专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06495586B2 Scytonemin and methods of using thereof 失效
公开(公告)号：US06495586B2
公开(公告)日：2002-12-17
申请号：US09790640
申请日：2001-02-23
申请人： Robert S. Jacobs , Lisa A. Marshall , William H. Gerwick , Christopher Stevenson
发明人： Robert S. Jacobs , Lisa A. Marshall , William H. Gerwick , Christopher Stevenson
IPC分类号： A61K3140
CPC分类号： A61K31/404
摘要： Disclosed are compounds having a scytoneman skeleton, such as scytonemin, and methods of using thereof. Methods of using a compound having a scytoneman skeleton to inhibit, modulate, attenuate, or prevent cell-cycle progression, cell proliferation, kinase activity, or induce apoptosis are disclosed. Also disclosed are methods of treating, preventing, or inhibiting diseases and disorders associated with cell cycle progression, cell proliferation, kinase activity, tissue hyperplasia or angiogenesis, such as cancer or an inflammatory disease.

2. 发明授权

US06313269B1 Tumor necrosis factor related receptor, TR6 失效
标题翻译：肿瘤坏死因子相关受体TR6
公开(公告)号：US06313269B1
公开(公告)日：2001-11-06
申请号：US09333593
申请日：1999-06-15
申请人： Keith C. Deen , Peter R. Young , Lisa A. Marshall , Amy K. Roshak , Kong B. Tan , Alemseged Truneh
发明人： Keith C. Deen , Peter R. Young , Lisa A. Marshall , Amy K. Roshak , Kong B. Tan , Alemseged Truneh
IPC分类号： C07K14715
CPC分类号： C07K14/70578 , A61K38/00 , C07K14/7151 , C07K2319/00 , C07K2319/30
摘要： TR6 polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing TR6 polypeptides and polynucleotides in the design of protocols for the treatment of chronic and acute inflammation, arthritis, septicemia, autoimmune diseases (e.g. inflammatory bowel disease, psoriasis), transplant rejection, graft vs. host disease, infection, stroke, ischemia, acute respiratory disease syndrome, restenosis, brain injury, AIDS, Bone diseases, cancer, atheroschlerosis, and Alzheimers disease, among others and diagnostic assays for such conditions.
摘要翻译：公开了TR6多肽和多核苷酸以及通过重组技术产生此类多肽的方法。还公开了在设计用于治疗慢性和急性炎症，关节炎，败血症，自身免疫性疾病（例如炎性肠病，牛皮癣），移植排斥，移植物抗宿主病，感染等的方案中使用TR6多肽和多核苷酸的方法，中风，局部缺血，急性呼吸系统疾病综合征，再狭窄，脑损伤，艾滋病，骨病，癌症，动脉粥样硬化，阿尔茨海默病等。

3. 发明授权

US06221629B1 Expression vectors and process for producing human B cell surface molecule RP105 失效
标题翻译：表达载体和生产人B细胞表面分子RP105的方法
公开(公告)号：US06221629B1
公开(公告)日：2001-04-24
申请号：US09060208
申请日：1998-01-14
申请人： Lisa A. Marshall , Amy K. Roshak
发明人： Lisa A. Marshall , Amy K. Roshak
IPC分类号： C12N1563
CPC分类号： C07K16/26 , A01K2217/05 , C07K14/705
摘要： Nucleic acid molecules encoding a human B cell surface molecule are provided. Polypeptides and antibodies which bind to these polypeptides are also provided. In addition, methods of detecting mutated forms of the molecule are provided.
摘要翻译：提供编码人B细胞表面分子的核酸分子。还提供了结合这些多肽的多肽和抗体。此外，提供检测突变形式的分子的方法。

4. 发明授权

US5470882A Anti-inflammatory compounds 失效
标题翻译：抗炎化合物
公开(公告)号：US5470882A
公开(公告)日：1995-11-28
申请号：US252716
申请日：1994-06-02
申请人： James S. Dixon , Raplh F. Hall , Lisa A. Marshall , Floyd H. Chilton, III , Ruth J. Mayer , James D. Winkler
发明人： James S. Dixon , Raplh F. Hall , Lisa A. Marshall , Floyd H. Chilton, III , Ruth J. Mayer , James D. Winkler
IPC分类号： A61K31/185 , A61P1/00 , A61P11/00 , A61P17/00 , A61P27/16 , A61P29/00 , A61P37/08 , A61P43/00 , C07C309/42 , A01N47/28
CPC分类号： A61K31/185
摘要： This invention relates to the novel pharmaceutical compositions of Formulas (I) and (II) each of which comprises a compound of Formula (I) or (II) and a pharmaceutically acceptable diluent or carrier.This invention also relates to a method of treating or reducing inflammation in a mammal in need thereof, which comprises administering to said mammal an effective amount of a compound or composition of Formula (I) or (II).
摘要翻译：本发明涉及式（I）和（II）的新型药物组合物，其各自包含式（I）或（II）的化合物和药学上可接受的稀释剂或载体。本发明还涉及在有需要的哺乳动物中治疗或减轻炎症的方法，其包括向所述哺乳动物施用有效量的式（I）或（II）的化合物或组合物。

5. 发明授权

US4933365A Phospholipase A2 inhibitors 失效
标题翻译：磷脂酶A2抑制剂
公开(公告)号：US4933365A
公开(公告)日：1990-06-12
申请号：US301937
申请日：1989-01-25
申请人： Lisa A. Marshall , Kurt E. Steiner , Guy A. Schiehser
发明人： Lisa A. Marshall , Kurt E. Steiner , Guy A. Schiehser
IPC分类号： A61K31/335
CPC分类号： A61K31/335
摘要： There is disclosed a method for the treatment of immunoinflammatory conditions, such as allergy, anaphylaxis, asthma and inflammation in mammals which comprises administering to a mammal so afflicated an effective amount of a compound having the formula: ##STR1## wherein R.sup.1 and R.sup.2 are each, independently, hydrogen, hydroxy, lower alkyl, lower alkoxy, haloloweralkyl, haloloweralkyl sulfonyl, halo or nitro;R.sup.3 is hydrogen, lower alkyl, or aryl of 7-12 carbon atoms;X is ##STR2## A is --CH.sub.2 --, --O-- or --S--; m is 0-8;n is 0-7, with the proviso that m+n.ltoreq.8;or a pharmacologically acceptable salt thereof.
摘要翻译：公开了一种用于治疗哺乳动物的免疫炎症状况，如过敏，过敏反应，哮喘和炎症的方法，其包括向受影响的哺乳动物施用有效量的具有下式的化合物：其中R1和R2各自为独立地是氢，羟基，低级烷基，低级烷氧基，卤代低级烷基，卤代烷基磺酰基，卤素或硝基; R3是7-12个碳原子的氢，低级烷基或芳基; X是-CH 2 - ， - O-或-S-; m为0-8; n为0-7，条件是m + n = 8; 或其药理学上可接受的盐。

6. 发明授权

US4845292A Hydroxy containing amines as phospholipase A2 inhibitors 失效
标题翻译：含羟基胺作为磷脂酶A2抑制剂
公开(公告)号：US4845292A
公开(公告)日：1989-07-04
申请号：US143776
申请日：1988-01-13
申请人： William H. McGregor , Lisa A. Marshall , John H. Musser
发明人： William H. McGregor , Lisa A. Marshall , John H. Musser
IPC分类号： C07C215/08 , C07C215/60 , C07C217/16 , C07D207/08
CPC分类号： C07D207/08 , C07C215/08 , C07C215/60 , C07C217/16
摘要： There are disclosed compounds of the formula ##STR1## R is --CH.sub.2 OH or --CO.sub.2 R.sup.3 ; R.sup.1 is hydrogen, lower alkyl, lower alkoxy or hydroxybenzyl;R.sup.2 is hydroxyloweralkyl or diloweralkoxyalkyl;R.sup.3 is hydrogen or lower alkyl;R.sup.4 is alkyl of 10-20 carbons atoms, phenylalkyl of 11-18 carbon atoms or phenoxyalkyl of 11-18 carbon atoms; orn is 1-3;or a pharmaceutically acceptable salt thereof, and their use in the prevention and/or treatment of conditions such as allergic rhinitis, allergic bronchial asthma and other naso-bronchial obstructive air-passageway conditions, other immediate hypersensitivity reactions such as allergic conjunctivitis and various inflammatory conditions.
摘要翻译：公开了式“IMAGE”的化合物，其中R是-CH 2 OH或-CO 2 R 3; R1是氢，低级烷基，低级烷氧基或羟基苄基; R2是羟基低级烷基或二低级烷氧基烷基; R3是氢或低级烷基; R4是10-20个碳原子的烷基，11-18个碳原子的苯基烷基或11-18个碳原子的苯氧基烷基; 或n为1-3; 或其药学上可接受的盐，以及它们在预防和/或治疗诸如过敏性鼻炎，过敏性支气管哮喘和其他鼻支气管阻塞性空气通道病症之类的病症中的用途，其它立即超敏反应如过敏性结膜炎和各种炎性病症。

7. 发明授权

US06495588B2 Scytonemin and methods of using thereof 失效
标题翻译： Scytonemin及其使用方法
公开(公告)号：US06495588B2
公开(公告)日：2002-12-17
申请号：US09960314
申请日：2001-09-24
申请人： Robert S. Jacobs , Lisa A. Marshall , William H. Gerwick , Christopher Stevenson
发明人： Robert S. Jacobs , Lisa A. Marshall , William H. Gerwick , Christopher Stevenson
IPC分类号： A61K4338
CPC分类号： A61K31/404 , Y02A50/409 , Y02A50/411 , Y02A50/414 , Y02A50/415 , Y02A50/419 , Y02A50/491
摘要： Disclosed are compounds having a scytoneman skeleton, such as scytonemin, and methods of using thereof. Methods of using a compound having a scytoneman skeleton to inhibit, modulate, attenuate, or prevent cell-cycle progression, cell proliferation, kinase activity, or induce apoptosis are disclosed. Also disclosed are methods of treating, preventing, or inhibiting diseases and disorders associated with cell cycle progression, cell proliferation, kinase activity, tissue hyperplasia or angiogenesis, such as cancer or an inflammatory disease.
摘要翻译：公开了具有scytoneman骨架的化合物，例如scytonemin，及其使用方法。公开了使用具有Scytoneman骨架的化合物抑制，调节，减弱或预防细胞周期进程，细胞增殖，激酶活性或诱导细胞凋亡的方法。还公开了治疗，预防或抑制与细胞周期进程，细胞增殖，激酶活性，组织增生或血管发生如癌症或炎性疾病相关的疾病和病症的方法。

8. 发明授权

US5780609A DNA sequence of human RP-105 失效
标题翻译：人RP-105的DNA序列
公开(公告)号：US5780609A
公开(公告)日：1998-07-14
申请号：US730771
申请日：1996-10-16
申请人： Lisa A. Marshall , Amy K. Roshak
发明人： Lisa A. Marshall , Amy K. Roshak
IPC分类号： C12N15/09 , C07K14/705 , C07K16/26 , C07K16/28 , C12P21/08 , C12Q1/68 , C07H21/04 , C12N15/63
CPC分类号： C07K16/26 , C07K14/705 , A01K2217/05
摘要： Nucleic acid molecules encoding a human B cell surface molecule are provided. Polypeptides and antibodies which bind to these polypeptides are also provided. In addition, methods of detecting mutated forms of the molecule are provided.
摘要翻译：提供编码人B细胞表面分子的核酸分子。还提供了结合这些多肽的多肽和抗体。此外，提供检测突变形式的分子的方法。

9. 发明授权

US4788304A Phospholipase A2 inhibitors 失效
标题翻译：磷脂酶A2抑制剂
公开(公告)号：US4788304A
公开(公告)日：1988-11-29
申请号：US129259
申请日：1987-12-07
申请人： Lisa A. Marshall , Kurt E. Steiner , Guy A. Schiehser
发明人： Lisa A. Marshall , Kurt E. Steiner , Guy A. Schiehser
IPC分类号： C07D303/48
CPC分类号： C07D303/48 , Y10S514/885 , Y10S514/886
摘要： There is disclosed a method for the treatment of immunoinflammatory conditions, such as allergy, anaphylaxis, asthma and inflammation in mammals which comprises administering to a mammal so afflicted an effective amount of a compound having the formula: ##STR1## wherein R.sup.1 and R.sup.2 are each, independently, hydrogen, hydroxy, lower alkyl, lower alkoxy, haloloweralkyl, haloloweralkyl sulfony., halo or nitro;R.sup.3 is hydrogen, lower alkyl, or aryl of 7-12 carbon atoms;X is ##STR2## A is --CH.sub.2 --,--O-- or --S--; m is 0-8;n is 0-7, with the proviso that m+n.ltoreq.8;or a pharmacologically acceptable salt thereof; and also novel compounds of the above formula in which X is ##STR3##
摘要翻译：公开了一种用于治疗哺乳动物的免疫炎症状况，如过敏，过敏反应，哮喘和炎症的方法，其包括向受影响的哺乳动物施用有效量的具有下式的化合物：其中R1和R2各自为独立地是氢，羟基，低级烷基，低级烷氧基，卤代低级烷基，卤代低级烷基磺酰基，卤素或硝基; R3是7-12个碳原子的氢，低级烷基或芳基; X是A，-CH 2 - ， - O-或-S-; m为0-8; n为0-7，条件是m + n = 8; 或其药理学上可接受的盐; 以及其中X是的上式的新化合物

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式