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1. 发明申请

WO2013066442A3 MAMMALIAN GENES AND GENE PRODUCTS INVOLVED IN INFECTION 审中-公开
标题翻译：涉及感染的MAMMALIAN基因和基因产物
公开(公告)号：WO2013066442A3
公开(公告)日：2013-07-18
申请号：PCT/US2012048507
申请日：2012-07-27
申请人： HODGE THOMAS W , MCDONALD NATALIE J , MURRAY JAMES L , SHAW MICHAEL W , RUBIN DONALD H , SANCHEZ ANTHONY
发明人： HODGE THOMAS W , MCDONALD NATALIE J , MURRAY JAMES L , SHAW MICHAEL W , RUBIN DONALD H , SANCHEZ ANTHONY
IPC分类号： A61K31/00 , A61K31/7088 , C12N15/113
CPC分类号： C07K14/47 , A61K48/005 , C12N2740/16011 , C12N2760/14111 , C12N2760/16111 , C12N2999/005 , C12Q1/18 , C12Q1/6883 , C12Q2600/156
摘要： The present disclosure relates to mammalian genes and gene products that are involved in infection or are otherwise associated with the life cycle of one or more pathogens. Disclosed herein are methods of reducing infection of a cell by a pathogen, for example to treat or prevent a pathogen infection. Exemplary pathogens include HIV-1, HIV-2, influenza A, Marburg virus and Ebola virus. The disclosure also relates to methods of identifying agents involved in pathogen infection.
摘要翻译：本公开涉及涉及感染或以其他方式与一种或多种病原体的生命周期相关的哺乳动物基因和基因产物。本文公开了减少病原体感染细胞的方法，例如治疗或预防病原体感染。示例性病原体包括HIV-1，HIV-2，甲型流感病毒，马尔堡病毒和埃博拉病毒。本公开还涉及鉴定涉及病原体感染的药剂的方法。

2. 发明申请

WO2005092924A8 RAB9A, RAB11A, AND MODULATORS THEREOF RELATED TO INFECTIOUS DISEASE 审中-公开
标题翻译： RAB9A，RAB11A及其与感染性疾病相关的调节剂
公开(公告)号：WO2005092924A8
公开(公告)日：2006-10-19
申请号：PCT/US2005006396
申请日：2005-02-24
申请人： US GOV HEALTH & HUMAN SERV , UNIV VANDERBILT , HODGE THOMAS W , MCDONALD NATALIE J , RUBIN DONALD , SHAW MICHAEL W , SANCHEZ ANTHONY , MURRAY JAMES L
发明人： HODGE THOMAS W , MCDONALD NATALIE J , RUBIN DONALD , SHAW MICHAEL W , SANCHEZ ANTHONY , MURRAY JAMES L
IPC分类号： A61K48/00 , C07K14/82 , C12N5/10 , C12N15/113 , C12N15/63
CPC分类号： C07K14/82 , A01K2217/075 , A01K2267/0337 , A61K48/00 , C12N15/113 , C12N15/1135 , C12N15/1138 , C12N2310/11 , C12N2310/121 , C12N2310/14 , G01N33/569 , G01N33/56983 , G01N2500/00 , G01N2800/26
摘要： Disclosed herein are methods of reducing infection of a cell by a pathogen, comprising decreasing activity of Rab9A or Rab11A in the cell, for example to treat or prevent a pathogen infection. Exemplary pathogens are those that use a lipid raft. The disclosure also relates to methods of identifying agents involved in pathogen infection, such as modulators of Rab9A and Rab11A.
摘要翻译：本文公开了减少病原体感染细胞的方法，包括降低细胞中Rab9A或Rab11A的活性，例如治疗或预防病原体感染。示例性病原体是使用脂筏的病原体。本公开还涉及鉴定涉及病原体感染的药物的方法，例如Rab9A和Rab11A的调节剂。

3. 发明申请

WO2006058277A3 METHOD FOR IDENTIFYING AND DESIGNING IMMUNOGENIC PEPTIDES 审中-公开
公开(公告)号：WO2006058277A3
公开(公告)日：2006-06-01
申请号：PCT/US2005/042882
申请日：2005-11-23
申请人： HEALTH RESEARCH INC. , BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , FERRONE, Soldano , IOANNIDES, Constantin , MURRAY, James, L., III , KAWANO, Kouichiro
发明人： FERRONE, Soldano , IOANNIDES, Constantin , MURRAY, James, L., III , KAWANO, Kouichiro
IPC分类号： G01N33/53
摘要： The invention provides a method for identifying peptides for use in increasing a cytotoxic T lymphocytes (CTL) response to an antigen. The method comprises the steps of comparing the amino acid sequence of the VH and/or VL portions of an anti-idiotypic monoclonal antibody to the amino acid sequence of an antigen to identify regions of homology between the Ab2 and the antigen, and to further identify and HLA binding motif in a homologous region. The identified homologous region which comprises an HLA binding motif defines a peptide sequence that is useful for stimulating a CTL response. Also provided are peptides identified by the method, and a method of using the peptides to stimulate a CTL response in an individual.

4. 发明申请

WO2006058277A2 METHOD FOR IDENTIFYING AND DESIGNING IMMUNOGENIC PEPTIDES 审中-公开
标题翻译：鉴定和设计免疫原性肽的方法
公开(公告)号：WO2006058277A2
公开(公告)日：2006-06-01
申请号：PCT/US2005042882
申请日：2005-11-23
申请人： HEALTH RESEARCH INC , FERRONE SOLDANO , IOANNIDES CONSTANTIN , MURRAY JAMES L III
发明人： FERRONE SOLDANO , IOANNIDES CONSTANTIN , MURRAY JAMES L III
IPC分类号： G01N33/53
CPC分类号： G01N33/686 , G01N33/6863 , G01N33/6878
摘要： The invention provides a method for identifying peptides for use in increasing a cytotoxic T lymphocytes (CTL) response to an antigen. The method comprises the steps of comparing the amino acid sequence of the VH and/or VL portions of an anti-idiotypic monoclonal antibody to the amino acid sequence of an antigen to identify regions of homology between the Ab2 and the antigen, and to further identify and HLA binding motif in a homologous region. The identified homologous region which comprises an HLA binding motif defines a peptide sequence that is useful for stimulating a CTL response. Also provided are peptides identified by the method, and a method of using the peptides to stimulate a CTL response in an individual.
摘要翻译：本发明提供了一种用于鉴定用于增加对抗原的细胞毒性T淋巴细胞（CTL）应答的肽的方法。该方法包括将抗独特型单克隆抗体的VH部分和/或VL部分的氨基酸序列与抗原的氨基酸序列进行比较的步骤，以鉴定Ab2与抗原之间的同源性区域，并进一步鉴定和HLA结合基序。鉴定的包含HLA结合基序的同源区定义了可用于刺激CTL应答的肽序列。还提供了通过该方法鉴定的肽以及使用肽刺激个体中CTL应答的方法。

5. 发明申请

WO2005092924A2 RAB9A, RAB11A, AND MODULATORS THEREOF RELATED TO INFECTIOUS DISEASE 审中-公开
标题翻译： RAB9A，RAB11A及其与感染性疾病相关的调节剂
公开(公告)号：WO2005092924A2
公开(公告)日：2005-10-06
申请号：PCT/US2005006396
申请日：2005-02-24
申请人： US GOV HEALTH & HUMAN SERV , UNIV VANDERBILT , HODGE THOMAS W , MCDONALD NATALIE J , RUBIN DONALD , SHAW MICHAEL W , SANCHEZ ANTHONY , MURRAY JAMES L
发明人： HODGE THOMAS W , MCDONALD NATALIE J , RUBIN DONALD , SHAW MICHAEL W , SANCHEZ ANTHONY , MURRAY JAMES L
IPC分类号： A61K48/00 , C07K14/82 , C12N15/113
CPC分类号： C07K14/82 , A01K2217/075 , A01K2267/0337 , A61K48/00 , C12N15/113 , C12N15/1135 , C12N15/1138 , C12N2310/11 , C12N2310/121 , C12N2310/14 , G01N33/569 , G01N33/56983 , G01N2500/00 , G01N2800/26
摘要： Disclosed herein are methods of reducing infection of a cell by a pathogen, for example to treat or prevent a pathogen infection. Exemplary pathogens include those that use a lipid raft. The disclosure also relates to methods of identifying agents involved in pathogen infection, such as modulators of Rab9A and Rab11A.
摘要翻译：本文公开的是减少病原体感染细胞的方法，例如治疗或预防病原体感染。示例性病原体包括使用脂筏的病原体。本公开还涉及鉴定参与病原体感染的药物的方法，例如Rab9A和Rab11A的调节剂。

6. 发明申请

WO2014160797A1 DUAL PROBE:ANTIPROBE COMPOSITIONS FOR DNA AND RNA DETECTION 审中-公开
标题翻译：双探针：用于DNA和RNA检测的抗体组合物
公开(公告)号：WO2014160797A1
公开(公告)日：2014-10-02
申请号：PCT/US2014/031898
申请日：2014-03-26
申请人： GENETAG TECHNOLOGY, INC. , SHAFER, David, A. , MURRAY, James, L. , HU, Peixu
发明人： SHAFER, David, A. , MURRAY, James, L. , HU, Peixu
IPC分类号： C12Q1/68 , C40B30/04
CPC分类号： C12Q1/6876 , C12Q1/6883 , C12Q2600/16
摘要： Provided herein are multi-probe systems and methods for amplifying and/or detecting multiple nucleic acid targets in a sample. The multi-probe systems comprise two or more probes having identical and/or different labels are used together to target two or more related signature sequences in a genus, a species, or a gene. The probes comprise one or more probe:antiprobe systems selected from iDDS probes, iDDS-2Q probes, MacMan probes, Flip probes, Universal probes, Half-Universal probes, ZIPR probes, and G-Force probes The probes are generally flanked by one set of primers, one primer, one primer-probe or two primers. The methods utilize the multi-probe systems in real time PCR analysis for facilitating the assessment and/or diagnosis of nucleic acid sequences by providing confirmation of target detection and/or by providing greater signaling per test.
摘要翻译：本文提供了用于在样品中扩增和/或检测多个核酸靶的多探针系统和方法。多探针系统包含具有相同和/或不同标记的两个或更多个探针一起用于靶向属，种或基因中的两个或多个相关特征序列。探针包括一个或多个探针：选自iDDS探针，iDDS-2Q探针，MacMan探针，Flip探针，通用探针，半通用探针，ZIPR探针和G-Force探针的探针系统。探针一般侧翼为一组引物，一个引物，一个引物探针或两个引物。该方法利用多探针系统进行实时PCR分析，以通过提供目标检测的确认和/或通过每个测试提供更大的信号来促进核酸序列的评估和/或诊断。

7. 发明申请

WO2005092924A3 RAB9A, RAB11A, AND MODULATORS THEREOF RELATED TO INFECTIOUS DISEASE 审中-公开
公开(公告)号：WO2005092924A3
公开(公告)日：2005-10-06
申请号：PCT/US2005/006396
申请日：2005-02-24
申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES, CENTERS FOR DISEASE CONTROL AND PREVENTION , VANDERBILT UNIVERSITY , HODGE, Thomas, W. , MCDONALD, Natalie, J. , RUBIN, Donald , SHAW, Michael, W. , SANCHEZ, Anthony , MURRAY, James, L.
发明人： HODGE, Thomas, W. , MCDONALD, Natalie, J. , RUBIN, Donald , SHAW, Michael, W. , SANCHEZ, Anthony , MURRAY, James, L.
IPC分类号： A61K48/00 , C07K14/82 , C12N15/11 , C12N15/63 , C12N5/10
摘要： Disclosed herein are methods of reducing infection of a cell by a pathogen, comprising decreasing activity of Rab9A or Rab11A in the cell, for example to treat or prevent a pathogen infection. Exemplary pathogens are those that use a lipid raft. The disclosure also relates to methods of identifying agents involved in pathogen infection, such as modulators of Rab9A and Rab11A.

8. 发明申请

WO2013066442A2 MAMMALIAN GENES AND GENE PRODUCTS INVOLVED IN INFECTION 审中-公开
标题翻译：哺乳动物基因和参与感染的基因产物
公开(公告)号：WO2013066442A2
公开(公告)日：2013-05-10
申请号：PCT/US2012/048507
申请日：2012-07-27
申请人： HODGE, Thomas, W. , MCDONALD, Natalie, J. , MURRAY, James, L. , SHAW, Michael, W. , RUBIN, Donald, H. , SANCHEZ, Anthony
发明人： HODGE, Thomas, W. , MCDONALD, Natalie, J. , MURRAY, James, L. , SHAW, Michael, W. , RUBIN, Donald, H. , SANCHEZ, Anthony
IPC分类号： A61K48/00
CPC分类号： C07K14/47 , A61K48/005 , C12N2740/16011 , C12N2760/14111 , C12N2760/16111 , C12N2999/005 , C12Q1/18 , C12Q1/6883 , C12Q2600/156
摘要： The present disclosure relates to mammalian genes and gene products that are involved in infection or are otherwise associated with the life cycle of one or more pathogens. Disclosed herein are methods of reducing infection of a cell by a pathogen, for example to treat or prevent a pathogen infection. Exemplary pathogens include HIV-1, HIV-2, influenza A, Marburg virus and Ebola virus. The disclosure also relates to methods of identifying agents involved in pathogen infection.
摘要翻译：本公开涉及参与感染或与一种或多种病原体的生活周期相关的哺乳动物基因和基因产物。本文公开了减少病原体感染细胞以例如治疗或预防病原体感染的方法。示例性病原体包括HIV-1，HIV-2，甲型流感病毒，马尔堡病毒和埃博拉病毒。本公开还涉及鉴定参与病原体感染的药剂的方法。

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