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1. 发明申请

WO2009050189A3 MULTIPART CAPSULE FOR STAGED RELEASE OF ONE OR MORE SUBSTANCES 审中-公开
标题翻译：一批或多种物质的多张胶囊
公开(公告)号：WO2009050189A3
公开(公告)日：2010-01-14
申请号：PCT/EP2008063852
申请日：2008-10-15
申请人： GLAXO GROUP LTD , MCALLISTER STEPHEN MARK , MATTHEWS WAYNE M
发明人： MCALLISTER STEPHEN MARK , MATTHEWS WAYNE M
IPC分类号： A61K9/48
CPC分类号： A61K9/4808
摘要： A multipart capsule, e.g., a dosage form, is provided which includes a plurality of capsule portions, at least one of which contains a substance to be released into a gastro-intestinal environment and at least one link component interconnecting two adjacent capsule portions. At least one capsule portion is formed from a polymer that is a transitional polymer, for example, a polymer that changes shape, form, or structure within a gastro-intestinal environment, e.g., dispersible, dissolvable, disintegrable, fracturable, breachable, swellable, partially or completely soluble, or otherwise changeable when exposed to stomach pH and/or in intestine pH to thereby release the substance. The capsule portions are connected together in an assembled dosage form. The link component includes at least one aperture in flow communication with interiors of two adjacent capsule portions to control the release of the substance.
摘要翻译：提供了多部分胶囊，例如剂型，其包括多个胶囊部分，其中至少一个包含要释放到胃肠环境中的物质和至少一个连接两个相邻胶囊部分的连接部件。至少一个胶囊部分由聚合物形成，所述聚合物是过渡聚合物，例如在肠胃环境内改变形状，形式或结构的聚合物，例如可分散，可溶解，可崩解，可破碎，可破裂，可溶胀，部分或完全可溶，或当暴露于胃pH和/或肠内pH时可以变化，从而释放物质。胶囊部分以组合剂型连接在一起。连杆部件包括与两个相邻胶囊部分的内部流动连通的至少一个孔，以控制物质的释放。

2. 发明申请

WO2009050190A3 LINKERS FOR MULTIPART DOSAGE FORMS FOR RELEASE OF ONE OR MORE PHARMACEUTICAL COMPOSITIONS, AND THE RESULTING DOSAGE FORMS 审中-公开
公开(公告)号：WO2009050190A3
公开(公告)日：2009-04-23
申请号：PCT/EP2008/063853
申请日：2008-10-15
申请人： GLAXO GROUP LIMITED , MCALLISTER, Stephen Mark
发明人： MCALLISTER, Stephen Mark
IPC分类号： A61J3/07
摘要： A linker for multicomponent dosage form has a preformed drug substance tablet and an injection molded jacket including one or both axial jacket ends open for dispensing the preformed drug substances. The jacket has snap-fit connection elements on the outer surface adjacent each end for engagement with complementary snap-fit element on capsule-type and cap-type dosage form units. Another multicomponent drug form linker is injection molded with a raised circumferential band and snap-fit elements between the band and respective ends engageable with complementary snap-fit elements on dosage form units to provide compressive abutting contact between ends of the units and the band. The band can have an axially tapered outer surface to accommodate dosage form units of different diameters. Still another multicomponent dosage form linker has separable male and female parts each engageable with, and separately sealing, respective dosage form units to be linked. Circumferential complementary grooves, groove segments, ridges and ridge segment- type snap-fit elements are disclosed, as are dosage forms using the above-described linkers.

3. 发明申请

WO2009087483A2 PHARMACEUTICAL FORMULATIONS 审中-公开
标题翻译：药物制剂
公开(公告)号：WO2009087483A2
公开(公告)日：2009-07-16
申请号：PCT/IB2008/003872
申请日：2008-11-01
申请人： GLAXO GROUP LIMITED , BROWN, Adrian , GORRINGE, Lee J. , MATTHEWS, Wayne M. , McALLISTER, Stephen, Mark , RUSSELL, Danielle, Geneviève, Rebecca
发明人： BROWN, Adrian , GORRINGE, Lee J. , MATTHEWS, Wayne M. , McALLISTER, Stephen, Mark , RUSSELL, Danielle, Geneviève, Rebecca
CPC分类号： A61K9/4816
摘要： The present invention is directed to novel pharmaceutically acceptable polymeric compositions suitable for melt extrusion and injection moulding of single or multi-component pharmaceutical dosage forms comprising a plurality of drug substance containing sub-units, being capsule compartments and/or solid sub-units comprising a solid matrix of a polymer which contains a drug substance, the sub-units being connected together in the assembled dosage form.
摘要翻译：本发明涉及适用于单组份或多组分药物剂型的熔体挤出和注射成型的新的药学上可接受的聚合物组合物，其包含多个含药物物质的子单元，其为胶囊隔室和 /或包含含有药物物质的聚合物固体基质的固体亚单位，所述亚单位以组装的剂型连接在一起。

4. 发明申请

WO2007012478A2 ENCAPSULATION OF LIPID-BASED FORMULATIONS IN ENTERIC POLYMERS 审中-公开
标题翻译：肠内聚合物中基于脂质的制剂的包封
公开(公告)号：WO2007012478A2
公开(公告)日：2007-02-01
申请号：PCT/EP2006007387
申请日：2006-07-24
申请人： GLAXO GROUP LTD , MCALLISTER STEPHEN MARK
发明人： MCALLISTER STEPHEN MARK
IPC分类号： A61K9/50
CPC分类号： A61K9/1617 , A61K9/5042 , B01J13/04
摘要： A microcapsule comprising a lipid-based core that is encapsulated in an enteric polymer shell providing enhanced bioavailability of a sparingly water-soluble drug as well as modulated release of the drug, wherein the microcapsule is, in one embodiment, prepared by a centrifugal coextrusion process. The lipid-based core comprises lipidic carriers, either liquid or solid (melting point
摘要翻译：一种微胶囊，其包含封装在肠溶性聚合物壳体中的脂质核，其提供了微量水溶性药物的增强的生物利用度以及药物的调节释放，其中在一个实施方案中，微胶囊通过离心共挤出方法。基于脂质的核心包括液体或固体（熔点<1000℃）的脂质载体，其将提供足够的药物溶解并且与肠衣壳材料相容。

5. 发明申请

WO2005089726A1 PHARMACEUTICAL FORMULATIONS 审中-公开
标题翻译：药物制剂
公开(公告)号：WO2005089726A1
公开(公告)日：2005-09-29
申请号：PCT/US2005/008147
申请日：2005-03-11
申请人： SMITHKLINE BEECHAM PLC , BROWN, Adrian , MARGETSON, Daniel, N. , MATTHEWS, Wayne, M. , McALLISTER, Stephen, Mark , RABY, Ronald, K., Jr.
发明人： BROWN, Adrian , MARGETSON, Daniel, N. , MATTHEWS, Wayne, M. , McALLISTER, Stephen, Mark , RABY, Ronald, K., Jr.
IPC分类号： A61K9/48
CPC分类号： A61K9/1617 , A61K9/1623 , A61K9/1647 , A61K9/1652 , A61K9/4816 , A61K9/5026 , A61K9/5047 , A61K47/32
摘要： The present invention is directed to novel pharmaceutically acceptable polymeric compositions suitable for melt extrusion and injection molding of single or multi-component pharmaceutical dosage forms comprising a plurality of drug substance containing sub-units, being capsule compartments and/or solid sub-units comprising a solid matrix of a polymer which contains a drug substance, the sub-units being connected together in the assembled dosage form.
摘要翻译：本发明涉及适于熔融挤出和注射成型单组分或多组分药物剂型的新型药学上可接受的聚合物组合物，其包含多个含药物物质的子单元，其为胶囊隔室和/或固体亚单元，其包含含有药物的聚合物的固体基质，所述子单元在组装的剂型中连接在一起。

6. 发明申请

WO2009050193A1 METHOD AND APPARATUS FOR MANUFACTURING FILLED LINKERS 审中-公开
标题翻译：制造填充连接器的方法和装置
公开(公告)号：WO2009050193A1
公开(公告)日：2009-04-23
申请号：PCT/EP2008/063857
申请日：2008-10-15
申请人： GLAXO GROUP LIMITED , MCALLISTER, Stephen Mark
发明人： MCALLISTER, Stephen Mark
IPC分类号： A61J3/07
CPC分类号： A61J3/077 , A61J3/005
摘要： A method of manufacturing a linker of the type having an injection molded jacket radially confining a preformed tablet. The method includes grasping the tablet about the outer surface with a plurality of pincers and positioning the grasped tablet and the pincers with respect to a molding apparatus. The method also includes supporting the tablet via the pincers and injecting jacket material to cover the outer tablet surface and the pincers. The method further includes extracting the jacketed tablet from the molding apparatus and removing the pincers from the jacketed tablet. The method may also include supporting and longitudinally positioning the tablet within the mold via a plurality of additional pincers.
摘要翻译：制造具有注射成型护套的类型的接头的方法，其径向限制预成型片剂。该方法包括用多个钳夹住围绕外表面的片剂，并将夹持的药片和钳子相对于成型装置定位。该方法还包括通过钳子支撑片剂并注射护套材料以覆盖外片剂表面和钳子。该方法还包括从成型设备中提取夹套的片剂并从夹套的片剂中除去钳子。该方法还可以包括通过多个额外的钳子来支撑和纵向地将片剂定位在模具内。

7. 发明申请

WO2009050192A1 PANELED CAPSULE SHELLS FOR RELEASE OF PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译：用于释放药物组合物的面团胶囊
公开(公告)号：WO2009050192A1
公开(公告)日：2009-04-23
申请号：PCT/EP2008/063856
申请日：2008-10-15
申请人： GLAXO GROUP LIMITED , MCALLISTER, Stephen Mark
发明人： MCALLISTER, Stephen Mark
IPC分类号： A61J3/07 , A61K9/48
CPC分类号： A61J3/071 , A61J3/077 , A61K9/4808
摘要： Capsule shells for use in multi-part dosage forms have generally cylindrical shell members (12) with a snap fit component on an interior surface adjacent an open end (16) for connection to a linker part (26) of the dosage form. The shell member (12) also has a plurality of spaced apart integrally formed thin (relative to cirmcumf erentially adjacent shell member portions) panels (30) located adjacent a closed shell member end (18) for preferential dissolution and release of pharmaceutical compositions from the shell member interior. The ratio of the thickness of the panels to the thickness of the shell member ranges from about 0.2 to about 0.6. The panels (30) can be integrally formed together with the shell member as reliefs or depressions on the inner surface of the shell member (12) by injection molding, and panel thicknesses as thin as about 0.1mm can be achieved.
摘要翻译：用于多部分剂型的胶囊壳体具有通常为圆柱形的壳体构件（12），其在靠近开口端（16）的内表面上具有卡扣配合部件，用于连接到剂型的接头部分（26）。外壳构件（12）还具有多个间隔开的整体形成的薄（相对于邻近的壳体构件部分），位于邻近封闭的壳构件端部（18）的面板（30），用于优先溶解和释放药物组合物外壳成员内部。面板的厚度与外壳构件的厚度的比例为约0.2至约0.6。面板（30）可以通过注射成型与外壳构件一体地形成在外壳构件（12）的内表面上的浮雕或凹陷，并且可以实现薄至约0.1mm的面板厚度。

8. 发明申请

WO2004010978A1 MULTICOMPONENT PHARMACEUTICAL DOSAGE FORM 审中-公开
标题翻译：多功能药物剂型
公开(公告)号：WO2004010978A1
公开(公告)日：2004-02-05
申请号：PCT/GB2003/003157
申请日：2003-07-24
申请人： GLAXO GROUP LIMITED , BONNEY, Stanley, George , BROWN, Adrian , DAVIES, Michael, Birsha , MARGETSON, Daniel, N , MATTHEWS, Wayne, M. , MCALLISTER, Stephen, Mark , RAND, Paul, Kenneth , WILSON, Alan, Anthony
发明人： BONNEY, Stanley, George , BROWN, Adrian , DAVIES, Michael, Birsha , MARGETSON, Daniel, N , MATTHEWS, Wayne, M. , MCALLISTER, Stephen, Mark , RAND, Paul, Kenneth , WILSON, Alan, Anthony
IPC分类号： A61K9/20
CPC分类号： A61J3/071 , A61K9/2072 , A61K9/4808
摘要： A multi-component pharmaceutical dosage form suitable for retaining drug substance which drug substance can be released to provide a controlled drug release profile in the gastrointestinal environment, characterised by a body e.g. comprising a delayed release polymeric material such as Eudragit 4135F, the body having at least one cavity said cavity having a mouth opening and a film means e.g. comprising an immediate release polymeric material e.g. Eudragit E100 or a blend thereof, connected to the body and closing the mouth opening.
摘要翻译：一种适用于保留药物物质的多组分药物剂型，该药物物质可以释放，以在胃肠环境中提供受控的药物释放特征，其特征在于身体例如。包括延迟释放聚合材料，例如Eudragit 4135F，所述本体具有至少一个腔，所述腔具有开口和膜装置，例如，包括立即释放的聚合材料，例如 Eudragit E100或其混合物，连接到身体并关闭开口。

9. 发明申请

WO2009150228A3 HYDROXYPROPYL CELLULOSE CAPSULE SHELL 审中-公开
公开(公告)号：WO2009150228A3
公开(公告)日：2009-12-17
申请号：PCT/EP2009/057292
申请日：2009-06-12
申请人： GLAXO GROUP LIMITED , BROWN, Adrian , MATTHEWS, Wayne M , MARGETSON, Daniel N , MCALLISTER, Stephen Mark , RUSSELL, Danielle Genevieve Rebecca
发明人： BROWN, Adrian , MATTHEWS, Wayne M , MARGETSON, Daniel N , MCALLISTER, Stephen Mark , RUSSELL, Danielle Genevieve Rebecca
IPC分类号： A61K9/48
摘要： The present invention is directed to novel pharmaceutically acceptable polymeric compositions suitable for melt extrusion and injection moulding of single or multi-component pharmaceutical dosage forms comprising a plurality of drug substance containing sub-units, being capsule compartments and/or solid sub-units comprising a solid matrix of a polymer which contains a drug substance, the sub-units being connected together in the assembled dosage form.

10. 发明申请

WO2009087483A3 PHARMACEUTICAL FORMULATIONS 审中-公开
标题翻译：药物制剂
公开(公告)号：WO2009087483A3
公开(公告)日：2009-10-22
申请号：PCT/IB2008003872
申请日：2008-11-07
申请人： GLAXO GROUP LTD , BROWN ADRIAN , GORRINGE LEE J , MATTHEWS WAYNE M , MCALLISTER STEPHEN MARK , RUSSELL DANIELLE GENEVIEVE REB
发明人： BROWN ADRIAN , GORRINGE LEE J , MATTHEWS WAYNE M , MCALLISTER STEPHEN MARK , RUSSELL DANIELLE GENEVIEVE REBECCA
IPC分类号： A61K9/48 , A61K47/38
CPC分类号： A61K9/4816
摘要： The present invention is directed to novel pharmaceutically acceptable polymeric compositions suitable for melt extrusion and injection moulding of single or multi-component pharmaceutical dosage forms comprising a plurality of drug substance containing sub-units, being capsule compartments and/or solid sub-units comprising a solid matrix of a polymer which contains a drug substance, the sub-units being connected together in the assembled dosage form.
摘要翻译：本发明涉及适用于单组分或多组分药物剂型的熔体挤出和注射成型的新型药学上可接受的聚合物组合物，其包含多个含药物物质的子单元，其是胶囊隔室和/或固体亚单元，其包含包含药物的聚合物的固体基质，所述亚单位以组装的剂型连接在一起。

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