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1. 发明申请

WO2006058277A2 METHOD FOR IDENTIFYING AND DESIGNING IMMUNOGENIC PEPTIDES 审中-公开
标题翻译：鉴定和设计免疫原性肽的方法
公开(公告)号：WO2006058277A2
公开(公告)日：2006-06-01
申请号：PCT/US2005042882
申请日：2005-11-23
申请人： HEALTH RESEARCH INC , FERRONE SOLDANO , IOANNIDES CONSTANTIN , MURRAY JAMES L III
发明人： FERRONE SOLDANO , IOANNIDES CONSTANTIN , MURRAY JAMES L III
IPC分类号： G01N33/53
CPC分类号： G01N33/686 , G01N33/6863 , G01N33/6878
摘要： The invention provides a method for identifying peptides for use in increasing a cytotoxic T lymphocytes (CTL) response to an antigen. The method comprises the steps of comparing the amino acid sequence of the VH and/or VL portions of an anti-idiotypic monoclonal antibody to the amino acid sequence of an antigen to identify regions of homology between the Ab2 and the antigen, and to further identify and HLA binding motif in a homologous region. The identified homologous region which comprises an HLA binding motif defines a peptide sequence that is useful for stimulating a CTL response. Also provided are peptides identified by the method, and a method of using the peptides to stimulate a CTL response in an individual.
摘要翻译：本发明提供了一种用于鉴定用于增加对抗原的细胞毒性T淋巴细胞（CTL）应答的肽的方法。该方法包括将抗独特型单克隆抗体的VH部分和/或VL部分的氨基酸序列与抗原的氨基酸序列进行比较的步骤，以鉴定Ab2与抗原之间的同源性区域，并进一步鉴定和HLA结合基序。鉴定的包含HLA结合基序的同源区定义了可用于刺激CTL应答的肽序列。还提供了通过该方法鉴定的肽以及使用肽刺激个体中CTL应答的方法。

2. 发明申请

WO2002072766A2 INDUCTION OF TUMOR IMMUNITY BY VARIANTS OF FOLATE BINDING PROTEIN 审中-公开
标题翻译：通过纤维蛋白结合蛋白的变体诱导肿瘤免疫
公开(公告)号：WO2002072766A2
公开(公告)日：2002-09-19
申请号：PCT/US2002/007167
申请日：2002-03-08
申请人： BOARD OF REGENTS, UNIVERSITX OF TEXAS SYSTEM , IOANNIDES, Constantin, G. , PEOPLES, George, E.
发明人： IOANNIDES, Constantin, G. , PEOPLES, George, E.
IPC分类号： C12N
CPC分类号： C07K7/06 , A61K38/00 , A61K39/00 , A61K39/0011 , A61K39/17 , A61K2039/54 , A61K2039/545 , C07K14/47
摘要： The present invention is directed to variants of antigens comprising folate binding protein epitopes as a composition associated with providing immunity against a tumor in an individual. The variant is effective in inducing cytotoxic T-lymphocytes but preferably not to the extent that they become sensitive to silencing by elimination, such as by apoptosis, or by anergy, as in unresponsiveness.
摘要翻译：本发明涉及包含叶酸结合蛋白表位作为与个体中提供针对肿瘤的免疫相关的组合物的抗原变体。该变体在诱导细胞毒性T淋巴细胞方面是有效的，但是优选地不是通过消除如通过凋亡或无反应性的消除而变得敏感的程度，如在无应答中。

3. 发明申请

WO2008108910A3 NEGATIVE GENETIC REGULATION OF CANCER CELL RENEWAL IN SYNERGY WITH NOTCH- OR NUMB-SPECIFIC IMMUNOTHERAPY 审中-公开
标题翻译：癌症细胞再生的阴性遗传调控与Notch-或NUMB特异性免疫治疗
公开(公告)号：WO2008108910A3
公开(公告)日：2008-11-20
申请号：PCT/US2008001694
申请日：2008-02-08
申请人： UNIV TEXAS , IOANNIDES CONSTANTIN G , EICH RAYMUND F
发明人： IOANNIDES CONSTANTIN G , EICH RAYMUND F
IPC分类号： A61K39/00 , A61K39/395 , A61P35/00 , C07K16/18 , C07K16/28
CPC分类号： A61K39/0011 , C07K16/30
摘要： We disclose a method of treating a cancer in a patient by immunizing the patient against a peptide derived from a protein selected from the group consisting of Notch 1, Notch2, Notch3, and Notch4. We further disclose a composition containing a peptide as described above and a pharmaceutically-acceptable carrier. In addition, we disclose a method of treating a cancer in a patient by immunizing the patient against a peptide derived from a protein selected from the group consisting of Numbl, Numb2, Numb3, and Numb4. We also disclose a composition containing a peptide as described above and a pharmaceutically- acceptable carrier. Further, we disclose a method of treating a cancer in a patient by administering to the patient a composition comprising an antibody against a peptide derived from a protein selected from the group consisting of Notch 1, Notch2, Notch3, Notch4, Numbl, Numb2, Numb3, and Numb4.
摘要翻译：我们公开了通过使患者免受来自选自Notch1，Notch2，Notch3和Notch4的蛋白质的肽的治疗患者的癌症的方法。我们进一步公开了含有如上所述的肽和药学上可接受的载体的组合物。此外，我们公开了通过使患者免受来自选自Numbl，Numb2，Numb3和Numb4的蛋白质的肽的治疗患者的癌症的方法。我们还公开了含有如上所述的肽和药学上可接受的载体的组合物。此外，我们公开了通过向患者施用包含针对来自选自Notch1，Notch2，Notch3，Notch4，Numbl，Numb2，Numb3的蛋白质的肽的抗体的组合物来治疗患者的癌症的方法，和Numb4。

4. 发明申请

WO2008108910A2 NEGATIVE GENETIC REGULATION OF CANCER CELL RENEWAL IN SYNERGY WITH NOTCH- OR NUMB-SPECIFIC IMMUNOTHERAPY 审中-公开
标题翻译：缺血 - 或者特异性免疫治疗联合治疗癌细胞的负性遗传学调控
公开(公告)号：WO2008108910A2
公开(公告)日：2008-09-12
申请号：PCT/US2008/001694
申请日：2008-02-08
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , IOANNIDES, Constantin, G. , EICH, Raymund, F.
发明人： IOANNIDES, Constantin, G. , EICH, Raymund, F.
IPC分类号： A61K39/00 , A61P35/00 , A61K39/395 , C07K16/28 , C07K16/18
CPC分类号： A61K39/0011 , C07K16/30
摘要： We disclose a method of treating a cancer in a patient by immunizing the patient against a peptide derived from a protein selected from the group consisting of Notch 1, Notch2, Notch3, and Notch4. We further disclose a composition containing a peptide as described above and a pharmaceutically-acceptable carrier. In addition, we disclose a method of treating a cancer in a patient by immunizing the patient against a peptide derived from a protein selected from the group consisting of Numbl, Numb2, Numb3, and Numb4. We also disclose a composition containing a peptide as described above and a pharmaceutically- acceptable carrier. Further, we disclose a method of treating a cancer in a patient by administering to the patient a composition comprising an antibody against a peptide derived from a protein selected from the group consisting of Notch 1, Notch2, Notch3, Notch4, Numbl, Numb2, Numb3, and Numb4.
摘要翻译：我们公开了通过使患者免疫来自选自由Notch1，Notch2，Notch3和Notch4组成的组的蛋白质的肽来治疗患者的癌症的方法。我们还公开了含有如上所述的肽和药学上可接受的载体的组合物。此外，我们公开了一种通过使患者免疫来自选自Numb1，Numb2，Numb3和Numb4的蛋白质的肽来治疗患者的癌症的方法。我们还公开了含有如上所述的肽和药学上可接受的载体的组合物。此外，我们公开了一种治疗患者癌症的方法，其通过向患者施用包含抗来自选自由Notch1，Notch2，Notch3，Notch4，Numb1，Numb2，Numb3组成的组的蛋白质的肽的抗体，和Numb4。

5. 发明申请

WO2006058277A3 METHOD FOR IDENTIFYING AND DESIGNING IMMUNOGENIC PEPTIDES 审中-公开
公开(公告)号：WO2006058277A3
公开(公告)日：2006-06-01
申请号：PCT/US2005/042882
申请日：2005-11-23
申请人： HEALTH RESEARCH INC. , BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , FERRONE, Soldano , IOANNIDES, Constantin , MURRAY, James, L., III , KAWANO, Kouichiro
发明人： FERRONE, Soldano , IOANNIDES, Constantin , MURRAY, James, L., III , KAWANO, Kouichiro
IPC分类号： G01N33/53
摘要： The invention provides a method for identifying peptides for use in increasing a cytotoxic T lymphocytes (CTL) response to an antigen. The method comprises the steps of comparing the amino acid sequence of the VH and/or VL portions of an anti-idiotypic monoclonal antibody to the amino acid sequence of an antigen to identify regions of homology between the Ab2 and the antigen, and to further identify and HLA binding motif in a homologous region. The identified homologous region which comprises an HLA binding motif defines a peptide sequence that is useful for stimulating a CTL response. Also provided are peptides identified by the method, and a method of using the peptides to stimulate a CTL response in an individual.

6. 发明申请

WO02072766A8 INDUCTION OF TUMOR IMMUNITY BY VARIANTS OF FOLATE BINDING PROTEIN 审中-公开
标题翻译：通过纤维蛋白结合蛋白的变体诱导肿瘤免疫
公开(公告)号：WO02072766A8
公开(公告)日：2004-09-02
申请号：PCT/US0207167
申请日：2002-03-08
申请人： REGENTS UNIVERSITX OF TEXAS SY , IOANNIDES CONSTANTIN G , PEOPLES GEORGE E
发明人： IOANNIDES CONSTANTIN G , PEOPLES GEORGE E
IPC分类号： A61K9/12 , A61K9/72 , A61K39/00 , A61P35/00 , C07K7/06 , C07K14/47 , C07K14/82 , C12N
CPC分类号： C07K7/06 , A61K38/00 , A61K39/00 , A61K39/0011 , A61K39/17 , A61K2039/54 , A61K2039/545 , C07K14/47

7. 发明申请

WO2003076585A3 CONTROLLED MODULATION OF AMINO ACID SIDE CHAIN LENGTH OF PEPTIDE ANTIGENS 审中-公开
公开(公告)号：WO2003076585A3
公开(公告)日：2003-09-18
申请号：PCT/US2003/006952
申请日：2003-03-06
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , IOANNIDES, Constantin, G. , CAMPBELL, Martin, L. , O'BRIAN, Catherine, A.
发明人： IOANNIDES, Constantin, G. , CAMPBELL, Martin, L. , O'BRIAN, Catherine, A.
IPC分类号： A61K38/04
摘要： The invention provides a method for the creation of peptide antigens comprising epitopes with at least a first modification comprising a shortened or lengthened amino acid side chain. By extension or shortening of the side chain with CH3/CH2 groups, for example, made by computer assisted modeling of the tumor antigen (peptide) bound in the MHC-I-groove, immunogenicity can be improved with minimal modification of adjacent tertiary structure, thereby avoiding cross-reactivity. Provided by the invention are methods of creating such antigens, as well as methods for therapeutic or prophylactic treatment of various conditions comprising administration of the antigens.

8. 发明申请

WO2003076585A2 CONTROLLED MODULATION OF AMINO ACID SIDE CHAIN LENGTH OF PEPTIDE ANTIGENS 审中-公开
标题翻译：氨基酸拮抗剂氨基酸链长度的控制调节
公开(公告)号：WO2003076585A2
公开(公告)日：2003-09-18
申请号：PCT/US2003/006952
申请日：2003-03-06
申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , IOANNIDES, Constantin, G. , CAMPBELL, Martin, L. , O'BRIAN, Catherine, A.
发明人： IOANNIDES, Constantin, G. , CAMPBELL, Martin, L. , O'BRIAN, Catherine, A.
IPC分类号： C12N
CPC分类号： C07K7/06 , C07K14/4705
摘要： The invention provides a method for the creation of peptide antigens comprising epitopes with at least a first modification comprising a shortened or lengthened amino acid side chain. By extension or shortening of the side chain with CH3/CH2 groups, for example, made by computer assisted modeling of the tumor antigen (peptide) bound in the MHC-I-groove, immunogenicity can be improved with minimal modification of adjacent tertiary structure, thereby avoiding cross-reactivity. Provided by the invention are methods of creating such antigens, as well as methods for therapeutic or prophylactic treatment of various conditions comprising administration of the antigens.
摘要翻译：本发明提供了一种产生肽抗原的方法，其包含具有至少第一修饰的表位，所述第一修饰包含缩短或延长的氨基酸侧链。通过用CH 3 / CH 2基团延伸或缩短侧链，例如通过在MHC-1-沟槽中结合的肿瘤抗原（肽）的计算机辅助建模制备，可以通过相邻三级结构的最小修饰来改善免疫原性，从而避免交叉反应。通过本发明提供了产生这种抗原的方法，以及用于治疗或预防性治疗包括施用抗原的各种病症的方法。

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