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1. 发明专利

IL240197D0 Method for preparing 1-(4-(4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)piperidin-1-yl)prop-2-en-1-one 未知
公开(公告)号：IL240197D0
公开(公告)日：2015-09-24
申请号：IL24019715
申请日：2015-07-28
申请人： HANMI PHARM IND CO LTD , BANG KEUK CHAN , JUNG JAE HYUK , MOON YOUNG HO
IPC分类号： C07D20060101
摘要： The present invention relates to a novel method for preparing 1-(4-(4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)piperidin-1-yl)prop-2-en-1-one in a simpler process as compared with conventional methods by allowing 4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-ol to react with an N-acyl piperidine derivative in an inert polar protic solvent in the presence of a base.

2. 发明专利

IL267303A Method for preparing 1-(4-(4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)piperidin-1-yl)prop-2-en-1-one 未知
公开(公告)号：IL267303A
公开(公告)日：2021-01-31
申请号：IL26730319
申请日：2019-06-12
申请人： HANMI PHARM IND CO LTD , BANG KEUK CHAN , JUNG JAE HYUK , MOON YOUNG HO
发明人： BANG KEUK CHAN , JUNG JAE HYUK , MOON YOUNG HO
摘要： The present invention relates to a novel method for preparing 1-(4-(4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)piperidin-1-yl)prop-2-en-1-one in a simpler process as compared with conventional methods by allowing 4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-ol to react with an N-acyl piperidine derivative in an inert polar protic solvent in the presence of a base.

3. 发明专利

IL267303D0 Method for preparing 1-(4-(4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)piperidin-1-yl)prop-2-en-1-one 未知
公开(公告)号：IL267303D0
公开(公告)日：2019-08-29
申请号：IL26730319
申请日：2019-06-12
申请人： HANMI PHARM IND CO LTD , BANG KEUK CHAN , JUNG JAE HYUK , MOON YOUNG HO
发明人： BANG KEUK CHAN , JUNG JAE HYUK , MOON YOUNG HO
IPC分类号： C07D20060101
摘要： The present invention relates to a novel method for preparing 1-(4-(4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)piperidin-1-yl)prop-2-en-1-one in a simpler process as compared with conventional methods by allowing 4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-ol to react with an N-acyl piperidine derivative in an inert polar protic solvent in the presence of a base.

4. 发明专利

IL240197A Method for preparing 1-(4-(4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)piperidin-1-yl)prop-2-en-1-one 未知
公开(公告)号：IL240197A
公开(公告)日：2019-06-30
申请号：IL24019715
申请日：2015-07-28
申请人： HANMI PHARM IND CO LTD , BANG KEUK CHAN , JUNG JAE HYUK , MOON YOUNG HO
发明人： BANG KEUK CHAN , JUNG JAE HYUK , MOON YOUNG HO
摘要： The present invention relates to a novel method for preparing 1-(4-(4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)piperidin-1-yl)prop-2-en-1-one in a simpler process as compared with conventional methods by allowing 4-(3,4-dichloro-2-fluorophenylamino)-7-methoxyquinazolin-6-ol to react with an N-acyl piperidine derivative in an inert polar protic solvent in the presence of a base.

5. 发明申请

WO2009057938A3 METHOD OF PREPARING (6R)-3-HEXYL-4-HYDROXY-6-UNDECYL-5,6-DIHYDROPYRAN-2-ONE, AND INTERMEDIATE USED IN THE METHOD 审中-公开
标题翻译：制备（6R）-3-甲基-4-羟基-6-二甲基-5,6-二氢吡喃-2-酮的方法和方法中使用的方法
公开(公告)号：WO2009057938A3
公开(公告)日：2009-06-18
申请号：PCT/KR2008006371
申请日：2008-10-29
申请人： HANMI PHARM IND CO LTD , YUN SANG MIN , MOON YOUNG HO , CHANG YOUNG-KIL , HONG DONG JIN , CHANG JI-YEON , LEE MOON SUB , YOO JAEHO , KIM JI SOOK , KIM CHEOL KYUNG
发明人： YUN SANG MIN , MOON YOUNG HO , CHANG YOUNG-KIL , HONG DONG JIN , CHANG JI-YEON , LEE MOON SUB , YOO JAEHO , KIM JI SOOK , KIM CHEOL KYUNG
IPC分类号： C07D309/36
CPC分类号： C07D309/32 , C07C249/02 , C07C251/08 , C07F7/1852 , C07F7/1856 , Y02P20/55
摘要： Provided is a method of preparing a (6R)-3-hexyl-4-hydroxy-6-undecyl-5,6-dihydropyran-2-one, and a (5R)-2-hexyl-5-hydroxy-3-iminohexadecanoate derivative used in said method as an intermediate.
摘要翻译：提供了制备（6R）-3-己基-4-羟基-6-十一烷基-5,6-二氢吡喃-2-酮的方法和（5R）-2-己基-5-羟基-3-亚氨基十六酸酯所述方法中使用的衍生物作为中间体。

6. 发明申请

WO2002079158A1 NOVEL AMLODIPINE CAMSYLATE AND METHOD FOR PREPARING THEREOF 审中-公开
标题翻译：新型茉莉酸甲酯及其制备方法
公开(公告)号：WO2002079158A1
公开(公告)日：2002-10-10
申请号：PCT/KR2002/000543
申请日：2002-03-28
申请人： HANMI PHARM. CO., LTD. , MOON, Young Ho , KIM, Nam Du , LEE, Kyung Ik , LEE, Gwan Sun , WOO, Jong Soo
发明人： MOON, Young Ho , KIM, Nam Du , LEE, Kyung Ik , LEE, Gwan Sun , WOO, Jong Soo
IPC分类号： C07D211/84
CPC分类号： C07D211/90
摘要： Amlodipine camsylate of the present invention is a crystalline salt of amlodipine suitable for pharmaceutical formulation, which is prepared by using low toxic camphor sulfonic acid to meet required pharmaceutical properties for treating cadiovacular diseases.
摘要翻译：本发明的氨氯地平樟脑磺酸盐是适用于药物制剂的氨氯地平的结晶盐，其通过使用低毒樟脑磺酸来满足治疗癌症性疾病所需的药物性质来制备。

7. 发明申请

WO1998008832A1 PROCESS FOR PREPARING PACLITAXEL 审中-公开
标题翻译：制备PACLITAXEL的方法
公开(公告)号：WO1998008832A1
公开(公告)日：1998-03-05
申请号：PCT/KR1997000157
申请日：1997-08-25
申请人： HANMI PHARM. CO., LTD. , KIM, Kyoung, Soo , CHAI, Ki, Byung , MOON, Young, Ho , LEE, Kwang, Ok , KIM, Nam, Du , HA, Tae, Hee , SHIN, Jung, Ae , LEE, Gwan, Sun , KIM, Wan, Joo
发明人： HANMI PHARM. CO., LTD.
IPC分类号： C07D305/14
CPC分类号： C07D263/04 , C07D305/14 , C07D413/12 , Y02P20/55
摘要： The present invention relates to a process for preparing paclitaxel represented by formula (1) characterized in that: (a) an oxazolidine derivative represented by formula (2) or its salt in which X represents halogen, is coupled with a 7-trihaloacetyl-baccatin III represented by formula (3) in which R1 represents trihaloacetyl, in a solvent in the presence of a condensing agent to produce an oxazolidine substituent-containing taxane represented by formula (4) in which X and R1 are each as previously defined; (b) the oxazolidine ring is opened in a solvent in the presence of an acid, and the product thus obtained is reacted with benzoyl chloride in the presence of a base to produce a protected paclitaxel wherein the hydroxy group at 7-position is protected with trihaloacetyl group represented by formula (5) in which R1 is as previously defined; (c) then the protecting group at 7-position is removed by ammonia or a salt of ammonia with a weak acid in a solvent.
摘要翻译：本发明涉及一种制备由式（1）表示的紫杉醇的方法，其特征在于：（a）由式（2）表示的恶唑烷衍生物或其中X表示卤素的盐与7-三卤代乙酰基浆果赤霉素（3）表示的化合物，其中R 1表示三卤代乙酰基，在溶剂中，在缩合剂存在下制备由式（4）表示的含恶唑烷取代基的紫杉烷，其中X和R 1各自如上所定义; （b）在酸存在下，在溶剂中打开恶唑烷环，将得到的产物与苯甲酰氯在碱的存在下反应，得到保护的紫杉醇，其中7位的羟基被由式（5）表示的三卤代乙酰基，其中R 1如前所定义; （c）然后在溶剂中用氨或氨与弱酸将7位保护基除去。

8. 发明申请

WO2011049322A2 METHOD FOR DETECTING METHYLATION OF BREAST CANCER-SPECIFIC METHYLATION MARKER GENE FOR BREAST CANCER DIAGNOSIS 审中-公开
标题翻译：检测乳腺癌特异性甲基化标记基因甲基化检测乳腺癌诊断的方法
公开(公告)号：WO2011049322A2
公开(公告)日：2011-04-28
申请号：PCT/KR2010007029
申请日：2010-10-14
申请人： GENOMICTREE INC , INDUSTRY AND ACADEMIC COOPERATION IN CHUNGNAM NAT UNIVERSITY , MOON YOUNG HO , OH TAE JEONG , KIM MYUNG SOON , LEE JEUNG HOON , CHANG EIL SUNG
发明人： MOON YOUNG HO , OH TAE JEONG , KIM MYUNG SOON , LEE JEUNG HOON , CHANG EIL SUNG
IPC分类号： C12Q1/68 , C12N15/11
CPC分类号： C12Q1/6827 , C12Q1/6886 , C12Q2565/501
摘要： The present invention relates to a method for detecting the methylation of a breast cancer-specific methylation marker gene for breast cancer diagnosis, and more particularly, to a method which involves detecting methylation of a breast cancer-specific methylation marker gene which is methylated specifically in a breast cancer cell, and provides information for the diagnosis of breast cancer or the stage of progression of breast cancer. When the methylation detection method of the present invention is used together with a diagnosis composition, a kit, and a nucleic acid chip, more accurate and quicker early diagnosis of breast cancer can be facilitated as compared to conventional methods, the stage of progression of breast cancer can be checked, and a non-invasive serum sample is made available, to thereby diagnose breast cancer in a more simple and accurate manner.
摘要翻译：本发明涉及用于乳腺癌诊断的乳腺癌特异性甲基化标记基因的甲基化检测方法，更具体地说，涉及检测乳腺癌特异性甲基化的乳腺癌特异性甲基化标记基因的甲基化的方法乳腺癌细胞，并提供乳腺癌诊断或乳腺癌进展阶段的信息。当将本发明的甲基化检测方法与诊断组合物，试剂盒和核酸芯片一起使用时，与常规方法相比，可以促进乳腺癌的更准确和更快速的早期诊断，乳房进展阶段可以检查癌症，并且提供非侵入性血清样品，从而以更简单和准确的方式诊断乳腺癌。

9. 发明申请

WO2009069984A2 DIAGNOSIS KIT AND CHIP FOR BLADDER CANCER USING BLADDER CANCER SPECIFIC METHYLATION MARKER GENE 审中-公开
标题翻译：使用刮刀癌特异性甲基标记基因的刀片诊断工具包和芯片
公开(公告)号：WO2009069984A2
公开(公告)日：2009-06-04
申请号：PCT/KR2008/007081
申请日：2008-12-01
申请人： GENOMICTREE, INC. , AN, Sung Whan , MOON, Young Ho , OH, Tae Jeong
发明人： AN, Sung Whan , MOON, Young Ho , OH, Tae Jeong
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q1/686 , C12Q2600/154 , C12Q2600/156
摘要： The present invention relates to a kit and nucleic acid chip for diagnosing bladder cancer using a bladder cancer-specific marker gene. More particularly, the invention relates to a kit and nucleic acid chip for diagnosing bladder cancer, which can detect the promoter methylation of a bladder cancer-specific gene, the promoter or exon region of which is methylated specifically in transformed cells of bladder cancer. The use of the diagnostic kit or nucleic acid chip of the invention enables diagnosis of bladder cancer at an early stage of transformation, thus enabling early diagnosis of bladder cancer, and can diagnose bladder cancer in a more accurate and rapid manner compared to a conventional method.
摘要翻译：本发明涉及一种用于使用膀胱癌特异性标志物基因诊断膀胱癌的试剂盒和核酸芯片。更具体地，本发明涉及用于诊断膀胱癌的试剂盒和核酸芯片，其可以检测膀胱癌特异性基因的启动子甲基化，其启动子或外显子区域在膀胱癌的转化细胞中特异性甲基化。使用本发明的诊断试剂盒或核酸芯片能够在转化的早期阶段诊断膀胱癌，从而能够早期诊断膀胱癌，并且可以以比传统方法更准确和更快速地诊断膀胱癌。

10. 发明申请

WO2008075834A1 METHOD OF PREPARING TAXANE DERIVATIVES AND INTERMEDIATES USED THEREIN 审中-公开
标题翻译：制备TAXANE衍生物的方法及其使用的中间体
公开(公告)号：WO2008075834A1
公开(公告)日：2008-06-26
申请号：PCT/KR2007/005829
申请日：2007-11-20
申请人： HANMI PHARM. CO., LTD. , KIM, Nam Du , SHIN, Wooseob , JUNG, Jaehyuk , KIM, Dong Jun , KIM, Gi Jeong , MOON, Young Ho , CHANG, Young-Kil , LEE, Gwan Sun , CHOI, Tae Jin
发明人： KIM, Nam Du , SHIN, Wooseob , JUNG, Jaehyuk , KIM, Dong Jun , KIM, Gi Jeong , MOON, Young Ho , CHANG, Young-Kil , LEE, Gwan Sun , CHOI, Tae Jin
IPC分类号： C07D305/14
CPC分类号： C07D305/14 , Y02P20/55
摘要： The present invention relates to a novel method of preparing a taxane derivative having an anti-tumor and anti-leukemia activity, and intermediates used therein.
摘要翻译：本发明涉及一种制备具有抗肿瘤和抗白血病活性的紫杉烷衍生物的新方法及其中使用的中间体。

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