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1. 发明申请

WO2005026211A3 ANTI-GHRELIN ANTIBODIES 审中-公开
标题翻译：抗GHRELIN抗体
公开(公告)号：WO2005026211A3
公开(公告)日：2005-06-16
申请号：PCT/US2004025604
申请日：2004-09-02
申请人： LILLY CO ELI , HEIMAN MARK LOUIS , KIKLY KRISTINE KAY , MANETTA JOSEPH VINCENT , WITCHER DERRICK RYAN
发明人： HEIMAN MARK LOUIS , KIKLY KRISTINE KAY , MANETTA JOSEPH VINCENT , WITCHER DERRICK RYAN
IPC分类号： C07K14/60 , C07K16/26 , C12N15/13 , C07K16/28 , A61K39/395 , C12N5/10 , C12N15/68
CPC分类号： C07K16/26 , A61K2039/505 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/92
摘要： Monoclonal antibodies, including humanized antibodies, which bind acylated and unacylated human ghrelin are disclosed. An antibody of the invention can be a full- length antibody or an antigen-binding portion thereof. The antibodies of the invention are useful for neutralizing ghrelin activity, e.g., in a human subject suffering from a disorder in which ghrelin activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant anti-ghrelin antibodies are also encompassed by the invention.
摘要翻译：公开了包含人源化抗体的单克隆抗体，其结合酰化和未被消化的人生长素释放肽。本发明的抗体可以是全长抗体或其抗原结合部分。本发明的抗体可用于中和生长素释放肽活性，例如在患有其中生长素释放肽活性是有害的病症的人类受试者中。用于表达重组抗Ghrelin抗体的核酸，载体和宿主细胞也包括在本发明中。

2. 发明申请

WO2005016951A3 ANTI-GHRELIN FAB ANTIBODIES 审中-公开
标题翻译：抗GHRELIN FAB抗体
公开(公告)号：WO2005016951A3
公开(公告)日：2005-05-26
申请号：PCT/US2004014537
申请日：2004-05-28
申请人： LILLY CO ELI , HEIMAN MARK LOUIS , KIKLY KRISTINE KAY , MANETTA JOSEPH VINCENT , WITCHER DERRICK RYAN
发明人： HEIMAN MARK LOUIS , KIKLY KRISTINE KAY , MANETTA JOSEPH VINCENT , WITCHER DERRICK RYAN
IPC分类号： C07K16/26 , A61K39/395 , A61P3/06
CPC分类号： C07K16/26 , A61K2039/505 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： Monoclonal antibodies, including humanized antibodies, which preferentially bind acetylated human ghrelin with respect to unacylated human ghrelin are disclosed. These antibodies have high affinity for acylated human ghrelin, a slow off rate for acylated human ghrelin dissociation and neutralize an acylated human ghrelin activity. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. The antibodies, or antigen-binding portions, of the invention are useful for neutralizing ghrelin activity, e.g., in a human subject suffering from a disorder in which ghrelin activity is detrimental. Nucleic acids, vectors and host cells for expressing the recombinant anti-ghrelin antibodies are also encompassed by the invention.
摘要翻译：公开了单克隆抗体，包括人源化抗体，其优先结合乙酰化的人生长素释放肽相对于未被抑制的人类生长素释放肽。这些抗体对酰化的人生长素释放肽具有高亲和力，是酰化人类生长素释放肽解离的缓慢速率，并中和酰基化的人类生长素释放肽活性。本发明的抗体可以是全长抗体或其抗原结合部分。本发明的抗体或抗原结合部分可用于中和生长素释放肽活性，例如在患有其中生长素释放肽活性有害的病症的人类受试者中。用于表达重组抗Ghrelin抗体的核酸，载体和宿主细胞也包括在本发明中。

3. 发明申请

WO2006055347A2 DESACYL GHRELIN ANTIBODIES AND THERAPEUTIC USES THEREOF 审中-公开
标题翻译： DESACYL GHRELIN抗体及其治疗用途
公开(公告)号：WO2006055347A2
公开(公告)日：2006-05-26
申请号：PCT/US2005040468
申请日：2005-11-08
申请人： LILLY CO ELI , WITCHER DERRICK RYAN , KIKLY KRISTINE KAY , MANETTA JOSEPH VINCENT
发明人： WITCHER DERRICK RYAN , KIKLY KRISTINE KAY , MANETTA JOSEPH VINCENT
CPC分类号： C07K16/26 , A61K2039/505 , C07K2317/34 , C07K2317/55 , C07K2317/565
摘要： A neutralizing epitope is identified within amino acids 1-3 of desacyl ghrelin. Antibodies that bind this epitope fall within the scope of the invention and can be murine, chimeric, or humanized antibodies, immunoconjugates of the antibodies, or antigen- binding fragments thereof. The antibodies of the invention are useful for the treatment or prevention of obesity and related disorders including, for example, Type II non-insulin dependent diabetes mellitus (NIDDM), Prader-Willi syndrome, eating disorders, hyperphagia, and impaired satiety. Additionally, such antibodies can be useful for the treatment or prevention of other disorders, including anxiety, gastric motility disorders (including e.g., irritable bowel syndrome and functional dyspepsia), insulin resistance syndrome, metabolic syndrome, dyslipidemia, atherosclerosis, hypertension, hyperandrogenism, polycystic ovarian syndrome, cancer, and cardiovascular disorders by administering a therapeutically effective amount of an anti-desacyl ghrelin monoclonal antibody of the invention.
摘要翻译：中和表位在脱酰基生长素释放肽的氨基酸1-3内被鉴定。结合该表位的抗体落入本发明的范围内，并且可以是鼠抗体，嵌合抗体或人源化抗体，抗体的免疫缀合物或其抗原结合片段。本发明的抗体可用于治疗或预防肥胖症和相关病症，包括例如II型非胰岛素依赖性糖尿病（NIDDM），Prader-Willi综合征，进食障碍，食欲过盛和饱腹感受损。此外，此类抗体可用于治疗或预防其他病症，包括焦虑症，胃动力障碍（包括例如肠易激综合征和功能性消化不良），胰岛素抵抗综合征，代谢综合征，血脂异常，动脉粥样硬化，高血压，雄激素过多症，多囊性卵巢综合征，癌症和心血管疾病的方法，通过施用治疗有效量的本发明的抗脱乙酰基生长素释放肽单克隆抗体。

4. 发明公开

EP1423432A4 INTERLEUKIN-1 BETA ANTIBODIES 审中-公开
标题翻译：白细胞介素1-β抗体
公开(公告)号：EP1423432A4
公开(公告)日：2006-01-11
申请号：EP02752171
申请日：2002-07-18
申请人： LILLY CO ELI
发明人： BRIGHT STUART WILLIS , JIA AUDREY YUNHUA , KUHSTOSS STUART ALLEN , MANETTA JOSEPH VINCENT , TSURUSHITA NAOYA , VASQUEZ MAXIMILIANO J
IPC分类号： C12N15/09 , A61K39/395 , A61P19/02 , C07K16/24 , C12N5/10 , C12P21/08 , C12N15/00 , C12P21/00
CPC分类号： C07K16/245 , A61K2039/505 , C07K2317/24 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76

5. 发明专利

CA2745618C ANTI-FERROPORTIN 1 MONOCLONAL ANTIBODIES AND USES THEREOF 未知
公开(公告)号：CA2745618C
公开(公告)日：2014-06-10
申请号：CA2745618
申请日：2009-12-01
申请人： LILLY CO ELI
发明人： LEUNG DONMIENNE DOEN MUN , LUAN PENG , MANETTA JOSEPH VINCENT , TANG YING , WITCHER DERRICK RYAN
IPC分类号： C07K16/28 , A61K39/395 , A61P7/06 , C07K14/705 , C12N15/13
摘要： Provided are monoclonal antibodies and antigen-binding fragments thereof that bind to, and inhibit the activity of human FPN1, and which are effective in maintaining or increasing the transport of iron out of mammalian cells and/or maintaining or increasing the level of serum iron, reticulocyte count, red blood cell count, hemoglobin, and/or hematocrit in a subject in vivo.

6. 发明专利

PE20030282A1 ANTICUERPOS DE INTERLEUCINA-1- BETA 未知
公开(公告)号：PE20030282A1
公开(公告)日：2003-03-25
申请号：PE2002000654
申请日：2002-07-24
申请人： LILLY CO ELI
发明人： BRIGHT STUART WILLIS , KUHSTOSS STUART ALLEN , TSURUSHITA NAOYA , VASQUEZ MAXIMILIANO J , JIA AUDREY YUNHUA , MANETTA JOSEPH VINCENT
IPC分类号： C12N15/09 , A61K39/395 , A61P19/02 , C07K16/24 , C12N1/00 , C12N5/10 , C12P21/08
摘要： SE REFIERE A UN ANTICUERPO QUE ESPECIFICAMENTE ENLAZA LA IL-1ß MADURA, CARACTERIZADO PORQUE EL ANTICUERPO ENLAZA EL MISMO EPITOPE EN LA IL-1ß HUMANA MADURA QUE EL ANTICUERPO MONOCLONAL DE RATON Mu007 O ANTICUERPO HUMANIZADO Hu007. EL ANTICUERPO COMPRENDE AL MENOS UNA REGION DETERMINANTE DE COMPLEMENTARIEDAD QUE TIENE UNA SECUENCIA SELECCIONADA DEL GRUPO QUE CONSISTE DE ID SEC No: 5, ID SEC No: 6, ID SEC No: 7, ID SEC No: 8, ID SEC No: 9, ID SEC No: 10 Y UNA REGION VARIABLE CON UNA CADENA LIGERA QUE TIENE LA SECUENC IA DE ID SEC No: 27, ID SEC No: 28. SE REFIERE TAMBIEN A ANTICUERPOS DE ALTA AFINIDAD QUE NEUTRALIZAN LA ACTIVIDAD DE LA INTERLEUCINA-1ß (IL-1ß) Y SE PUEDEN USAR PARA EL TRATAMIENTO DE ARTRITIS REUMATOIDE Y OSTEOARTRITIS

7. 发明专利

DK470489A 未知
公开(公告)号：DK470489A
公开(公告)日：1990-03-27
申请号：DK470489
申请日：1989-09-25
申请人： LILLY CO ELI
发明人： BOBBITT JESSE LEROY , MANETTA JOSEPH VINCENT
IPC分类号： C12P21/00 , C07K1/113 , C07K1/30 , C07K14/00 , C07K14/52 , C07K14/54 , C07K14/55 , C07K14/555 , C07K14/575 , C07K14/61 , C07K14/65 , C12P21/02 , C07K3/12
摘要： The present invention discloses a new method for solubilizing and refolding recombinant proteins expressed as granules. The method involves sulfitolysis and the formation of a precipitate of protein-S-sulfonate by warming. The precipitate has been found to contain protein in high purity. In addition, proper folding takes place if the desired protein is fully reduced and passed through an intermediate concentration of denaturant which allows for a transition between its folded and unfolded states.

8. 发明专利

HUE028585T2 Anti-ferroportin monoklonális ellenanyagok és alkalmazásuk 未知
公开(公告)号：HUE028585T2
公开(公告)日：2016-12-28
申请号：HUE09760073
申请日：2009-12-01
申请人： LILLY CO ELI
发明人： LEUNG DONMIENNE DOEN MUN , LUAN PENG , MANETTA JOSEPH VINCENT , TANG YING , WITCHER DERRICK RYAN
IPC分类号： C07K16/28

9. 发明专利

PE02822003A1 ANTICUERPOS DE INTERLEUCINA-1- BETA 未知
公开(公告)号：PE02822003A1
公开(公告)日：2003-03-25
申请号：PE0006542002
申请日：2002-07-24
申请人： LILLY CO ELI
发明人： BRIGHT STUART WILLIS , KUHSTOSS STUART ALLEN , TSURUSHITA NAOYA , VASQUEZ MAXIMILIANO J , JIA AUDREY YUNHUA , MANETTA JOSEPH VINCENT
IPC分类号： C12N15/09 , A61K39/395 , A61P19/02 , C07K16/24 , C12N1/00 , C12N5/10 , C12P21/08
CPC分类号： C07K16/245 , A61K2039/505 , C07K2317/24 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/76
摘要： SE REFIERE A UN ANTICUERPO QUE ESPECIFICAMENTE ENLAZA LA IL-1ß MADURA, CARACTERIZADO PORQUE EL ANTICUERPO ENLAZA EL MISMO EPITOPE EN LA IL-1ß HUMANA MADURA QUE EL ANTICUERPO MONOCLONAL DE RATON Mu007 O ANTICUERPO HUMANIZADO Hu007. EL ANTICUERPO COMPRENDE AL MENOS UNA REGION DETERMINANTE DE COMPLEMENTARIEDAD QUE TIENE UNA SECUENCIA SELECCIONADA DEL GRUPO QUE CONSISTE DE ID SEC No: 5, ID SEC No: 6, ID SEC No: 7, ID SEC No: 8, ID SEC No: 9, ID SEC No: 10 Y UNA REGION VARIABLE CON UNA CADENA LIGERA QUE TIENE LA SECUENC IA DE ID SEC No: 27, ID SEC No: 28. SE REFIERE TAMBIEN A ANTICUERPOS DE ALTA AFINIDAD QUE NEUTRALIZAN LA ACTIVIDAD DE LA INTERLEUCINA-1ß (IL-1ß) Y SE PUEDEN USAR PARA EL TRATAMIENTO DE ARTRITIS REUMATOIDE Y OSTEOARTRITIS

10. 发明专利

DE69212911D1 未知
公开(公告)号：DE69212911D1
公开(公告)日：1996-09-26
申请号：DE69212911
申请日：1992-06-03
申请人： LILLY CO ELI
发明人： HEATH WILLIAM FRANCIS , LAI MEI-HUEI TSAI , MANETTA JOSEPH VINCENT , SPORTSMAN JOHN RICHARD , YAN SAU-CHI BETTY
IPC分类号： C07K7/08 , C07K7/06 , C07K7/22 , C07K14/16 , C07K14/78 , C12Q1/34 , C12Q1/37 , G01N21/78 , G01N33/573

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