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1. 发明申请

WO2009050189A3 MULTIPART CAPSULE FOR STAGED RELEASE OF ONE OR MORE SUBSTANCES 审中-公开
标题翻译：一批或多种物质的多张胶囊
公开(公告)号：WO2009050189A3
公开(公告)日：2010-01-14
申请号：PCT/EP2008063852
申请日：2008-10-15
申请人： GLAXO GROUP LTD , MCALLISTER STEPHEN MARK , MATTHEWS WAYNE M
发明人： MCALLISTER STEPHEN MARK , MATTHEWS WAYNE M
IPC分类号： A61K9/48
CPC分类号： A61K9/4808
摘要： A multipart capsule, e.g., a dosage form, is provided which includes a plurality of capsule portions, at least one of which contains a substance to be released into a gastro-intestinal environment and at least one link component interconnecting two adjacent capsule portions. At least one capsule portion is formed from a polymer that is a transitional polymer, for example, a polymer that changes shape, form, or structure within a gastro-intestinal environment, e.g., dispersible, dissolvable, disintegrable, fracturable, breachable, swellable, partially or completely soluble, or otherwise changeable when exposed to stomach pH and/or in intestine pH to thereby release the substance. The capsule portions are connected together in an assembled dosage form. The link component includes at least one aperture in flow communication with interiors of two adjacent capsule portions to control the release of the substance.
摘要翻译：提供了多部分胶囊，例如剂型，其包括多个胶囊部分，其中至少一个包含要释放到胃肠环境中的物质和至少一个连接两个相邻胶囊部分的连接部件。至少一个胶囊部分由聚合物形成，所述聚合物是过渡聚合物，例如在肠胃环境内改变形状，形式或结构的聚合物，例如可分散，可溶解，可崩解，可破碎，可破裂，可溶胀，部分或完全可溶，或当暴露于胃pH和/或肠内pH时可以变化，从而释放物质。胶囊部分以组合剂型连接在一起。连杆部件包括与两个相邻胶囊部分的内部流动连通的至少一个孔，以控制物质的释放。

2. 发明申请

WO2007012478A2 ENCAPSULATION OF LIPID-BASED FORMULATIONS IN ENTERIC POLYMERS 审中-公开
标题翻译：肠内聚合物中基于脂质的制剂的包封
公开(公告)号：WO2007012478A2
公开(公告)日：2007-02-01
申请号：PCT/EP2006007387
申请日：2006-07-24
申请人： GLAXO GROUP LTD , MCALLISTER STEPHEN MARK
发明人： MCALLISTER STEPHEN MARK
IPC分类号： A61K9/50
CPC分类号： A61K9/1617 , A61K9/5042 , B01J13/04
摘要： A microcapsule comprising a lipid-based core that is encapsulated in an enteric polymer shell providing enhanced bioavailability of a sparingly water-soluble drug as well as modulated release of the drug, wherein the microcapsule is, in one embodiment, prepared by a centrifugal coextrusion process. The lipid-based core comprises lipidic carriers, either liquid or solid (melting point
摘要翻译：一种微胶囊，其包含封装在肠溶性聚合物壳体中的脂质核，其提供了微量水溶性药物的增强的生物利用度以及药物的调节释放，其中在一个实施方案中，微胶囊通过离心共挤出方法。基于脂质的核心包括液体或固体（熔点<1000℃）的脂质载体，其将提供足够的药物溶解并且与肠衣壳材料相容。

3. 发明申请

WO2009087483A3 PHARMACEUTICAL FORMULATIONS 审中-公开
标题翻译：药物制剂
公开(公告)号：WO2009087483A3
公开(公告)日：2009-10-22
申请号：PCT/IB2008003872
申请日：2008-11-07
申请人： GLAXO GROUP LTD , BROWN ADRIAN , GORRINGE LEE J , MATTHEWS WAYNE M , MCALLISTER STEPHEN MARK , RUSSELL DANIELLE GENEVIEVE REB
发明人： BROWN ADRIAN , GORRINGE LEE J , MATTHEWS WAYNE M , MCALLISTER STEPHEN MARK , RUSSELL DANIELLE GENEVIEVE REBECCA
IPC分类号： A61K9/48 , A61K47/38
CPC分类号： A61K9/4816
摘要： The present invention is directed to novel pharmaceutically acceptable polymeric compositions suitable for melt extrusion and injection moulding of single or multi-component pharmaceutical dosage forms comprising a plurality of drug substance containing sub-units, being capsule compartments and/or solid sub-units comprising a solid matrix of a polymer which contains a drug substance, the sub-units being connected together in the assembled dosage form.
摘要翻译：本发明涉及适用于单组分或多组分药物剂型的熔体挤出和注射成型的新型药学上可接受的聚合物组合物，其包含多个含药物物质的子单元，其是胶囊隔室和/或固体亚单元，其包含包含药物的聚合物的固体基质，所述亚单位以组装的剂型连接在一起。

4. 发明申请

WO2009150228A2 PHARMACEUTICAL FORMULATIONS 审中-公开
标题翻译：药物制剂
公开(公告)号：WO2009150228A2
公开(公告)日：2009-12-17
申请号：PCT/EP2009057292
申请日：2009-06-12
申请人： GLAXO GROUP LTD , BROWN ADRIAN , MATTHEWS WAYNE M , MARGETSON DANIEL N , MCALLISTER STEPHEN MARK , RUSSELL DANIELLE GENEVIEVE REB
发明人： BROWN ADRIAN , MATTHEWS WAYNE M , MARGETSON DANIEL N , MCALLISTER STEPHEN MARK , RUSSELL DANIELLE GENEVIEVE REBECCA
IPC分类号： A61K9/48
CPC分类号： A61K9/4816
摘要： The present invention is directed to novel pharmaceutically acceptable polymeric compositions suitable for melt extrusion and injection moulding of single or multi-component pharmaceutical dosage forms comprising a plurality of drug substance containing sub-units, being capsule compartments and/or solid sub-units comprising a solid matrix of a polymer which contains a drug substance, the sub-units being connected together in the assembled dosage form.
摘要翻译：本发明涉及适于熔融挤出和注射成型单组分或多组分药物剂型的新型药学上可接受的聚合物组合物，其包含多个含药物物质的子单元，其为胶囊隔室和/或固体亚单元，其包含含有药物的聚合物的固体基质，所述子单元在组装的剂型中连接在一起。

5. 发明申请

WO2009050190A2 LINKERS FOR MULTIPART DOSAGE FORMS FOR RELEASE OF ONE OR MORE PHARMACEUTICAL COMPOSITIONS, AND THE RESULTING DOSAGE FORMS 审中-公开
标题翻译：用于释放一种或多种药物组合物的多组分剂型的链接剂以及所推荐的剂型
公开(公告)号：WO2009050190A2
公开(公告)日：2009-04-23
申请号：PCT/EP2008063853
申请日：2008-10-15
申请人： GLAXO GROUP LTD , MCALLISTER STEPHEN MARK
发明人： MCALLISTER STEPHEN MARK
IPC分类号： A61J3/07
CPC分类号： A61J3/071 , A61J3/072
摘要： A linker for multicomponent dosage form has a preformed drug substance tablet and an injection molded jacket including one or both axial jacket ends open for dispensing the preformed drug substances. The jacket has snap-fit connection elements on the outer surface adjacent each end for engagement with complementary snap-fit element on capsule-type and cap-type dosage form units. Another multicomponent drug form linker is injection molded with a raised circumferential band and snap-fit elements between the band and respective ends engageable with complementary snap-fit elements on dosage form units to provide compressive abutting contact between ends of the units and the band. The band can have an axially tapered outer surface to accommodate dosage form units of different diameters. Still another multicomponent dosage form linker has separable male and female parts each engageable with, and separately sealing, respective dosage form units to be linked. Circumferential complementary grooves, groove segments, ridges and ridge segment- type snap-fit elements are disclosed, as are dosage forms using the above-described linkers.
摘要翻译：用于多组分剂型的接头具有预成形的药物片剂和注射模制护套，注射模制护套包括一个或两个轴向护套端部以打开用于分配预成形的药物物质。护套在邻近每个端部的外表面上具有搭扣配合连接元件，用于与胶囊型和帽型剂型单元上的互补搭扣配合元件接合。另一种多组分药物形式的连接体是用凸起的周向带注射模制的，并且带和相应端之间的搭扣配合元件可与剂型单元上的互补搭扣配合元件接合，以在单元端部和带之间提供压缩邻接接触。该带可以具有轴向渐缩的外表面以适应不同直径的剂型单位。另一种多组分剂型连接剂具有可分离的雄性和雌性部分，每个部分可与待连接的各剂型单元接合并分别密封。公开了与使用上述接头的剂型一样的周向互补凹槽，凹槽段，脊和脊段型卡扣元件。

6. 发明申请

WO02060384A3 PHARMACEUTICAL FORMULATION 审中-公开
标题翻译：药物制剂
公开(公告)号：WO02060384A3
公开(公告)日：2003-05-30
申请号：PCT/US0202694
申请日：2002-01-30
申请人： SMITHKLINE BEECHAM PLC , MCALLISTER STEPHEN MARK , RABY RONALD K JR , BROWN ADRIAN , CLARKE ALLAN J , MATTHEWS WAYNE , MARGETSON DANIEL N
发明人： MCALLISTER STEPHEN MARK , RABY RONALD K JR , BROWN ADRIAN , CLARKE ALLAN J , MATTHEWS WAYNE , MARGETSON DANIEL N
IPC分类号： A61K47/32 , A61K9/32 , A61K9/48 , A61K9/52 , A61K9/54 , A61K9/58 , A61K47/04 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/20 , A61K47/22 , A61K47/24 , A61K47/26 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/44
CPC分类号： A61K9/4816 , A61K9/4808
摘要： The present invention is directed to pharmaceutically acceptable polymeric compositions suitable for injection molding of single or multi-component pharmaceutical dosage forms comprising a plurality of drug substance containing sub-units, being capsule compartments and/or solid sub-units comprising a solid matrix of a polymer which contains a drug substance, the sub-units being connected together in the assembled dosage form by a weld between parts of the assembled dosage form.
摘要翻译：本发明涉及适于注射模塑单组分或多组分药物剂型的药学上可接受的聚合物组合物，其包含多个含药物物质的子单元，包括胶囊隔室和/或包含固体基质的固体亚单元含有药物的聚合物，所述子单元通过组装的剂型的部分之间的焊接在组装的剂型中连接在一起。

7. 发明申请

WO2005009380A3 PHARMACEUTICAL FORMULATIONS 审中-公开
标题翻译：药物制剂
公开(公告)号：WO2005009380A3
公开(公告)日：2005-06-02
申请号：PCT/US2004023542
申请日：2004-07-21
申请人： SMITHKLINE BEECHAM PLC , MCALLISTER STEPHEN MARK , RABY RONALD K JR , BROWN ADRIAN
发明人： MCALLISTER STEPHEN MARK , RABY RONALD K JR , BROWN ADRIAN
IPC分类号： A61K20060101 , A61K9/48
CPC分类号： A61K9/4816 , A61K9/4808 , A61K9/4866
摘要： The present invention is directed to novel pharmaceutically acceptable polymeric compositions suitable for injection molding of single or multi-component pharmaceutical dosage forms comprising a plurality of drug substance containing sub-units, being capsule compartments and/or solid sub-units comprising a solid matrix of a polymer which contains a drug substance, the sub-units being connected together in the assembled dosage form by a weld between parts of the assembled dosage form.
摘要翻译：本发明涉及适用于注射模塑单组分或多组分药物剂型的新型药学上可接受的聚合物组合物，其包含多个含药物物质的子单元，其为胶囊隔室和/或固体亚单位，其包含固体基质含有药物的聚合物，所述子单元通过组装的剂型的各部分之间的焊接在组装的剂型中连接在一起。

8. 发明申请

WO02060385A2 PHARMACEUTICAL FORMULATION 审中-公开
标题翻译：药物制剂
公开(公告)号：WO02060385A2
公开(公告)日：2002-08-08
申请号：PCT/US0202698
申请日：2002-01-30
申请人： SMITHKLINE BEECHAM PLC , MCALLISTER STEPHEN MARK , RABY RONALD K JR , BROWN ADRIAN , CLARKE ALLAN J
发明人： MCALLISTER STEPHEN MARK , RABY RONALD K JR , BROWN ADRIAN , CLARKE ALLAN J
IPC分类号： A61K47/32 , A61K9/32 , A61K9/48 , A61K9/52 , A61K9/54 , A61K9/58 , A61K47/04 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/20 , A61K47/22 , A61K47/24 , A61K47/26 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/44 , A61K
CPC分类号： A61K9/4816 , A61K9/4808
摘要： The present invention is directed to pharmaceutically acceptable polymeric compositions suitable for injection molding of single or multi-component pharmaceutical dosage forms comprising a plurality of drug substance containing sub-units, being capsule compartments and/or solid sub-units comprising a solid matrix of a polymer which contains a drug substance, the sub- units being connected together in the assembled dosage form by a weld between parts of the assembled dosage form.
摘要翻译：本发明涉及适于注射模塑单组分或多组分药物剂型的药学上可接受的聚合物组合物，其包含多个含药物物质的子单元，包括胶囊隔室和/或包含固体基质的固体亚单元含有药物物质的聚合物，所述子单元通过组装的剂型的各部分之间的焊接在组装的剂型中连接在一起。

9. 发明专利

PL374867A1 MULTICOMPONENT PHARMACEUTICAL DOSAGE FORM 未知
公开(公告)号：PL374867A1
公开(公告)日：2005-11-14
申请号：PL37486703
申请日：2003-07-24
申请人： GLAXO GROUP LTD
发明人： BONNEY STANLEY GEORGE , BROWN ADRIAN , DAVIES MICHAEL BIRSHA , MARGETSON DANIEL N , MATTHEWS WAYNE M , MCALLISTER STEPHEN MARK , RAND PAUL KENNETH , WILSON ALAN ANTHONY
IPC分类号： A61K9/00 , A61J3/07 , A61K9/20 , A61K9/48 , A61K47/32 , A61K47/38
摘要： The present invention relates to a multi-component pharmaceutical dosage form for retaining a drug substance to provide a controlled drug release profile in the gastrointestinal environment, in particular a multicomponent dosage form comprising components in the form of either a body and a film means, or a capsule shell, linker and a film means, both forms being suitable for oral dosing.

10. 发明专利

MXPA05000948A FORMA DE DOSIFICACION FARMACEUTICA MULTICOMPONENTE. 未知
公开(公告)号：MXPA05000948A
公开(公告)日：2005-05-16
申请号：MXPA05000948
申请日：2003-07-24
申请人： GLAXO GROUP LTD
发明人： MCALLISTER STEPHEN MARK
IPC分类号： A61K9/00 , A61J3/07 , A61K9/20 , A61K9/48 , A61K47/32 , A61K47/38
摘要： Una forma de dosificacion farmaceutica multi-componente apropiada para retener una sustancia medicamentosa que puede liberarse para proporcionar un perfil controlado de liberacion del farmaco en el entorno gastrointestinal, caracterizada por un cuerpo que por ejemplo comprende un material polimero de liberacion retardada, tal como Eudragit 4135F, teniendo el cuerpo al menos una cavidad, teniendo dicha cavidad una abertura de boca y medios de pelicula que comprenden por ejemplo un material polimero de liberacion inmediata, por ejemplo Eudragit E100 o una de sus mezclas, conectado al cuerpo y que cierra la abertura de boca.

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