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1. 发明公开

EP0815110A1 HALOGENIERTE $g(b)-CARBOLIN-DERIVATE, VERFAHREN ZU IHRER HERSTELLUNG UND VERWENDUNG DIESER SUBSTANZEN ZUR HEMMUNG DER ATMUNGSKETTE 失效
标题翻译：卤化-g（b）中的咔啉衍生物，METHOD用于生产和物质用于抑制呼吸链USE
公开(公告)号：EP0815110A1
公开(公告)日：1998-01-07
申请号：EP95935329.0
申请日：1995-10-10
申请人： Bringmann, Gerhard , Reichmann, Heinz, Neurologische Klinik und Poliklinik der Universität Würzburg , Feineis, Doris , God, Ralf , Janetzky, Bernd, Neurologische Klinik und Poliklinik der Universität Würzburg
发明人： Bringmann, Gerhard , Reichmann, Heinz, Neurologische Klinik und Poliklinik der Universität Würzburg , Feineis, Doris , God, Ralf , Janetzky, Bernd, Neurologische Klinik und Poliklinik der Universität Würzburg
IPC分类号： C07D471 , C12N9
CPC分类号： C07D471/04 , C12N9/99
摘要： The invention concerns a novel substance class of nonpolar halogenated β-carbolines having the structural formula (I), wherein the C ring has one, two or three double bonds, X means -C(Hal)3, -CH(Hal)2, -CH2(Hal) or =C(Hal)2 where Hal = F, Cl, Br or I, and the substituents R?1, R2, R3 and R4¿ have the following meanings: R1: -H, a C¿1?-C18 alkyl group (e.g. methyl, ethyl, propyl, n-butyl, iso-butyl, tert.butyl, etc.), -CH2-CH=CH2, CH2-C6H5, an acyl or aroyl group provided that R?1¿ can also be a free electron pair if nitrogen participates in the formation of a double bond; R2: -H, -COOH, -COOCH¿3?, -COOC2H5, -COOCH2-CH=CH2, -COOCH2-C6H5, -COONH2, -CO2NR2, -CH2OAc, -CH2-OH, etc.; R?3¿: H-, HO-, CH¿3?O-, C2H5O-, C6-H5CH2O-, CH3COO-, C2H5COO-, etc.; R?4¿: H-, HO-, CH¿3?O-, C2H5O-, C6H5-CH2O-, CH3COO-, C2H5COO-, etc. Synthetically produced derivatives of this substance class and also derivatives with halogenated alkyl and alkylide groups in position 1 inhibit complex I and II of the mitochondrial respiratory chain even in very low concentrations.

2. 发明公开

EP0793496A2 VERWENDUNG HALOGENIERTER $g(b)-CARBOLINE ALS MODELLSUBSTANZEN ZUR ERZEUGUNG NEURODEGENERATIVER ERKRANKUNGEN 失效
标题翻译：使用卤化-g（B）咔啉作为模型FOR产生物质神经退行性疾病
公开(公告)号：EP0793496A2
公开(公告)日：1997-09-10
申请号：EP95936988.0
申请日：1995-11-27
申请人： Bringmann, Gerhard , Wesemann, Wolfgang , Sontag, Karl-Heinz , Riederer, Peter , Rausch, Wolf-Dieter , Feineis, Doris , God, Ralf , Clement, Hans-Willi , Grote, Christoph , Gsell, Wieland , Götz, Mario E. , Zielke, Barbara
发明人： Bringmann, Gerhard , Wesemann, Wolfgang , Sontag, Karl-Heinz , Riederer, Peter , Rausch, Wolf-Dieter , Feineis, Doris , God, Ralf , Clement, Hans-Willi , Grote, Christoph , Gsell, Wieland , Götz, Mario E. , Zielke, Barbara
IPC分类号： A61K31
CPC分类号： A61K31/437
摘要： Disclosed is the use of halogenated β-carbolines to produce neurodegenerative disorders. The induction of neurodegenerative processes is performed in experimental studies using animals and using in vitro test systems (such as cell homogenates or neurone cell cultures). The aim is to shed light on the causes, origin and pathogenesis of neurodegenerative disorders such as Parkinsonism or Alzheimer's disease.

3. 发明授权

EP0793496B1 VERWENDUNG HALOGENIERTER beta-CARBOLINE ALS MODELLSUBSTANZEN ZUR ERZEUGUNG NEURODEGENERATIVER ERKRANKUNGEN 失效
标题翻译：使用卤化的β-卡博线作为模型产生物质神经退行性疾病
公开(公告)号：EP0793496B1
公开(公告)日：2000-07-05
申请号：EP95936988.5
申请日：1995-11-27
申请人： Bringmann, Gerhard , Wesemann, Wolfgang , Sontag, Karl-Heinz , Riederer, Peter , Rausch, Wolf-Dieter , Feineis, Doris , God, Ralf , Clement, Hans-Willi , Grote, Christoph , Gsell, Wieland , Götz, Mario E. , Zielke, Barbara
发明人： Bringmann, Gerhard , Wesemann, Wolfgang , Sontag, Karl-Heinz , Riederer, Peter , Rausch, Wolf-Dieter , Feineis, Doris , God, Ralf , Clement, Hans-Willi , Grote, Christoph , Gsell, Wieland , Götz, Mario E. , Zielke, Barbara
IPC分类号： A61K31/435
CPC分类号： A61K31/437
摘要： Disclosed is the use of halogenated beta -carbolines to produce neurodegenerative disorders. The induction of neurodegenerative processes is performed in experimental studies using animals and using in vitro test systems (such as cell homogenates or neurone cell cultures). The aim is to shed light on the causes, origin and pathogenesis of neurodegenerative disorders such as Parkinsonism or Alzheimer's disease.

4. 发明授权

EP0815110B1 HALOGENIERTE -CARBOLIN-DERIVATE, VERFAHREN ZU IHRER HERSTELLUNG UND VERWENDUNG DIESER SUBSTANZEN ZUR HEMMUNG DER ATMUNGSKETTE 失效
标题翻译：卤化衍生物咔啉，方法用于生产和物质用于抑制呼吸链USE
公开(公告)号：EP0815110B1
公开(公告)日：1999-04-28
申请号：EP95935329.3
申请日：1995-10-10
申请人： Bringmann, Gerhard , Reichmann, Heinz, Neurologische Klinik und Poliklinik der Universität Würzburg , Feineis, Doris , God, Ralf , Janetzky, Bernd, Neurologische Klinik und Poliklinik der Universität Würzburg
发明人： Bringmann, Gerhard , Reichmann, Heinz, Neurologische Klinik und Poliklinik der Universität Würzburg , Feineis, Doris , God, Ralf , Janetzky, Bernd, Neurologische Klinik und Poliklinik der Universität Würzburg
IPC分类号： C07D471/00 , A61K31/435
CPC分类号： C07D471/04 , C12N9/99
摘要： The invention concerns a novel substance class of nonpolar halogenated β-carbolines having the structural formula (I), wherein the C ring has one, two or three double bonds, X means -C(Hal)3, -CH(Hal)2, -CH2(Hal) or =C(Hal)2 where Hal = F, Cl, Br or I, and the substituents R?1, R2, R3 and R4¿ have the following meanings: R1: -H, a C¿1?-C18 alkyl group (e.g. methyl, ethyl, propyl, n-butyl, iso-butyl, tert.butyl, etc.), -CH2-CH=CH2, CH2-C6H5, an acyl or aroyl group provided that R?1¿ can also be a free electron pair if nitrogen participates in the formation of a double bond; R2: -H, -COOH, -COOCH¿3?, -COOC2H5, -COOCH2-CH=CH2, -COOCH2-C6H5, -COONH2, -CO2NR2, -CH2OAc, -CH2-OH, etc.; R?3¿: H-, HO-, CH¿3?O-, C2H5O-, C6-H5CH2O-, CH3COO-, C2H5COO-, etc.; R?4¿: H-, HO-, CH¿3?O-, C2H5O-, C6H5-CH2O-, CH3COO-, C2H5COO-, etc. Synthetically produced derivatives of this substance class and also derivatives with halogenated alkyl and alkylide groups in position 1 inhibit complex I and II of the mitochondrial respiratory chain even in very low concentrations.

5. 发明申请

WO2012048894A1 HYBRIDVERBINDUNGEN AUS 4- UND 8-AMINOCHINOLINEN ZUR PROPHYLAKTISCHEN UND THERAPEUTISCHEN BEHANDLUNG VON MALARIA UND ANDEREN PARASITÄREN ERKRANKUNGEN 审中-公开
标题翻译： FROM 4杂化化合物和8-氨基喹啉为疟疾和其它侵扰预防和治疗
公开(公告)号：WO2012048894A1
公开(公告)日：2012-04-19
申请号：PCT/EP2011/005173
申请日：2011-10-14
申请人： JULIUS-MAXIMILIANS-UNIVERSITÄT WÜRZBURG , RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG , BRINGMANN, Gerhard , LÖDIGE, Melanie , PRADEL, Gabriele , LEWIS, Matthew , MUELLER, Ann-Kristin , LEHMANN, Leane , SCHURIGT, Uta , MOLL, Heidrun , BRUN, Reto
发明人： BRINGMANN, Gerhard , LÖDIGE, Melanie , PRADEL, Gabriele , LEWIS, Matthew , MUELLER, Ann-Kristin , LEHMANN, Leane , SCHURIGT, Uta , MOLL, Heidrun , BRUN, Reto
IPC分类号： C07D215/42 , A61K31/4709 , A61K31/496 , A61P33/06
CPC分类号： C07D215/42
摘要： Die vorliegende Erfindung bezieht sich auf Hybridverbindungen aus 4- und 8-Aminochinolinen, Verfahren zu deren Herstellung und ihre medizinischen Verwendungen. Die vorliegende Erfindung betrifft insbesondere die prophylaktischen, kausal- und suppressivprophylaktischen sowie therapeutischen Eigenschaften der Hybridverbindungen aus der Klasse der 4- und 8-Aminochinoline auf Malaria-Erreger, Leishmanien und andere Parasiten und deren Verwendung, insbesondere als bioaktive Wirkstoffe für biotechnologische und medizinische Anwendungen.
摘要翻译：本发明涉及的4-和8-氨基喹啉杂化复合材料，其制备方法，以及它们的医疗用途。本发明特别涉及预防，以及因果和suppressivprophylaktischen上疟原虫，利什曼原虫属和其他寄生虫和它们的用途，特别是作为用于生物技术和医学应用的生物活性剂类的4-和8-氨基喹啉的的杂化化合物的治疗性质。

6. 发明申请

WO2012041493A1 AMINOQUINOLINIUM SALTS, METHODS OF THEIR PRODUCTION AND THEIR USE AS ACTIVE AGENTS FOR BIOTECHNOLOGICAL AND MEDICAL APPLICATIONS AGAINST BINARY TOXINS 审中-公开
标题翻译：氨UM UM UM TS S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S S
公开(公告)号：WO2012041493A1
公开(公告)日：2012-04-05
申请号：PCT/EP2011/004846
申请日：2011-09-28
申请人： JULIUS-MAXIMILIANS-UNIVERSITÄT WÜRZBURG , UNIVERSITÄT ULM , BRINGMANN, Gerhard , LÖDIGE, Melanie , KRONHARDT, Angelika , BEITZINGER, Christoph , BARTH, Holger , BENZ, Roland
发明人： BRINGMANN, Gerhard , LÖDIGE, Melanie , KRONHARDT, Angelika , BEITZINGER, Christoph , BARTH, Holger , BENZ, Roland
IPC分类号： C07D215/42 , C07D215/46 , C07D401/06 , A61K31/4706 , A61K31/4709 , A61P31/00
CPC分类号： C07D215/42 , C07D215/46 , C07D401/06
摘要： The present invention relates to aminoquinoline salts, their uses and to methods of synthesizing such aminoquinoline salts. Moreover, the present invention relates to compositions comprising aminoquinoline salts in accordance with the present invention. The present invention relates to bioactive compounds from the class of aminoquinoline compounds, and in particular their inhibitory effects on the binary toxins of an AB-type of a number of bacteria, such as Clostridium perfringens, Clostridium botulinum, and Bacillus anthracis. The invention also relates to the use of these aminoquinoline compounds as drugs, more particularly as drugs for the treatment of bacterial infections, even more particularly bacterial infections caused by bacteria which produce pore forming toxins of a binary type. The present invention also relates to methods of producing the compounds in accordance with the present invention.
摘要翻译：本发明涉及氨基喹啉盐，其用途和合成这种氨基喹啉盐的方法。此外，本发明涉及根据本发明的包含氨基喹啉盐的组合物。本发明涉及氨基喹啉化合物类的生物活性化合物，特别是其对许多细菌如产气荚膜梭菌，肉毒杆菌和炭疽芽孢杆菌的AB型二元毒素的抑制作用。本发明还涉及这些氨基喹啉化合物作为药物的用途，更具体地，涉及用于治疗细菌感染的药物，甚至更特别是由产生二元型成孔毒素的细菌引起的细菌感染。本发明还涉及根据本发明的化合物的制备方法。

7. 发明申请

WO2005042442A3 2-METHYLTHIO-1,4-NAPHTHOQUINONE DERIVATIVES, METHODS FOR THE PRODUCTION THEREOF, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME, AND USE THEREOF 审中-公开
标题翻译： 2-甲硫基-1,4-萘醌衍生物，用于生产它们，含有它们的用途的药物组合物
公开(公告)号：WO2005042442A3
公开(公告)日：2005-07-07
申请号：PCT/EP2004010465
申请日：2004-09-17
申请人： UNIV MAINZ JOHANNES GUTENBERG , UNIV WUERZBURG J MAXIMILIANS , MUELLER WERNER E G , THAKUR NARSHINH L , THAKUR ARACHANA N , SCHROEDER HEINZ C , LANG GERHARD , TSURUTA HIDEYUKI , BRINGMANN GERHARD
发明人： MUELLER WERNER E G , THAKUR NARSHINH L , THAKUR ARACHANA N , SCHROEDER HEINZ C , LANG GERHARD , TSURUTA HIDEYUKI , BRINGMANN GERHARD
IPC分类号： C07C323/22 , C12P11/00 , A61K31/10 , A61P31/04 , A61P35/00
CPC分类号： C07C323/22 , C12P11/00
摘要： Disclosed are the compounds 2-methylthio-1,4-naphthoquinone (MTN) and MTN derivatives of general formula (2) as well as methods for the production or isolation thereof. MTN and MTN derivatives have antitumor properties, especially antiangiogenetic properties in cell culture models while being provided with characteristics preventing/inhibiting neointimal proliferation.
摘要翻译：有化合物2-甲硫基-1,4-萘醌（MTN）和通式（2）的MTN衍生物; 所描述的，以及它们的制备或分离方法。 MTN和MTN衍生物具有在细胞培养模型的抗肿瘤，尤其是抗血管生成的属性。进一步具有MTN和MTN衍生物内膜增殖预防/抑制性质。

8. 发明申请

WO2009098082A3 ANTIINFECTIVE AND ANTITUMORAL COMPOUNDS ISOLATED FROM TROPICAL LIANAS 审中-公开
公开(公告)号：WO2009098082A3
公开(公告)日：2009-08-13
申请号：PCT/EP2009/000855
申请日：2009-02-06
申请人： JULIUS-MAXIMILIANS-UNIVERSITÄT WÜRZBURG , BRINGMANN, Gerhard , RÜDENAUER, Stefan , BRUN, Reto , IRMER, Andreas , BARGOU, Ralf , CHATTERJEE, Manik , VOSKOBOJNIK, Anastasia
发明人： BRINGMANN, Gerhard , RÜDENAUER, Stefan , BRUN, Reto , IRMER, Andreas , BARGOU, Ralf , CHATTERJEE, Manik , VOSKOBOJNIK, Anastasia
IPC分类号： C07C46/02 , C07C50/32 , A61K31/122 , A61P33/02
摘要： The present invention relates to naphthoquinone derivatives isolated from solid callus cultures from two species of the palaeotropical plant families Dioncophyllaceae and Ancistrocladaceae. It further relates to methods of their production as well as to their use as antiinfective and antitumoral pharmaceuticals.

9. 发明申请

WO2005003085A2 TAJIXANTHONE HYDRATE AND TAJIXANTHONE HYDRATE DERIVATIVES, BIOLOGICAL ACTIVITIES THEREOF, AND USE THEREOF 审中-公开
标题翻译： TAJIXANTHONHYDRAT和TAJIXANTHONHYDRAT衍生物，它们的生物活性及其用途
公开(公告)号：WO2005003085A2
公开(公告)日：2005-01-13
申请号：PCT/EP2004007238
申请日：2004-07-02
申请人： UNIV WUERZBURG J MAXIMILIANS , UNIV MAINZ JOHANNES GUTENBERG , STIFTUNG A WEGENER INST POLAR , BRINGMANN GERHARD , HENTSCHEL UTE , ZIEBUHR WILMA , KOZITSKAYA SVETLANA , LANG GERHARD , SCHAUMANN KARSTEN , STEFFENS STEFAN , MUELLER WERNER E G
发明人： BRINGMANN GERHARD , HENTSCHEL UTE , ZIEBUHR WILMA , KOZITSKAYA SVETLANA , LANG GERHARD , SCHAUMANN KARSTEN , STEFFENS STEFAN , MUELLER WERNER E G
IPC分类号： A61K31/352 , C07D311/86 , C07D493/04 , C07D
CPC分类号： C07D493/04 , A61K31/352 , C07D311/86
摘要： Disclosed are tajixanthone hydrate and tajixanthone hydrate derivatives of general formula (1) as well as a method for the production thereof. Tajixanthone hydrate has a distinctive biofilm-inhibiting effect against Staphylococcus epidermis.
摘要翻译：下面将描述通式（1）和用于它们的制备方法的Tajixanthonhydrat和Tajixanthonhydrat衍生物。 Tajixanthonhydrat具有抗表皮葡萄球菌有明显的生物膜抑制活性。

10. 发明申请

WO1996011197A1 HALOGENATED 'beta'-CARBOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND USE OF THESE SUBSTANCES FOR INHIBITING THE RESPIRATORY CHAIN 审中-公开
标题翻译：卤化的β咔啉衍生物，方法用于生产和物质用于抑制呼吸链USE
公开(公告)号：WO1996011197A1
公开(公告)日：1996-04-18
申请号：PCT/DE1995001403
申请日：1995-10-10
申请人： BRINGMANN, Gerhard , REICHMANN, Heinz , FEINEIS, Doris , GOD, Ralf , JANETZKY, Bernd
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , C12N9/99
摘要： The invention concerns a novel substance class of nonpolar halogenated beta -carbolines having the structural formula (I), wherein the C ring has one, two or three double bonds, X means -C(Hal)3, -CH(Hal)2, -CH2(Hal) or =C(Hal)2 where Hal = F, Cl, Br or I, and the substituents R , R , R and R have the following meanings: R : -H, a C1-C18 alkyl group (e.g. methyl, ethyl, propyl, n-butyl, iso-butyl, tert.butyl, etc.), -CH2-CH=CH2, CH2-C6H5, an acyl or aroyl group provided that R can also be a free electron pair if nitrogen participates in the formation of a double bond; R : -H, -COOH, -COOCH3, -COOC2H5, -COOCH2-CH=CH2, -COOCH2-C6H5, -COONH2, -CO2NR2, -CH2OAc, -CH2-OH, etc.; R : H-, HO-, CH3O-, C2H5O-, C6-H5CH2O-, CH3COO-, C2H5COO-, etc.; R : H-, HO-, CH3O-, C2H5O-, C6H5-CH2O-, CH3COO-, C2H5COO-, etc. Synthetically produced derivatives of this substance class and also derivatives with halogenated alkyl and alkylide groups in position 1 inhibit complex I and II of the mitochondrial respiratory chain even in very low concentrations.
摘要翻译：有一类新的非极性的，呈现卤化的β-咔啉，其具有结构式（I），其中一个，两个或三个双键存在于环C，X是-C（哈尔）3，-CH（哈尔）2 ，-CH 2（HAL）或= C（哈尔）2其中Hal = F，氯，溴，我有，和取代基R <1>，R <2>，R <3>和R <4>其中下面的含义有，R <1>：-H，一个C1-C18烷基（例如甲基，乙基，丙基，正丁基，异丁基，叔丁基等），-CH2-CH = CH2，CH2-C6H5 ，酰基或芳酰基，条件是R <1>也可以是自由电子对当氮参与双键，R的形成<2>：-H，-COOH，-COOCH 3，-COOC 2 H 5 ，-COOCH 2 CH = CH 2，-COOCH 2 C 6 H 5，-COONH 2，-CO2NR2，-CH2OAc，-CH 2 OH，等; [R <3>：H-，HO-，CH 3 O-，C2H5O-，C6-H5CH2O-，CH3COO-，C2H5COO-等; [R <4>：H-，HO-，CH 3 O-，C2H5O-，C6H5-CH 2 O-，CH 3 COO - ，C2H5COO-衍生物等合成产生的这类物质，以及与卤代烷基和亚烷基衍生物在1- 位置时，使得所述复合物I或线粒体呼吸链的II的抑制在非常低的浓度。

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