专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2004084822A3 METHODS FOR INDUCING IMMUNE TOLERANCE 审中-公开
标题翻译：诱导免疫耐受的方法
公开(公告)号：WO2004084822A3
公开(公告)日：2007-02-01
申请号：PCT/US2004008500
申请日：2004-03-19
申请人： INIVERSITY OF CALIFORNIA , MODLIN ROBERT L , BLEHARSKI JOSHUA R , COLLONNA MARCO
发明人： MODLIN ROBERT L , BLEHARSKI JOSHUA R , COLLONNA MARCO
IPC分类号： A61K39/02 , A61K20060101 , A61K39/395 , A61P17/00 , A61P29/00 , A61P37/00
CPC分类号： C07K16/2803 , C07K14/70503
摘要： The regulatory mechanisms that influence resistance versus susceptibility to progressive infection by microbial pathogens are of fundamental importance to understanding pathogenesis and to developing effective vaccines. Susceptibility to progressive infection in the lepromatous form correlated with the local expression of genes encoding members of the leukocyte immunoglobulin-like receptor (LIR) family, including LIR-3, -4, -7, and - 8. The gene expression profiles provided a clear and consistent distinction between the different clinical courses of the disease. The present invention shows that gene expression technology may be useful for predicting the clinical course of leprosy and perhaps other infectious diseases. Further, the invention provides methods of treatment of inflammatory or infectious diseases based on regulation of LIR-7 expression or activity.
摘要翻译：影响抗性与微生物病原体进行性感染易感性的调节机制对于了解发病机制和开发有效疫苗至关重要。易感性的前列腺形态的进行性感染与编码白细胞免疫球蛋白样受体（LIR）家族成员的基因的局部表达相关，包括LIR-3，-4，-7和-8。基因表达谱提供了对疾病的不同临床病程进行清晰一致的区分。本发明表明，基因表达技术可用于预测麻风病和其他感染性疾病的临床病程。此外，本发明提供了基于LIR-7表达或活性调节来治疗炎性或感染性疾病的方法。

2. 发明申请

WO2005026194A2 GRANULYSIN PEPTIDES AND METHODS OF USE THEREOF 审中-公开
标题翻译：颗粒蛋白肽及其使用方法
公开(公告)号：WO2005026194A2
公开(公告)日：2005-03-24
申请号：PCT/US2004029586
申请日：2004-09-09
申请人： UNIV CALIFORNIA , MODLIN ROBERT L , KIM JENNY J , ANDERSON DANIEL H , EISENBERG DAVID S , GALLO RICHARD L
发明人： MODLIN ROBERT L , KIM JENNY J , ANDERSON DANIEL H , EISENBERG DAVID S , GALLO RICHARD L
IPC分类号： A61K38/00 , C07K20060101 , C07K14/47 , C07K
CPC分类号： C07K14/4723 , A61K38/00 , C07K14/47
摘要： Granulysin peptides are small antimicrobial agents with potent activity against bacteria and inflammation. A pharmaceutical composition comprising granulysin peptides as an active agent is administered therapeutically to a patient suffering from a microbial infection.
摘要翻译：颗粒溶素肽是具有抗细菌和炎症的有效活性的小型抗微生物剂。包含颗粒溶素肽作为活性剂的药物组合物对患有微生物感染的患者进行治疗性给药。

3. 发明申请

WO2003066820A3 NUCLEIC ACID MOLECULES ENCODING CD1-DERIVED ENDOSOMAL TARGETING PROTEINS AND USES THEREOF 审中-公开
公开(公告)号：WO2003066820A3
公开(公告)日：2003-08-14
申请号：PCT/US2003/003550
申请日：2003-02-05
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , MODLIN, Robert, L.
发明人： MODLIN, Robert, L.
IPC分类号： A61K39/395
摘要： The present invention provides chimeric nucleic acid molecules encoding CD1 fusion proteins, comprising a leader peptide sequence, a CD1 endosomal targeting sequence, and an antigen of interest. In the CD1 fusion protein, the leader peptide sequence and CD1 endosomal targeting sequence direct production, processing, trafficking, and cell surface presentation of the antigen of interest via the MHCII antigen presenting pathway. The invention also provides methods for producing the CD1 fusion protein or the antigen of interest or fragments thereof, methods for targeting the antigen of interest to the MHCII antigen presenting pathway, and methods for presenting on a cell the antigen of interest. Additionally, the present invention provides methods for inducing in a subject an immune response mediated by a CD1 endosomal targeting sequence, methods for inducing in a subject an immune response to an antigen of interest, and methods for inducing in a subject an immune response mediated by an MHCII antigen presenting pathway.

5. 发明申请

WO2005026194A3 GRANULYSIN PEPTIDES AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：WO2005026194A3
公开(公告)日：2005-03-24
申请号：PCT/US2004/029586
申请日：2004-09-09
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , MODLIN, Robert, L. , KIM, Jenny, J. , ANDERSON, Daniel, H. , EISENBERG, David, S. , GALLO, Richard, L.
发明人： MODLIN, Robert, L. , KIM, Jenny, J. , ANDERSON, Daniel, H. , EISENBERG, David, S. , GALLO, Richard, L.
IPC分类号： A61K38/00
摘要： Granulysin peptides are small antimicrobial agents with potent activity against bacteria and inflammation. A pharmaceutical composition comprising granulysin peptides as an active agent is administered therapeutically to a patient suffering from a microbial infection.

6. 发明申请

WO2003090685A3 METHODS FOR STIMULATING TLR/IRF3 PATHWAYS FOR INDUCING ANTI-MICROBIAL, ANTI-INFLAMMATORY AND ANTICANCER RESPONSES 审中-公开
公开(公告)号：WO2003090685A3
公开(公告)日：2003-11-06
申请号：PCT/US2003/012751
申请日：2003-04-24
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , CHENG, Genhong , MODLIN, Robert, L. , VAIDYA, Sagar , DOYLE, Sean
发明人： CHENG, Genhong , MODLIN, Robert, L. , VAIDYA, Sagar , DOYLE, Sean
IPC分类号： G01N33/53
摘要： The present invention provides methods for stimulating Toll-like receptors (TLR) to activate IRF (e.g., an IRF3) and signaling pathway, and thereby directing an antimicrobial activity. The present invention also provides methods for identifying agents that bind and/or stimulate TLR and mediate induction of an IRF3 pathway, thereby directing an antimicrobial activity. Additionally, the invention provides methods and agents for suppressing stimulation of TLR, thereby directing an anti-inflammatory response.

7. 发明申请

WO03066820A2 NUCLEIC ACID MOLECULES ENCODING CD1-DERIVED ENDOSOMAL TARGETING PROTEINS AND USES THEREOF 审中-公开
标题翻译：编码CD1衍生的核内靶向蛋白的核酸分子及其用途
公开(公告)号：WO03066820A2
公开(公告)日：2003-08-14
申请号：PCT/US0303550
申请日：2003-02-05
申请人： UNIV CALIFORNIA , MODLIN ROBERT L
发明人： MODLIN ROBERT L
IPC分类号： C07K14/74 , C12N
CPC分类号： C07K14/70539 , A61K2039/6031 , C07K2319/00
摘要： The present invention provides chimeric nucleic acid molecules encoding CD1 fusion proteins, comprising a leader peptide sequence, a CD1 endosomal targeting sequence, and an antigen of interest. In the CD1 fusion protein, the leader peptide sequence and CD1 endosomal targeting sequence direct production, processing, trafficking, and cell surface presentation of the antigen of interest via the MHCII antigen presenting pathway. The invention also provides methods for producing the CD1 fusion protein or the antigen of interest or fragments thereof, methods for targeting the antigen of interest to the MHCII antigen presenting pathway, and methods for presenting on a cell the antigen of interest. Additionally, the present invention provides methods for inducing in a subject an immune response mediated by a CD1 endosomal targeting sequence, methods for inducing in a subject an immune response to an antigen of interest, and methods for inducing in a subject an immune response mediated by an MHCII antigen presenting pathway.
摘要翻译：本发明提供了编码CD1融合蛋白的嵌合核酸分子，其包含前导肽序列，CD1内体靶向序列和感兴趣的抗原。在CD1融合蛋白中，前导肽序列和CD1内体靶向序列通过MHCII抗原呈递途径指导目的抗原的产生，加工，运输和细胞表面呈递。本发明还提供了产生CD1融合蛋白或感兴趣的抗原或其片段的方法，将感兴趣的抗原靶向MHCII抗原呈递途径的方法，以及在细胞上呈递感兴趣的抗原的方法。此外，本发明提供了用于在受试者中诱导由CD1内体内靶向序列介导的免疫应答的方法，用于在受试者中诱导针对目标抗原的免疫应答的方法，以及用于在受试者中诱导由 MHCII抗原呈递途径。

8. 发明申请

WO2004084822A2 METHODS FOR INDUCING IMMUNE TOLERANCE 审中-公开
标题翻译：诱导免疫耐受的方法
公开(公告)号：WO2004084822A2
公开(公告)日：2004-10-07
申请号：PCT/US2004/008500
申请日：2004-03-19
申请人： THE REGENTS OF INIVERSITY OF CALIFORNIA , MODLIN, Robert, L. , BLEHARSKI, Joshua, R. , COLLONNA, Marco
发明人： MODLIN, Robert, L. , BLEHARSKI, Joshua, R. , COLLONNA, Marco
IPC分类号： A61K
CPC分类号： C07K16/2803 , C07K14/70503
摘要： The regulatory mechanisms that influence resistance versus susceptibility to progressive infection by microbial pathogens are of fundamental importance to understanding pathogenesis and to developing effective vaccines. Susceptibility to progressive infection in the lepromatous form correlated with the local expression of genes encoding members of the leukocyte immunoglobulin-like receptor (LIR) family, including LIR-3, -4, -7, and - 8. The gene expression profiles provided a clear and consistent distinction between the different clinical courses of the disease. The present invention shows that gene expression technology may be useful for predicting the clinical course of leprosy and perhaps other infectious diseases. Further, the invention provides methods of treatment of inflammatory or infectious diseases based on regulation of LIR-7 expression or activity.
摘要翻译：影响抗性与微生物病原体进行性感染易感性的调节机制对于了解发病机制和开发有效疫苗至关重要。易感性的前列腺形态的进行性感染与编码白细胞免疫球蛋白样受体（LIR）家族的成员（包括LIR-3，-4，-7和-8）的基因的局部表达相关。基因表达谱提供了在疾病的不同临床病程之间清晰一致的区分。本发明表明，基因表达技术可用于预测麻风病和其他感染性疾病的临床病程。此外，本发明提供了基于LIR-7表达或活性调节来治疗炎性或感染性疾病的方法。

9. 发明申请

WO2003090685A2 METHODS FOR STIMULATING TLR/IRF3 PATHWAYS FOR INDUCING ANTI-MICROBIAL, ANTI-INFLAMMATORY AND ANTICANCER RESPONSES 审中-公开
标题翻译：刺激TLR / IRF3途径诱导抗微生物，抗炎和反应性反应的方法
公开(公告)号：WO2003090685A2
公开(公告)日：2003-11-06
申请号：PCT/US2003/012751
申请日：2003-04-24
申请人： THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , CHENG, Genhong , MODLIN, Robert, L. , VAIDYA, Sagar , DOYLE, Sean
发明人： CHENG, Genhong , MODLIN, Robert, L. , VAIDYA, Sagar , DOYLE, Sean
IPC分类号： A61K
CPC分类号： A61K31/337 , A61K31/4745 , A61K31/739 , A61K38/162 , A61K39/00 , A61K39/39 , A61K2039/55511 , A61K2039/55516 , A61K2039/55561 , A61K2039/55572 , A61K2039/55594 , C12Q1/18 , G01N33/6866 , G01N33/6872 , G01N2333/565
摘要： The present invention provides methods for stimulating Toll-like receptors (TLR) to activate IRF (e.g., an IRF3) and signaling pathway, and thereby directing an antimicrobial activity. The present invention also provides methods for identifying agents that bind and/or stimulate TLR and mediate induction of an IRF3 pathway, thereby directing an antimicrobial activity. Additionally, the invention provides methods and agents for suppressing stimulation of TLR, thereby directing an anti-inflammatory response.
摘要翻译：本发明提供刺激Toll样受体（TLR）激活IRF（例如IRF3）和信号传导途径，从而引导抗微生物活性的方法。本发明还提供用于鉴定结合和/或刺激TLR并介导IRF3途径的诱导从而引导抗微生物活性的试剂的方法。此外，本发明提供抑制TLR刺激的方法和试剂，从而引发抗炎反应。

10. 发明申请

WO9612190A2 PRESENTATION OF HYDROPHOBIC ANTIGENS TO T-CELLS BY CD1 MOLECULES 审中-公开
标题翻译：通过CD1分子表达对T细胞的疏水性抗原
公开(公告)号：WO9612190A2
公开(公告)日：1996-04-25
申请号：PCT/US9513274
申请日：1995-10-13
申请人： BRIGHAM & WOMENS HOSPITAL , UNIV CALIFORNIA LOS ANGELES , UNIV COLORADO STATE RES FOUND , MODLIN ROBERT L , SIELING PETER A , BRENNER MICHAEL B , BRENNAN PATRICK J , PORCELLI STEVEN A , FURLONG STEPHEN T
发明人： MODLIN ROBERT L , SIELING PETER A , BRENNER MICHAEL B , BRENNAN PATRICK J , PORCELLI STEVEN A , FURLONG STEPHEN T
IPC分类号： G01N33/53 , A61K39/04 , A61K47/48 , C07K14/74 , C07K16/28 , C08B37/00 , C12N5/10 , C12P19/04 , C12Q1/02 , G01N33/566 , A61K38/17 , A61K39/00 , A61K39/395 , C12N5/00 , G01N33/569
CPC分类号： A61K39/04 , C07K14/70539 , C07K16/2803 , C12P19/04
摘要： Provided are CD1 presented antigens, compositions, cells, inhibitors and methods relating to the use of lipoarabinomannan (LAM) antigen presentation by CD1 molecules, including: methods for detecting the presence of a CD1-presented LAM antigen in a sample; methods for isolating such CD1-presented LAM antigens and the isolated antigens; vaccines containing CD1-presented LAM antigens and vaccination methods; methods of blocking CD1 LAM antigen presentation; methods of identifying and/or isolating CD1 blocking agents and the isolated CD1 blocking agents; methods of inducing CD1 expression; and T-cells for use in the methods disclosed herein.
摘要翻译： CD1提供的抗原，组合物，细胞，抑制剂和与使用由CD1分子表达的抗脂沙门氏菌（LAM）抗原相关的方法，包括：用于检测样品中存在CD1的LAM抗原的方法; 用于分离此类CD1呈递的LAM抗原和分离的抗原的方法; 含有CD1呈递的LAM抗原和疫苗接种方法的疫苗; 阻断CD1 LAM抗原呈递的方法; 识别和/或分离CD1阻断剂和分离的CD1阻断剂的方法; 诱导CD1表达的方法; 和T细胞用于本文公开的方法中。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式