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1. 发明申请

WO2006108760A3 ADSORBENTS COMPRISING ANTHRAQUINONE DYE-LIGANDS FOR THE SEPARATION OF BIOLOGICAL MATERIALS 审中-公开
标题翻译：包含用于分离生物材料的蒽醌衍生物的吸附剂
公开(公告)号：WO2006108760A3
公开(公告)日：2007-07-19
申请号：PCT/EP2006061121
申请日：2006-03-29
申请人： CIBA SC HOLDING AG , EKKUNDI VADIRAJ SUBBANNA , PUNEKAR NARAYAN S , FONDEKAR KAMALESH PAI , ROENTGEN GEORG , KORDE SHILPA S , SHINDE AJIT B , MOORTHY MASANA
发明人： EKKUNDI VADIRAJ SUBBANNA , PUNEKAR NARAYAN S , FONDEKAR KAMALESH PAI , ROENTGEN GEORG , KORDE SHILPA S , SHINDE AJIT B , MOORTHY MASANA
IPC分类号： C09B1/20 , C09B1/26 , C09B62/04
CPC分类号： C09B69/101 , C09B62/06
摘要： A process for the separation of biological materials, wherein an adsorbent is used, which comprises a reaction product of a compound of formula and a substrate having a group capable of reaction with a reactive group in said compound of formula (1) to form a covalent bond, in which B is C 2 -C 12 alkylene radical, which can be interrupted by 1, 2 or 3 members from the group consisting of -NR 1 - or -O- and is unsubstituted or substituted by hydroxyl, sulfo, sulfato, cyano or carboxyl, R 1 is hydrogen or C 1 -C 4 alkyl, or B is a C 5 -C 9 cycloalkylene radical, C 1 -C 4 alkylene-C 5 -C 9 cycloalkylene radical or C 1 -C 4 alkylene-C 5 -C 9 cycloalkylene-C 1 -C 4 alkylene radical, which are unsubstituted or substituted by C 1 -C 4 alkyl, C 1 -C 4 alkoxy, sulfo, halogen or carboxyl, or a phenylene radical, C 1 -C 4 alkylene-phenylene radical or C 1 -C 4 alkylene-phenylene-C 1 -C 4 alkylene radical, which are unsubstituted or substituted by C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 2 -C 4 alkanoylamino, sulfo, halogen or carboxyl, V is a non-fibre-reactive substituent or is a fibre-reactive substituent of formula wherein R 2 is hydrogen or unsubstituted or substituted C 1 -C 4 alkyl or a radical , R 3 is hydrogen, hydroxy, sulfo, sulfato, carboxy, cyano, halogen, C 1 -C 4 alkoxycarbonyl, C 1 -C 4 - alkanoyloxy, carbamoyl or a group -SO 2 -Y, R 4 is hydrogen or C 1 -C 4 alkyl, alk and alk 1 are each independently of the other linear or branched C 1 -C 6 alkylene, arylene is a phenylene or naphthylene radical which is unsubstituted or substituted by sulfo, carboxy, hydroxy, C 1 -C 4 alkyl, C 1 -C 4 alkoxy or by halogen, Y is vinyl or a radical -CH 2 -CH 2 -U and U is a leaving group, Y 1 is a group -CH(Hal)-CH 2 (Hal) or -C(Hal)=CH 2 wherein Hal is chlorine or bromine, W is a group -SO 2 -NR 4 -, -CONR 4 - or -NR 4 CO- wherein R 4 is as defined above, Q is a radical -O- or -NR 4 - wherein R 4 is as defined above, and n is a number 0 or 1, X is halogen, and k and m are each independently of the other a number 0 or 1 and the sum of k+m is 1 or 2, with the exception of an adsorbent, comprising a compound of formula wherein Q is sulfo or carboxy, provides various dye-ligand structures available for screening in dye-ligand affinity chromatography.
摘要翻译：一种用于分离生物材料的方法，其中使用吸附剂，其包含式（1）化合物与具有能与所述式（1）化合物中的反应性基团反应的基团的底物的反应产物，以形成共价键，其中B是C 2 -C 12亚烷基，其可以被1,2或3个成员所组成的组中断，其由-NR 1 - 或-O-，并且是未取代的或被羟基，磺基，硫酸基，氰基或羧基取代，R 1是氢或C 1 -C 3 > C 1-4烷基，或B是C 5 -C 9亚环烷基，C 1 -C 4烷基， /亚烷基-C 5亚烷基亚环烷基或C 1 -C 4亚烷基-C 亚烷基-C 1 -C 3亚烷基-C 1 -C 4亚烷基，其未被取代或被C _{如上所定义，Q是基团-O-或-NR 4 - ，其中R 4如上定义，并且n是数字0或1，X 是卤素，并且k和m各自彼此独立地为0或1，并且k + m的和为1或2，除了吸附剂外，其中Q为磺基或羧基的式可用于染料 - 配体亲和层析中筛选的各种染料 - 配体结构。}

2. 发明申请

WO2006108760A2 ADSORBENTS COMPRISING ANTHRAQUINONE DYE-LIGANDS FOR THE SEPARATION OF BIOLOGICAL MATERIALS 审中-公开
标题翻译：包含用于分离生物材料的蒽醌衍生物的吸附剂
公开(公告)号：WO2006108760A2
公开(公告)日：2006-10-19
申请号：PCT/EP2006/061121
申请日：2006-03-29
申请人： CIBA SPECIALTY CHEMICALS HOLDING INC. , EKKUNDI, Vadiraj, Subbanna , PUNEKAR, Narayan, S. , FONDEKAR, Kamalesh, Pai , ROENTGEN, Georg , KORDE, Shilpa, S. , SHINDE, Ajit, B. , MOORTHY, Masana
发明人： EKKUNDI, Vadiraj, Subbanna , PUNEKAR, Narayan, S. , FONDEKAR, Kamalesh, Pai , ROENTGEN, Georg , KORDE, Shilpa, S. , SHINDE, Ajit, B. , MOORTHY, Masana
IPC分类号： C09B1/20 , C09B1/26 , C09B62/04
CPC分类号： C09B69/101 , C09B62/06
摘要： A process for the separation of biological materials, wherein an adsorbent is used, which comprises a reaction product of a compound of formula and a substrate having a group capable of reaction with a reactive group in said compound of formula (1) to form a covalent bond, in which B is C 2 -C 12 alkylene radical, which can be interrupted by 1, 2 or 3 members from the group consisting of -NR 1 - or -O- and is unsubstituted or substituted by hydroxyl, sulfo, sulfato, cyano or carboxyl, R 1 is hydrogen or C 1 -C 4 alkyl, or B is a C 5 -C 9 cycloalkylene radical, C 1 -C 4 alkylene-C 5 -C 9 cycloalkylene radical or C 1 -C 4 alkylene-C 5 -C 9 cycloalkylene-C 1 -C 4 alkylene radical, which are unsubstituted or substituted by C 1 -C 4 alkyl, C 1 -C 4 alkoxy, sulfo, halogen or carboxyl, or a phenylene radical, C 1 -C 4 alkylene-phenylene radical or C 1 -C 4 alkylene-phenylene-C 1 -C 4 alkylene radical, which are unsubstituted or substituted by C 1 -C 4 alkyl, C 1 -C 4 alkoxy, C 2 -C 4 alkanoylamino, sulfo, halogen or carboxyl, V is a non-fibre-reactive substituent or is a fibre-reactive substituent of formula wherein R 2 is hydrogen or unsubstituted or substituted C 1 -C 4 alkyl or a radical , R 3 is hydrogen, hydroxy, sulfo, sulfato, carboxy, cyano, halogen, C 1 -C 4 alkoxycarbonyl, C 1 -C 4 - alkanoyloxy, carbamoyl or a group -SO 2 -Y, R 4 is hydrogen or C 1 -C 4 alkyl, alk and alk 1 are each independently of the other linear or branched C 1 -C 6 alkylene, arylene is a phenylene or naphthylene radical which is unsubstituted or substituted by sulfo, carboxy, hydroxy, C 1 -C 4 alkyl, C 1 -C 4 alkoxy or by halogen, Y is vinyl or a radical -CH 2 -CH 2 -U and U is a leaving group, Y 1 is a group -CH(Hal)-CH 2 (Hal) or -C(Hal)=CH 2 wherein Hal is chlorine or bromine, W is a group -SO 2 -NR 4 -, -CONR 4 - or -NR 4 CO- wherein R 4 is as defined above, Q is a radical -O- or -NR 4 - wherein R 4 is as defined above, and n is a number 0 or 1, X is halogen, and k and m are each independently of the other a number 0 or 1 and the sum of k+m is 1 or 2, with the exception of an adsorbent, comprising a compound of formula wherein Q is sulfo or carboxy, provides various dye-ligand structures available for screening in dye-ligand affinity chromatography.
摘要翻译：一种用于分离生物材料的方法，其中使用吸附剂，其包含式（1）化合物与具有能与所述式（1）化合物中的反应性基团反应的基团的底物的反应产物，以形成共价键，其中B是C 2 -C 12亚烷基，其可以被1,2或3个成员所组成的组中断，其由-NR 1 - 或-O-，并且是未取代的或被羟基，磺基，硫酸基，氰基或羧基取代，R 1是氢或C 1 -C 3 > C 1-4烷基，或B是C 5 -C 9亚环烷基，C 1 -C 4烷基， /亚烷基-C 5亚烷基亚环烷基或C 1 -C 4亚烷基-C 亚烷基-C 1 -C 3亚烷基-C 1 -C 4亚烷基，其未被取代或被C _{如上所定义，Q是基团-O-或-NR 4 - ，其中R 4如上定义，并且n是数字0或1，X 是卤素，并且k和m各自彼此独立地为0或1，并且k + m的和为1或2，除了吸附剂外，其中Q为磺基或羧基的式可用于染料 - 配体亲和层析中筛选的各种染料 - 配体结构。}

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