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1. 发明授权

US06458932B1 Interferon-&agr;/&bgr; binding protein, its preparation and use 失效
标题翻译：干扰素-α/β结合蛋白，其制备和应用
公开(公告)号：US06458932B1
公开(公告)日：2002-10-01
申请号：US08472402
申请日：1995-06-07
申请人： Daniela Novick , Batya Cohen , Menachem Rubinstein
发明人： Daniela Novick , Batya Cohen , Menachem Rubinstein
IPC分类号： C07K14715
CPC分类号： C07K16/00 , A61K38/00 , C07K14/715 , C07K16/2866 , C07K2319/00
摘要： Interferon &agr;/&bgr; binding proteins are provided, which are capable of modulating the activity of interferon-&agr; subtypes as well as interferon-&bgr;. Cloning of DNA molecules encoding these proteins, expression in host cells and antibodies against the proteins are also provided.
摘要翻译：提供干扰素α/β结合蛋白，其能够调节干扰素-α亚型以及干扰素-β的活性。还提供了编码这些蛋白质的DNA分子的克隆，宿主细胞中的表达和针对蛋白质的抗体。

2. 发明授权

US06417328B1 Trail receptors, nucleic acids encoding the same, and methods of use thereof 失效
公开(公告)号：US06417328B1
公开(公告)日：2002-07-09
申请号：US09134618
申请日：1998-08-14
申请人： Emad S. Alnemri
发明人： Emad S. Alnemri
IPC分类号： C07K14715
摘要： In accordance with the present invention, there are provided isolated mammalian TRAIL receptor proteins, antibodies thereto, therapeutic compositions, and nucleic acids encoding such. Bioassays and therapeutic methods employing invention DR5 and TRAIL-R3 proteins are also provided.

3. 发明授权

US06677434B2 Soluble human flk-2 protein 失效
标题翻译：可溶性人类flk-2蛋白
公开(公告)号：US06677434B2
公开(公告)日：2004-01-13
申请号：US09872136
申请日：2001-06-01
申请人： Ihor R. Lemischka
发明人： Ihor R. Lemischka
IPC分类号： C07K14715
CPC分类号： C07K14/52 , C07K14/47 , C07K14/705 , C07K14/70596 , C07K14/71 , C07K14/715 , C07K16/28 , C07K2319/00 , C07K2319/32 , C07K2319/43 , C07K2319/61 , C12N5/0647 , C12N9/1205 , Y10S435/971
摘要： Isolated mammalian nucleic acid molecules encoding receptor protein tyrosine kinases expressed in primitive hematopoietic cells and not expressed in mature hematopoietic cells are provided. Also included are the receptors encoded by such nucleic acid molecules; the nucleic acid molecules encoding receptor protein tyrosine kinases having the sequences shown in FIG. 1a (murine flk-2), FIG. 1b (human flk-2) and FIG. 2 (murine flk-1); the receptor protein tyrosine kinases having the amino acid sequences shown in FIG. 1a, FIG. 1b and FIG. 2; ligands for the receptors; nucleic acid sequences that encode the ligands; and methods of stimulating the proliferation and/or differentiation of primitive mammalian hematopoietic stem cells comprising contacting the stem cells with a ligand that binds to a receptor protein tyrosine kinase expressed in primitive mammalian hematopoietic cells and not expressed in mature hematopoietic cells.
摘要翻译：提供编码在原始造血细胞中表达并且未在成熟造血细胞中表达的受体蛋白酪氨酸激酶的分离的哺乳动物核酸分子。还包括由这种核酸分子编码的受体; 编码具有图1所示序列的受体蛋白酪氨酸激酶的核酸分子。 1a（鼠flk-2），图。 1b（人类flk-2）， 2（鼠flk-1）; 具有图1所示氨基酸序列的受体蛋白酪氨酸激酶。 1a， 1b， 2; 受体配体; 编码配体的核酸序列; 以及刺激原始哺乳动物造血干细胞的增殖和/或分化的方法，其包括使干细胞与在原始哺乳动物造血细胞中表达但不在成熟造血细胞中表达的受体蛋白酪氨酸激酶结合的配体接触。

4. 发明授权

US06271347B1 Eosinophil eotaxin receptor 失效
标题翻译：嗜酸性粒细胞嗜酸性粒细胞趋化因子受体
公开(公告)号：US06271347B1
公开(公告)日：2001-08-07
申请号：US08847296
申请日：1997-04-24
申请人： Bruce L. Daugherty , Julie A. Demartino , Salvatore J. Siciliano , Martin S. Springer
发明人： Bruce L. Daugherty , Julie A. Demartino , Salvatore J. Siciliano , Martin S. Springer
IPC分类号： C07K14715
CPC分类号： C12Q1/6883 , A61K38/00 , C07K14/7158 , C12Q2600/158 , G01N33/6863 , G01N2333/715
摘要： The eosinophil eotaxin receptor has been isolated, cloned and sequenced. This receptor is a human &bgr;-chemokine receptor and has been designated “CC CKR3”. The eosinophil eotaxin receptor may be used to screen and identify compounds that bind to the eosinophil eotaxin receptor. Such compounds would be useful in the treatment and prevention of atopic conditions including allergic rhinitis, dermatitis, conjunctivitis, and particularly bronchial asthma.
摘要翻译：已经分离，克隆和测序嗜酸性粒细胞嗜酸性粒细胞趋化因子受体。该受体是人β-趋化因子受体，并被称为“CC CKR3”。嗜酸性粒细胞嗜酸性粒细胞趋化因子受体可用于筛选和鉴定结合嗜酸性粒细胞嗜酸性粒细胞趋化嗜酸性粒细胞趋化因子受体的化合物。这些化合物可用于治疗和预防特应性疾病，包括过敏性鼻炎，皮炎，结膜炎，特别是支气管哮喘。

5. 发明授权

US06664374B1 Polypeptides comprising IL-6 ligand-binding receptor domains 失效
标题翻译：包含IL-6配体结合受体结构域的多肽
公开(公告)号：US06664374B1
公开(公告)日：2003-12-16
申请号：US09721108
申请日：2000-11-22
申请人： Carl Saxinger
发明人： Carl Saxinger
IPC分类号： C07K14715
CPC分类号： C07K14/7155 , A61K38/00
摘要： The present invention provides, among other things, a polypeptide, and a pharmaceutically acceptable salt. thereof, that inhibits the binding of IL-6 ligand with IL-6 receptor under physiological conditions, a nucleic acid that encodes such a polypeptide and can be expressed in a cell, a nucleic acid that comprises or encodes an antisense nucleic acid molecule or a ribozyme that is specific for such a polypeptide, an antibody that is specific to such a polypeptide, an anti-antibody thereto, a composition comprising such a polypeptide, nucleic acid, antibody or an anti-body and a carrier therefor, a composition comprising a solid support matrix to which is attached an above-described polypeptide or an anti-antibody to a specified polypeptide sequence, a method of prophylactically or therapeutically inhibiting IL-6 signaling in a mammal in need thereof, a mammal in need thereof, and a method of removing IL-6 ligand from a bodily fluid of an animal.
摘要翻译：本发明尤其提供了多肽和药学上可接受的盐。其在生理条件下抑制IL-6配体与IL-6受体的结合，编码这种多肽并可在细胞中表达的核酸，包含或编码反义核酸分子的核酸或对这种多肽特异的核酶，对这种多肽具有特异性的抗体，其抗抗体，包含这种多肽，核酸，抗体或抗体及其载体的组合物，包含固定支持基质，其上附着有指定多肽序列的上述多肽或抗体抗体，在有需要的哺乳动物中预防性或治疗性地抑制IL-6信号传导的方法，有需要的哺乳动物和方法从动物的体液中除去IL-6配体。

6. 发明授权

US06271343B1 Mammalian cytokine-like receptor 5 失效
标题翻译：哺乳动物细胞因子样受体5
公开(公告)号：US06271343B1
公开(公告)日：2001-08-07
申请号：US09071224
申请日：1998-05-01
申请人： Si Lok , Scott R. Presnell , Anna C. Jelmberg , Teresa Gilbert , Theodore E. Whitmore , Donald C. Foster , Robyn L. Adams , Joyce M. Lehner
发明人： Si Lok , Scott R. Presnell , Anna C. Jelmberg , Teresa Gilbert , Theodore E. Whitmore , Donald C. Foster , Robyn L. Adams , Joyce M. Lehner
IPC分类号： C07K14715
CPC分类号： C07K14/715
摘要： Novel receptor polypeptides, polynucleotides encoding the polypeptides, and related compositions. The polypeptides of the present invention can be used to down-regulate their natural ligands. The polynucleotides and subsequences thereof can be used as diagnostic probes to determine if chromosome 19 is mutated. The antibodies which bind to the polypeptides can be used to purify the receptors and to inhibit the binding of the ligands onto the receptors.
摘要翻译：新型受体多肽，编码多肽的多核苷酸和相关组合物。本发明的多肽可用于下调其天然配体。其多核苷酸及其亚序列可用作诊断探针，以确定染色体19是否突变。结合多肽的抗体可用于纯化受体并抑制配体结合到受体上。

7. 发明授权

US06268477B1 Chemokine receptor 88-C 失效
标题翻译：趋化因子受体88-C
公开(公告)号：US06268477B1
公开(公告)日：2001-07-31
申请号：US08661393
申请日：1996-06-07
申请人： Patrick W. Gray , Vicki L. Schweickart , Carol J. Raport
发明人： Patrick W. Gray , Vicki L. Schweickart , Carol J. Raport
IPC分类号： C07K14715
CPC分类号： C07K16/18 , C07K14/7158 , C07K16/2866 , C07K2319/43
摘要： The present invention provides polynucleotides that encode the chemokine receptors 88-2B or 88C and materials and methods for the recombinant production of these two chemokine receptors. Also provided are assays utilizing the polynucleotides which facilitate the identification of ligands and modulators of the chemokine receptors. Receptor fragments, ligands, modulators, and antibodies are useful in the detection and treatment of disease states associated with the chemokine receptors such as atherosclerosis, rheumatoid arthritis, tumor growth suppression, asthma, viral infection, AIDS, and other inflammatory conditions.
摘要翻译：本发明提供编码趋化因子受体88-2B或88C的多核苷酸以及用于重组产生这两种趋化因子受体的材料和方法。还提供了利用促进鉴定趋化因子受体的配体和调节剂的多核苷酸的测定。受体片段，配体，调节剂和抗体可用于检测和治疗与趋化因子受体相关的疾病状态，例如动脉粥样硬化，类风湿性关节炎，肿瘤生长抑制，哮喘，病毒感染，艾滋病和其它炎性病症。

8. 发明授权

US06686448B2 Class II cytokine receptor-7 有权
标题翻译： II类细胞因子受体-7
公开(公告)号：US06686448B2
公开(公告)日：2004-02-03
申请号：US09861779
申请日：2001-05-21
申请人： Si Lok , Choon J. Kho , Anna C. Jelmberg , Robyn L. Adams , Theodore E. Whitmore , Theresa M. Farrah
发明人： Si Lok , Choon J. Kho , Anna C. Jelmberg , Robyn L. Adams , Theodore E. Whitmore , Theresa M. Farrah
IPC分类号： C07K14715
CPC分类号： C07K14/715 , C07K2319/02 , Y10S930/12 , Y10S930/14
摘要： Novel receptor polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed. The polypeptides comprise an extracellular domain of a cell-surface receptor that is expressed in kidneys, pancreas, prostate, adrenal cortex and nervous tissue. The polypeptides may be used within methods for detecting ligands that promote the proliferation and/or differentiation of these organs.
摘要翻译：公开了新颖的受体多肽，编码多肽的多核苷酸，以及相关的组合物和方法。多肽包含在肾脏，胰腺，前列腺，肾上腺皮质和神经组织中表达的细胞表面受体的细胞外结构域。多肽可用于检测促进这些器官的增殖和/或分化的配体的方法中。

9. 发明授权

US06667390B2 Human tumor necrosis factor receptor TR9 有权
公开(公告)号：US06667390B2
公开(公告)日：2003-12-23
申请号：US09756854
申请日：2001-01-10
申请人： Jian Ni , Guo-Liang Yu , Ping Fan , Reiner L. Gentz
发明人： Jian Ni , Guo-Liang Yu , Ping Fan , Reiner L. Gentz
IPC分类号： C07K14715
CPC分类号： C07K14/70578 , A61K38/00 , C07K14/4747 , C07K14/7151 , C12N2799/026
摘要： The present invention relates to a novel member of the tumor necrosis factor family of receptors. In particular, isolated nucleic acid molecules are provided encoding the human TR9 receptor. TR9 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR9 receptor activity.

10. 发明授权

US06350855B1 Human interleukin-11 receptor 失效
标题翻译：人白细胞介素-11受体
公开(公告)号：US06350855B1
公开(公告)日：2002-02-26
申请号：US08929846
申请日：1997-09-15
申请人： James Tobin
发明人： James Tobin
IPC分类号： C07K14715
CPC分类号： C07K14/7155 , A61K38/00 , C07K14/715 , G01N2500/02
摘要： Polynucleotides encoding the human IL-11 receptor and fragments thereof are disclosed. IL-11 receptor proteins, methods for their production, inhibitors of binding of human IL-11 and its receptor and methods for their identification are also disclosed.
摘要翻译：公开了编码人IL-11受体的多核苷酸及其片段。还公开了IL-11受体蛋白质，其生产方法，人IL-11及其受体的结合抑制剂及其鉴定方法。

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