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1. 发明申请

WO2009085458A1 SYSTEM AND METHOD FOR MEASUREMENT OF AN IMPEDANCE USING A CATHETER SUCH AS AN ABLATION CATHETER 审中-公开
标题翻译：使用导管等测量阻抗的系统和方法
公开(公告)号：WO2009085458A1
公开(公告)日：2009-07-09
申请号：PCT/US2008/084200
申请日：2008-11-20
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC. , MILLER, Stephan P. , KASTNER, Glen H. , DENO, D. Curtis
发明人： MILLER, Stephan P. , KASTNER, Glen H. , DENO, D. Curtis
IPC分类号： A61B18/14
CPC分类号： A61B18/1206 , A61B18/1492 , A61B2018/00577 , A61B2018/00875
摘要： A catheter and patch electrode system (10) for use with an apparatus (e.g., an ablation generator) having a 4-wire interface (62) for improved impedance measurements which includes two source connectors for receiving excitation signals and a pair of sense connector wires for measuring impedances. A radiofrequency ablation generator (16) can produce a signal between a source wire and an indifferent return patch electrode (37). A source lead (46) is electrically coupled to a tip electrode (28T) and extends through to a proximal end (and an optional sense lead can couple the tip electrode as well). A source return (56) and a sense return (56) (e.g., skin patch(es)) can be combined with the indifferent return (37) for improved performance when placed on opposite sides of a patient. The excitation signal traverses the complex (tissue) load returning to the generator (16) via patch electrode and impedance is measured by observing the voltage drop across the sense connectors.
摘要翻译：一种用于与具有用于改善阻抗测量的4线接口（62）的装置（例如，消融发生器）一起使用的导管和贴片电极系统（10），其包括用于接收激励信号的两个源连接器和一对感测连接器线用于测量阻抗。射频消融发生器（16）可以在源极线和无关的返回贴片电极（37）之间产生信号。源极（46）电耦合到尖端电极（28T）并且延伸到近端（并且可选的感测引线也可以连接尖端电极）。可以将源返回（56）和感测返回（56）（例如，皮肤贴片）与无关的返回（37）组合，以在放置在患者的相对侧时改善性能。激励信号通过贴片电极穿过返回发生器（16）的复合（组织）负载，并通过观察感测连接器两端的电压降来测量阻抗。

2. 发明申请

WO2011062681A1 SYSTEM AND METHOD FOR ASSESSING EFFECTIVE DELIVERY OF ABLATION THERAPY 审中-公开
标题翻译：用于评估有效递送治疗的系统和方法
公开(公告)号：WO2011062681A1
公开(公告)日：2011-05-26
申请号：PCT/US2010/050239
申请日：2010-09-24
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC. , DENO, D., Curtis , MILLER, Stephan P.
发明人： DENO, D., Curtis , MILLER, Stephan P.
IPC分类号： A61B5/05
CPC分类号： A61B18/1492 , A61B5/01 , A61B5/0538 , A61B5/068 , A61B5/4848 , A61B5/6843 , A61B5/6844 , A61B5/6885 , A61B5/743 , A61B18/02 , A61B90/37 , A61B2017/00044 , A61B2017/00199 , A61B2018/00351 , A61B2018/00577 , A61B2018/00642 , A61B2218/002 , A61N7/022
摘要： A system and method for assessing effective delivery of ablation therapy to a tissue (12) in a body (14) is provided. A three-dimensional anatomical map of the tissue (12) is generated and displayed with the map defining a corresponding volume (74). An index is generated corresponding to a location (76) within the volume (74) with the index indicative of a state of ablation therapy at the location (76). The index may be derived from one or more factors such as the duration an ablation electrode (52) is present at the location (76), the amount of energy provided, the degree of electrical coupling between an ablation electrode (52) and the tissue (12) at the location (76) and temperature. A visual characteristic (e.g., color intensity) of a portion of the anatomical map corresponding to the location (76) is then altered responsive to the index.
摘要翻译：提供了一种用于评估对身体（14）中的组织（12）的消融治疗的有效递送的系统和方法。生成并显示组织（12）的三维解剖图，并且其中定义相应体积的图（74）显示。生成对应于体积（74）内的位置（76）的索引，其中索引指示在位置处的消融治疗的状态（76）。索引可以从一个或多个因素导出，例如消融电极（52）存在于位置（76）的持续时间，所提供的能量的量，消融电极（52）和组织之间的电耦合程度（12）在位置（76）和温度。然后响应于索引改变与位置（76）对应的解剖图的一部分的视觉特征（例如，颜色强度）。

3. 发明申请

WO2011062653A1 SYSTEM AND METHOD FOR ASSESSING LESIONS IN TISSUE 审中-公开
标题翻译：用于评估组织中LESIONS的系统和方法
公开(公告)号：WO2011062653A1
公开(公告)日：2011-05-26
申请号：PCT/US2010/034414
申请日：2010-05-11
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC. , MILLER, Stephan P. , DENO, D. Curtis , PAUL, Saurav , TEPLITSKY, Liane R.
发明人： MILLER, Stephan P. , DENO, D. Curtis , PAUL, Saurav , TEPLITSKY, Liane R.
IPC分类号： A61B5/053
CPC分类号： A61B18/1492 , A61B18/1233 , A61B18/14 , A61B2018/00178 , A61B2018/00577 , A61B2018/00648 , A61B2018/00696 , A61B2018/00773 , A61B2018/00791 , A61B2018/00863 , A61B2018/00875 , A61B2090/065
摘要： A method and system for assessing lesion formation in tissue (16) is provided. The system includes an electronic control unit (ECU). The ECU (32) is configured to acquire values for first and second components of a complex impedance between the electrode (12) and the tissue (16), and to calculate an index responsive to the first and second values. The ECU (32) is further configured to process the ECI to assess lesion formation in the tissue (16).
摘要翻译：提供了一种用于评估组织中病变形成的方法和系统（16）。该系统包括电子控制单元（ECU）。 ECU（32）被配置为获取电极（12）和组织（16）之间的复阻抗的第一和第二分量的值，并且响应于第一和第二值来计算索引。 ECU（32）还被配置为处理ECI以评估组织（16）中的病变形成。

4. 发明申请

WO2010132472A1 SYSTEM AND METHOD FOR ASSESSING THE PROXIMITY OF AN ELECTRODE TO TISSUE IN A BODY 审中-公开
标题翻译：用于评估电极对身体组织的接近度的系统和方法
公开(公告)号：WO2010132472A1
公开(公告)日：2010-11-18
申请号：PCT/US2010/034412
申请日：2010-05-11
申请人： ST. JUDE MEDICAL, ATRIAL FIBRILLATION DIVISION, INC. , AIKEN, Robert D. , DENO, D. Curtis , KASTNER, Glen H. , MILLER, Stephan P.
发明人： AIKEN, Robert D. , DENO, D. Curtis , KASTNER, Glen H. , MILLER, Stephan P.
IPC分类号： A61B1/04
CPC分类号： A61B5/053 , A61B5/0538 , A61B5/06 , A61B5/063 , A61B5/068 , A61B18/1206 , A61B18/1492 , A61B18/16 , A61B2218/002
摘要： A method and system for assessing proximity between an electrode (12) and tissue (16) is provided. The system includes an electronic control unit (ECU). The ECU (32) is configured to acquire values for first and second components of a complex impedance between the electrode (12) and the tissue (16), and to calculate an electrical coupling index (ECI) responsive to the first and second values. The ECU (32) is further configured to process the ECI to determine the proximity of the electrode (12) to the tissue (16). The ECU (32) may be configured to calculate an electrical coupling index rate (ECIR) based on the calculated ECI and information relating to the change in location of the electrode (12), and to assess proximity based on the ECIR. Alternatively, the ECU (32) may be configured to assess the proximity using the calculated ECI, as opposed to the ECIR.
摘要翻译：提供了用于评估电极（12）和组织（16）之间的接近性的方法和系统。该系统包括电子控制单元（ECU）。 ECU（32）被配置为获取电极（12）和组织（16）之间的复阻抗的第一和第二分量的值，并且响应于第一和第二值来计算电耦合指数（ECI）。 ECU（32）还被配置为处理ECI以确定电极（12）与组织（16）的接近度。 ECU（32）可以被配置为基于所计算的ECI和与电极（12）的位置变化相关的信息来计算电耦合指数率（ECIR），并且基于ECIR评估接近度。或者，ECU（32）可以被配置为使用所计算的ECI来评估邻近度，而不是ECIR。

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