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    • 1. 发明申请
    • INSTRUMENT AND METHOD FOR HIGH-SPEED PERFUSION IMAGING
    • 用于高速灌注成像的仪器和方法
    • WO2006111836A1
    • 2006-10-26
    • PCT/IB2006/000940
    • 2006-04-20
    • CVL COSMETICS SASEROV, AlexandreLASSER, Theo
    • SEROV, AlexandreLASSER, Theo
    • A61B5/026
    • A61B5/0059A61B5/0261A61B5/413
    • An instrument for high-speed laser perfusion imaging comprises a laser source, a detector, a signal-processing unit, data memory, and a screen to display the results. A section of the sample surface is illuminated with laser light; the reemitted light from the irradiated surface is collected by the focusing optics on a 2D array of integrating photo detectors. The elements of the 2D array can be accessed individually or in a pre-defined selection of pixels at high speed. This 2D array of random-pixel-access integrating photo detectors (for example an integrating CMOS image senor) is utilized to measure the intensity variations at each individual pixel. The average amplitude and the mean frequency of the measured signal contain information about concentration and speed of moving blood cells. For real-time imaging, the exposure time is used as a parameter to measure relative perfusion changes. These data are stored in a memory and processed with a signal-processing unit. The instrument delivers 2D flow maps of the illuminated sample section. In parallel a conventional image of the sample can be obtained with the same 2D array of photo detectors allowing a simple overlay between a conventional image and processed flow maps. The instrument enables objective high-speed tissue perfusion imaging and real-time perfusion monitoring.
    • 用于高速激光灌注成像的仪器包括激光源,检测器,信号处理单元,数据存储器和用于显示结果的屏幕。 用激光照射样品表面的一部分; 来自照射表面的再发射的光被聚焦光学器件收集在集成光电检测器的2D阵列上。 2D阵列的元素可以单独访问或以高速度预先定义的像素选择。 随机像素访问集成光电检测器(例如集成CMOS图像传感器)的2D阵列被用于测量每个单独像素处的强度变化。 测量信号的平均幅度和平均频率包含关于移动血细胞的浓度和速度的信息。 对于实时成像,将曝光时间用作测量相对灌注变化的参数。 这些数据存储在存储器中并用信号处理单元进行处理。 仪器提供照明样品部分的2D流程图。 平行地,可以使用相同的2D光学检测器阵列获得样品的传统图像,从而允许在常规图像和经处理的流程图之间简单的覆盖。 该仪器可实现客观的高速组织灌注成像和实时灌注监测。