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1. 发明申请

WO2004084822A3 METHODS FOR INDUCING IMMUNE TOLERANCE 审中-公开
标题翻译：诱导免疫耐受的方法
公开(公告)号：WO2004084822A3
公开(公告)日：2007-02-01
申请号：PCT/US2004008500
申请日：2004-03-19
申请人： INIVERSITY OF CALIFORNIA , MODLIN ROBERT L , BLEHARSKI JOSHUA R , COLLONNA MARCO
发明人： MODLIN ROBERT L , BLEHARSKI JOSHUA R , COLLONNA MARCO
IPC分类号： A61K39/02 , A61K20060101 , A61K39/395 , A61P17/00 , A61P29/00 , A61P37/00
CPC分类号： C07K16/2803 , C07K14/70503
摘要： The regulatory mechanisms that influence resistance versus susceptibility to progressive infection by microbial pathogens are of fundamental importance to understanding pathogenesis and to developing effective vaccines. Susceptibility to progressive infection in the lepromatous form correlated with the local expression of genes encoding members of the leukocyte immunoglobulin-like receptor (LIR) family, including LIR-3, -4, -7, and - 8. The gene expression profiles provided a clear and consistent distinction between the different clinical courses of the disease. The present invention shows that gene expression technology may be useful for predicting the clinical course of leprosy and perhaps other infectious diseases. Further, the invention provides methods of treatment of inflammatory or infectious diseases based on regulation of LIR-7 expression or activity.
摘要翻译：影响抗性与微生物病原体进行性感染易感性的调节机制对于了解发病机制和开发有效疫苗至关重要。易感性的前列腺形态的进行性感染与编码白细胞免疫球蛋白样受体（LIR）家族成员的基因的局部表达相关，包括LIR-3，-4，-7和-8。基因表达谱提供了对疾病的不同临床病程进行清晰一致的区分。本发明表明，基因表达技术可用于预测麻风病和其他感染性疾病的临床病程。此外，本发明提供了基于LIR-7表达或活性调节来治疗炎性或感染性疾病的方法。

2. 发明申请

WO2004084822A2 METHODS FOR INDUCING IMMUNE TOLERANCE 审中-公开
标题翻译：诱导免疫耐受的方法
公开(公告)号：WO2004084822A2
公开(公告)日：2004-10-07
申请号：PCT/US2004/008500
申请日：2004-03-19
申请人： THE REGENTS OF INIVERSITY OF CALIFORNIA , MODLIN, Robert, L. , BLEHARSKI, Joshua, R. , COLLONNA, Marco
发明人： MODLIN, Robert, L. , BLEHARSKI, Joshua, R. , COLLONNA, Marco
IPC分类号： A61K
CPC分类号： C07K16/2803 , C07K14/70503
摘要： The regulatory mechanisms that influence resistance versus susceptibility to progressive infection by microbial pathogens are of fundamental importance to understanding pathogenesis and to developing effective vaccines. Susceptibility to progressive infection in the lepromatous form correlated with the local expression of genes encoding members of the leukocyte immunoglobulin-like receptor (LIR) family, including LIR-3, -4, -7, and - 8. The gene expression profiles provided a clear and consistent distinction between the different clinical courses of the disease. The present invention shows that gene expression technology may be useful for predicting the clinical course of leprosy and perhaps other infectious diseases. Further, the invention provides methods of treatment of inflammatory or infectious diseases based on regulation of LIR-7 expression or activity.
摘要翻译：影响抗性与微生物病原体进行性感染易感性的调节机制对于了解发病机制和开发有效疫苗至关重要。易感性的前列腺形态的进行性感染与编码白细胞免疫球蛋白样受体（LIR）家族的成员（包括LIR-3，-4，-7和-8）的基因的局部表达相关。基因表达谱提供了在疾病的不同临床病程之间清晰一致的区分。本发明表明，基因表达技术可用于预测麻风病和其他感染性疾病的临床病程。此外，本发明提供了基于LIR-7表达或活性调节来治疗炎性或感染性疾病的方法。

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