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1. 发明专利

AT5588U1 未知
公开(公告)号：AT5588U1
公开(公告)日：2002-08-26
申请号：AT5762001
申请日：2001-07-19
申请人： MANFRED BERGER ZERN AT KUEHLSY
IPC分类号： H01L23/473 , F28D21/00

2. 发明授权

US08529911B2 Small Streptococcus pyogenes antigens and their use 失效
标题翻译：小型化脓性链球菌抗原及其用途
公开(公告)号：US08529911B2
公开(公告)日：2013-09-10
申请号：US12304981
申请日：2007-07-06
申请人： Andreas Meinke , Eszter Nagy , Alexander von Gabain , Manfred Berger , Beatrice Senn , Michael Schunn
发明人： Andreas Meinke , Eszter Nagy , Alexander von Gabain , Manfred Berger , Beatrice Senn , Michael Schunn
IPC分类号： A61K39/09 , C07K14/315
CPC分类号： C07K14/315 , A61K39/00
摘要： The present invention relates to a peptide consisting of one antigen of Streptococcus pyogenes (S. pyogenes) of any of the SEQ ID NOS: 1 to 7 or a functional active variant thereof, optionally further consisting of additional amino acid residue(s); a nucleic acid coding for the same; a pharmaceutical composition, especially a vaccine, comprising said peptide or said nucleic acid; an antibody or functional active fragment thereof specifically binding to the antigen; a hybridoma cell line which produces said antibody; a method for producing said antibody; a pharmaceutical composition comprising said antibody; the use of said peptide or said nucleic acid for the manufacture of a medicament for the immunization or treatment of a subject; the use of said antibody or functional fragment thereof for the manufacture of a medicament for the treatment of an infection; a method of diagnosing a S. pyogenes infection; a method for identifying a ligand capable of binding to said peptide; and the use of said peptide for the isolation and/or purification and/or identification of an interaction partner of the peptide.
摘要翻译：本发明涉及由SEQ ID NO：1至7中任一项所述的化脓性链球菌（化脓性链球菌）的一种抗原或其功能活性变体组成的肽，任选地还包含另外的氨基酸残基; 编码该核酸的核酸; 包含所述肽或所述核酸的药物组合物，特别是疫苗; 与抗原特异性结合的抗体或功能活性片段; 产生所述抗体的杂交瘤细胞系; 一种生产所述抗体的方法; 包含所述抗体的药物组合物; 所述肽或所述核酸用于制备用于免疫或治疗受试者的药物的用途; 所述抗体或其功能片段在制备用于治疗感染的药物中的用途; 一种诊断化脓性链球菌感染的方法; 用于鉴定能够结合所述肽的配体的方法; 以及所述肽用于分离和/或纯化和/或鉴定肽的相互作用配偶体的用途。

3. 发明授权

US08343510B2 Protective proteins of S. agalactiae, combinations thereof and methods of using the same 有权
标题翻译：无乳糖乳杆菌的保护性蛋白质，其组合及其使用方法
公开(公告)号：US08343510B2
公开(公告)日：2013-01-01
申请号：US12522636
申请日：2008-01-10
申请人： Beatrice Senn , Eszter Nagy , Andreas Meinke , Alexander Von Gabain , Barbara Maierhofer , Ulrike Stierschneider , Manfred Berger , Christina Neubauer , Katherine Cohen
发明人： Beatrice Senn , Eszter Nagy , Andreas Meinke , Alexander Von Gabain , Barbara Maierhofer , Ulrike Stierschneider , Manfred Berger , Christina Neubauer , Katherine Cohen
IPC分类号： A61K39/09 , C07K14/315 , C12P21/04
CPC分类号： A61K39/092 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/315 , C07K16/1275
摘要： The invention relates to a composition comprising at least two protective proteins against Streptococcus agalactiae (S. agalactiae) or functionally active variant thereof; a protective peptide against S. agalactiae; one or more nucleic acid(s) encoding the at least two proteins and/or the protective peptide; a method of producing the composition; a pharmaceutical composition, especially a vaccine, comprising the composition and/or at least one protective peptide; methods for producing antibodies; a mixture of antibodies against the at least two proteins of the composition; the use of the composition and/or at least one protective peptide and/or one or more nucleic acid(s) for the manufacture of a medicament for the immunization or treatment of a subject; methods of diagnosing a S. agalactiae infection; a method for identifying a ligand capable of binding the composition and/or at least one protective peptide; and the use of the composition and/or at least one protective peptide for the isolation and/or purification and/or identification of an interaction partner of the composition and/or peptide.
摘要翻译：本发明涉及一种组合物，其包含至少两种针对无乳链球菌（无乳链球菌）或其功能活性变体的保护性蛋白质; 针对无乳糖乳杆菌的保护性肽; 编码所述至少两种蛋白质和/或保护性肽的一种或多种核酸; 一种制备该组合物的方法; 包含该组合物和/或至少一种保护性肽的药物组合物，特别是疫苗; 生产抗体的方法; 针对组合物的至少两种蛋白质的抗体的混合物; 组合物和/或至少一种保护性肽和/或一种或多种核酸用于制备用于免疫或治疗受试者的药物的用途; 诊断无乳乳酸菌感染的方法; 用于鉴定能够结合组合物和/或至少一种保护性肽的配体的方法; 以及组合物和/或至少一种保护性肽用于分离和/或纯化和/或鉴定组合物和/或肽的相互作用配偶体的用途。

4. 发明申请

US20100166732A1 SMALL STREPTOCOCCUS PYOGENES ANTIGENS AND THEIR USE 失效
标题翻译：小肠杆菌抗原及其使用
公开(公告)号：US20100166732A1
公开(公告)日：2010-07-01
申请号：US12304981
申请日：2007-07-06
申请人： Andreas Meinke , Eszter Nagy , Alexander von Gabain , Manfred Berger , Beatrice Senn , Michael Schunn
发明人： Andreas Meinke , Eszter Nagy , Alexander von Gabain , Manfred Berger , Beatrice Senn , Michael Schunn
IPC分类号： A61K39/395 , C07K14/315 , C07H21/04 , C12N15/74 , A61K39/09 , C07K16/00 , C07K16/12 , A61K39/40 , C12N5/16 , C12P21/02 , A61K31/7088 , G01N33/53 , A61P31/04 , A61P37/04
CPC分类号： C07K14/315 , A61K39/00
摘要： The present invention relates to a peptide consisting of one antigen of Streptococcus pyogenes (S. pyogenes) of any of the SEQ ID NOS: 1 to 7 or a functional active variant thereof, optionally further consisting of additional amino acid residue(s); a nucleic acid coding for the same; a pharmaceutical composition, especially a vaccine, comprising said peptide or said nucleic acid; an antibody or functional active fragment thereof specifically binding to the antigen; a hybridoma cell line which produces said antibody; a method for producing said antibody; a pharmaceutical composition comprising said antibody; the use of said peptide or said nucleic acid for the manufacture of a medicament for the immunization or treatment of a subject; the use of said antibody or functional fragment thereof for the manufacture of a medicament for the treatment of an infection; a method of diagnosing a S. pyogenes infection; a method for identifying a ligand capable of binding to said peptide; and the use of said peptide for the isolation and/or purification and/or identification of an interaction partner of the peptide.
摘要翻译：本发明涉及由SEQ ID NO：1至7中任一项所述的化脓性链球菌（化脓性链球菌）的一种抗原或其功能活性变体组成的肽，任选地还包含另外的氨基酸残基; 编码该核酸的核酸; 包含所述肽或所述核酸的药物组合物，特别是疫苗; 与抗原特异性结合的抗体或功能活性片段; 产生所述抗体的杂交瘤细胞系; 一种生产所述抗体的方法; 包含所述抗体的药物组合物; 所述肽或所述核酸用于制备用于免疫或治疗受试者的药物的用途; 所述抗体或其功能片段在制备用于治疗感染的药物中的用途; 一种诊断化脓性链球菌感染的方法; 用于鉴定能够结合所述肽的配体的方法; 以及所述肽用于分离和/或纯化和/或鉴定肽的相互作用配偶体的用途。

5. 发明授权

US4946747A Machine element and method of making 失效
标题翻译：机器元件和制作方法
公开(公告)号：US4946747A
公开(公告)日：1990-08-07
申请号：US186589
申请日：1988-04-27
申请人： Erich Bergmann , Manfred Berger
发明人： Erich Bergmann , Manfred Berger
IPC分类号： F16C33/64 , C23C14/16 , F16C33/12 , F16C33/30 , F16H55/06
CPC分类号： F16H57/041 , C23C14/16 , F16C33/12 , F16C33/30 , F16H55/06 , F16C2204/22 , F16C2204/60 , Y10S384/912 , Y10S428/925 , Y10S428/938 , Y10T29/49693 , Y10T29/49694 , Y10T428/12486 , Y10T428/12757 , Y10T428/12924
摘要： Machine elements formed which overcome the problems associated with rolling bearings or rolling drive units, which, apart from load under rolling are simultaneously exposed to frictional load, which leads in particular zones to frictional wear. In order to keep this to a minimum the invention teaches to apply on the effected surfaces of such structural parts a coating of a friction bearing material, which, however, according to the findings of the invention must be applied with the PVD method and must have a thickness of the order of magnitude of the surface roughness of the base body; known thicker friction bearing coatings are not suitable. The invention is especially for forming gear wheels, rolling bearings, shafts, compressor screws, and rolling pistons.
摘要翻译：形成的克服与滚动轴承或滚动驱动单元相关的问题的机器元件，其除了在滚动之下的负载同时暴露于摩擦负载，这特别导致摩擦磨损。为了将本发明保持在最低限度，本发明教导了在这种结构部件的受影响的表面上施加摩擦轴承材料的涂层，然而，根据本发明的发现必须使用PVD方法并且必须具有基体的表面粗糙度的数量级的厚度; 已知的较厚的摩擦轴承涂层是不合适的。本发明特别用于形成齿轮，滚动轴承，轴，压缩机螺杆和滚动活塞。

6. 发明授权

US07101137B2 Loading means for workpieces 有权
标题翻译：工件装载方式
公开(公告)号：US07101137B2
公开(公告)日：2006-09-05
申请号：US10839416
申请日：2004-05-04
申请人： Eberhard Schwarz , Manfred Berger
发明人： Eberhard Schwarz , Manfred Berger
IPC分类号： B65H5/00
CPC分类号： B23Q7/1494 , B23Q7/14
摘要： A loading device for transporting workpieces (3) from a readiness position, preferably a workpiece transport means, to a machining unit (1) and vice versa, or between machining units, is provided with a loading portal arranged above the machining site, on which linear robots (5, 6), bent-arm robots or similar means are arranged displaceably for transporting and releasing or picking up the workpieces (3) at or from the machining unit (1). One or more tray-like catching means (7) arranged under the workpieces (3) are also arranged displaceably at the loading portal (4, 10) with the displaceable means (5, 6).
摘要翻译：用于将工件（3）从就绪位置（优选工件传送装置）输送到加工单元（1）或反之亦然或在加工单元之间的装载装置设置有设置在加工位置上方的装载门线性机器人（5,6），弯臂机器人或类似装置被布置成可移动地用于在加工单元（1）处或从加工单元（1）移动和释放或拾起工件（3）。布置在工件（3）下方的一个或多个托盘状捕获装置（7）也通过可移动装置（5,6）可移位地安装在装载入口（4,10）处。

7. 发明申请

US20130243779A1 PEPTIDES PROTECTIVE AGAINST E. FAECALIS, METHODS AND USES RELATING THERETO 审中-公开
标题翻译：抗生素的保护作用与其相关的E. FAECALIS，方法和用途
公开(公告)号：US20130243779A1
公开(公告)日：2013-09-19
申请号：US13147612
申请日：2010-02-04
申请人： Eszter Nagy , Beatrice Tschanun , Markus Hanner , Manfred Berger , Andreas Meinke , Alexander Von Gabain , Barbara Murray , Kavindra Singh
发明人： Eszter Nagy , Beatrice Tschanun , Markus Hanner , Manfred Berger , Andreas Meinke , Alexander Von Gabain , Barbara Murray , Kavindra Singh
IPC分类号： C07K14/335 , C07K16/12
CPC分类号： C07K14/335 , A61K39/012 , A61K2039/55566 , C07K16/1267 , G01N33/56916
摘要： The present invention relates to a protective peptide of Enterococcus faecalis (E. faecalis) or a functional active variant thereof, optionally further consisting of additional amino acid residue(s); a nucleic acid coding for the same; a pharmaceutical composition comprising said peptide or said nucleic acid; an antibody or functional active fragment thereof specifically binding to the antigen; a hybridoma cell line which produces said antibody; a method for producing said antibody; a pharmaceutical composition comprising said antibody; the use of said peptide or said nucleic acid for the manufacture of a medicament for the immunization or treatment of a subject; the use of said antibody or functional fragment thereof for the manufacture of a medicament for the treatment of an infection; a method of diagnosing an E. faecalis infection; and the use of said peptide for the isolation and/or purification and/or identification of an interaction partner of the peptide.
摘要翻译：本发明涉及粪肠球菌（粪肠球菌）或其功能性活性变体的保护性肽，任选地还包含另外的氨基酸残基; 编码该核酸的核酸; 包含所述肽或所述核酸的药物组合物; 与抗原特异性结合的抗体或功能活性片段; 产生所述抗体的杂交瘤细胞系; 一种生产所述抗体的方法; 包含所述抗体的药物组合物; 所述肽或所述核酸用于制备用于免疫或治疗受试者的药物的用途; 所述抗体或其功能片段在制备用于治疗感染的药物中的用途; 一种诊断粪肠球菌感染的方法; 以及所述肽用于分离和/或纯化和/或鉴定肽的相互作用配偶体的用途。

8. 发明申请

US20100263694A1 DECOATING DEVICE FOR AXIALLY SYMMETRIC COMPONENTS, PARTICULARLY FROM AIRCRAFT ENGINES 审中-公开
标题翻译：用于轴对称组件的特殊装置，特别是来自飞机发动机
公开(公告)号：US20100263694A1
公开(公告)日：2010-10-21
申请号：US12312273
申请日：2007-10-27
申请人： Thomas Uihlein , Wolfgang Eichmann , Falko Heutling , Markus Uecker , Thomas Brendel , Georgios Paronis , Anton Albrecht , Manfred Berger
发明人： Thomas Uihlein , Wolfgang Eichmann , Falko Heutling , Markus Uecker , Thomas Brendel , Georgios Paronis , Anton Albrecht , Manfred Berger
IPC分类号： B08B3/00
CPC分类号： C23G3/00 , C23F1/08 , C25F5/00
摘要： A decoating device for axially symmetric components, particularly from aircraft engines is provided, the decoating process being carried out through the use of a decoating fluid-which is brought on a localized basis into contact with the component to be decoated, a receptacle for holding the decoating fluid being provided that rotates at least about one axis of rotation, and the decoating fluid surface forming a rotation paraboloid in response to the rotation, the component(s) to be decoated on a localized basis being accommodated in the receptacle and being dipped on the radially outer side into the decoating fluid. A decoating device is thereby devised which makes it possible for radially symmetric components to be decoated in the radially outer region in a simple process.
摘要翻译：提供了一种用于轴向对称部件的脱色装置，特别是来自飞机发动机的脱色装置，其通过使用与局部基准成一体的脱色液体进行脱色处理，与脱漆部件接触，提供了旋转至少约一个旋转轴线的旋转流体，并且旋转流体表面响应于旋转而形成旋转抛物面，待局部放置的待分解的部件被容纳在容器中并被浸入径向外侧进入脱水流体。从而设计出一种可以在简单的过程中将径向对称的部件在径向外部区域中解体的装置。

9. 发明申请

US20100129388A1 PROTECTIVE PROTEINS OF S. AGALACTIAE, COMBINATIONS THEREOF AND METHODS OF USING THE SAME 有权
标题翻译： S. AGALACTIAE的保护性蛋白质，其组合及其使用方法
公开(公告)号：US20100129388A1
公开(公告)日：2010-05-27
申请号：US12522636
申请日：2008-01-10
申请人： Beatrice Senn , Eszter Nagy , Andreas Meinke , Alexander Von Gabain , Barbara Maierhofer , Ulrike Stierschneider , Manfred Berger , Christina Neubauer , Katherine Cohen
发明人： Beatrice Senn , Eszter Nagy , Andreas Meinke , Alexander Von Gabain , Barbara Maierhofer , Ulrike Stierschneider , Manfred Berger , Christina Neubauer , Katherine Cohen
IPC分类号： A61K39/09 , C07K14/00 , C07H21/04 , C12P21/02 , A61K38/16 , A61K31/7088 , C12P21/00 , C07K16/00 , G01N33/53 , C12Q1/68 , A61P31/04
CPC分类号： A61K39/092 , A61K39/00 , A61K2039/505 , A61K2039/53 , C07K14/315 , C07K16/1275
摘要： The invention relates to a composition comprising at least two protective proteins against Streptococcus agalactiae (S. agalactiae) or functionally active variant thereof; a protective peptide against S. agalactiae; one or more nucleic acid(s) encoding the at least two proteins and/or the protective peptide; a method of producing the composition; a pharmaceutical composition, especially a vaccine, comprising the composition and/or at least one protective peptide; methods for producing antibodies; a mixture of antibodies against the at least two proteins of the composition; the use of the composition and/or at least one protective peptide and/or one or more nucleic acid(s) for the manufacture of a medicament for the immunization or treatment of a subject; methods of diagnosing a S. agalactiae infection; a method for identifying a ligand capable of binding the composition and/or at least one protective peptide; and the use of the composition and/or at least one protective peptide for the isolation and/or purification and/or identification of an interaction partner of the composition and/or peptide.
摘要翻译：本发明涉及一种组合物，其包含至少两种针对无乳链球菌（无乳链球菌）或其功能活性变体的保护性蛋白质; 针对无乳糖乳杆菌的保护性肽; 编码所述至少两种蛋白质和/或保护性肽的一种或多种核酸; 一种制备该组合物的方法; 包含该组合物和/或至少一种保护性肽的药物组合物，特别是疫苗; 生产抗体的方法; 针对组合物的至少两种蛋白质的抗体的混合物; 组合物和/或至少一种保护性肽和/或一种或多种核酸用于制备用于免疫或治疗受试者的药物的用途; 诊断无乳乳酸菌感染的方法; 用于鉴定能够结合组合物和/或至少一种保护性肽的配体的方法; 以及组合物和/或至少一种保护性肽用于分离和/或纯化和/或鉴定组合物和/或肽的相互作用配偶体的用途。

10. 发明授权

US4999380A Treatment of lipoprotein disorders associated with cholesterol metabolism 失效
标题翻译：治疗与胆固醇代谢相关的脂蛋白紊乱
公开(公告)号：US4999380A
公开(公告)日：1991-03-12
申请号：US259156
申请日：1988-10-18
申请人： Manfred Berger , Daniele Spielmann , Helmut Traitler
发明人： Manfred Berger , Daniele Spielmann , Helmut Traitler
IPC分类号： A23L1/30 , A61K31/23 , A61K36/185
CPC分类号： A61K31/23 , A23L33/115 , A61K36/185 , Y10S514/824
摘要： Lipid of blackcurrant seed is employed for treating of lipoprotein disorders associated with cholesterol metabolism. Its administration to humans produces an increase of cholesterol of the high-density lipoproteins and a reduction of the cholesterol of the low-density lipoproteins.
摘要翻译：黑加仑种子的脂质用于治疗与胆固醇代谢相关的脂蛋白病症。其对人的管理产生高密度脂蛋白的胆固醇升高和低密度脂蛋白的胆固醇降低。

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