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1. 发明申请

WO2010065496A1 ANTI-FERROPORTIN 1 MONOCLONAL ANTIBODIES AND USES THEREOF 审中-公开
标题翻译：抗皮质素1单克隆抗体及其用途
公开(公告)号：WO2010065496A1
公开(公告)日：2010-06-10
申请号：PCT/US2009/066187
申请日：2009-12-01
申请人： ELI LILLY AND COMPANY , LEUNG, Donmienne, Doen, Mun , LUAN, Peng , MANETTA, Joseph, Vincent , TANG, Ying , WITCHER, Derrick, Ryan
发明人： LEUNG, Donmienne, Doen, Mun , LUAN, Peng , MANETTA, Joseph, Vincent , TANG, Ying , WITCHER, Derrick, Ryan
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/28 , A61K2039/505 , C07K2317/34 , C07K2317/76 , C07K2317/77 , C07K2317/92
摘要： Provided are monoclonal antibodies and antigen-binding fragments thereof that bind to, and inhibit the activity of human FPN1, and which are effective in maintaining or increasing the transport of iron out of mammalian cells and/or maintaining or increasing the level of serum iron, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a subject in vivo .
摘要翻译：提供了结合并抑制人FPN1的活性的单克隆抗体和其抗原结合片段，并且其有效维持或增加铁离开哺乳动物细胞的运输和/或维持或提高血清铁的水平，网织红细胞计数，红细胞计数，血红蛋白和/或体内血细胞比容。

2. 发明申请

WO2006019577A1 ANTI-GHRELIN ANTIBODIES 审中-公开
标题翻译：抗GHRELIN抗体
公开(公告)号：WO2006019577A1
公开(公告)日：2006-02-23
申请号：PCT/US2005/023968
申请日：2005-07-06
申请人： ELI LILLY AND COMPANY , KIKLY, Kristine, Kay , MANETTA, Joseph, Vincent , WITCHER, Derrick, Ryan
发明人： KIKLY, Kristine, Kay , MANETTA, Joseph, Vincent , WITCHER, Derrick, Ryan
IPC分类号： C07K16/26
CPC分类号： C07K16/26 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： Monoclonal antibodies, including humanized antibodies, which bind acylated and unacylated human ghrelin are disclosed. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies of the invention are useful for neutralizing ghrelin activity, e.g ., in a human subject suffering from a disorder in which ghrelin activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant anti-ghrelin antibodies are also encompassed by the invention.
摘要翻译：公开了包含人源化抗体的单克隆抗体，其结合酰化和未被消化的人类生长素释放肽。本发明的抗体可以是全长抗体或其抗原结合部分。本发明的抗体可用于中和生长素释放肽活性，例如在患有其中生长素释放肽活性有害的病症的人类受试者中。用于表达重组抗Ghrelin抗体的核酸，载体和宿主细胞也包括在本发明中。

3. 发明申请

WO2005016951A3 ANTI-GHRELIN FAB ANTIBODIES 审中-公开
标题翻译：抗GHRELIN FAB抗体
公开(公告)号：WO2005016951A3
公开(公告)日：2005-05-26
申请号：PCT/US2004014537
申请日：2004-05-28
申请人： LILLY CO ELI , HEIMAN MARK LOUIS , KIKLY KRISTINE KAY , MANETTA JOSEPH VINCENT , WITCHER DERRICK RYAN
发明人： HEIMAN MARK LOUIS , KIKLY KRISTINE KAY , MANETTA JOSEPH VINCENT , WITCHER DERRICK RYAN
IPC分类号： C07K16/26 , A61K39/395 , A61P3/06
CPC分类号： C07K16/26 , A61K2039/505 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： Monoclonal antibodies, including humanized antibodies, which preferentially bind acetylated human ghrelin with respect to unacylated human ghrelin are disclosed. These antibodies have high affinity for acylated human ghrelin, a slow off rate for acylated human ghrelin dissociation and neutralize an acylated human ghrelin activity. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antigen-binding portions, of the invention are useful for neutralizing ghrelin activity, e.g., in a human subject suffering from a disorder in which ghrelin activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant anti-ghrelin antibodies are also encompassed by the invention.
摘要翻译：公开了单克隆抗体，包括人源化抗体，其优先结合乙酰化的人生长素释放肽相对于未被抑制的人类生长素释放肽。这些抗体对酰化的人生长素释放肽具有高亲和力，是酰化人类生长素释放肽解离的缓慢速率，并中和酰基化的人类生长素释放肽活性。本发明的抗体可以是全长抗体或其抗原结合部分。本发明的抗体或抗原结合部分可用于中和生长素释放肽活性，例如在患有其中生长素释放肽活性有害的病症的人类受试者中。用于表达重组抗Ghrelin抗体的核酸，载体和宿主细胞也包括在本发明中。

4. 发明申请

WO2005026211A2 ANTI-GHRELIN ANTIBODIES 审中-公开
标题翻译：抗GHRELIN抗体
公开(公告)号：WO2005026211A2
公开(公告)日：2005-03-24
申请号：PCT/US2004/025604
申请日：2004-09-02
申请人： ELI LILLY AND COMPANY , HEIMAN, Mark, Louis , KIKLY, Kristine, Kay , MANETTA, Joseph, Vincent , WITCHER, Derrick, Ryan
发明人： HEIMAN, Mark, Louis , KIKLY, Kristine, Kay , MANETTA, Joseph, Vincent , WITCHER, Derrick, Ryan
IPC分类号： C07K16/28
CPC分类号： C07K16/26 , A61K2039/505 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/92
摘要： Monoclonal antibodies, including humanized antibodies, which bind acylated and unacylated human ghrelin are disclosed. An antibody of the invention can be a full- length antibody or an antigen-binding portion thereof. The antibodies of the invention are useful for neutralizing ghrelin activity, e.g., in a human subject suffering from a disorder in which ghrelin activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant anti-ghrelin antibodies are also encompassed by the invention.
摘要翻译：公开了结合酰化和未酰化的人生长素释放肽的单克隆抗体，包括人源化抗体。本发明的抗体可以是全长抗体或其抗原结合部分。本发明的抗体可用于中和生长素释放肽活性，例如在患有其中生长素释放肽活性是有害的病症的人类对象中。用于表达重组抗Ghrelin抗体的核酸，载体和宿主细胞也包括在本发明中。

5. 发明申请

WO2003010282A3 INTERLEUKIN-1 BETA ANTIBODIES 审中-公开
公开(公告)号：WO2003010282A3
公开(公告)日：2003-02-06
申请号：PCT/US2002/021281
申请日：2002-07-18
申请人： ELI LILLY AND COMPANY , BRIGHT, Stuart, Willis , JIA, Audrey, Yunhua , KUHSTOSS, Stuart, Allen , MANETTA, Joseph, Vincent , TSURUSHITA, Naoya , VASQUEZ, Maximiliano, J.
发明人： BRIGHT, Stuart, Willis , JIA, Audrey, Yunhua , KUHSTOSS, Stuart, Allen , MANETTA, Joseph, Vincent , TSURUSHITA, Naoya , VASQUEZ, Maximiliano, J.
IPC分类号： C07K16/24
摘要： The present invention encompasses high affinity antibodies that neutralize IL-1β activity in vivo. These antibodies can be used to treat various diseases such as rheumatoid arthritis and osteoarthritis.

6. 发明申请

WO2006055347A3 DESACYL GHRELIN ANTIBODIES AND THERAPEUTIC USES THEREOF 审中-公开
公开(公告)号：WO2006055347A3
公开(公告)日：2006-05-26
申请号：PCT/US2005/040468
申请日：2005-11-08
申请人： ELI LILLY AND COMPANY , WITCHER, Derrick, Ryan , KIKLY, Kristine, Kay , MANETTA, Joseph, Vincent
发明人： WITCHER, Derrick, Ryan , KIKLY, Kristine, Kay , MANETTA, Joseph, Vincent
IPC分类号： C07K16/26 , A61K39/395 , A61P3/04 , A61P3/06 , A61P3/10
摘要： A neutralizing epitope is identified within amino acids 1-3 of desacyl ghrelin. Antibodies that bind this epitope fall within the scope of the invention and can be murine, chimeric, or humanized antibodies, immunoconjugates of the antibodies, or antigen- binding fragments thereof. The antibodies of the invention are useful for the treatment or prevention of obesity and related disorders including, for example, Type II non-insulin dependent diabetes mellitus (NIDDM), Prader-Willi syndrome, eating disorders, hyperphagia, and impaired satiety. Additionally, such antibodies can be useful for the treatment or prevention of other disorders, including anxiety, gastric motility disorders (including e.g., irritable bowel syndrome and functional dyspepsia), insulin resistance syndrome, metabolic syndrome, dyslipidemia, atherosclerosis, hypertension, hyperandrogenism, polycystic ovarian syndrome, cancer, and cardiovascular disorders by administering a therapeutically effective amount of an anti-desacyl ghrelin monoclonal antibody of the invention.

7. 发明申请

WO2005026211A3 ANTI-GHRELIN ANTIBODIES 审中-公开
标题翻译：抗GHRELIN抗体
公开(公告)号：WO2005026211A3
公开(公告)日：2005-06-16
申请号：PCT/US2004025604
申请日：2004-09-02
申请人： LILLY CO ELI , HEIMAN MARK LOUIS , KIKLY KRISTINE KAY , MANETTA JOSEPH VINCENT , WITCHER DERRICK RYAN
发明人： HEIMAN MARK LOUIS , KIKLY KRISTINE KAY , MANETTA JOSEPH VINCENT , WITCHER DERRICK RYAN
IPC分类号： C07K14/60 , C07K16/26 , C12N15/13 , C07K16/28 , A61K39/395 , C12N5/10 , C12N15/68
CPC分类号： C07K16/26 , A61K2039/505 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/92
摘要： Monoclonal antibodies, including humanized antibodies, which bind acylated and unacylated human ghrelin are disclosed. An antibody of the invention can be a full- length antibody or an antigen-binding portion thereof. The antibodies of the invention are useful for neutralizing ghrelin activity, e.g., in a human subject suffering from a disorder in which ghrelin activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant anti-ghrelin antibodies are also encompassed by the invention.
摘要翻译：公开了包含人源化抗体的单克隆抗体，其结合酰化和未被消化的人生长素释放肽。本发明的抗体可以是全长抗体或其抗原结合部分。本发明的抗体可用于中和生长素释放肽活性，例如在患有其中生长素释放肽活性是有害的病症的人类受试者中。用于表达重组抗Ghrelin抗体的核酸，载体和宿主细胞也包括在本发明中。

8. 发明申请

WO2006055347A2 DESACYL GHRELIN ANTIBODIES AND THERAPEUTIC USES THEREOF 审中-公开
标题翻译： DESACYL GHRELIN抗体及其治疗用途
公开(公告)号：WO2006055347A2
公开(公告)日：2006-05-26
申请号：PCT/US2005040468
申请日：2005-11-08
申请人： LILLY CO ELI , WITCHER DERRICK RYAN , KIKLY KRISTINE KAY , MANETTA JOSEPH VINCENT
发明人： WITCHER DERRICK RYAN , KIKLY KRISTINE KAY , MANETTA JOSEPH VINCENT
CPC分类号： C07K16/26 , A61K2039/505 , C07K2317/34 , C07K2317/55 , C07K2317/565
摘要： A neutralizing epitope is identified within amino acids 1-3 of desacyl ghrelin. Antibodies that bind this epitope fall within the scope of the invention and can be murine, chimeric, or humanized antibodies, immunoconjugates of the antibodies, or antigen- binding fragments thereof. The antibodies of the invention are useful for the treatment or prevention of obesity and related disorders including, for example, Type II non-insulin dependent diabetes mellitus (NIDDM), Prader-Willi syndrome, eating disorders, hyperphagia, and impaired satiety. Additionally, such antibodies can be useful for the treatment or prevention of other disorders, including anxiety, gastric motility disorders (including e.g., irritable bowel syndrome and functional dyspepsia), insulin resistance syndrome, metabolic syndrome, dyslipidemia, atherosclerosis, hypertension, hyperandrogenism, polycystic ovarian syndrome, cancer, and cardiovascular disorders by administering a therapeutically effective amount of an anti-desacyl ghrelin monoclonal antibody of the invention.
摘要翻译：中和表位在脱酰基生长素释放肽的氨基酸1-3内被鉴定。结合该表位的抗体落入本发明的范围内，并且可以是鼠抗体，嵌合抗体或人源化抗体，抗体的免疫缀合物或其抗原结合片段。本发明的抗体可用于治疗或预防肥胖症和相关病症，包括例如II型非胰岛素依赖性糖尿病（NIDDM），Prader-Willi综合征，进食障碍，食欲过盛和饱腹感受损。此外，此类抗体可用于治疗或预防其他病症，包括焦虑症，胃动力障碍（包括例如肠易激综合征和功能性消化不良），胰岛素抵抗综合征，代谢综合征，血脂异常，动脉粥样硬化，高血压，雄激素过多症，多囊性卵巢综合征，癌症和心血管疾病的方法，通过施用治疗有效量的本发明的抗脱乙酰基生长素释放肽单克隆抗体。

9. 发明申请

WO2005016951A2 ANTI-GHRELIN ANTIBODIES 审中-公开
标题翻译：抗GHRELIN抗体
公开(公告)号：WO2005016951A2
公开(公告)日：2005-02-24
申请号：PCT/US2004/014537
申请日：2004-05-28
申请人： ELI LILLY AND COMPANY , HEIMAN, Mark, Louis , KIKLY, Kristine, Kay , MANETTA, Joseph, Vincent , WITCHER, Derrick, Ryan
发明人： HEIMAN, Mark, Louis , KIKLY, Kristine, Kay , MANETTA, Joseph, Vincent , WITCHER, Derrick, Ryan
IPC分类号： C07K
CPC分类号： C07K16/26 , A61K2039/505 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： Monoclonal antibodies, including humanized antibodies, which preferentially bind acetylated human ghrelin with respect to unacylated human ghrelin are disclosed. These antibodies have high affinity for acylated human ghrelin, a slow off rate for acylated human ghrelin dissociation and neutralize an acylated human ghrelin activity. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antigen-binding portions, of the invention are useful for neutralizing ghrelin activity, e.g., in a human subject suffering from a disorder in which ghrelin activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant anti-ghrelin antibodies are also encompassed by the invention.
摘要翻译：公开了单克隆抗体，包括人源化抗体，其优先结合乙酰化的人生长素释放肽相对于未被抑制的人类生长素释放肽。这些抗体对酰化的人生长素释放肽具有高亲和力，是酰化人类生长素释放肽解离的缓慢速率，并中和酰基化的人类生长素释放肽活性。本发明的抗体可以是全长抗体或其抗原结合部分。本发明的抗体或抗原结合部分可用于中和生长素释放肽活性，例如在患有生长素释放肽活性有害的病症的人类受试者中。用于表达重组抗Ghrelin抗体的核酸，载体和宿主细胞也包括在本发明中。

10. 发明申请

WO2003010282A2 INTERLEUKIN-1 BETA ANTIBODIES 审中-公开
标题翻译： INTERLEUKIN-1 BETA抗体
公开(公告)号：WO2003010282A2
公开(公告)日：2003-02-06
申请号：PCT/US2002/021281
申请日：2002-07-18
申请人： ELI LILLY AND COMPANY , BRIGHT, Stuart, Willis , JIA, Audrey, Yunhua , KUHSTOSS, Stuart, Allen , MANETTA, Joseph, Vincent , TSURUSHITA, Naoya , VASQUEZ, Maximiliano, J.
发明人： BRIGHT, Stuart, Willis , JIA, Audrey, Yunhua , KUHSTOSS, Stuart, Allen , MANETTA, Joseph, Vincent , TSURUSHITA, Naoya , VASQUEZ, Maximiliano, J.
IPC分类号： C12N
CPC分类号： C07K16/245 , A61K2039/505 , C07K2317/24 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76
摘要： The present invention encompasses high affinity antibodies that neutralize IL-1β activity in vivo. These antibodies can be used to treat various diseases such as rheumatoid arthritis and osteoarthritis.
摘要翻译：本发明包括在体内中和IL-1β活性的高亲和力抗体。这些抗体可用于治疗各种疾病，例如类风湿性关节炎和骨关节炎。

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