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1. 发明授权

US5912015A Modulated release from biocompatible polymers 失效
公开(公告)号：US5912015A
公开(公告)日：1999-06-15
申请号：US56566
申请日：1998-04-07
申请人： Howard Bernstein , Yan Zhang , M. Amin Khan , Mark A. Tracy
发明人： Howard Bernstein , Yan Zhang , M. Amin Khan , Mark A. Tracy
IPC分类号： A61K9/16 , A61K9/22 , A61K9/70 , A61K38/21 , A61K38/27 , A61K38/35 , A61K38/46 , A61K9/14
CPC分类号： A61K9/7007 , A61K38/212 , A61K38/27 , A61K38/35 , A61K38/465 , A61K9/1611 , A61K9/1647 , A61K9/1694 , C12Y301/27005 , Y10S514/805 , Y10S514/965
摘要： The present invention relates to a composition for the modulated release of a biologically active agent. The composition comprises a biocompatible polymeric matrix, a biologically active agent which is dispersed within the polymeric matrix, and a metal cation component which is separately dispersed within the polymeric matrix, whereby the metal cation component modulates the release of the biologically active agent from the polymeric matrix. The present invention also relates to a method for modulating the release of a biologically active agent from a biocompatible polymeric matrix, comprising the steps of dissolving a biocompatible polymer in a solvent to form a polymer solution and also separately dispersing a metal cation component and a biologically active agent within the polymer solution. The polymer solution is then solidified to form a polymeric matrix, wherein at least a significant portion of the metal cation component is dispersed in the polymeric matrix separately from the biologically active protein, and whereby the metal cation component modulates the release of the biologically active agent from the polymeric matrix.

2. 发明授权

US5656297A Modulated release from biocompatible polymers 失效
标题翻译：生物相容聚合物的调制释放
公开(公告)号：US5656297A
公开(公告)日：1997-08-12
申请号：US237057
申请日：1994-05-03
申请人： Howard Bernstein , Yan Zhang , M. Amin Khan , Mark A. Tracy
发明人： Howard Bernstein , Yan Zhang , M. Amin Khan , Mark A. Tracy
IPC分类号： A61K9/00 , A61K9/16 , A61K9/52 , A61K9/70 , A61K38/21 , A61K38/22 , A61K38/35 , A61K38/46 , A61K47/30 , A61K47/34 , A61K9/14
CPC分类号： A61K9/1694 , A61K33/10 , A61K33/30 , A61K38/212 , A61K38/27 , A61K38/35 , A61K38/465 , A61K9/1611 , A61K9/1647 , A61K9/7007 , C12Y301/27005 , Y10S514/805 , Y10S514/935
摘要： The present invention relates to a composition for the modulated release of a biologically active agent. The composition comprises a biocompatible polymeric matrix, a biologically active agent which is dispersed within the polymeric matrix, and a metal cation component which is separately dispersed within the polymeric matrix, whereby the metal cation component modulates the release of the biologically active agent from the polymeric matrix. The present invention also relates to a method for modulating the release of a biologically active agent from a biocompatible polymeric matrix, comprising the steps of dissolving a biocompatible polymer in a solvent to form a polymer solution and also separately dispersing a metal cation component and a biologically active agent within the polymer solution. The polymer solution is then solidified to form a polymeric matrix, wherein at least a significant portion of the metal cation component is dispersed in the polymeric matrix separately from the biologically active protein, and whereby the metal cation component modulates the release of the biologically active agent from the polymeric matrix.
摘要翻译：本发明涉及用于调节释放生物活性剂的组合物。组合物包含生物相容性聚合物基质，分散在聚合物基质内的生物活性剂和分散分散在聚合物基质内的金属阳离子组分，由此金属阳离子组分调节生物活性剂从聚合物中的释放矩阵。本发明还涉及一种用于调节生物相容性聚合物基质释放生物活性剂的方法，包括以下步骤：将生物相容性聚合物溶解在溶剂中以形成聚合物溶液，并且还分别分散金属阳离子组分和生物相容性聚合物聚合物溶液中的活性剂。然后将聚合物溶液固化以形成聚合物基质，其中至少大部分金属阳离子组分与生物活性蛋白质分开分散在聚合物基质中，由此金属阳离子组分调节生物活性剂的释放从聚合物基质。

3. 发明授权

US5654010A Composition for sustained release of human growth hormone 失效
标题翻译：用于持续释放人生长激素的组合物
公开(公告)号：US5654010A
公开(公告)日：1997-08-05
申请号：US473544
申请日：1995-06-07
申请人： OluFunmi Lily Johnson , Medha M. Ganmukhi , Howard Bernstein , Henry Auer , M. Amin Khan
发明人： OluFunmi Lily Johnson , Medha M. Ganmukhi , Howard Bernstein , Henry Auer , M. Amin Khan
IPC分类号： A01N25/28 , A61F2/02 , A61K9/16 , A61K9/26 , A61K9/50 , A61K9/52 , A61K31/415 , A61K31/74 , A61K38/27 , A61K47/32 , A61K47/34 , A61K9/14 , A61K38/24
CPC分类号： B82Y5/00 , A61K38/27 , A61K9/1611 , A61K9/1647 , A61K9/1694 , Y10S514/839 , Y10S530/839 , Y10T428/2985
摘要： A composition, and methods of forming and using said composition, for the sustained release of biologically active, stabilized human growth hormone (hGH). The sustained release composition of this invention comprises a polymeric matrix of a biocompatible polymer and particles of biologically active, stabilized hGH, wherein said particles are dispersed within the biocompatible polymer. The method of the invention for producing a composition for the sustained release of biologically active hGH, includes dissolving a biocompatible polymer in a polymer solvent to form a polymer solution, dispersing particles of biologically active, stabilized hGH in the polymer solution, and then solidifying the polymer to form a polymeric matrix containing a dispersion of said hGH particles. The method for using a composition of the invention is a method for providing a therapeutically effective blood level of biologically active, non-aggregated hGH in a subject for a sustained period. In this method, a subject is administered an effective dose of the sustained release composition of the present invention. The method of using the sustained release composition of the present invention comprises providing a therapeutically effective blood level of biologically active, non-aggregated human growth hormone in a subject for a sustained period by administering to the subject a dose of said sustained release composition.
摘要翻译：一种组合物，以及形成和使用所述组合物用于持续释放生物活性稳定的人生长激素（hGH）的方法。本发明的持续释放组合物包含生物相容性聚合物的聚合物基质和生物活性稳定的hGH颗粒，其中所述颗粒分散在生物相容性聚合物内。用于生产用于持续释放生物活性的hGH的组合物的本发明的方法包括将生物相容性聚合物溶解在聚合物溶剂中以形成聚合物溶液，将生物活性稳定的hGH的颗粒分散在聚合物溶液中，然后固化聚合物以形成含有所述hGH颗粒的分散体的聚合物基质。使用本发明组合物的方法是在持续时间内在受试者中提供治疗有效的血液水平的生物活性，非聚集的hGH的方法。在该方法中，给予受试者有效剂量的本发明的持续释放组合物。使用本发明的持续释放组合物的方法包括通过向受试者施用一定剂量的所述持续释放组合物，在持续的时间内提供治疗有效的血液中的生物活性的，非聚集的人生长激素。

4. 发明申请

US20130035292A1 NMDA Receptors Modulators and Uses Thereof 有权
标题翻译： NMDA受体调节剂及其用途
公开(公告)号：US20130035292A1
公开(公告)日：2013-02-07
申请号：US13525861
申请日：2012-06-18
申请人： Joseph Moskal , M. Amin Khan
发明人： Joseph Moskal , M. Amin Khan
IPC分类号： A61K38/07 , A61P25/24 , A61P25/22 , A61P25/00 , A61P25/18 , C07K5/103 , A61P25/28
CPC分类号： C07K5/1013 , A61K38/00 , A61K38/07 , C07D403/06 , C07K5/06165 , C07K5/0823
摘要： Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of diseases and disorders, such as learning, cognitive activities, and analgesia, particularly in alleviating and/or reducing neuropathic pain. Orally available formulations and other pharmaceutically acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed.
摘要翻译：公开了具有增强NMDA受体活性调节效力的化合物。预期这些化合物可用于治疗疾病和病症，例如学习，认知活动和止痛，特别是在缓解和/或减少神经性疼痛方面。还公开了可口服制剂和其它药学上可接受的化合物递送形式，包括静脉内制剂。

5. 发明申请

US20120035250A1 PLASMALOGEN COMPOUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME AND METHODS FOR TREATING DISEASES OF THE AGING 有权
标题翻译：等离子体化合物，含有它们的药物组合物和治疗老化疾病的方法
公开(公告)号：US20120035250A1
公开(公告)日：2012-02-09
申请号：US13141035
申请日：2009-12-18
申请人： M. Amin Khan , Paul L. Wood , Dayan Goodenowe , Rishikesh Mankidy , Pearson Ahiahonu
发明人： M. Amin Khan , Paul L. Wood , Dayan Goodenowe , Rishikesh Mankidy , Pearson Ahiahonu
IPC分类号： A61K31/232 , C07C69/587 , C07C227/18 , C07D339/04 , C07C231/12 , C07C233/47 , A61P25/28 , A61P25/16 , A61P27/02 , C07C229/30 , A61K31/385
CPC分类号： C07C323/59 , C07C229/22 , C07C279/14 , C07D339/04 , C07F9/106
摘要： Described herein are routes of synthesis and therapeutic uses of 1-alkyl, 2-acyl glycerol derivatives of formula I: which when administered to mammalian biological systems result in increased cellular concentrations of specific sn-2 substituted ethanolamine plasmalogens independent of the ether lipid synthesis capacity of the system. Elevating levels of the specific sn-2 substituted species in this way can cause lowering of membrane cholesterol levels and the lowering of amyloid secretion. These compounds can be used for the treatment or prevention of diseases of aging associated with increased membrane cholesterol, increased amyloid, and decreased plasmalogen levels, such as neurodegeneration (including Alzheimer's disease, Parkinson's disease and age-related macular degeneration), cognitive impairment, dementia, cancer (e.g. prostate, lung, breast, ovarian, and kidney cancers), osteoporosis, bipolar disorder and vascular diseases (such as atherosclerosis, hypercholesterolemia).
摘要翻译：本文描述了式I的1-烷基，2-酰基甘油衍生物的合成途径和治疗用途：当向哺乳动物生物系统施用时，其导致独特于醚脂质合成能力的特异性sn-2取代的乙醇胺plasmalogen的细胞浓度增加的系统。以这种方式提高特定sn-2取代物种的水平可能导致膜胆固醇水平的降低和淀粉样蛋白分泌的降低。这些化合物可用于治疗或预防与增加的膜胆固醇，增加的淀粉样蛋白相关的老化疾病和降低的血浆素水平，例如神经变性（包括阿尔茨海默病，帕金森病和年龄相关性黄斑变性），认知障碍，痴呆，癌症（例如前列腺癌，肺癌，乳腺癌，卵巢癌和肾癌），骨质疏松症，双相性精神障碍和血管疾病（如动脉粥样硬化，高胆固醇血症）。

6. 发明授权

US06780434B2 Controlled release of metal cation-stabilized interferon 失效
标题翻译：金属阳离子稳定的干扰素的控制释放
公开(公告)号：US06780434B2
公开(公告)日：2004-08-24
申请号：US10092365
申请日：2002-03-06
申请人： Mark A. Tracy , Howard Bernstein , M. Amin Khan
发明人： Mark A. Tracy , Howard Bernstein , M. Amin Khan
IPC分类号： A61K910
CPC分类号： B82Y5/00 , A61K9/1611 , A61K9/1647 , A61K38/212 , C07K14/56
摘要： This invention relates to a composition, and method of forming said composition, for the controlled release of interferon. The controlled release composition of this invention comprises a biocompatible polymer and particles of metal cation-stabilized interferon, wherein the particles are dispersed within the biocompatible polymer. The method of the invention, for producing a composition for the controlled release of interferon, includes dissolving a polymer in a polymer solvent to form a polymer solution, dispersing particles of metal cation stabilized-interferon particles in the polymer solution, and then solidifying the polymer to form a polymeric matrix containing a dispersion of the interferon particles.
摘要翻译：本发明涉及用于控制释放干扰素的组合物和形成所述组合物的方法。本发明的控释组合物包含生物相容性聚合物和金属阳离子稳定化干扰素颗粒，其中颗粒分散在生物相容性聚合物内。本发明的制备用于干扰素控制释放的组合物的方法包括将聚合物溶解在聚合物溶剂中以形成聚合物溶液，将金属阳离子稳定的干扰素颗粒的颗粒分散在聚合物溶液中，然后固化聚合物以形成含有干扰素颗粒的分散体的聚合物基质。

7. 发明授权

US06500448B1 Composition for sustained release of human growth hormone 失效
标题翻译：用于持续释放人生长激素的组合物
公开(公告)号：US06500448B1
公开(公告)日：2002-12-31
申请号：US09505508
申请日：2000-02-17
申请人： OluFunmi Lily Johnson , Medha M. Ganmukhi , Howard Bernstein , Henry Auer , M. Amin Khan
发明人： OluFunmi Lily Johnson , Medha M. Ganmukhi , Howard Bernstein , Henry Auer , M. Amin Khan
IPC分类号： A61F202
CPC分类号： B82Y5/00 , A61K9/1611 , A61K9/1647 , A61K9/1694 , A61K38/27 , Y10S514/839 , Y10S530/839 , Y10T428/2985
摘要： A pharmaceutical composition for the sustained release of human growth hormone from a polymer matrix is disclosed. The pharmaceutical composition comprises a biocompatible polymer, particles of metal cation-complexed human growth hormone wherein said particles are dispersed within the biocompatible polymer and an aqueous injection vehicle.
摘要翻译：公开了用于从聚合物基质中持续释放人生长激素的药物组合物。药物组合物包含生物相容性聚合物，金属阳离子络合的人生长激素的颗粒，其中所述颗粒分散在生物相容性聚合物和水性注射载体中。

8. 发明授权

US06379701B1 Controlled release of metal cation-stabilized interferon 失效
标题翻译：金属阳离子稳定的干扰素的控制释放
公开(公告)号：US06379701B1
公开(公告)日：2002-04-30
申请号：US09664299
申请日：2000-09-18
申请人： Mark A. Tracy , Howard Bernstein , M. Amin Khan
发明人： Mark A. Tracy , Howard Bernstein , M. Amin Khan
IPC分类号： A61K910
CPC分类号： B82Y5/00 , A61K9/1611 , A61K9/1647 , A61K38/212 , C07K14/56
摘要： This invention relates to a composition, and method of forming said composition, for the controlled release of interferon. The controlled release composition of this invention comprises a biocompatible polymer and particles of metal cation-stabilized interferon, wherein the particles are dispersed within the biocompatible polymer. The method of the invention, for producing a composition for the controlled release of interferon, includes dissolving a polymer in a polymer solvent to form a polymer solution, dispersing particles of metal cation stabilized-interferon particles in the polymer solution, and then solidifying the polymer to form a polymeric matrix containing a dispersion of the interferon particles.
摘要翻译：本发明涉及用于控制释放干扰素的组合物和形成所述组合物的方法。本发明的控释组合物包含生物相容性聚合物和金属阳离子稳定化干扰素颗粒，其中颗粒分散在生物相容性聚合物内。本发明的用于制备用于控制释放干扰素的组合物的方法包括将聚合物在聚合物溶剂中以形成聚合物溶液，将金属阳离子稳定的干扰素颗粒的颗粒分散在聚合物溶液中，然后固化聚合物以形成含有干扰素颗粒分散体的聚合物基质。

9. 发明授权

US08673843B2 NMDA receptors modulators and uses thereof 有权
标题翻译： NMDA受体调节剂及其用途
公开(公告)号：US08673843B2
公开(公告)日：2014-03-18
申请号：US13525861
申请日：2012-06-18
申请人： Joseph Moskal , M. Amin Khan
发明人： Joseph Moskal , M. Amin Khan
IPC分类号： A61K38/00
CPC分类号： C07K5/1013 , A61K38/00 , A61K38/07 , C07D403/06 , C07K5/06165 , C07K5/0823
摘要： Disclosed are compounds having enhanced potency in the modulation of NMDA receptor activity. Such compounds are contemplated for use in the treatment of diseases and disorders, such as learning, cognitive activities, and analgesia, particularly in alleviating and/or reducing neuropathic pain. Orally available formulations and other pharmaceutically acceptable delivery forms of the compounds, including intravenous formulations, are also disclosed.
摘要翻译：公开了具有增强NMDA受体活性调节效力的化合物。预期这些化合物可用于治疗疾病和病症，例如学习，认知活动和止痛，特别是在缓解和/或减少神经性疼痛方面。还公开了可口服制剂和其它药学上可接受的化合物递送形式，包括静脉内制剂。

10. 发明申请

US20120136057A1 HYDROXY FATTY ACID COMPOUNDS AND USES THEREOF FOR DISEASE TREATMENT AND DIAGNOSIS 审中-公开
标题翻译：羟基脂肪酸化合物及其用于疾病治疗和诊断的用途
公开(公告)号：US20120136057A1
公开(公告)日：2012-05-31
申请号：US13387110
申请日：2010-07-29
申请人： Shawn Ritchie , Dayan Goodenowe , M. Amin Khan , Pearson W.K. Ahiahonu
发明人： Shawn Ritchie , Dayan Goodenowe , M. Amin Khan , Pearson W.K. Ahiahonu
IPC分类号： A61K31/20 , A61P35/00 , A61P1/00 , A61P29/00 , H01J49/26 , C07K14/00 , C12N9/96 , C07F7/08 , C07C31/18 , C07C69/52 , C07C59/42 , G01N33/566
CPC分类号： A61K31/202 , C07C33/048 , C07C59/42 , C07C67/303 , C07C67/347 , C07C69/606 , C07C69/65 , C07C69/732 , G01N33/57407 , G01N33/57419 , G01N33/6893 , G01N2800/24 , A61K2300/00
摘要： A compound of formula (I): wherein R represents a hydroxy substituted C24-C40 straight chain aliphatic group containing at least one double bond in the carbon chain; and at least one carbon in the chain is substituted with a hydroxy group. Such compounds are useful for detecting inflammation, inflammatory disorders and cancer in a subject, and can also be used in therapeutic applications including treatment and/or prevention of these conditions. Pharmaceutical compositions, combinations and supplements, as well as methods of treatment using the described compounds are therefore also described.
摘要翻译：式（I）的化合物：其中R表示在碳链中含有至少一个双键的羟基取代的C24-C40直链脂族基团; 并且链中的至少一个碳被羟基取代。这样的化合物可用于检测受试者中的炎症，炎性疾病和癌症，并且还可用于治疗应用，包括治疗和/或预防这些病症。因此，还描述了药物组合物，组合和补充剂以及使用所述化合物的治疗方法。

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