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1. 发明申请

WO2010004365A1 FUNCTIONAL OPTICAL COHERENT IMAGING 审中-公开
标题翻译：功能光学相干成像
公开(公告)号：WO2010004365A1
公开(公告)日：2010-01-14
申请号：PCT/IB2008/052787
申请日：2008-07-10
申请人： ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL) , LASSER, Theo , VAN DE VILLE, Dimitri , MARTIN-WILLIAMS, Erica , LEUTENEGGER, Marcel , MAERKI, Iwan , FRIEDRICH, Michael , VILLIGER, Martin
发明人： LASSER, Theo , VAN DE VILLE, Dimitri , MARTIN-WILLIAMS, Erica , LEUTENEGGER, Marcel , MAERKI, Iwan , FRIEDRICH, Michael , VILLIGER, Martin
IPC分类号： A61B5/00 , A61B5/026 , A61B3/12
CPC分类号： A61B5/0066 , A61B3/102 , A61B3/1233 , A61B5/0048 , A61B5/0059 , A61B5/02028 , A61B5/413 , A61B5/7203 , A61B5/726 , A61B5/7278 , A61B5/742
摘要： The present invention relates to a functional optical coherent imaging (fOCI) platform comprising at least one active camera unit (ACU) comprising a coherent and/or a partially coherent light source, and means for spectral filtering and imaging a selected body area of interest; an image processing unit (IPU) for pre-processing data received from an ACU; at least one stimulation unit (STU) transmitting a stimulation to a subject; at least one body function reference measurement unit (BFMU); a central clock and processing unit (CCU), with interconnections to the ACU, the IPU, the STU, for collecting pre-processed data from the IPU, stimuli from the STU body function reference data from the BFMU in a synchronized manner; a post-processing unit (statistical analysis unit, SAU); and an operator interface (HOI). Further the invention relates to a process for acquiring stimuli activated subject data comprising the steps of aligning a body function unit at a subject and monitoring pre-selected body function; selecting a stimulus or stimuli; imaging a body area of interest; exerting one or a series of stimuli on the subject; imaging the body area of interest synchronous with said stimuli and the preselected body functions; and transferring said synchronized image, stimuli and body function data to a statistical analysis unit (SAU) and performing calculations to generate results pertaining to body functions.
摘要翻译：功能性光学相干成像（fOCI）平台本发明涉及包括至少一个包括相干和/或部分相干光源的有源相机单元（ACU）的功能性光学相干成像（fOCI）平台，以及用于对感兴趣的所选择的身体区域进行频谱滤波和成像的装置; 用于预处理从ACU接收的数据的图像处理单元（IPU）; 向受试者传送刺激的至少一个刺激单元（STU）; 至少一个身体功能参考测量单元（BFMU）; 中央时钟和处理单元（CCU），与ACU，IPU，STU的互连，用于从IPU收集预处理的数据，以同步方式从BFMU的STU主体功能参考数据的刺激; 后处理单位（统计分析单位，SAU）; 和操作界面（HOI）。此外，本发明涉及一种用于获取刺激激活的受试者数据的方法，包括以下步骤：对准受试者的身体功能单元并监测预先选择的身体功能; 选择刺激或刺激; 成像感兴趣的身体区域; 在该主题上施加一个或一系列刺激; 对与所述刺激同步的感兴趣的身体区域和预选的身体功能进行成像; 以及将所述同步图像，刺激和身体功能数据传送到统计分析单元（SAU）并执行计算以产生与身体功能有关的结果。

2. 发明申请

WO2009046985A2 SYSTEM AND METHOD FOR EXAMINING AN OBJECT 审中-公开
标题翻译：用于检查对象的系统和方法
公开(公告)号：WO2009046985A2
公开(公告)日：2009-04-16
申请号：PCT/EP2008/008547
申请日：2008-10-09
申请人： CARL ZEISS SURGICAL GMBH , HAUGER, Christoph , NAHM, Werner , LASSER, Theo , LEUTENEGGER, Marcel , MARTIN-WILLIAMS, Erica , LOPEZ, Antonio
发明人： HAUGER, Christoph , NAHM, Werner , LASSER, Theo , LEUTENEGGER, Marcel , MARTIN-WILLIAMS, Erica , LOPEZ, Antonio
IPC分类号： G01N21/64 , A61B5/026
CPC分类号： G01N21/6408 , A61B5/0042 , A61B5/0261 , A61B5/14546 , A61B5/1455 , A61B5/14553 , A61B2018/00446 , A61B2576/026 , G01N21/4795 , G01N21/6428 , G01N21/6456 , G01N2021/6482 , G06T7/0012 , G06T2207/30016
摘要： A system and a method for examining an object containing a fluid liquid are provided, wherein the object is illuminated with measuring light and images are temporarily shortly subsequently recorded. The images are evaluated per pixel to determine perfusion data from a high frequency portion above 1 kHz and to determine further information about properties of the object from a low frequency portion below 100 Hz, such as a degree of oxygenation of haemoglobin, a concentration of haemoglobin or a concentration of ICG. This information determined by evaluation is displayed in a form of an image in superposition with a white light image of the object.
摘要翻译：提供了一种用于检查包含流体液体的物体的系统和方法，其中用测量光照射物体，并且暂时不久后记录图像。每像素评估图像以确定来自高于1kHz的高频部分的灌注数据，并且从低于100Hz的低频部分确定关于对象的属性的进一步信息，诸如血红蛋白的氧合程度，血红蛋白浓度或ICG的浓度。由评估确定的信息以与对象的白光图像重叠的图像的形式显示。

3. 发明申请

WO2009046985A3 SYSTEM AND METHOD FOR EXAMINING AN OBJECT 审中-公开
标题翻译：用于检查对象的系统和方法
公开(公告)号：WO2009046985A3
公开(公告)日：2009-07-09
申请号：PCT/EP2008008547
申请日：2008-10-09
申请人： ZEISS CARL SURGICAL GMBH , HAUGER CHRISTOPH , NAHM WERNER , LASSER THEO , LEUTENEGGER MARCEL , MARTIN-WILLIAMS ERICA , LOPEZ ANTONIO
发明人： HAUGER CHRISTOPH , NAHM WERNER , LASSER THEO , LEUTENEGGER MARCEL , MARTIN-WILLIAMS ERICA , LOPEZ ANTONIO
IPC分类号： G01N21/64 , A61B5/026
CPC分类号： G01N21/6408 , A61B5/0042 , A61B5/0261 , A61B5/14546 , A61B5/1455 , A61B5/14553 , A61B2018/00446 , A61B2576/026 , G01N21/4795 , G01N21/6428 , G01N21/6456 , G01N2021/6482 , G06T7/0012 , G06T2207/30016
摘要： A system and a method for examining an object containing a fluid liquid are provided, wherein the object is illuminated with measuring light and images are temporarily shortly subsequently recorded. The images are evaluated per pixel to determine perfusion data from a high frequency portion above 1 kHz and to determine further information about properties of the object from a low frequency portion below 100 Hz, such as a degree of oxygenation of haemoglobin, a concentration of haemoglobin or a concentration of ICG. This information determined by evaluation is displayed in a form of an image in superposition with a white light image of the object.
摘要翻译：提供了用于检查包含流体液体的物体的系统和方法，其中利用测量光照亮物体，并且随后暂时记录图像。对每个像素评估图像以确定来自1kHz以上的高频部分的灌注数据，并且从低于100Hz的低频部分（例如血红蛋白的氧合程度，血红蛋白浓度或ICG的浓度。通过评估确定的该信息以与对象的白光图像叠加的图像的形式显示。

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