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1. 发明申请

WO2009158585A3 ESTIMATING HEALTHCARE OUTCOMES FOR INDIVIDUALS 审中-公开
标题翻译：估计个人健康成就
公开(公告)号：WO2009158585A3
公开(公告)日：2010-04-22
申请号：PCT/US2009048803
申请日：2009-06-26
申请人： ARCHIMEDES INC , MORRIS MACDONALD
发明人： MORRIS MACDONALD
IPC分类号： G06Q50/00
CPC分类号： G06Q40/08 , G06F19/325 , G06F19/328 , G06F19/3437 , G06Q10/10 , G06Q50/22 , G06Q50/24 , G16H50/50
摘要： A method and apparatus for predicting a health benefit for an individual is provided. Outcomes from a first simulation on a set of simulated individuals reflecting a population are stored and used to determine a first risk function and corresponding cost values. Outcomes from a second simulation on a set of simulated individuals reflecting having a healthcare intervention are stored and used to determine a second risk function reflecting the intervention and corresponding cost values of the intervention. A benefit function is derived from the difference of the first and second risk functions. A cost function that describes the cost of the intervention is derived from the respective cost values. The derived benefit function and cost function are used to predict the corresponding benefit and cost of the healthcare intervention for a given individual. Individuals can be ranked by degree of expected benefit.
摘要翻译：提供了一种用于预测个体的健康益处的方法和装置。存储一组反映人口的模拟个体的第一次模拟的结果，并用于确定第一风险函数和相应的成本值。存储用于反映具有医疗保健干预的一组模拟个体的第二模拟的结果并用于确定反映干预的干预和相应成本值的第二风险函数。利益函数来源于第一和第二风险函数的差异。描述干预成本的成本函数是从各自的成本值得出的。衍生的福利函数和成本函数用于预测给定个人的医疗干预的相应收益和成本。个人可以按预期收益程度排列。

2. 发明申请

WO2004042346A3 METHODS AND COMPOSITIONS FOR DIAGNOSING AND MONITORING TRANSPLANT REJECTION 审中-公开
标题翻译：用于诊断和监测移植物排斥的方法和组合物
公开(公告)号：WO2004042346A3
公开(公告)日：2005-11-24
申请号：PCT/US0312946
申请日：2003-04-24
申请人： EXPRESSION DIAGNOSTICS INC , WOHLGEMUTH JAY , FRY KIRK , WOODWARD ROBERT , LY NGOC , PRENTICE JAMES , MORRIS MACDONALD , ROSENBERG STEVEN
发明人： WOHLGEMUTH JAY , FRY KIRK , WOODWARD ROBERT , LY NGOC , PRENTICE JAMES , MORRIS MACDONALD , ROSENBERG STEVEN
IPC分类号： C12N15/09 , C07H21/00 , C12N15/12 , C12P19/34 , C12Q20060101 , C12Q1/00 , C12Q1/04 , C12Q1/68 , G01N20060101 , G01N1/00 , G01N24/08 , G01N33/53 , G01N33/564 , G01N33/567
CPC分类号： C12Q1/6883 , C12Q1/6881 , C12Q1/6888 , C12Q2600/158 , G01N33/564 , G01N33/6863 , G01N2800/245
摘要： Methods of diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection and kits or systems containing the same are also described.
摘要翻译：描述了通过检测患者中一种或多种基因的表达水平来诊断或监测患者中移植排斥，特别是心脏移植排斥的方法。还描述了用于诊断或监测移植排斥反应的诊断性寡核苷酸，特别是心脏移植排斥反应及其含有该移植排斥反应的试剂盒或系统。

3. 发明申请

WO1997039151A1 PHOTOLABILE POLYMER ARRAY SYNTHESIS METHODS 审中-公开
标题翻译：可溶性聚合物阵列合成方法
公开(公告)号：WO1997039151A1
公开(公告)日：1997-10-23
申请号：PCT/US1997006535
申请日：1997-04-16
申请人： AFFYMETRIX, INC. , GOLDBERG, Martin , DIGGELMAN, Martin , HUBBELL, Earl , MCGALL, Glenn , NGO, Nam, Quoc , MORRIS, Macdonald , YAMAMOTO, Mel , TAN, Jennifer , RAVA, Richard, P.
发明人： AFFYMETRIX, INC.
IPC分类号： C12Q01/68
CPC分类号： C07K1/047 , B01J19/0046 , B01J2219/00432 , B01J2219/00527 , B01J2219/00529 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00621 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00689 , B01J2219/00711 , B01J2219/00722 , B01J2219/00725 , B82Y30/00 , C07B2200/11 , C07H21/00 , C40B40/06 , C40B40/10 , C40B60/14 , Y02P20/55 , Y10S436/809
摘要： The present invention provides novel processes for the large scale preparation of arrays of polymer sequences wherein each array includes a plurality of different, positionally distinct polymer sequences having known monomer sequences. The methods of the invention combine high throughput process steps with high resolution photolithographic techniques in the manufacture of polymer arrays.
摘要翻译：本发明提供了用于大规模制备聚合物序列阵列的新方法，其中每个阵列包括具有已知单体序列的多个不同的位置不同的聚合物序列。本发明的方法将高通量处理步骤与高分辨率光刻技术结合在聚合物阵列的制造中。

4. 发明申请

WO2011056757A3 USING DATA IMPUTATION TO DETERMINE AND RANK OF RISKS OF HEALTH OUTCOMES 审中-公开
标题翻译：使用数据推算确定和排除健康危害的风险
公开(公告)号：WO2011056757A3
公开(公告)日：2011-09-09
申请号：PCT/US2010055010
申请日：2010-11-01
申请人： ARCHIMEDES INC , MORRIS MACDONALD , LUCAS DONALD
发明人： MORRIS MACDONALD , LUCAS DONALD
IPC分类号： G06F19/00
CPC分类号： G06Q10/10 , G06Q50/24 , G16H50/30
摘要： Apparatus may be configured to receive a patient record for the patient from a database of a data storage unit, wherein demographic data values or biometric data values in the patient record are missing or have null values; create clone patient records in the database; impute different substitute demographic data values or biometric data values and substitute different substitute values into the clone patient records; determine, create and store a first metric, based on the clone patient records, wherein the first metric comprises a current health related metric for the patient; determine, create and store medical intervention metrics, each based on an associated medical intervention and the clone patient records, representing a predicted health related metric for the patient when the associated medical intervention is performed; transform the database by updating the patient record to include the first metric and the medical intervention metrics.
摘要翻译：装置可以被配置为从数据存储单元的数据库接收患者的患者记录，其中患者记录中的人口统计学数据值或生物特征数据值丢失或具有空值; 在数据库中创建克隆患者记录; 补充不同的替代人口统计数据值或生物特征数据值，并将不同的替代值替换为克隆患者记录; 基于所述克隆患者记录来确定，创建和存储第一度量，其中所述第一度量包括所述患者的当前健康相关度量; 确定，创建和存储医疗干预指标，每个基于相关联的医疗干预和克隆患者记录，表示在执行相关医疗干预时患者预测的与健康相关的度量; 通过更新患者记录来转换数据库，以包括第一度量和医疗干预度量。

5. 发明申请

WO2011056757A2 USING DATA IMPUTATION TO DETERMINE AND RANK OF RISKS OF HEALTH OUTCOMES 审中-公开
标题翻译：用数据推导来确定健康结果的风险和排名
公开(公告)号：WO2011056757A2
公开(公告)日：2011-05-12
申请号：PCT/US2010/055010
申请日：2010-11-01
申请人： ARCHIMEDES, INC. , MORRIS, Macdonald , LUCAS, Donald
发明人： MORRIS, Macdonald , LUCAS, Donald
IPC分类号： G06F19/00
CPC分类号： G06Q10/10 , G06F19/00 , G06Q50/24 , G16H50/30
摘要： Apparatus may be configured to receive a patient record for the patient from a database of a data storage unit, wherein demographic data values or biometric data values in the patient record are missing or have null values; create clone patient records in the database; impute different substitute demographic data values or biometric data values and substitute different substitute values into the clone patient records; determine, create and store a first metric, based on the clone patient records, wherein the first metric comprises a current health related metric for the patient; determine, create and store medical intervention metrics, each based on an associated medical intervention and the clone patient records, representing a predicted health related metric for the patient when the associated medical intervention is performed; transform the database by updating the patient record to include the first metric and the medical intervention metrics.
摘要翻译：装置可以被配置为从数据存储单元的数据库接收患者的患者记录，其中患者记录中的人口统计数据值或生物统计数据值缺失或具有空值; 在数据库中创建克隆患者记录; 归纳不同的替代人口统计数据值或生物统计学数据值，并将不同的替代值替换为克隆病人记录; 基于所述克隆患者记录来确定，创建和存储第一度量，其中所述第一度量包括所述患者的当前健康相关度量; 确定，创建和存储医疗干预度量，每个医疗干预度量基于相关联的医疗干预和克隆患者记录，表示当执行相关联的医学干预时针对患者的预测的健康相关度量; 通过更新患者记录来转换数据库，以包含第一个指标和医疗干预指标。

6. 发明申请

WO9830883A2 ANALYSIS OF GENETIC POLYMORPHISMS AND GENE COPY NUMBER 审中-公开
标题翻译：遗传多态性分析及遗传复制数
公开(公告)号：WO9830883A2
公开(公告)日：1998-07-16
申请号：PCT/US9806414
申请日：1998-01-02
申请人： AFFYMETRIX INC , CRONIN MAUREEN T , MIYADA CHARLES G , HUBBELL EARL A , CHEE MARK , FODOR STEPHEN P A , HUANG XIAOHUA C , LIPSHUTZ ROBERT J , LOBBAN PETER E , MORRIS MACDONALD S , SHELDON EDWARD L
发明人： CRONIN MAUREEN T , MIYADA CHARLES G , HUBBELL EARL A , CHEE MARK , FODOR STEPHEN P A , HUANG XIAOHUA C , LIPSHUTZ ROBERT J , LOBBAN PETER E , MORRIS MACDONALD S , SHELDON EDWARD L
IPC分类号： B01J19/00 , C07B61/00 , C07H21/00 , C12Q1/68 , C40B40/06 , C40B60/14 , G01N
CPC分类号： B01J19/0046 , B01J2219/00432 , B01J2219/00529 , B01J2219/00605 , B01J2219/00608 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00644 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , B82Y30/00 , C07B2200/11 , C07H21/00 , C12Q1/6827 , C12Q1/6837 , C12Q1/6874 , C12Q1/6876 , C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C40B40/06 , C40B60/14 , C12Q2565/513
摘要： The invention provides methods for detecting variations in polymorphic sites and/or variations in gene copy number. The methods are particularly useful for analysis of biotransformation genes, such as cytochromes P450.
摘要翻译：本发明提供了用于检测多态位点变异和/或基因拷贝数变异的方法。该方法对生物转化基因如细胞色素P450的分析特别有用。

7. 发明申请

WO2010138640A3 HEALTHCARE QUALITY MEASUREMENT 审中-公开
标题翻译：健康质量测量
公开(公告)号：WO2010138640A3
公开(公告)日：2011-03-03
申请号：PCT/US2010036266
申请日：2010-05-26
申请人： ARCHIMEDES INC , EDDY DAVID M , ADLER JOSHUA , MORRIS MACDONALD SCOTT
发明人： EDDY DAVID M , ADLER JOSHUA , MORRIS MACDONALD SCOTT
IPC分类号： G06Q50/00
CPC分类号： G06Q50/22 , G16H40/20
摘要： A method of determining a quality of care provided by a healthcare provider to individuals in a population is provided. A data processing apparatus that has one or more processors is disclosed. Data representing biomarkers for individuals in a population is received. Baseline and present risks are determined. Risk reduction values are determined. Based on the current risk reduction, a quality score is determined. A scale is created, and the quality score is mapped to the scale. The global quality score of the disclosure provides numerous benefits over past performance measures.
摘要翻译：提供了一种确定由医疗保健提供者向个体提供的护理质量的方法。公开了具有一个或多个处理器的数据处理装置。收到代表人群中个体生物标志物的数据。确定基线和现有风险。确定风险降低值。根据目前的风险降低，确定质量得分。创建一个比例，并将质量得分映射到比例。披露的全球质量得分比以往的绩效指标提供了许多好处。

8. 发明申请

WO2009158585A2 ESTIMATING HEALTHCARE OUTCOMES FOR INDIVIDUALS 审中-公开
标题翻译：估计个人健康成就
公开(公告)号：WO2009158585A2
公开(公告)日：2009-12-30
申请号：PCT/US2009/048803
申请日：2009-06-26
申请人： ARCHIMEDES, INC. , MORRIS, MacDonald
发明人： MORRIS, MacDonald
IPC分类号： G06Q50/00
CPC分类号： G06Q40/08 , G06F19/00 , G06F19/325 , G06F19/328 , G06Q10/10 , G06Q50/22 , G06Q50/24 , G16H50/50
摘要： A method and apparatus for predicting a health benefit for an individual is provided. Outcomes from a first simulation on a set of simulated individuals reflecting a population are stored and used to determine a first risk function and corresponding cost values. Outcomes from a second simulation on a set of simulated individuals reflecting having a healthcare intervention are stored and used to determine a second risk function reflecting the intervention and corresponding cost values of the intervention. A benefit function is derived from the difference of the first and second risk functions. A cost function that describes the cost of the intervention is derived from the respective cost values. The derived benefit function and cost function are used to predict the corresponding benefit and cost of the healthcare intervention for a given individual. Individuals can be ranked by degree of expected benefit.
摘要翻译：提供了一种用于预测个体的健康益处的方法和装置。存储一组反映人口的模拟个体的第一次模拟的结果，并用于确定第一风险函数和相应的成本值。存储用于反映具有医疗保健干预的一组模拟个体的第二模拟的结果并用于确定反映干预的干预和相应成本值的第二风险函数。利益函数来源于第一和第二风险函数的差异。描述干预成本的成本函数是从各自的成本值得出的。衍生的福利函数和成本函数用于预测给定个人的医疗干预的相应收益和成本。个人可以按预期收益程度排列。

9. 发明申请

WO2004042346A2 METHODS AND COMPOSITIONS FOR DIAGNOSING AND MONITORING TRANSPLANT REJECTION 审中-公开
标题翻译：用于诊断和监测移植物排斥的方法和组合物
公开(公告)号：WO2004042346A2
公开(公告)日：2004-05-21
申请号：PCT/US2003/012946
申请日：2003-04-24
申请人： EXPRESSION DIAGNOSTICS, INC. , WOHLGEMUTH, Jay , FRY, Kirk , WOODWARD, Robert , LY, Ngoc , PRENTICE, James , MORRIS, MacDonald , ROSENBERG, Steven
发明人： WOHLGEMUTH, Jay , FRY, Kirk , WOODWARD, Robert , LY, Ngoc , PRENTICE, James , MORRIS, MacDonald , ROSENBERG, Steven
IPC分类号： G01N
CPC分类号： C12Q1/6883 , C12Q1/6881 , C12Q1/6888 , C12Q2600/158 , G01N33/564 , G01N33/6863 , G01N2800/245
摘要： Methods of diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection and kits or systems containing the same are also described.
摘要翻译：描述了通过检测患者中一种或多种基因的表达水平来诊断或监测患者中移植排斥，特别是心脏移植排斥的方法。还描述了用于诊断或监测移植排斥反应的诊断性寡核苷酸，特别是心脏移植排斥反应及其含有该移植排斥反应的试剂盒或系统。

10. 发明申请

WO1995011995A1 ARRAYS OF NUCLEIC ACID PROBES ON BIOLOGICAL CHIPS 审中-公开
标题翻译：核酸探针在生物科学领域的阵列
公开(公告)号：WO1995011995A1
公开(公告)日：1995-05-04
申请号：PCT/US1994012305
申请日：1994-10-26
申请人： AFFYMAX TECHNOLOGIES N.V. , CHEE, Mark , CRONIN, Maureen, T. , FODOR, Stephen, P., A. , GINGERAS, Thomas, R. , HUANG, Xiaohua, C. , HUBBELL, Earl, A. , LIPSHUTZ, Robert, J. , LOBBAN, Peter, E. , MIYADA, Charles, Garrett , MORRIS, MacDonald, S. , SHAH, Nila , SHELDON, Edward, L.
发明人： AFFYMAX TECHNOLOGIES N.V.
IPC分类号： C12Q01/68
CPC分类号： B82Y30/00 , B01J2219/00432 , B01J2219/00529 , B01J2219/00608 , B01J2219/00626 , B01J2219/00659 , B01J2219/00711 , B01J2219/00722 , C07B2200/11 , C07H21/00 , C12Q1/6837 , C12Q1/6874 , C40B40/06 , C40B60/14 , C12Q2525/197 , C12Q2525/161
摘要： The invention provides chips of immobilized probes, and methods employing the chips, for comparing a reference polynucleotide sequence of known sequence with a target sequence showing substantial similarity with the reference sequence, but differing in the presence of e.g., mutations.
摘要翻译：本发明提供了固定化探针的芯片，以及使用该芯片的方法，用于将已知序列的参考多核苷酸序列与显示与参考序列基本相似的靶序列进行比较，但在例如突变的存在下不同。

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