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    • 2. 发明授权
    • Modulated release from biocompatible polymers
    • 生物相容聚合物的调制释放
    • US5656297A
    • 1997-08-12
    • US237057
    • 1994-05-03
    • Howard BernsteinYan ZhangM. Amin KhanMark A. Tracy
    • Howard BernsteinYan ZhangM. Amin KhanMark A. Tracy
    • A61K9/00A61K9/16A61K9/52A61K9/70A61K38/21A61K38/22A61K38/35A61K38/46A61K47/30A61K47/34A61K9/14
    • A61K9/1694A61K33/10A61K33/30A61K38/212A61K38/27A61K38/35A61K38/465A61K9/1611A61K9/1647A61K9/7007C12Y301/27005Y10S514/805Y10S514/935
    • The present invention relates to a composition for the modulated release of a biologically active agent. The composition comprises a biocompatible polymeric matrix, a biologically active agent which is dispersed within the polymeric matrix, and a metal cation component which is separately dispersed within the polymeric matrix, whereby the metal cation component modulates the release of the biologically active agent from the polymeric matrix. The present invention also relates to a method for modulating the release of a biologically active agent from a biocompatible polymeric matrix, comprising the steps of dissolving a biocompatible polymer in a solvent to form a polymer solution and also separately dispersing a metal cation component and a biologically active agent within the polymer solution. The polymer solution is then solidified to form a polymeric matrix, wherein at least a significant portion of the metal cation component is dispersed in the polymeric matrix separately from the biologically active protein, and whereby the metal cation component modulates the release of the biologically active agent from the polymeric matrix.
    • 本发明涉及用于调节释放生物活性剂的组合物。 组合物包含生物相容性聚合物基质,分散在聚合物基质内的生物活性剂和分散分散在聚合物基质内的金属阳离子组分,由此金属阳离子组分调节生物活性剂从聚合物中的释放 矩阵。 本发明还涉及一种用于调节生物相容性聚合物基质释放生物活性剂的方法,包括以下步骤:将生物相容性聚合物溶解在溶剂中以形成聚合物溶液,并且还分别分散金属阳离子组分和生物相容性聚合物 聚合物溶液中的活性剂。 然后将聚合物溶液固化以形成聚合物基质,其中至少大部分金属阳离子组分与生物活性蛋白质分开分散在聚合物基质中,由此金属阳离子组分调节生物活性剂的释放 从聚合物基质。
    • 3. 发明授权
    • Composition for sustained release of human growth hormone
    • 用于持续释放人生长激素的组合物
    • US5654010A
    • 1997-08-05
    • US473544
    • 1995-06-07
    • OluFunmi Lily JohnsonMedha M. GanmukhiHoward BernsteinHenry AuerM. Amin Khan
    • OluFunmi Lily JohnsonMedha M. GanmukhiHoward BernsteinHenry AuerM. Amin Khan
    • A01N25/28A61F2/02A61K9/16A61K9/26A61K9/50A61K9/52A61K31/415A61K31/74A61K38/27A61K47/32A61K47/34A61K9/14A61K38/24
    • B82Y5/00A61K38/27A61K9/1611A61K9/1647A61K9/1694Y10S514/839Y10S530/839Y10T428/2985
    • A composition, and methods of forming and using said composition, for the sustained release of biologically active, stabilized human growth hormone (hGH). The sustained release composition of this invention comprises a polymeric matrix of a biocompatible polymer and particles of biologically active, stabilized hGH, wherein said particles are dispersed within the biocompatible polymer. The method of the invention for producing a composition for the sustained release of biologically active hGH, includes dissolving a biocompatible polymer in a polymer solvent to form a polymer solution, dispersing particles of biologically active, stabilized hGH in the polymer solution, and then solidifying the polymer to form a polymeric matrix containing a dispersion of said hGH particles. The method for using a composition of the invention is a method for providing a therapeutically effective blood level of biologically active, non-aggregated hGH in a subject for a sustained period. In this method, a subject is administered an effective dose of the sustained release composition of the present invention. The method of using the sustained release composition of the present invention comprises providing a therapeutically effective blood level of biologically active, non-aggregated human growth hormone in a subject for a sustained period by administering to the subject a dose of said sustained release composition.
    • 一种组合物,以及形成和使用所述组合物用于持续释放生物活性稳定的人生长激素(hGH)的方法。 本发明的持续释放组合物包含生物相容性聚合物的聚合物基质和生物活性稳定的hGH颗粒,其中所述颗粒分散在生物相容性聚合物内。 用于生产用于持续释放生物活性的hGH的组合物的本发明的方法包括将生物相容性聚合物溶解在聚合物溶剂中以形成聚合物溶液,将生物活性稳定的hGH的颗粒分散在聚合物溶液中,然后固化 聚合物以形成含有所述hGH颗粒的分散体的聚合物基质。 使用本发明组合物的方法是在持续时间内在受试者中提供治疗有效的血液水平的生物活性,非聚集的hGH的方法。 在该方法中,给予受试者有效剂量的本发明的持续释放组合物。 使用本发明的持续释放组合物的方法包括通过向受试者施用一定剂量的所述持续释放组合物,在持续的时间内提供治疗有效的血液中的生物活性的,非聚集的人生长激素。
    • 6. 发明授权
    • Controlled release of metal cation-stabilized interferon
    • 金属阳离子稳定的干扰素的控制释放
    • US06780434B2
    • 2004-08-24
    • US10092365
    • 2002-03-06
    • Mark A. TracyHoward BernsteinM. Amin Khan
    • Mark A. TracyHoward BernsteinM. Amin Khan
    • A61K910
    • B82Y5/00A61K9/1611A61K9/1647A61K38/212C07K14/56
    • This invention relates to a composition, and method of forming said composition, for the controlled release of interferon. The controlled release composition of this invention comprises a biocompatible polymer and particles of metal cation-stabilized interferon, wherein the particles are dispersed within the biocompatible polymer. The method of the invention, for producing a composition for the controlled release of interferon, includes dissolving a polymer in a polymer solvent to form a polymer solution, dispersing particles of metal cation stabilized-interferon particles in the polymer solution, and then solidifying the polymer to form a polymeric matrix containing a dispersion of the interferon particles.
    • 本发明涉及用于控制释放干扰素的组合物和形成所述组合物的方法。 本发明的控释组合物包含生物相容性聚合物和金属阳离子稳定化干扰素颗粒,其中颗粒分散在生物相容性聚合物内。 本发明的制备用于干扰素控制释放的组合物的方法包括将聚合物溶解在聚合物溶剂中以形成聚合物溶液,将金属阳离子稳定的干扰素颗粒的颗粒分散在聚合物溶液中,然后固化聚合物 以形成含有干扰素颗粒的分散体的聚合物基质。
    • 8. 发明授权
    • Controlled release of metal cation-stabilized interferon
    • 金属阳离子稳定的干扰素的控制释放
    • US06379701B1
    • 2002-04-30
    • US09664299
    • 2000-09-18
    • Mark A. TracyHoward BernsteinM. Amin Khan
    • Mark A. TracyHoward BernsteinM. Amin Khan
    • A61K910
    • B82Y5/00A61K9/1611A61K9/1647A61K38/212C07K14/56
    • This invention relates to a composition, and method of forming said composition, for the controlled release of interferon. The controlled release composition of this invention comprises a biocompatible polymer and particles of metal cation-stabilized interferon, wherein the particles are dispersed within the biocompatible polymer. The method of the invention, for producing a composition for the controlled release of interferon, includes dissolving a polymer in a polymer solvent to form a polymer solution, dispersing particles of metal cation stabilized-interferon particles in the polymer solution, and then solidifying the polymer to form a polymeric matrix containing a dispersion of the interferon particles.
    • 本发明涉及用于控制释放干扰素的组合物和形成所述组合物的方法。 本发明的控释组合物包含生物相容性聚合物和金属阳离子稳定化干扰素颗粒,其中颗粒分散在生物相容性聚合物内。本发明的用于制备用于控制释放干扰素的组合物的方法包括将 聚合物在聚合物溶剂中以形成聚合物溶液,将金属阳离子稳定的干扰素颗粒的颗粒分散在聚合物溶液中,然后固化聚合物以形成含有干扰素颗粒分散体的聚合物基质。