胶原水解酶的病理过度水平降低至基本正常水平的方法。

3. 发明授权

US6043231A Inhibition of excessive phospholipase A.sub.2 activity and/or production by non-antimicrobial tetracyclines 失效
标题翻译：抑制过量磷脂酶A2活性和/或非抗微生物四环素生产
公开(公告)号：US6043231A
公开(公告)日：2000-03-28
申请号：US115158
申请日：1993-08-31
申请人： Waldemar Pruzanski , Lorne M. Golub , Peter Vadas , Robert A. Greenwald , Nangavarum S. Ramamurthy , Thomas F. McNamara
发明人： Waldemar Pruzanski , Lorne M. Golub , Peter Vadas , Robert A. Greenwald , Nangavarum S. Ramamurthy , Thomas F. McNamara
IPC分类号： A61K31/65
CPC分类号： A61K31/65 , Y10S514/825 , Y10S514/863 , Y10S514/895
摘要： A method for treating mammals suffering from conditions associated with excess phospholipase A.sub.2 activity and/or production comprising administering to the mammal an effective amount of a non-antimicrobial tetracycline sufficient to inhibit excess phospholipase A.sub.2 activity and/or production is disclosed. A pharmaceutical composition is also disclosed.
摘要翻译：公开了一种治疗患有与过量磷脂酶A2活性和/或产物相关的病症的哺乳动物的方法，包括向哺乳动物施用有效量的足以抑制过量磷脂酶A2活性和/或产生的非抗微生物四环素。还公开了药物组合物。

4. 发明授权

US5827840A Promotion of wound healing by chemically-modified tetracyclines 失效
标题翻译：通过化学改性的四环素促进伤口愈合
公开(公告)号：US5827840A
公开(公告)日：1998-10-27
申请号：US691135
申请日：1996-08-01
申请人： Nungavaram S. Ramamurthy , Lorne M. Golub , Thomas F. McNamara
发明人： Nungavaram S. Ramamurthy , Lorne M. Golub , Thomas F. McNamara
IPC分类号： A61K31/65 , A61K45/06 , A61L15/44 , A61P17/02
CPC分类号： A61L15/44 , A61K31/65 , A61K45/06 , A61L2300/406 , A61L2300/41 , A61L2300/412
摘要： A method for improving the healing response of epithelialized tissue (e.g., skin, mucosae) to acute traumatic injury is disclosed. The method includes employing a tetracycline compound, having substantially no antibacterial activity, to improve the capacity of the epithelialized tissue to heal acute wounds. Specifically, the method involves increasing the rate of collagen accumulation of the healing epithelialized tissue above that associated with wound healing in the individual. The method decreases proteolytic activity in the epithelialized tissue by means of the tetracycline compound, most commonly decreasing collagenolytic activity and/or decreasing gelatinolytic activity. Collagenase and gelatinase activity have been shown to be decreased by the method of the invention. Preferably, the method is employed to improve the wound healing capacity of human or animal subjects in whom such capacity is impaired. Also, the non-antibiotic tetracycline is preferably administered topically at the site of the wound.
摘要翻译：公开了一种改善上皮组织（例如皮肤，粘膜）对急性创伤性损伤的愈合反应的方法。该方法包括使用基本上没有抗菌活性的四环素化合物，以改善上皮组织治愈急性创伤的能力。具体地说，该方法包括增加愈合上皮组织的胶原蛋白积累速率高于个体伤口愈合以上。该方法通过四环素化合物降低上皮组织中的蛋白水解活性，最常降低胶原分解活性和/或降低明胶溶解活性。通过本发明的方法已显示胶原酶和明胶酶活性降低。优选地，该方法用于改善受损的人或动物受试者的伤口愈合能力。此外，非抗生素四环素优选在伤口部位局部施用。

5. 发明授权

US5045538A Inhibition of wasting and protein degradation of mammalian muscle by tetracyclines 失效
标题翻译：通过四环素抑制哺乳动物肌肉的浪费和蛋白质降解
公开(公告)号：US5045538A
公开(公告)日：1991-09-03
申请号：US545395
申请日：1990-06-28
申请人： Bruce Schneider , Robert A. Greenwald , Jonathan Maimon , Kenneth Gorray , Lorne M. Golub , Thomas F. McNamara , Nangavarum S. Ramamurthy
发明人： Bruce Schneider , Robert A. Greenwald , Jonathan Maimon , Kenneth Gorray , Lorne M. Golub , Thomas F. McNamara , Nangavarum S. Ramamurthy
IPC分类号： A61K31/65 , A61P21/00 , A61P43/00
CPC分类号： A61K31/65
摘要： A method for treating mammals suffering from skeletal muscle wasting and/or intracellular protein degradation of skeletal muscle systems by administering to the mammal an amount of tetracycline which results in a significant reduction of the muscle wasting and protein degradation is disclosed. In addition, there is also disclosed a method of increasing the protein content of skeletal muscle systems of mammals by administration of tetracyclines. The tetracyclines useful in the above methods are both antimicrobial and non-antimicrobial. In a preferred embodiment, the method of treatment utilizes a non-antimicrobial tetracycline such as dedimethylaminotetracycline (CMT).

6. 发明授权

US4861582A Dental compositions containing monovalent ions 失效
标题翻译：含有一价离子的牙科组合物
公开(公告)号：US4861582A
公开(公告)日：1989-08-29
申请号：US886276
申请日：1986-07-16
申请人： Jerry J. Pollock , Thomas F. McNamara
发明人： Jerry J. Pollock , Thomas F. McNamara
IPC分类号： A61K8/19 , A61K8/21 , A61K8/23 , A61Q11/00
CPC分类号： A61K8/23 , A61K8/19 , A61K8/21 , A61Q11/00 , Y10S514/901
摘要： Dental compositions containing bicarbonate anion in combination with a monovalent anion such as fluoride, chloride or thiocyanate and methods of using them in anti-carogenic, antiplaque and antiperiodontopathic therapy are disclosed herein.
摘要翻译：本文公开了含有碳酸氢根阴离子与一价阴离子如氟化物，氯化物或硫氰酸盐的组合物以及将其用于抗老化，抗菌和抗周期性治疗的方法。

7. 发明授权

US4704383A Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same 失效
公开(公告)号：US4704383A
公开(公告)日：1987-11-03
申请号：US699048
申请日：1985-02-07
申请人： Thomas F. McNamara , Nungavaram S. Ramamurthy , Lorne M. Golub
发明人： Thomas F. McNamara , Nungavaram S. Ramamurthy , Lorne M. Golub
IPC分类号： A23K1/165 , A23K1/16 , A23K1/17 , A61K31/65 , A61P1/02 , A61P3/00 , A61P43/00
CPC分类号： A61K31/65
摘要： Tetracyclines having substantially no effective antibiotic or antibacterial activity and possessing anti-collagen-destructive enzyme activity or anti-collagenase activity and compositions containing the same have been found useful as anti-collagenolytic agents. Such tetracyclines and compositions containing the same are useful in the treatment of periodontal diseases, corneal ulcers, bone deficiency disorders, rheumatoid arthritis diseases characterized by excessive collagen destruction. A special aspect of this invention involves the incorporation of such tetracyclines in animal feed compositions for improved animal nutrition, such as may be evidenced by increased weight gain.

8. 发明授权

US4618489A Dental compositions and method of use therefor 失效
标题翻译：牙科组合物及其使用方法
公开(公告)号：US4618489A
公开(公告)日：1986-10-21
申请号：US529163
申请日：1983-09-02
申请人： Jerry J. Pollock , Thomas F. McNamara
发明人： Jerry J. Pollock , Thomas F. McNamara
IPC分类号： A61K8/19 , A61K8/20 , A61K8/21 , A61K8/23 , A61Q11/00 , A61K9/16 , A61K9/18
CPC分类号： A61Q11/00 , A61K8/19 , A61K8/20 , A61K8/21 , A61K8/23
摘要： Dental compositions containing bicarbonate anion in combination with a monovalent anion such as fluoride, chloride or thiocyanate and methods of using them in anti-caries therapy are disclosed herein.
摘要翻译：本文公开了含有碳酸氢根阴离子与一价阴离子如氟化物，氯化物或硫氰酸盐的组合物以及在抗龋齿疗法中使用它们的方法。

9. 发明授权

US5223248A Non-antibacterial tetracycline compositions possessing antiplaque properties 失效
标题翻译：非抗菌TETRACYCLINE组合物抗静电性能
公开(公告)号：US5223248A
公开(公告)日：1993-06-29
申请号：US654073
申请日：1991-02-11
申请人： Thomas F. McNamara , Lorne M. Golub , Nangavarum S. Ramamurthy
发明人： Thomas F. McNamara , Lorne M. Golub , Nangavarum S. Ramamurthy
IPC分类号： A61K8/00 , A61K8/42 , A61K31/65 , A61P1/02 , A61Q11/00
CPC分类号： A61Q11/00 , A61K31/65 , A61K8/42
摘要： A method of inhibiting plaque formation on mammalian tooth surfaces is disclosed. The method includes contacting the tooth surfaces with an effective amount of a non-antibacterial tetracycline. In a preferred embodiment, such tetracyclines are included in various oral hygiene products such as dentifrices, lozenges, chewing gums and the like to contact the tooth surfaces and prevent plaque accumulation thereon.
摘要翻译：公开了一种抑制哺乳动物牙齿表面形成斑块的方法。该方法包括使牙齿表面与有效量的非抗菌四环素接触。在优选的实施方案中，这些四环素包括在各种口腔卫生产品如洁齿剂，锭剂，口香糖等中以接触牙齿表面并防止其上积累斑块。

10. 发明授权

US4935411A Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same 失效
公开(公告)号：US4935411A
公开(公告)日：1990-06-19
申请号：US117376
申请日：1987-10-28
申请人： Thomas F. McNamara , Nungavaram S. Ramamurthy , Lorne M. Golub
发明人： Thomas F. McNamara , Nungavaram S. Ramamurthy , Lorne M. Golub
IPC分类号： A61K31/65
CPC分类号： A61K31/65
摘要： Tetracyclines having substantially no effective antibiotic or antibacterial activity and possessing anti-collagen-destructive enzyme activity or anti-collagenase activity and compositions containing the same have been found useful as anti-collagenolytic agents. Such tetracyclines and compositions containing the same are useful in the treatment of periodontal diseases, corneal ulcers, bone deficiency disorders, rheumatoid arthritis diseases characterized by excessive collagen destruction. A special aspect of this invention involves the incorporation of such tetracyclines in animal feed compositions for improved animal nutrition, such as may be evidenced by increased weight gain.

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