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1. 发明申请

WO2013182217A1 QUANTIFICATION OF IMPURITIES FOR RELEASE TESTING OF PEPTIDE PRODUCTS 审中-公开
标题翻译：定量检测产品的污染物
公开(公告)号：WO2013182217A1
公开(公告)日：2013-12-12
申请号：PCT/EP2012/057771
申请日：2012-04-27
申请人： SANOFI-AVENTIS DEUTSCHLAND GMBH , VOGEL, Martin , MUELLER, Werner
发明人： VOGEL, Martin , MUELLER, Werner
IPC分类号： G01N33/68
CPC分类号： G01N33/6848
摘要： The present invention relates to a method for the quantitative determination of an impurity present in a peptide product, wherein the impurity cannot be separated from other impurities or the main product. The method particularly involves the use of high resolution mass spectrometry (MS) detection with or without high performance liquid chromatography (HPLC). The method can be used for the investigation of the quality of peptides and proteins, particularly of pharmaceutical peptides and proteins.
摘要翻译：本发明涉及定量测定肽产品中存在的杂质的方法，其中杂质不能与其他杂质或主要产物分离。该方法特别涉及使用或不使用高效液相色谱（HPLC）的高分辨率质谱（MS）检测。该方法可用于研究肽和蛋白质，特别是药物肽和蛋白质的质量。

2. 发明申请

WO2011144673A3 LONG - ACTING FORMULATIONS OF INSULINS 审中-公开
标题翻译：长效胰岛素制剂
公开(公告)号：WO2011144673A3
公开(公告)日：2012-05-03
申请号：PCT/EP2011058079
申请日：2011-05-18
申请人： SANOFI SA , BECKER REINHARD , FRICK ANNKE , BODERKE PETER , FUERST CHRISTIANE , MUELLER WERNER , TERTSCH KATRIN , WERNER ULRICH , LOOS PETRA , SCHOETTLE ISABELL
发明人： BECKER REINHARD , FRICK ANNKE , BODERKE PETER , FUERST CHRISTIANE , MUELLER WERNER , TERTSCH KATRIN , WERNER ULRICH , LOOS PETRA , SCHOETTLE ISABELL
IPC分类号： A61K38/28 , A61K9/00 , A61K9/08 , A61K31/00 , A61K38/00
CPC分类号： A61K38/28 , A61K9/0019 , A61K9/08 , A61K38/2278 , A61K38/26 , A61K47/02 , A61K47/10 , A61K47/26
摘要： The application relates to an aqueous pharmaceutical formulation comprising 200 - 1000 U/mL [equimolar to 200 -1000 IU human insulin] of insulin glargine, with the proviso that the concentration of said formulation is not 684 U/mL of insulin glargine, and its use.
摘要翻译：本申请涉及包含200-1000U / mL [等摩尔至200-1000IU人胰岛素]甘精胰岛素的水性药物制剂，条件是所述制剂的浓度不是684U / mL甘精胰岛素，其它使用。

3. 发明申请

WO2010108903A1 2,3-DIARYL- OR HETEROARYL-SUBSTITUTED 1,1,1-TRIFLUORO-2-HYDROXYPROPYL COMPOUNDS 审中-公开
标题翻译： 2,3-二取代或取代的1,1,1-三氟-2-羟基丙酸化合物
公开(公告)号：WO2010108903A1
公开(公告)日：2010-09-30
申请号：PCT/EP2010/053737
申请日：2010-03-23
申请人： F. HOFFMANN-LA ROCHE AG , HUNZIKER, Daniel , LERNER, Christian , MUELLER, Werner , OBST SANDER, Ulrike , PFLIEGER, Philippe , WALDMEIER, Pius
发明人： HUNZIKER, Daniel , LERNER, Christian , MUELLER, Werner , OBST SANDER, Ulrike , PFLIEGER, Philippe , WALDMEIER, Pius
IPC分类号： C07D213/63 , C07D235/26 , C07D263/58 , C07D265/36 , C07D285/14 , C07D317/46 , C07D317/54 , C07D401/12 , C07D413/12 , C07D455/02 , C07D498/04 , A61K31/536 , A61K31/5415 , C07C255/53 , A61P3/10
CPC分类号： C07D413/10 , C07C255/54 , C07C255/57 , C07D213/63 , C07D235/26 , C07D263/58 , C07D265/36 , C07D285/14 , C07D317/46 , C07D317/54 , C07D317/60 , C07D401/10 , C07D401/12 , C07D403/12 , C07D413/12 , C07D455/02 , C07D498/04
摘要： The present invention relates to compounds of formula (I), wherein R 1a to R 1e , R 2 , R 3 and R 5 are as defined in the description and claims and R 4 signifies a bicyclic heteroaryl group or a cyanophenyl group, as well as pharmaceutically 5 acceptable salts thereof. The compounds are glucocorticoid receptor antagonists useful for the treatment and/or prevention of diseases such as diabetes, dyslipidemia, obesity, hypertension, cardiovascular diseases, adrenal imbalance or depression.
摘要翻译：本发明涉及式（I）化合物，其中R1a至R1e，R2，R3和R5如说明书和权利要求中所定义，R4表示双环杂芳基或氰基苯基，以及其药学上可接受的盐。该化合物是可用于治疗和/或预防糖尿病，血脂异常，肥胖，高血压，心血管疾病，肾上腺不平衡或抑郁症等疾病的糖皮质激素受体拮抗剂。

4. 发明申请

WO2008071541A3 MODULE FOR A TEST DEVICE FOR TESTING CIRCUIT BOARDS 审中-公开
标题翻译： MODULE FOR测试仪，电路板检测
公开(公告)号：WO2008071541A3
公开(公告)日：2008-08-21
申请号：PCT/EP2007062888
申请日：2007-11-27
申请人： ATG LUTHER & MAELZER GMBH , GUELZOW ANDREAS , ROMANOV VIKTOR , GOLDSCHMITT VOLKER , MUELLER WERNER , DEHMEL RUEDIGER , ROTHAUG UWE
发明人： GUELZOW ANDREAS , ROMANOV VIKTOR , GOLDSCHMITT VOLKER , MUELLER WERNER , DEHMEL RUEDIGER , ROTHAUG UWE
IPC分类号： G01R1/073 , G01R31/28
CPC分类号： G01R31/2808 , G01R1/07328
摘要： The invention relates to a module (1) for a test device for testing circuit boards. Such test devices have a basic grid on which an adaptor or translator can be arranged, in order to connect contact points on the base grid to a circuit board for testing. The module comprises a support plate (2) and a contact plate. The contact plate is made from a rigid circuit board section (10), called a base grid element and at least one flexible circuit board section (17). Contact points are provided on the base grid element each forming a part of the contact points of the base grid. The base grid element is arranged on a front face of the support plate and the flexible circuit board section is bent such that at least a part of the remaining region of the contact plate is parallel to the support plate. The contact points of the base grid element are in contact with conductor tracks running in the contact plate which run from the base grid element into the flexible conductor section.
摘要翻译：本发明涉及一种用于测试印刷电路板的测试装置的模块（1）。这样的测试装置具有在其上的适配器和/或翻译可以被布置为连接用的印刷电路板的电路板的测试点的基本格的接触点被测试的基本画面。该模块具有一个支撑板（2）和一个接触板。接触板由刚性电路板部分（10）中，被称为基本栅格元件制成，并且至少一个柔性的印刷电路板部分（17）。上设置在基本光栅元件的接触点，每个成形的基本网格的接触点的一部分。基本网格元件被布置在支撑板和柔性电路板部的端部表面被弯曲，以使得至少所述接触板的剩余部分的一部分被布置成平行于支撑板。基本网格元件的接触点的每个都与其中从在柔性导体部分的基本栅格元件延伸导体轨迹延伸的接触板的电接触。

5. 发明申请

WO2006027116A2 P277 PEPTIDE FORMULATIONS OR VARIANTS THEREOF HAVING OPTIMISED STABILITY 审中-公开
标题翻译：肽P277配方或其与改进稳定性导
公开(公告)号：WO2006027116A2
公开(公告)日：2006-03-16
申请号：PCT/EP2005009223
申请日：2005-08-26
申请人： SANOFI AVENTIS DEUTSCHLAND , HOPS CAROLINE , MUELLER WERNER
发明人： HOPS CAROLINE , MUELLER WERNER
IPC分类号： A61K9/19 , A61K38/17 , A61K47/12
CPC分类号： A61K47/12 , A61K9/19 , A61K38/1709 , A61K47/26
摘要： The invention relates to p277 peptide formulations or variants thereof having optimised stability. The invention also relates to formulations containing the p277 peptide and to the variations thereof which are characterised by having increased stability during storage and transportation. The invention further relates to formulations containing the p277 peptide or the variants thereof and to a citrate buffer.
摘要翻译：肽P277或其与优化的稳定性本发明涉及一种包含所述肽P277及其变体，储存和运输过程中，其特征是具有增加的稳定性的制剂变体的制剂。因此，本发明涉及含有肽P277或其变体和柠檬酸盐缓冲剂的制剂。

6. 发明申请

WO2006013048A1 INDOLE, INDAZOLE OR INDOLINE DERIVATIVES 审中-公开
标题翻译：吲哚，吲唑或吲哚衍生物
公开(公告)号：WO2006013048A1
公开(公告)日：2006-02-09
申请号：PCT/EP2005/008142
申请日：2005-07-27
申请人： F.HOFFMANN-LA ROCHE AG , CONTE-MAYWEG, Aurelia , KUEHNE, Holger , LUEBBERS, Thomas , MAUGEAIS, Cyrille , MUELLER, Werner , PFLIEGER, Philippe
发明人： CONTE-MAYWEG, Aurelia , KUEHNE, Holger , LUEBBERS, Thomas , MAUGEAIS, Cyrille , MUELLER, Werner , PFLIEGER, Philippe
IPC分类号： C07D209/30 , A61K31/404 , A61P3/06
CPC分类号： C07D209/30
摘要： The present invention relates to compounds of formula (I), wherein -X-Y-, R l to R 11 and n are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are mediated by CETP inhibitors.
摘要翻译：本发明涉及式（I）化合物，其中-X-Y-，R

7. 发明申请

WO2005072711A3 METHOD FOR PRODUCING SORBICILLACTONE A 审中-公开
标题翻译：制备山梨糖醇A的方法A.
公开(公告)号：WO2005072711A3
公开(公告)日：2005-09-15
申请号：PCT/EP2005000923
申请日：2005-01-31
申请人： UNIV MAINZ JOHANNES GUTENBERG , UNIV WUERZBURG J MAXIMILIANS , BRINGMANN GERHARD , LANG GERHARD , GULDER TOBIAS , SCHAUMANN KARSTEN , MUELLER WERNER E G , PEROVIC-OTTSTADT SANJA , STOEHR RUEDIGER , WIESE JUTTA , SCHMALJOHANN ROLF , IMHOFF JOHANN
发明人： BRINGMANN GERHARD , LANG GERHARD , GULDER TOBIAS , SCHAUMANN KARSTEN , MUELLER WERNER E G , PEROVIC-OTTSTADT SANJA , STOEHR RUEDIGER , WIESE JUTTA , SCHMALJOHANN ROLF , IMHOFF JOHANN
IPC分类号： A61K31/343 , C07D307/83 , C12N1/38 , C12P17/04 , A61P25/00 , A61P31/00 , A61P35/00 , A61P35/02
CPC分类号： C07D307/83 , A61K31/343 , C12P17/04
摘要： The invention relates to an improved method for cultivating the fungus Penicillium chrysogenum, especially strain KIP 3201, for producing the antitumoral natural substance Sorbicillactone A of formula (I) and its derivatives in an optimized manner and in large amounts. The invention also relates to an optimized method for obtaining and purifying said substance from the fungal biomass and from the culture medium. The invention also describes the biological activity of Sorbicillactone A of formula (I) and investigations relating to the genotoxicity of the compound.
摘要翻译：存在针对真菌产黄青霉的改进的培养方法，特别是应变KIP 3201，对于优化的生产抗肿瘤天然物质sorbicillactone A的（2）以及它们的大量式（I），以及优化过程中其回收和纯化从真菌类生物质和从衍生物描述的培养基。此外，描述了山梨内酯A（2）的生物活性和该化合物的遗传毒性研究。

8. 发明申请

WO8909601A3 MONOSACCHARIDES OR POLYSACCHARIDES USED AS ANTIVIRAL AGENT 审中-公开
标题翻译：单糖或多糖用作抗病毒剂
公开(公告)号：WO8909601A3
公开(公告)日：1989-12-14
申请号：PCT/EP8900399
申请日：1989-04-13
申请人： MUELLER WERNER E G
发明人： MUELLER WERNER E G
IPC分类号： A61K31/715 , A61K39/395 , A61K31/70
CPC分类号： A61K31/7004 , A61K31/715 , A61K39/39583
摘要： Disclosure of antiviral immunoprophylactic and/or immunotherapeutic properties of natural and/or chemically modified monosaccharides or polysaccharides.
摘要翻译：披露天然和/或化学修饰的单糖或多糖的抗病毒免疫预防性和/或免疫治疗性质。

9. 发明申请

WO2011144673A2 LONG - ACTING FORMULATIONS OF INSULINS 审中-公开
标题翻译：长效胰岛素制剂
公开(公告)号：WO2011144673A2
公开(公告)日：2011-11-24
申请号：PCT/EP2011/058079
申请日：2011-05-18
申请人： SANOFI , BECKER, Reinhard , FRICK, Annke , BODERKE, Peter , FUERST, Christiane , MUELLER, Werner , TERTSCH, Katrin , WERNER, Ulrich , LOOS, Petra , SCHOETTLE, Isabell
发明人： BECKER, Reinhard , FRICK, Annke , BODERKE, Peter , FUERST, Christiane , MUELLER, Werner , TERTSCH, Katrin , WERNER, Ulrich , LOOS, Petra , SCHOETTLE, Isabell
IPC分类号： A61K38/28 , A61K9/08 , A61P5/50 , A61P3/10 , A61K9/00 , A61K38/00 , A61K31/00
CPC分类号： A61K38/28 , A61K9/0019 , A61K9/08 , A61K38/2278 , A61K38/26 , A61K47/02 , A61K47/10 , A61K47/26
摘要： The application relates to an aqueous pharmaceutical formulation comprising 200 – 1000 U/mL [equimolar to 200 –1000 IU human insulin] of insulin glargine, with the proviso that the concentration of said formulation is not 684 U/mL of insulin glargine, and its use.
摘要翻译：本申请涉及包含200-1000U / mL [等摩尔至200-1000IU人胰岛素]甘精胰岛素的水性药物制剂，条件是所述制剂的浓度不是684U / mL甘精胰岛素，其它使用。

10. 发明申请

WO2010108902A1 1,1,1-TRIFLUORO-2-HYDROXYPROPYL COMPOUNDS 审中-公开
标题翻译： 1,1,1-三氟-2-羟基丙酸化合物
公开(公告)号：WO2010108902A1
公开(公告)日：2010-09-30
申请号：PCT/EP2010/053736
申请日：2010-03-23
申请人： F. HOFFMANN-LA ROCHE AG , HUNZIKER, Daniel , LERNER, Christian , MUELLER, Werner , OBST SANDER, Ulrike , PFLIEGER, Philippe , WALDMEIER, Pius
发明人： HUNZIKER, Daniel , LERNER, Christian , MUELLER, Werner , OBST SANDER, Ulrike , PFLIEGER, Philippe , WALDMEIER, Pius
IPC分类号： C07D207/34 , C07D213/30 , C07D213/61 , C07D213/64 , C07D215/14 , C07D217/16 , C07D241/12 , C07D241/42 , C07D333/38 , C07D401/12 , C07D413/12 , C07D471/02 , A61K31/381 , A61K31/40 , A61K31/437
CPC分类号： C07D241/12 , C07D207/34 , C07D213/30 , C07D213/61 , C07D213/64 , C07D215/14 , C07D217/16 , C07D241/42 , C07D333/38 , C07D401/12 , C07D413/12 , C07D471/02
摘要： The present invention relates to compounds of formula I wherein R la to R le and R 2 to R 5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are glucocorticoid receptor antagonists useful for the treatment and/or prevention of diseases such as diabetes, dyslipidemia, obesity, hypertension, cardiovascular diseases, adrenal imbalance or depression.
摘要翻译：本发明涉及其中R 1a至Rle和R 2至R 5如在说明书和权利要求书中所定义的式I化合物及其药学上可接受的盐。该化合物是可用于治疗和/或预防糖尿病，血脂异常，肥胖症，高血压，心血管疾病，肾上腺不平衡或抑郁症等疾病的糖皮质激素受体拮抗剂。

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