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1. 发明授权

US10390746B2 Catheter 有权
公开(公告)号：US10390746B2
公开(公告)日：2019-08-27
申请号：US11920632
申请日：2006-05-25
申请人： Richard Harley Grenville Owen , Stephen Blatcher , Stewart Maddison Fox , Martin Lawrence Hughes
发明人： Richard Harley Grenville Owen , Stephen Blatcher , Stewart Maddison Fox , Martin Lawrence Hughes
IPC分类号： A61B5/155 , A61B5/15 , A61B5/153 , A61B5/154 , A61M25/00 , A61B1/00
摘要： A catheter for insertion into a blood vessel, the catheter having a sampling part arranged to capture a blood sample at a plurality of locations along a length of the blood vessel and an apparatus arranged to analyze blood taken from a plurality of locations along the length of the blood vessel and to provide a profile of concentration levels along the length of the blood vessel.

2. 发明授权

US08280924B2 Object-relational mapping with dynamic relational schemas 有权
标题翻译：具有动态关系模式的对象关系映射
公开(公告)号：US08280924B2
公开(公告)日：2012-10-02
申请号：US12412135
申请日：2009-03-26
申请人： Brad Mark Olenick , Gregory Lawrence Hughes , Siddharth Jayadevan , Carll Bennett Hoffman , Clemens Kerer
发明人： Brad Mark Olenick , Gregory Lawrence Hughes , Siddharth Jayadevan , Carll Bennett Hoffman , Clemens Kerer
IPC分类号： G06F7/00 , G06F17/30
CPC分类号： G06F17/30607
摘要： In an embodiment, a generic database application of a computer system receives a portion of input data from a database. The generic database application can communicate with the database using a variety of different database schemas. The generic database application of the computer system infers a portion of ORM metadata associated with the received input data. The computer system accesses a generic ORM query where the ORM query is configured to provide mapping information to map the input data into a graph of objects according to the database object properties included in the ORM metadata. The computer system maps the input data into a graph of objects using the database object properties included in the ORM metadata and displays an ORM object view which includes the graph of objects.
摘要翻译：在一个实施例中，计算机系统的通用数据库应用从数据库接收输入数据的一部分。通用数据库应用程序可以使用各种不同的数据库模式与数据库通信。计算机系统的通用数据库应用程序推断与接收到的输入数据相关联的一部分ORM元数据。计算机系统访问通用ORM查询，其中ORM查询被配置为提供映射信息，以根据ORM元数据中包含的数据库对象属性将输入数据映射到对象图中。计算机系统使用ORM元数据中包含的数据库对象属性将输入数据映射到对象的图形中，并显示包含对象图形的ORM对象视图。

3. 发明授权

US07835065B2 Optical packages and methods for aligning optical packages 有权
标题翻译：用于对准光学封装的光学封装和方法
公开(公告)号：US07835065B2
公开(公告)日：2010-11-16
申请号：US12200661
申请日：2008-08-28
申请人： Etienne Almoric , Jacques Gollier , Lawrence Hughes , Garrett Andrew Piech
发明人： Etienne Almoric , Jacques Gollier , Lawrence Hughes , Garrett Andrew Piech
IPC分类号： G02F1/35 , G02F2/02 , H01S3/08
CPC分类号： G02B6/4214 , G01B11/272 , G02F1/377 , G02F2001/3546 , H01S5/005 , H01S5/0071 , H01S5/0092
摘要： An optical package includes a semiconductor laser, a wavelength conversion device and a MEMS-actuated mirror oriented on a base module to form a folded optical pathway between an output of the semiconductor laser and an input of the wavelength conversion device. An optical assembly is located in a mechanical positioning device and the mechanical positioning device is disposed on the base module along the optical pathway such that the beam of the semiconductor laser passes through the optical assembly, is reflected by the MEMS-actuated mirror back through the optical assembly and into the waveguide portion of the wavelength conversion device. The MEMS-actuated mirror is operable to scan the beam of the semiconductor laser over the input of the wavelength conversion device. The optical assembly may be adjusted along the optical pathway with the mechanical positioning device to focus the beam into the waveguide portion of the wavelength conversion device.
摘要翻译：光学封装包括半导体激光器，波长转换器件和面向基底模块的MEMS致动镜，以在半导体激光器的输出端与波长转换器件的输入端之间形成折叠光路。光学组件位于机械定位装置中，并且机械定位装置沿着光学路径设置在基座模块上，使得半导体激光器的光束通过光学组件，被MEMS致动的反射镜反射回通过光学组件并进入波长转换装置的波导部分。 MEMS致动反射镜可操作以通过波长转换装置的输入来扫描半导体激光束的光束。光学组件可以利用机械定位装置沿光学路径调节，以将光束聚焦到波长转换装置的波导部分中。

4. 发明申请

US20060195128A1 Method and apparatus for loading penetrating members 审中-公开
标题翻译：用于装载穿透构件的方法和装置
公开(公告)号：US20060195128A1
公开(公告)日：2006-08-31
申请号：US10541123
申请日：2003-12-31
申请人： Don Alden , Timothy Barrow-Williams , Charlie Dean , Martin-Lawrence Hughes , Mark Humphries , Douglas Jennings , Thomas Neudeck , John Stephenson
发明人： Don Alden , Timothy Barrow-Williams , Charlie Dean , Martin-Lawrence Hughes , Mark Humphries , Douglas Jennings , Thomas Neudeck , John Stephenson
IPC分类号： A61B17/32
CPC分类号： A61B5/157 , A61B5/150022 , A61B5/150152 , A61B5/150167 , A61B5/150175 , A61B5/150412 , A61B5/150526 , A61B5/150702 , A61B5/15113 , A61B5/15123 , A61B5/15146 , A61B5/15169 , A61B5/15171 , A61B5/1518 , A61B5/15184
摘要： A body fluid sampling system is provided. In one embodiment, the system may comprise a penetrating member driver, a plurality of penetrating members sufficient for penetrating tissue; a tape coupling together at least two of the penetrating members; and a penetrating member release device removing the penetrating member from a sterile environment prior to use and moving the penetrating member into position to be operatively coupled to the penetrating member driver. The driver may comprises of a drive force generator for advancing the penetrating member and a processor coupled to the drive force generator capable of changing the direction and magnitude of force exerted on the penetrating member during the lancing cycle. The driver may further include a human interface on the housing providing at least one output for communicating with the patient.
摘要翻译：提供体液采样系统。在一个实施例中，系统可以包括穿透构件驱动器，足以穿透组织的多个穿透构件; 将至少两个所述穿透构件联接在一起的带; 以及穿透构件释放装置，在使用之前将穿透构件从无菌环境中移除，并将穿透构件移动到可操作地联接到穿透构件驱动器的位置。驾驶员可以包括用于推进穿透构件的驱动力发生器和联接到驱动力发生器的处理器，其能够改变在穿刺周期期间施加在穿透构件上的力的方向和大小。驱动器还可以在壳体上包括人体接口，提供至少一个用于与患者通信的输出。

5. 发明授权

US5365108A Metal matrix composite semiconductor power switch assembly 失效
标题翻译：金属基复合半导体电源开关总成
公开(公告)号：US5365108A
公开(公告)日：1994-11-15
申请号：US979088
申请日：1992-11-19
申请人： W. Kyle Anderson , Richard J. Hoppe , William J. Durako, Jr. , Mark Metzler , Lawrence Hughes , Stephen E. Jackson
发明人： W. Kyle Anderson , Richard J. Hoppe , William J. Durako, Jr. , Mark Metzler , Lawrence Hughes , Stephen E. Jackson
IPC分类号： H01L23/057 , H01L23/373 , H01L23/49 , H01L23/02 , H01L23/12
CPC分类号： H01L24/49 , H01L23/057 , H01L23/3733 , H01L2224/48091 , H01L2224/48247 , H01L2224/4911 , H01L24/48 , H01L2924/00014 , H01L2924/01006 , H01L2924/01013 , H01L2924/01014 , H01L2924/01028 , H01L2924/01029 , H01L2924/01033 , H01L2924/01042 , H01L2924/01082 , H01L2924/014 , H01L2924/12042 , H01L2924/1305 , H01L2924/16195 , H01L2924/19107
摘要： A power semiconductor assembly, particularly a semiconductor switch assembly which has a number of discrete emitter connection pads, comprised of a metal matrix composite housing and a copper or aluminum post with a cross-sectional area sufficiently large to carry the rated current providing a single-point, external connection to all emitter pads. The post passes through and is supported by an insulating ceramic insert such as aluminum oxide in the wall of the metal matrix composite housing. The post is hollowed out in the region where it passes through the ceramic insert in order to reduce the mechanical stress between the post and the insulating insert as a result of the mismatch in their thermal expansion coefficients. Buses on either side of the semiconductor die provide surfaces for connection from the post to the discrete emitter connection pads on the die.
摘要翻译：功率半导体组件，特别是具有多个分立的发射器连接焊盘的半导体开关组件，其包括金属基体复合壳体和具有足够大的横截面积的铜或铝柱，以承载额定电流，点，外部连接到所有发射极焊盘。柱穿过并由金属基体复合壳体的壁中的绝缘陶瓷插入物例如氧化铝支撑。该柱在其通过陶瓷插入件的区域中被挖空，以便由于它们的热膨胀系数不匹配而减小柱和绝缘插入件之间的机械应力。在半导体管芯的任一侧上的公共汽车提供用于从管柱连接到管芯上的分立发射器连接焊盘的表面。

6. 发明授权

US08646591B2 Apparatus for handling capsules and capsule processing equipment including such an apparatus 有权
标题翻译：用于处理胶囊的装置和包括这种装置的胶囊加工设备
公开(公告)号：US08646591B2
公开(公告)日：2014-02-11
申请号：US13130322
申请日：2009-11-05
申请人： Thomas Marcelina Louis De Ruijter , Nigel David Harrison , Martin Lawrence Hughes , Mark Robson Humphries , Paul Antony Merritt , Stefaan Jaak Vanquickenborne , Philip Jonathan West
发明人： Thomas Marcelina Louis De Ruijter , Nigel David Harrison , Martin Lawrence Hughes , Mark Robson Humphries , Paul Antony Merritt , Stefaan Jaak Vanquickenborne , Philip Jonathan West
IPC分类号： A61J3/00 , A61J3/07
CPC分类号： A61J3/007 , A61J3/074 , B65G47/1471 , G01N21/9508
摘要： The invention relates to an apparatus for handling capsules in a capsule processing equipment. The invention also relates to capsule processing equipment, such as an inspection equipment or a capsule printing equipment that includes such an apparatus.
摘要翻译：本发明涉及一种在胶囊加工设备中处理胶囊的装置。本发明还涉及胶囊加工设备，例如包括这种装置的检查设备或胶囊印刷设备。

7. 发明申请

US20070201797A1 Glass-based micropositioning systems and methods 有权
标题翻译：玻璃微定位系统和方法
公开(公告)号：US20070201797A1
公开(公告)日：2007-08-30
申请号：US11365391
申请日：2006-02-28
申请人： Richard Grzybowski , Brewster Hemenway , Lawrence Hughes , Stephan Logunov , Kamjula Reddy , Joseph Schroeder , James Sutherland
发明人： Richard Grzybowski , Brewster Hemenway , Lawrence Hughes , Stephan Logunov , Kamjula Reddy , Joseph Schroeder , James Sutherland
IPC分类号： G02B6/42
CPC分类号： G02B6/423 , B29D11/00384 , G02B6/30 , G02B6/3636 , G02B6/3656 , G02B6/4226 , G02B6/4227 , G02B6/4231 , G02B6/4234 , G02B6/4239
摘要： Glass-based micropositioning systems and methods are disclosed. The micropositioning systems and methods utilize microbumps (40) formed in a glass substrate (12 or 100). The microbumps are formed by subjecting a portion of the glass substrate to localized heating, which results in local rapid expansion of glass where the heat was applied. The height and shape of the microbumps depend on the type of glass substrate and the amount and form of heat delivered to the substrate. The microbumps allow for active or passive micropositioning of optical elements, including planar waveguides and optical fibers. Optical assemblies formed using microbump micropositioners are also disclosed.
摘要翻译：公开了玻璃基微定位系统和方法。微定位系统和方法利用形成在玻璃基板（12或100）中的微胶片（40）。通过对玻璃基板的一部分进行局部加热来形成微胶囊，这导致玻璃的加热局部快速膨胀。微丸的高度和形状取决于玻璃基板的类型和输送到基底的热量和形式。微胶片允许包括平面波导和光纤在内的光学元件的主动或被动微定位。还公开了使用微型微量定位器形成的光学组件。

8. 发明申请

US20050100073A1 Cladding-pumped quasi 3-level fiber laser/amplifier 审中-公开
标题翻译：包层泵浦准3级光纤激光器/放大器
公开(公告)号：US20050100073A1
公开(公告)日：2005-05-12
申请号：US10705032
申请日：2003-11-10
申请人： Lawrence Hughes , Xingsheng Liu , Donnell Walton , Chung-En Zah , Luis Zenteno
发明人： Lawrence Hughes , Xingsheng Liu , Donnell Walton , Chung-En Zah , Luis Zenteno
IPC分类号： H01S3/067 , H01S3/094 , H01S3/0941 , H01S3/091
CPC分类号： H01S3/06708 , H01S3/067 , H01S3/06716 , H01S3/094 , H01S3/094007 , H01S3/09415 , H01S5/2036
摘要： An optically active fiber (30) is disclosed for making a fiber laser (18) or an amplifier (16) for optically pumping by a broad area laser diode for operation in the 1.5 micron band. This double-clad structured active fiber (30) has a core (34), doped with an optically excitable erbium ion having a quasi-three-level transition. The core (3) has a core refractive index and a core cross-sectional area. An inner cladding (32) surrounds the core (34). The inner cladding (32) has an inner cladding refractive index less than the core refractive index, an inner cladding cross-sectional area between 2 and 25 times greater than that of the core cross-sectional area, and an aspect ratio greater than 1.5:1. An outer cladding (36) surrounds the inner cladding (32) and has an outer cladding refractive index less than the inner cladding refractive index.
摘要翻译：公开了一种用于制造光纤激光器（18）或放大器（16）的光学有源光纤（30），用于通过广域激光二极管光学泵浦以在1.5微米波段内操作。这种双包层结构的有源光纤（30）具有掺杂有具有准三电平转换的光学可激发的铒离子的芯（34）。芯（3）具有芯折射率和芯横截面积。内包层（32）围绕芯部（34）。内包层（32）的内包层折射率小于纤芯折射率，内包层横截面积比芯横截面积大2至25倍，纵横比大于1.5： 1。外包层（36）围绕内包层（32）并且具有小于内包层折射率的外包层折射率。

9. 发明授权

US4109014A Pharmaceutical, compositions containing substituted 4'-hydroxyphenyl guanidines and methods of using same 失效
标题翻译：药物组合物，包含取代的4“ - 羟基苯甲酰基的组合物及其使用方法
公开(公告)号：US4109014A
公开(公告)日：1978-08-22
申请号：US762358
申请日：1977-01-25
申请人： Robert Chung-Huan Liu , John Lawrence Hughes
发明人： Robert Chung-Huan Liu , John Lawrence Hughes
IPC分类号： A61K31/155
CPC分类号： A61K31/155
摘要： Novel aromatic guanidine compounds having the formula: ##STR1## wherein: R.sub.1 is hydroxyl, methyl or hydroxymethyl and R.sub.2 is hydrogen or methyl, are found to have biological activity. The guanidine compounds and their salts are shown to be active as vasoconstrictor agents and create useful pharmaceutical preparations when deployed with a pharmaceutically acceptable carrier for administration to a host, e.g., man, requiring vasoconstrictive therapy.

10. 发明授权

US3976787A Pharmaceutical guanidine preparations and methods of using same 失效
标题翻译：药物胍制剂及其使用方法
公开(公告)号：US3976787A
公开(公告)日：1976-08-24
申请号：US556067
申请日：1975-03-06
申请人： John Lawrence Hughes , Robert Chung-Huan Liu , Takashi Enkoji , James Winslow Bastian
发明人： John Lawrence Hughes , Robert Chung-Huan Liu , Takashi Enkoji , James Winslow Bastian
IPC分类号： C07C279/18 , A61K31/155
CPC分类号： C07C279/18
摘要： Pharmaceutical preparations and methods of using the same to treat a host having a condition requiring vasoconstrictive therapy. The preparations comprise a pharmaceutically acceptable carrier and a guanidine compound, or non-toxic acid addition salt thereof, having the structural notation: ##SPC1##Wherein: R.sub.1 is hydrogen or alkyl having 1-4 carbon atoms; R.sub.2 is hydrogen, hydroxy, chloro, fluoro or bromo; and R.sub.3 is hydrogen or the same as R.sub.2 when R.sub.2 is chloro, bromo or fluoro.
摘要翻译：药物制剂及其使用方法来治疗需要血管收缩治疗的病症的宿主。制剂包含具有结构符号的药学上可接受的载体和胍化合物或其无毒的酸加成盐：

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