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1. 发明申请

US20020132120A1 Ultrasonically generated paramagnetic polymer particles 失效
公开(公告)号：US20020132120A1
公开(公告)日：2002-09-19
申请号：US10143903
申请日：2002-05-14
申请人： MDS Proteomics, Inc.
发明人： Irving Sucholeiki , Nak-Ho Sung , Jun Young Lee
IPC分类号： B32B005/16
CPC分类号： C08K3/22 , Y10T428/2991 , Y10T428/2998
摘要： A composite paramagnetic particle and method of making are provided. In one aspect of the invention, a particle comprising a multitude of submicron polymer bead aggregates covalently cross-linked to each other to form larger diameter particles is presented. Distributed throughout the composite paramagnetic particle are vacuous cavities. Each submicron polymer bead has distributed throughout its interior and surface submicron magnetite crystals. In another aspect of the invention, composite particles are made using high energy ultrasound during polymerization of one or more vinyl monomers. In one embodiment, high energy ultrasound is used during an emulsification step and during the early stages of the polymerization process to produce micron sized composite paramagnetic particles. The particles according to the invention exhibit a high percent magnetite incorporation and water and organic solvent stability.

2. 发明申请

US20040161795A1 Systems and methods for analysis of protein post-translational modification 审中-公开
标题翻译：分析蛋白质翻译后修饰的系统和方法
公开(公告)号：US20040161795A1
公开(公告)日：2004-08-19
申请号：US10627309
申请日：2003-07-25
申请人： MDS Proteomics Inc.
发明人： Jarrod A. Marto
IPC分类号： G01N033/53 , C12Q001/37
CPC分类号： G01N33/6803 , G06Q50/22
摘要： The invention relates to a method for the detection and identification of amino acid modifications, such as phosphorylation, using a combination of affinity capture and mass-spectroscopy.
摘要翻译：本发明涉及使用亲和捕获和质谱法的组合来检测和鉴定氨基酸修饰如磷酸化的方法。

3. 发明申请

US20040053356A1 Enzyme/chemical reactor based protein processing method for proteomics analysis by mass spectrometry 审中-公开
公开(公告)号：US20040053356A1
公开(公告)日：2004-03-18
申请号：US10602545
申请日：2003-06-23
申请人： MDS Proteomics Inc.
发明人： Henry Duewel , Theo Goh , Thierry Le Bihan
IPC分类号： C12P021/06
CPC分类号： G01N33/6848 , G01N33/6842 , G01N33/6851
摘要： A method and tools for the biochemical processing of protein samples towards their analysis and identification by, for example, mass spectrometry (MS). The method involves the reversible (non-covalent) immobilization, purification and concentration of proteins onto a solid surface and subsequent solid-phase enzyme-catalyzed proteolysis of the proteins. The constituent peptides are recovered in near-quantitative yields in a format ideally suited for identification by routine MS technologies. The process is easily adapted such that additional chemical and/or enzymatic transformation(s) of the immobilized proteins or peptides can be performed to facilitate the acquisition of and increase the information content obtained from the MS analysis.

4. 发明申请

US20040009567A1 Enzyme/chemical reactor based protein processing method for proteomics analysis by mass spectrometry 审中-公开
标题翻译：基于酶/化学反应器的蛋白质加工方法，通过质谱法进行蛋白质组学分析
公开(公告)号：US20040009567A1
公开(公告)日：2004-01-15
申请号：US10455746
申请日：2003-06-05
申请人： MDS Proteomics Inc.
发明人： Henry Duewel , Theo Goh , Thierry Le Bihan
IPC分类号： C12N009/00 , C12Q001/00
CPC分类号： G01N33/6848 , G01N33/6842
摘要： A method and tools for the biochemical processing of protein samples towards their analysis and identification by, for example, mass spectrometry (MS). The method involves the reversible (non-covalent) immobilization, purification and concentration of proteins onto a solid surface and subsequent solid-phase enzyme-catalyzed proteolysis of the proteins. The constituent peptides are recovered in near-quantitative yields in a format ideally suited for identification by routine MS technologies. The process is easily adapted such that additional chemical and/or enzymatic transformation(s) of the immobilized proteins or peptides can be performed to facilitate the acquisition of and increase the information content obtained from the MS analysis.
摘要翻译：用于通过例如质谱（MS）对蛋白质样品进行生物化学处理以进行其分析和鉴定的方法和工具。该方法涉及可逆（非共价）固定，纯化和将蛋白质浓缩到固体表面上，随后进行固相酶催化的蛋白质分解。以非常适合通过常规MS技术鉴定的形式以近定量产率回收组成肽。该方法易于适应，使得可以执行固定的蛋白质或肽的额外的化学和/或酶转化以便于获得并增加从MS分析获得的信息内容。

5. 发明申请

US20030232014A1 Phosphorylated proteins and uses related thereto 审中-公开
标题翻译：磷酸化蛋白质及其相关用途
公开(公告)号：US20030232014A1
公开(公告)日：2003-12-18
申请号：US10378173
申请日：2003-03-03
申请人： MDS Proteomics Inc. , University of Virginia
发明人： Daniel J. Burke , Mark M. Ross , P. Todd Stukenberg , Forest M. White
IPC分类号： A61K051/00 , C07K016/18 , C07K014/00
CPC分类号： C12Q1/485 , A61K38/00 , A61K51/088 , C07K14/395 , G01N33/5011 , G01N2500/00 , G06Q50/22 , Y02A90/22
摘要： Methods and systems of applying mass spectrometry to the analysis of peptides and amino acids, especially in the proteome setting. More particularly, the invention relates to a mass spectrometry-based method for detection of amino acid modifications, such as phosphorylation.
摘要翻译：应用质谱法分析肽和氨基酸，特别是蛋白质组的方法和系统。更具体地，本发明涉及用于检测氨基酸修饰如磷酸化的基于质谱法的方法。

6. 发明申请

US20030166007A1 Chemical proteomics 审中-公开
标题翻译：化学蛋白质组学
公开(公告)号：US20030166007A1
公开(公告)日：2003-09-04
申请号：US10358119
申请日：2003-02-03
申请人： MDS Proteomics Inc.
发明人： Shane Climie , Leroi Victor Desouza , Henry Duewel , Christopher Mark Hosfield , Linda Chiou-Lin Liao , Linda D. B. McBroom , Irving Sucholeiki , Leticia M. Toledo-Sherman
IPC分类号： G01N033/53 , G01N033/543
CPC分类号： G01N33/6848 , G01N33/6803 , G01N2500/04
摘要： The invention relates to methods and reagents for identifying/isolating protein targets of chemical compounds (for example, drug candidates) using mass spectrometry. The invention provides a method for capturing and identifying proteins using tethered small-molecule probes. This technology also allows the market expansion of known drugs by finding new therapeutic targets; identification of the mechanism of toxicity of drug candidates or drugs which failed in the clinic; identification of new chemical tools for chemically-driven target validation; identification of new drug leads; and identification of the mechanism of action of drugs and drug candidates. A key advantage of the technology is that a single experiment can identify the numerous proteins which interact with a probe (or nullbaitnull).
摘要翻译：本发明涉及使用质谱鉴定/分离化学化合物（例如候选药物）的蛋白质靶标的方法和试剂。本发明提供了使用系留小分子探针捕获和鉴定蛋白质的方法。该技术还可以通过发现新的治疗靶点来扩大已知药物的市场; 鉴定诊所失败的候选药物或药物的毒性机制; 识别用于化学驱动目标验证的新化学工具; 鉴定新药引线; 并确定药物和候选药物的作用机制。该技术的一个主要优点是单个实验可以识别与探针（或“诱饵”）相互作用的许多蛋白质。

7. 发明申请

WO2003074992A3 PHOSPHORYLATED PROTEINS AND USES RELATED THERETO 审中-公开
公开(公告)号：WO2003074992A3
公开(公告)日：2003-09-12
申请号：PCT/US2003/006553
申请日：2003-03-03
申请人： MDS PROTEOMICS INC. , UNIVERSITY OF VIRGINIA PATENT FOUNDATION , BURKE, Daniel, J. , ROSS, Mark, M. , STUKENBERG, P., Todd , WHITE, Forest, M.
发明人： BURKE, Daniel, J. , ROSS, Mark, M. , STUKENBERG, P., Todd , WHITE, Forest, M.
IPC分类号： A61K38/04
摘要： Methods and systems of applying mass spectrometry to the analysis of peptides and amino acids, especially in the proteome setting. More particularly, the invention relates to a mass spectrometry-based method for detection of amino acid modifications, such as phosphorylation.

8. 发明申请

WO2003074992A2 PHOSPHORYLATED PROTEINS AND USES RELATED THERETO 审中-公开
标题翻译：磷酸钙蛋白及其相关用途
公开(公告)号：WO2003074992A2
公开(公告)日：2003-09-12
申请号：PCT/US2003/006553
申请日：2003-03-03
申请人： MDS PROTEOMICS INC. , UNIVERSITY OF VIRGINIA PATENT FOUNDATION , BURKE, Daniel, J. , ROSS, Mark, M. , STUKENBERG, P., Todd , WHITE, Forest, M.
发明人： BURKE, Daniel, J. , ROSS, Mark, M. , STUKENBERG, P., Todd , WHITE, Forest, M.
IPC分类号： G01N
CPC分类号： C12Q1/485 , A61K38/00 , A61K51/088 , C07K14/395 , G01N33/5011 , G01N2500/00 , G06Q50/22 , Y02A90/22
摘要： Methods and systems of applying mass spectrometry to the analysis of peptides and amino acids, especially in the proteome setting. More particularly, the invention relates to a mass spectrometry-based method for detection of amino acid modifications, such as phosphorylation.
摘要翻译：应用质谱法分析肽和氨基酸，特别是蛋白质组的方法和系统。更具体地，本发明涉及用于检测氨基酸修饰如磷酸化的基于质谱法的方法。

9. 发明申请

WO2003038055A3 PROTEINS INVOLVED IN REGULATION OF ADIPOCYTES AND USES RELATED THERETO 审中-公开
公开(公告)号：WO2003038055A3
公开(公告)日：2003-05-08
申请号：PCT/US2002/035050
申请日：2002-10-31
申请人： MDS PROTEOMICS, INC. , BLAGOEV, Blagoy, Andonov , KRATCHMAROVA, Irina, Hristova , MANN, Matthias , PANDEY, Akilesh , PODTELEJNIKOV, Alexandre, V.
发明人： BLAGOEV, Blagoy, Andonov , KRATCHMAROVA, Irina, Hristova , MANN, Matthias , PANDEY, Akilesh , PODTELEJNIKOV, Alexandre, V.
IPC分类号： C07H21/04
摘要： The invention relates to the identification and quantification of proteins differentially expressed during adipogenesis. More specifically, the invention relates to methods for identifying and/or quantitating proteins differentially expressed in one or more specific stage(s) of adipocyte differenciation, using mass spectrometry. The invention also provides those differentially expressed genes as marker genes of adipogenesis. The invention further provides treatment for patients suffering from conditions associated with hyper- or hypo-adipogenesis.

10. 发明申请

WO2002080649A2 METHODS AND SYSTEMS FOR SEARCHING GENOMIC DATABASES 审中-公开
标题翻译：搜索基因组数据库的方法和系统
公开(公告)号：WO2002080649A2
公开(公告)日：2002-10-17
申请号：PCT/US2002/011417
申请日：2002-04-09
申请人： MDS PROTEOMICS, INC. , MANN, Matthias , MORTENSEN, Peter
发明人： MANN, Matthias , MORTENSEN, Peter
IPC分类号： G06F17/30 , G06F19/22 , G06F19/28
CPC分类号： G06F19/28 , G06F19/22
摘要： The instant invention provides methods and systems for searching genomic databases using polypeptide sequence information, such as those obtained from peptide sequencing projects, especially those using mass spectrometers. According to the instant invention, polypeptide sequences can be reverse translated into multiple sequence tags wich are then used to search for identical or similar sequences in genomic databases, such as unanotated genomic databases of human or other organisms. Alternatively, the polypeptide sequences can be directly compared to sequences translated from at least 3, preferably all 6 reading frames of genomic sequences. The instant invention also provides systems for performing the methods of the instant invention, including computer systems, and systems including said computer systems and mass spectrometers linked to said computer systems. The instant invention further provides methods of conducting proteomic businesses using the methods of the instant invention.
摘要翻译：本发明提供了使用多肽序列信息搜索基因组数据库的方法和系统，例如从肽测序项目获得的信息，特别是使用质谱仪的那些。根据本发明，多肽序列可以反向翻译成多个序列标签，然后用于在基因组数据库中搜索相同或相似的序列，例如人或其他生物体的未经转化的基因组数据库。或者，可以将多肽序列直接与从基因组序列的至少3个，优选全部6个阅读框翻译的序列进行比较。本发明还提供用于执行本发明的方法的系统，包括计算机系统和包括与所述计算机系统相连的所述计算机系统和质谱仪的系统。本发明还提供使用本发明的方法进行蛋白质组业务的方法。

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