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1. 发明专利

GB307238A Improved process for the dyeing of vat sulphur and mineral khaki colours on fabrics 未知
公开(公告)号：GB307238A
公开(公告)日：1929-03-14
申请号：GB1667327
申请日：1928-03-23
申请人： JAMES WAKEFIELD
IPC分类号： D06P1/00 , D06P1/22 , D06P1/30

2. 发明专利

GB620527A Improvements in or relating to sheet-metal constructions in gas-turbine-engines 未知
公开(公告)号：GB620527A
公开(公告)日：1949-03-25
申请号：GB3755846
申请日：1946-12-20
申请人： JAMES WAKEFIELD
IPC分类号： F16L23/024 , F23R3/60
摘要： 620,527. Making conduits; sheetmetal joints; jointing by stamping. WAKEFIELD, J. Dec. 20, 1946, No. 37558. [Classes 83 (ii) and 83 (iv)] To avoid welding-stresses in securing a rigid end-fitting 15, Fig. 2, to a tubular sheet-metal part 10 in the manufacture of casings, jet pipes, exhaust-assemblies &c. of gas-turbineengines, the part 10 is formed with a bead or lip 17 which is inserted in an annular recess 18 formed in the fitting 15 and then one or both walls 19 of the recess is or are pressed inwardly, 119. The lip or bead may extend outwardly of the part 10 and a bead may be reinforced by a wire. The fitting may have an axial extension 23, Fig. 1, to spigot in a nozzle box 21, or a radial flange 16, Fig. 2, to be bolted to the flange of a similar fitting. In a modification a fitting may have two oppositely-directed recesses 18 to receive the beads &c. of adjacent parts 10 to be connected. The part 10 may be connected to other hollow shells as described in Specification 620,525.

3. 发明专利

GB464875A A chuck for toothed or serrated members 未知
公开(公告)号：GB464875A
公开(公告)日：1937-04-27
申请号：GB3509035
申请日：1935-12-18
申请人： JAMES WAKEFIELD
IPC分类号： B23B31/02
摘要： 464,875. Chucks. WAKEFIELD, J. Dec. 18, 1935, No. 35090. [Class 83 (iii)] In a chuck for gripping toothed or serrated work-pieces such as gear wheels, two concentric members are relatively rotatable and carry toothed parts engageable between the teeth of the work so that the relative rotation of the members will cause opposing balanced forces to grip and centre the work. ' In one form, for gripping internally toothed gears, concentric sleeves A, A , Figs. 1 and 2, carry toothed segments B, B respectively which engage between the teeth of the work C, the sleeve A being secured to the chuck body A by screws A and the sleeve A being rotatable by means of an arm D thereon and a tangential screw D in the body. A tangential spring D acting through a plunger D on the arm tends to rotate the sleeve A to the released position. In another form, for gripping an externally toothed gear G , Fig. 3, the outer sleeve F has toothed segments F between which project toothed segments F on the inner sleeve which is fixed to the body G3 by screws F . The sleeve F is rotated for gripping the work by the screw H against the action of the spring H' and the front of the chuck is completely closed by a cover plate secured by screws G'. Each tooth of the segments F , F has a central gap H to assist in centring the work, and any teeth which would extend from one segment to the adjacent one are omitted. In another modification, each sleeve carries a complete ring of teeth, the two rings lying adjacent each other, one being fixed to the body and the other rotatable by means of a screw anchored to a swivel on the body and screwing in a lug projecting from the sleeve. In each form a surface machined accurately perpendicular to the chuck axis is provided for engagement by the inner end of the work.

4. 发明专利

FR324404A 未知
公开(公告)号：FR324404A
公开(公告)日：1903-03-31
申请号：FR324404D
申请日：1902-07-28
申请人： CARVER JAMES WAKEFIELD
发明人： WAKEFIELD CARVER JAMES
IPC分类号： B27M3/30

5. 发明专利

CA76989A MACHINE FOR MAKING SPOOL BLANKS 未知
公开(公告)号：CA76989A
公开(公告)日：1902-08-05
申请号：CA76989D
申请日：1902-04-17
申请人： CARVER JAMES WAKEFIELD
发明人： CARVER JAMES WAKEFIELD

6. 发明专利

GB179429A Improvements in cutting and burnishing broaches 未知
公开(公告)号：GB179429A
公开(公告)日：1922-05-11
申请号：GB1255221
申请日：1921-05-02
申请人： JAMES WAKEFIELD , ERNEST HENRY COWGILL , ROLLS ROYCE
IPC分类号： B23D43/02
摘要： 179,429. Wakefield, J., Cowgill, E. H., and Rolls-Royce Ltd. May 2, 1921. Tools.-An adjustable broach consists of a mandrel a carrying a number of burnishing or cutting discs b, Figs. 1 and 2 respectively, of substantially conical section, separated by washers c. The mandrel is screwed at a to take a nut d , which tightens the discs against a shoulder a , thereby expanding them diametrically. A slot a is provided for securing to a machine.

7. 发明专利

GB620525A Improvements in or relating to combustion-equipment for gas-turbine-engines 未知
公开(公告)号：GB620525A
公开(公告)日：1949-03-25
申请号：GB3611846
申请日：1946-12-06
申请人： JAMES WAKEFIELD
IPC分类号： F02K1/78 , F23R3/00
摘要： 620,525. Making tubes. WAKEFIELD, J. Dec. 6, 1946, No. 36118. [Class 83 (ii)] To avoid stresses due to welding in making a flame-tube or air-casing for a gas-turbineengine, two or more tubular shells 10, 11, 12, formed from deep drawn cups, are connected by interlocking end flanges 13, 15 thereof. The shells 11 and 12 are preferably tapered and the shells 10 and 11 have inturned flanges 15 at the smaller ends, preferably formed by cutting away the centre of the bases 14. The entire base of the shell 12 and the outward flange 13 of the shell 10 may be cut away. The interlocked flanges are rolled to make them secure and gastight. An air inlet head may be secured to the section 10 and an outlet connection may be secured to the section 12 by similar joints, or as described in Specification 620,527, or by welding. The cups may be annealed before turning over the flanges and the complete casing may be plated or metal sprayed before or after or before and after rolling. Any holes necessary in the tube may be stamped out before assembling the shells. Any number of shells may be joined.

8. 发明授权

US08888900B2 Apparatus for treating gas 有权
标题翻译：用于处理气体的设备
公开(公告)号：US08888900B2
公开(公告)日：2014-11-18
申请号：US12599681
申请日：2008-05-15
申请人： Andrew James Seeley , Andrew James Wakefield
发明人： Andrew James Seeley , Andrew James Wakefield
IPC分类号： B03C3/00 , B03C3/16 , B01D53/14 , B01D47/00 , B01D47/06 , B03C3/014 , B03C3/53 , B03C3/49 , B01D47/14
CPC分类号： B03C3/014 , B01D47/14 , B01J2219/315 , B03C3/16 , B03C3/49 , B03C3/53 , B03C2201/08 , B03C2201/10
摘要： Apparatus for treating gas comprises a casing (100) containing a gas scrubber section (118) and an electrostatic precipitator section (120) located above the scrubber section. A partition (136) may be located within the casing (100) to separate the precipitator section (120) from the scrubber section (118). The casing has a gas inlet (102) for supplying gas to the scrubber section, a gas outlet (104) for exhausting gas from the precipitator section, a scrubbing liquid inlet (106) for supplying scrubbing liquid to the precipitator section, and a scrubbing liquid outlet (126) for draining scrubbing liquid from the scrubber section. In one embodiment the partition comprises a set of apertures (138) through which scrubbing liquid drains from the precipitator section into the scrubber section, and a set of gas passages (140) for conveying gas from the scrubber section to the precipitator section.
摘要翻译：用于处理气体的设备包括容纳气体洗涤器部分（118）的壳体（100）和位于洗涤器部分上方的静电除尘器部分（120）。分隔件（136）可以位于壳体（100）内，以将除尘器部分（120）与洗涤器部分（118）分离。壳体具有用于向洗涤器部分供应气体的气体入口（102），用于从沉淀器部分排出气体的气体出口（104），用于向除尘器部分供应洗涤液体的洗涤液入口（106）液体出口（126），用于从洗涤器部分排出洗涤液体。在一个实施例中，分隔件包括一组孔（138），洗涤液从该除尘器部分排出到洗涤器部分中，以及一组气体通道（140），用于将气体从洗涤器部分输送到除尘器部分。

9. 发明申请

US20120324984A1 ASSAY METHOD AND APPARATUS 审中-公开
标题翻译：测定方法和装置
公开(公告)号：US20120324984A1
公开(公告)日：2012-12-27
申请号：US13513339
申请日：2010-11-30
申请人： James Wakefield , Robert Chilcott
发明人： James Wakefield , Robert Chilcott
IPC分类号： G01N15/08
CPC分类号： G01N3/12 , G01N3/36 , G01N2013/003 , G01N2013/006 , G01N2203/0016 , G01N2203/0051
摘要： A skin sample is mounted in a diffusion cell between a receptor and a donor chamber. A substance to be tested is provided to the skin sample via the donor chamber. The diffusion cell has a driver for applying pressure variations to fluid in the receptor chamber in order to cause repeated flexing of the skin sample to simulate the behaviour of living (moving) skin.
摘要翻译：皮肤样品安装在受体和供体室之间的扩散池中。通过供体室将待测物质提供给皮肤样品。扩散池具有用于对受体室中的流体施加压力变化的驱动器，以便引起皮肤样品的反复弯曲以模拟生物（移动）皮肤的行为。

10. 发明授权

US5985242A Modulators of .beta.-amyloid peptide aggregation comprising D-amino acids 失效
标题翻译：包含D-氨基酸的β-淀粉样肽聚集体的调节剂
公开(公告)号：US5985242A
公开(公告)日：1999-11-16
申请号：US920162
申请日：1997-08-27
申请人： Mark A. Findeis , Malcolm L. Gefter , Gary Musso , Ethan R. Signer , James Wakefield , Susan Molineaux , Joseph Chin , Jung-Ja Lee , Michael Kelley , Sonja Komar-Panicucci , Christopher C. Arico-Muendel , Kathryn Phillips , Neil J. Hayward
发明人： Mark A. Findeis , Malcolm L. Gefter , Gary Musso , Ethan R. Signer , James Wakefield , Susan Molineaux , Joseph Chin , Jung-Ja Lee , Michael Kelley , Sonja Komar-Panicucci , Christopher C. Arico-Muendel , Kathryn Phillips , Neil J. Hayward
IPC分类号： A61K38/00 , C07K14/47 , A61K38/06 , A61K38/07 , A61K38/08 , C07K7/06
CPC分类号： C07K14/4711 , A61K38/00
摘要： Compounds that modulate natural .beta. amyloid peptide aggregation are provided. The modulators of the invention comprise a peptide, preferably based on a .beta. amyloid peptide, that is comprised entirely of D-amino acids. Preferably, the peptide comprises 3-5 D-amino acid residues and includes at least two D-amino acid residues independently selected from the group consisting of D-leucine, D-phenylalanine and D-valine. In a particularly preferred embodiment, the peptide is a retro-inverso isomer of a .beta. amyloid peptide, preferably a retro-inverso isomer of A.beta..sub.17-21. In certain embodiments, the peptide is modified at the amino-terminus, the carboxy-terminus, or both. Preferred amino-terminal modifying groups include cyclic, heterocyclic, polycyclic and branched alkyl groups. Preferred carboxy-terminal modifying groups include an amide group, an alkyl amide group, an aryl amide group or a hydroxy group. Pharmaceutical compositions comprising the compounds of the invention, and diagnostic and treatment methods for amyloidogenic diseases using the compounds of the invention, are also disclosed.
摘要翻译：提供调节天然β淀粉样肽聚集的化合物。本发明的调节剂包含优选基于β-淀粉样肽的肽，其完全由D-氨基酸组成。优选地，肽包含3-5个D-氨基酸残基，并且包括独立地选自D-亮氨酸，D-苯丙氨酸和D-缬氨酸的至少两个D-氨基酸残基。在特别优选的实施方案中，肽是β淀粉样蛋白肽的逆反异构体，优选Aβ17-21的逆反式异构体。在某些实施方案中，肽在氨基末端，羧基末端或两者都被修饰。优选的氨基末端修饰基团包括环状，杂环，多环和支链烷基。优选的羧基末端修饰基团包括酰胺基，烷基酰胺基，芳基酰胺基或羟基。还公开了包含本发明化合物的药物组合物，以及使用本发明化合物的淀粉样变性疾病的诊断和治疗方法。

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