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1. 发明授权

US06531584B1 2'modified oligonucleotides 失效
标题翻译： 2'修饰的寡核苷酸
公开(公告)号：US06531584B1
公开(公告)日：2003-03-11
申请号：US09389283
申请日：1999-09-02
申请人： Phillip Dan Cook , Andrew Mamoru Kawasaki
发明人： Phillip Dan Cook , Andrew Mamoru Kawasaki
IPC分类号： C07H2104
CPC分类号： C07H21/04 , A61K31/7125 , A61K38/00 , A61K48/00 , C07H19/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H23/00 , C07J43/003 , C12N9/0069 , C12N15/111 , C12N15/113 , C12N15/1137 , C12N2310/11 , C12N2310/3125 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/333 , C12N2310/336 , C12N2310/3521 , C12N2310/3523 , C12N2310/3527 , C12N2310/3531 , C12N2310/3533 , C12Q1/68 , C12Y113/11012
摘要： Compositions and methods are provided for the treatment and diagnosis of diseases amenable to modulation of the production of selected proteins. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the 2′-deoxyfuranosyl moieties of the nucleoside unit is modified. Treatment of diseases caused by various viruses and other causative agents is provided.
摘要翻译：提供组合物和方法用于治疗和诊断适于调节所选蛋白质生产的疾病。根据优选实施方案，提供寡核苷酸和寡核苷酸类似物，其与所选择的RNA或DNA序列特异性杂交，其中核苷单元的2'-脱氧呋喃糖基部分中的至少一个被修饰。提供了治疗各种病毒和其他致病因素引起的疾病。

2. 发明授权

US06337561B1 Apparatus for stabilizing a power system adapted to generating systems 失效
标题翻译：用于稳定适于产生系统的电力系统的装置
公开(公告)号：US06337561B1
公开(公告)日：2002-01-08
申请号：US09615778
申请日：2000-07-13
申请人： Yoshinari Sudou , Akira Takeuchi , Yoshinobu Mitani , Mamoru Kawasaki , Mikihito Andou , Kaiichirou Hirayama , Yoichi Uemura , Nobuo Fukushima , Toshiaki Sogabe
发明人： Yoshinari Sudou , Akira Takeuchi , Yoshinobu Mitani , Mamoru Kawasaki , Mikihito Andou , Kaiichirou Hirayama , Yoichi Uemura , Nobuo Fukushima , Toshiaki Sogabe
IPC分类号： H02K1728
CPC分类号： H02P9/105 , H02P2101/10
摘要： A generating system having a rotating type generator to interconnect a power system in order to output power of the generator to the power system comprises a generator, an exciting circuit and an excitation control section. It also comprises short-cycle stabilizing sections for outputting a short-cycle stabilizing signal for suppressing short-cycle power fluctuations according to at least one of an electric parameter and a mechanical parameter of the generator and a long-cycle stabilizing section for outputting a long-cycle stabilizing signal for suppressing long-cycle power fluctuations having a cycle time longer than short-cycle power fluctuations according to the mechanical parameter of the generator. The outputs of the short-cycle stabilizing sections and the long-cycle stabilizing section are sent to the excitation control section.
摘要翻译：具有用于互连电力系统以将发电机的功率输出到电力系统的旋转型发电机的发电系统包括发电机，励磁电路和励磁控制部分。它还包括短周期稳定部分，用于根据发电机的电参数和机械参数中的至少一个输出用于抑制短周期功率波动的短周期稳定信号，以及用于输出长周期稳定部分的长周期稳定部分 - 循环稳定信号，用于根据发电机的机械参数抑制具有比短周期功率波动更长的周期时间的长周期功率波动。短周期稳定部分和长周期稳定部分的输出被送到励磁控制部分。

3. 发明授权

US5859221A 2'-modified oligonucleotides 失效
公开(公告)号：US5859221A
公开(公告)日：1999-01-12
申请号：US468037
申请日：1995-06-06
申请人： Phillip Dan Cook , Andrew Mamoru Kawasaki
发明人： Phillip Dan Cook , Andrew Mamoru Kawasaki
IPC分类号： A61K38/00 , A61K47/48 , A61K48/00 , C07H19/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H23/00 , C07J43/00 , C12N9/02 , C12N15/113 , C12Q1/68 , C07H21/04
CPC分类号： C12N15/113 , A61K47/48007 , C07H19/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H23/00 , C07J43/003 , C12N15/1131 , C12N15/1132 , C12N15/1133 , C12N15/1135 , C12N15/1137 , C12N15/1138 , C12N9/0069 , C12Q1/68 , C12Y113/11012 , A61K38/00 , A61K48/00 , C12N2310/3125 , C12N2310/315 , C12N2310/318 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/333 , C12N2310/336 , C12N2310/3521 , C12N2310/3523 , C12N2310/3527 , C12N2310/3531 , C12N2310/3533
摘要： Compositions and methods are provided for the treatment and diagnosis of diseases amenable to modulation of the production of selected proteins. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the 2'-deoxyfuranosyl moieties of the nucleoside unit is modified. Treatment of diseases caused by various viruses and other causative agents is provided.

4. 发明授权

US09475224B2 Injection molding machine and method for controlling injection molding machine 有权
标题翻译：注塑机及注塑机控制方法
公开(公告)号：US09475224B2
公开(公告)日：2016-10-25
申请号：US13983926
申请日：2011-04-06
申请人： Masaaki Ikarashi , Mamoru Kawasaki
发明人： Masaaki Ikarashi , Mamoru Kawasaki
IPC分类号： B29C45/18 , B29C45/67 , B29C45/76 , B29C45/82
CPC分类号： B29C45/18 , B29C45/67 , B29C45/7653 , B29C45/82 , B29C2045/826
摘要： A hydraulic supply device of an injection molding machine is provided with: a first main hydraulic power source including a first main hydraulic pump having a variable capacity and driven by a first constant rotational speed motor, and a first main discharge pipe through which working oil flows; an auxiliary hydraulic power source including an auxiliary hydraulic pump driven by a servo motor and operated at a specific capacity, an auxiliary discharge pipe through which the working oil flows, and a check valve that regulates the inflow of working oil to the auxiliary hydraulic pump; a hydraulic control unit that controls the first main hydraulic power source and the auxiliary hydraulic power source; a junction pipe at which the first main discharge pipe and the auxiliary discharge pipe join; and a switching unit that switches the supply/non-supply of working oil for a hydraulic actuator.
摘要翻译：一种注射成型机的液压供给装置，具备：第一主液压动力源，具备由第一恒定转速马达驱动的可变容量的第一主液压泵和工作油流过的第一主排出管 ; 辅助液压动力源，包括由伺服马达驱动并以特定容量运转的辅助液压泵，工作油流过的辅助排出管，以及调节工作油向辅助液压泵流入的止回阀; 液压控制单元，其控制第一主液压动力源和辅助液压动力源; 第一主排水管和辅助排出管接合的连接管; 以及切换单元，其切换用于液压致动器的工作油的供应/不供应。

5. 发明授权

US06660466B1 Di-nitrogen heterocycle compositions 有权
标题翻译：二氮杂环组合物
公开(公告)号：US06660466B1
公开(公告)日：2003-12-09
申请号：US09128036
申请日：1998-08-03
申请人： Phillip Dan Cook , Pei-Pei Kung , Andrew Mamoru Kawasaki
发明人： Phillip Dan Cook , Pei-Pei Kung , Andrew Mamoru Kawasaki
IPC分类号： C12Q100
CPC分类号： C07D295/13 , A61K31/495 , A61K31/496 , C07D261/08 , C07D277/82 , C07D295/15 , C40B40/00 , Y02A50/473 , A61K2300/00
摘要： Compositions comprising novel di-nitrogen heterocycle compounds containing at least one N-meta-substituted alkaryl group are prepared. The compounds of the present invention are useful as antibacterial and as other pharmaceutical agents and as intermediates for preparation of other pharmaceutical agents. In addition, compounds of the present invention are useful as research reagents.
摘要翻译：制备包含含有至少一个N-间位取代的烷芳基的新型二氮杂环化合物的组合物。本发明的化合物可用作抗细菌剂和其他药剂以及用于制备其它药剂的中间体。此外，本发明的化合物可用作研究试剂。

6. 发明申请

US20090198047A1 2'-Modified Oligonucleotides 审中-公开
标题翻译： 2'-修饰的寡核苷酸
公开(公告)号：US20090198047A1
公开(公告)日：2009-08-06
申请号：US11764087
申请日：2007-06-15
申请人： Phillip Dan Cook , Andrew Mamoru Kawasaki
发明人： Phillip Dan Cook , Andrew Mamoru Kawasaki
IPC分类号： C07H21/02
CPC分类号： C07H21/04 , A61K31/7125 , A61K38/00 , A61K48/00 , C07H19/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H23/00 , C07J43/003 , C12N9/0069 , C12N15/111 , C12N15/113 , C12N15/1137 , C12N2310/11 , C12N2310/3125 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/333 , C12N2310/336 , C12N2310/3521 , C12N2310/3523 , C12N2310/3527 , C12N2310/3531 , C12N2310/3533 , C12Q1/68 , C12Y113/11012
摘要： Compositions and methods are provided for the treatment and diagnosis of diseases amenable to modulation of the production of selected proteins. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the 2′-deoxyfuranosyl moieties of the nucleoside unit is modified. Treatment of diseases caused by various viruses and other causative agents is provided.
摘要翻译：提供组合物和方法用于治疗和诊断适于调节所选蛋白质生产的疾病。根据优选实施方案，提供寡核苷酸和寡核苷酸类似物，其与所选择的RNA或DNA序列特异性杂交，其中核苷单元的2'-脱氧呋喃糖基部分中的至少一个被修饰。提供了治疗各种病毒和其他致病因素引起的疾病。

7. 发明授权

US07138517B2 Sugar modified oligonucleotides 失效
公开(公告)号：US07138517B2
公开(公告)日：2006-11-21
申请号：US09996263
申请日：2001-11-28
申请人： Phillip Dan Cook , Andrew Mamoru Kawasaki
发明人： Phillip Dan Cook , Andrew Mamoru Kawasaki
IPC分类号： C07H21/04 , A61K48/00 , C12Q1/68
CPC分类号： C12N15/1138 , A61K38/00 , A61K47/51 , A61K48/00 , C07H19/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H23/00 , C07J43/003 , C12N9/0069 , C12N15/113 , C12N15/1131 , C12N15/1132 , C12N15/1133 , C12N15/1135 , C12N15/1137 , C12N2310/3125 , C12N2310/315 , C12N2310/318 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/333 , C12N2310/336 , C12N2310/3521 , C12N2310/3523 , C12N2310/3527 , C12N2310/3531 , C12N2310/3533 , C12Q1/68 , C12Q1/6813 , C12Q1/6832 , C12Q2525/125 , C12Y113/11012 , C12Q2521/319 , C12Q2525/101
摘要： Compositions and methods are provided for the treatment and diagnosis of diseases amenable to modulation of the production of selected proteins. In accordance with preferred embodiments, oligonucleotides and oligonucleotide analogs are provided which are specifically hybridizable with a selected sequence of RNA or DNA wherein at least one of the 2′-deoxyfuranosyl moieties of the nucleoside unit is modified. Treatment of diseases caused by various viruses and other causative agents is provided.

8. 发明授权

US06358931B1 Compositions and methods for modulating RNA 失效
标题翻译：用于调节RNA的组合物和方法
公开(公告)号：US06358931B1
公开(公告)日：2002-03-19
申请号：US08295744
申请日：1994-08-30
申请人： Phillip Dan Cook , Thomas Bruice , Charles John Guinosso , Andrew Mamoru Kawasaki , Richard Griffey
发明人： Phillip Dan Cook , Thomas Bruice , Charles John Guinosso , Andrew Mamoru Kawasaki , Richard Griffey
IPC分类号： C07H2107
CPC分类号： C12N15/113 , A61K38/00 , A61K48/00 , C07H19/04 , C07H19/06 , C07H19/10 , C07H19/16 , C07H19/20 , C07H21/00 , C07H23/00 , C07J43/003 , C07K14/005 , C12N9/0069 , C12N15/1137 , C12N2310/3125 , C12N2310/315 , C12N2310/32 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/333 , C12N2310/336 , C12N2310/3511 , C12N2310/3521 , C12N2310/3523 , C12N2310/3527 , C12N2310/3531 , C12N2310/3533 , C12N2740/16322 , C12Q1/68 , C12Q1/6813 , C12Y113/11012
摘要： Compositions and methods for modulating the activity of RNA are disclosed, In accordance with preferred embodiments, antisense compositions are prepared targeting reactive portions. The reactive portions preferably comprise one or two imidazole functionalities conjugated to the targeting oligonucleotide via linkers with or without intervening intercalating moieties. Therapeutics, diagnostics and research methods also are disclosed, as are synthetic nucleosides and nucleoside fragments that can be elaborated into oligonucleotides.
摘要翻译：公开了调节RNA活性的组合物和方法。根据优选实施方案，制备靶向反应部分的反义组合物。反应性部分优选包含通过具有或不具有插入插入部分的接头与靶向寡核苷酸缀合的一个或两个咪唑官能团。还公开了治疗学，诊断和研究方法，合成核苷和可以被制成寡核苷酸的核苷片段也是公开的。

9. 外观设计

USD441888S1 Portable florescent lamp 失效
标题翻译：便携式荧光灯
公开(公告)号：USD441888S1
公开(公告)日：2001-05-08
申请号：US29132610
申请日：2000-11-14
申请人： Koji Haneda , Mamoru Kawasaki , Yuriko Nagaya , Hidenori Ito
设计人： Koji Haneda , Mamoru Kawasaki , Yuriko Nagaya , Hidenori Ito

10. 发明申请

US20130313746A1 INJECTION MOLDING MACHINE AND METHOD FOR CONTROLLING INJECTION MOLDING MACHINE 有权
标题翻译：注射成型机及注射成型机的控制方法
公开(公告)号：US20130313746A1
公开(公告)日：2013-11-28
申请号：US13983926
申请日：2011-04-06
申请人： Masaaki Ikarashi , Mamoru Kawasaki
发明人： Masaaki Ikarashi , Mamoru Kawasaki
IPC分类号： B29C45/18
CPC分类号： B29C45/18 , B29C45/67 , B29C45/7653 , B29C45/82 , B29C2045/826
摘要： A hydraulic supply device of an injection molding machine is provided with: a first main hydraulic power source including a first main hydraulic pump having a variable capacity and driven by a first constant rotational speed motor, and a first main discharge pipe through which working oil flows; an auxiliary hydraulic power source including an auxiliary hydraulic pump driven by a servo motor and operated at a specific capacity, an auxiliary discharge pipe through which the working oil flows, and a check valve that regulates the inflow of working oil to the auxiliary hydraulic pump; a hydraulic control unit that controls the first main hydraulic power source and the auxiliary hydraulic power source; a junction pipe at which the first main discharge pipe and the auxiliary discharge pipe join; and a switching unit that switches the supply/non-supply of working oil for a hydraulic actuator.
摘要翻译：一种注射成型机的液压供给装置，具备：第一主液压动力源，具备由第一恒定转速马达驱动的可变容量的第一主液压泵和工作油流过的第一主排出管 ; 辅助液压动力源，包括由伺服马达驱动并以特定容量运转的辅助液压泵，工作油流过的辅助排出管，以及调节工作油向辅助液压泵流入的止回阀; 液压控制单元，其控制第一主液压动力源和辅助液压动力源; 第一主排水管和辅助排出管接合的连接管; 以及切换单元，其切换用于液压致动器的工作油的供应/不供应。

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