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1. 发明申请

US20180334020A1 Vehicle Cover 审中-公开
公开(公告)号：US20180334020A1
公开(公告)日：2018-11-22
申请号：US16049268
申请日：2018-07-30
申请人： Marc B. Garnick
发明人： Marc B. Garnick , Joshua B. Lederer
IPC分类号： B60J11/04
CPC分类号： B60J11/04
摘要： Methods and devices are provided for vehicle covers. For example, a method of covering a vehicle is provided including placing a pre-folded vehicle cover between front and rear wheels of the vehicle and then driving the vehicle forwards until the rear wheels of the vehicle are on top of the vehicle cover. The method includes extending a rear portion of the vehicle cover and driving the vehicle backwards until the front wheels of the vehicle are on top of the vehicle cover. The method further includes extending a front portion of the vehicle cover and covering at least a bottom and at least part of each side of the vehicle with the vehicle cover to form a barrier underneath and at least partially around the vehicle. The method can also include covering a top of the vehicle and entirely enclosing the vehicle.

2. 发明授权

US10035412B2 Vehicle cover 有权
公开(公告)号：US10035412B2
公开(公告)日：2018-07-31
申请号：US15607233
申请日：2017-05-26
申请人： Marc B. Garnick
发明人： Marc B. Garnick , Joshua B. Lederer
IPC分类号： B60J11/04
CPC分类号： B60J11/04
摘要： Methods and devices are provided for using vehicle covers. For example, a method of covering a vehicle is provided including placing a pre-folded vehicle cover between front and rear wheels of the vehicle and then driving the vehicle forwards until the rear wheels of the vehicle are on top of the vehicle cover. The method includes extending a rear portion of the vehicle cover and driving the vehicle backwards until the front wheels of the vehicle are on top of the vehicle cover. The method further includes extending a front portion of the vehicle cover and covering at least a bottom and at least part of each side of the vehicle with the vehicle cover to form a barrier underneath and at least partially around the vehicle. The method can also include covering a top of the vehicle and entirely enclosing the vehicle.

3. 发明申请

US20170341497A1 Vehicle Cover 审中-公开
公开(公告)号：US20170341497A1
公开(公告)日：2017-11-30
申请号：US15607233
申请日：2017-05-26
申请人： Marc B. Garnick
发明人： Marc B. Garnick , Joshua B. Lederer
IPC分类号： B60J11/04
CPC分类号： B60J11/04
摘要： Methods and devices are provided for using vehicle covers. For example, a method of covering a vehicle is provided including placing a pre-folded vehicle cover between front and rear wheels of the vehicle and then driving the vehicle forwards until the rear wheels of the vehicle are on top of the vehicle cover. The method includes extending a rear portion of the vehicle cover and driving the vehicle backwards until the front wheels of the vehicle are on top of the vehicle cover. The method further includes extending a front portion of the vehicle cover and covering at least a bottom and at least part of each side of the vehicle with the vehicle cover to form a barrier underneath and at least partially around the vehicle. The method can also include covering a top of the vehicle and entirely enclosing the vehicle.

4. 发明授权

US06540979B2 Methods for detecting lesions in dense breast tissue using LHRH antagonists 失效
标题翻译：使用LHRH拮抗剂检测致密乳腺组织病变的方法
公开(公告)号：US06540979B2
公开(公告)日：2003-04-01
申请号：US09764626
申请日：2001-01-18
申请人： Marc B. Garnick
发明人： Marc B. Garnick
IPC分类号： A61B5055
CPC分类号： A61K49/00
摘要： Improved methods for detecting lesions in dense breast tissue are disclosed. The methods of the invention generally feature administration to a subject of an LHRH antagonist in an amount and for a period of time sufficient to reduce the density of breast tissue prior to generating an image of the breast tissue, for example by mammography, to detect a lesion in the breast tissue. Packaged formulations for reducing breast density in a subject prior to generating an image of the subject's breast tissue, comprising an LHRH antagonist packaged with instructions for using the LHRH antagonist to reduce breast density in a subject prior to imaging the breast tissue, are also disclosed.
摘要翻译：公开了用于检测致密乳房组织中病变的改进方法。本发明的方法通常特征在于在产生乳房组织的图像（例如通过乳房X线照相术）之前足以减少乳房组织的密度的量和一段时间的时间内向LHRH拮抗剂的受试者施用，以检测乳腺组织病变。还公开了用于在产生受试者的乳腺组织的图像之前减少受试者的乳房密度的包装制剂，其包含与在成像乳腺组织之前使用LHRH拮抗剂降低受试者的乳腺密度的说明书一起包装的LHRH拮抗剂。

5. 发明授权

US06737039B2 Methods for detecting lesions in dense breast tissue using LHRH antagonists 失效
标题翻译：使用LHRH拮抗剂检测致密乳腺组织病变的方法
公开(公告)号：US06737039B2
公开(公告)日：2004-05-18
申请号：US10319140
申请日：2002-12-12
申请人： Marc B. Garnick
发明人： Marc B. Garnick
IPC分类号： A61B5055
CPC分类号： A61K49/00
摘要： Improved methods for detecting lesions in dense breast tissue are disclosed. The methods of the invention generally feature administration to a subject of an LHRH antagonist in an amount and for a period of time sufficient to reduce the density of breast tissue prior to generating an image of the breast tissue, for example by mammography, to detect a lesion in the breast tissue. Packaged formulations for reducing breast density in a subject prior to generating an image of the subject's breast tissue, comprising an LHRH antagonist packaged with instructions for using the LHRH antagonist to reduce breast density in a subject prior to imaging the breast tissue, are also disclosed.
摘要翻译：公开了用于检测致密乳房组织中病变的改进方法。本发明的方法通常特征在于在产生乳房组织的图像（例如通过乳房X线照相术）之前足以减少乳房组织的密度的量和一段时间的时间内向LHRH拮抗剂的受试者施用，以检测乳腺组织病变。还公开了用于在产生受试者的乳腺组织的图像之前减少受试者的乳房密度的包装制剂，其包含与在成像乳腺组织之前使用LHRH拮抗剂降低受试者的乳腺密度的说明书一起包装的LHRH拮抗剂。

6. 发明授权

US06703367B1 Methods for treating hot flashes and gynaecomastia 失效
标题翻译：治疗潮热和女性乳房发育的方法
公开(公告)号：US06703367B1
公开(公告)日：2004-03-09
申请号：US09674132
申请日：2001-02-16
申请人： Marc B. Garnick
发明人： Marc B. Garnick
IPC分类号： A61K3809
CPC分类号： C07K7/23 , A61K38/00 , Y10S514/80
摘要： Methods to inhibit hot flashes or gynaecomastia in a subject are provided. In the methods of the invention, an LHRH antagonist is administered to a subject in need of treatment for hot flashes or gynaecomastia such that hot flashes or gynaecomastia are inhibited in the subject. In a particularly preferred embodiment, the invention provides a method for inhibiting menopause-related hot flashes in which an LHRH antagonist is administered to a subject in need of treatment for menopause-related hot flashes such that the hot flashes are inhibited in the subject.
摘要翻译：提供了抑制受试者中的潮热或女性乳房发育的方法。在本发明的方法中，将LHRH拮抗剂施用于需要治疗热潮红或女性乳房发育的受试者，使得受试者中的潮热或女性乳房发育被抑制。在特别优选的实施方案中，本发明提供了一种抑制更年期相关热潮红的方法，其中将LHRH拮抗剂施用于需要治疗绝经期相关热潮红的受试者，使得受试者中的潮热被抑制。

7. 发明授权

US5854204A A.beta. peptides that modulate .beta.-amyloid aggregation 失效
标题翻译：调节β-淀粉样蛋白聚集的β肽
公开(公告)号：US5854204A
公开(公告)日：1998-12-29
申请号：US612785
申请日：1996-03-14
申请人： Mark A. Findeis , Howard Benjamin , Marc B. Garnick , Malcolm L. Gefter , Arvind Hundal , Laura Kasman , Gary Musso , Ethan R. Signer , James Wakefield , Michael Reed , Susan Molineaux , William Kubasek , Joseph Chin , Jung-Ja Lee , Michael Kelley
发明人： Mark A. Findeis , Howard Benjamin , Marc B. Garnick , Malcolm L. Gefter , Arvind Hundal , Laura Kasman , Gary Musso , Ethan R. Signer , James Wakefield , Michael Reed , Susan Molineaux , William Kubasek , Joseph Chin , Jung-Ja Lee , Michael Kelley
IPC分类号： A61K39/02 , A61K31/00 , A61K38/00 , A61K51/00 , A61P25/00 , C07K7/06 , C07K14/47 , C07K14/435 , C07K7/08
CPC分类号： C07K14/4711 , A61K38/00
摘要： Compounds that modulate the aggregation of amyloidogenic proteins or peptides are disclosed. The modulators of the invention can promote amyloid aggregation or, more preferably, can inhibit natural amyloid aggregation. In a preferred embodiment, the compounds modulate the aggregation of natural .beta. amyloid peptides (.beta.-AP). In a preferred embodiment, the .beta. amyloid modulator compounds of the invention are comprised of an A.beta. aggregation core domain and a modifying group coupled thereto such that the compound alters the aggregation or inhibits the neurotoxicity of natural .beta. amyloid peptides when contacted with the peptides. Furthermore, the modulators are capable of altering natural .beta.-AP aggregation when the natural .beta.-APs are in a molar excess amount relative to the modulators. Pharmaceutical compositions comprising the compounds of the invention, and diagnostic and treatment methods for amyloidogenic diseases using the compounds of the invention, are also disclosed.
摘要翻译：公开了调节淀粉样蛋白形成蛋白或肽聚集的化合物。本发明的调节剂可以促进淀粉样蛋白聚集，更优选可以抑制天然淀粉样蛋白聚集。在优选的实施方案中，化合物调节天然β淀粉样蛋白肽（β-AP）的聚集。在优选的实施方案中，本发明的β淀粉样蛋白调节剂化合物由Aβ聚集核心结构域和与其偶联的修饰基团组成，使得当与肽接触时，该化合物改变聚集或抑制天然β淀粉样肽的神经毒性。此外，当天然β-APs相对于调节剂摩尔过量时，调节剂能够改变天然的β-AP聚集。还公开了包含本发明化合物的药物组合物，以及使用本发明化合物的淀粉样变性疾病的诊断和治疗方法。

8. 发明授权

US5780435A Methods for treating prostate cancer with LHRH-R antagonists 失效
公开(公告)号：US5780435A
公开(公告)日：1998-07-14
申请号：US573109
申请日：1995-12-15
申请人： Marc B. Garnick , Christopher J. Molineaux , Malcolm L. Gefter
发明人： Marc B. Garnick , Christopher J. Molineaux , Malcolm L. Gefter
IPC分类号： A61K38/00 , A61K38/04 , A61K38/09
CPC分类号： A61K38/09 , Y10S514/80
摘要： Methods for treating prostate cancer are disclosed. The methods of the invention generally feature administration to a subject of an LHRH-R antagonist, in combination with a second therapy. In one embodiment, this second therapy is performance of a procedure that removes or destroys prostatic tumor tissue, such as a radical prostatectomy, cryosurgery or X-ray therapy (external or interstitial). In another embodiment, the second therapy is treatment with an LHRH-R agonist, either simultaneous with or subsequent to LHRH-R antagonist therapy. The methods of the invention can further involve administering an antiandrogen and/or an inhibitor of sex steroid biosynthesis to the subject in combination with the LHRH-R antagonist.

9. 发明申请

US20090197813A1 Methods for treating FSH related conditions with GnRH antagonists 审中-公开
公开(公告)号：US20090197813A1
公开(公告)日：2009-08-06
申请号：US12315500
申请日：2008-12-03
申请人： Marc B. Garnick , Paul M. Martha, JR. , Christopher J. Molineaux , Alex DePaoli
发明人： Marc B. Garnick , Paul M. Martha, JR. , Christopher J. Molineaux , Alex DePaoli
IPC分类号： A61K38/08
CPC分类号： A61K38/09 , A61K47/46
摘要： Methods for treating FSH related conditions, such as prostatic intraepithelial neoplasia, pedophilia, infertility, or vaginal bleeding, with GnRH antagonists are disclosed. The methods of the invention generally feature administering to a subject a GnRH antagonist suitable for in vivo administration and able to reduce both plasma FSH and LH levels in a subject, in an amount or in a formulation effective to reduce plasma FSH levels in the subject to a symptom alleviating level. In vitro fertilization and male contraceptive methods are also provided.

10. 发明授权

US06211153B1 Methods for treating LHRH associated disorders with LHRH antagonists 失效
公开(公告)号：US06211153B1
公开(公告)日：2001-04-03
申请号：US09438718
申请日：1999-11-11
申请人： Marc B. Garnick , Christopher J. Molineaux , Malcolm L. Gefter
发明人： Marc B. Garnick , Christopher J. Molineaux , Malcolm L. Gefter
IPC分类号： A61K3800
CPC分类号： A61K38/09 , Y10S514/80 , A61K2300/00
摘要： Methods for treating prostate cancer are disclosed. The methods of the invention generally feature administration to a subject of an LHRH-R antagonist, in combination with a second therapy. In one embodiment, this second therapy is performance of a procedure that removes or destroys prostatic tumor tissue, such as a radical prostatectomy, cryosurgery or X-ray therapy (external or interstitial). In another embodiment, the second therapy is treatment with an LHRH-R agonist, either simultaneous with or subsequent to LHRH-R antagonist therapy. The methods of the invention can further involve administering an antiandrogen and/or an inhibitor of sex steroid biosynthesis to the subject in combination with the LHRH-R antagonist.

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