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1. 发明授权

US08337783B2 Magnetic connectors for microfluidic applications 有权
标题翻译：用于微流控应用的磁连接器
公开(公告)号：US08337783B2
公开(公告)日：2012-12-25
申请号：US12820218
申请日：2010-06-22
申请人： Laurie E. Locascio , Francisco Javier Atencia-Fernandez
发明人： Laurie E. Locascio , Francisco Javier Atencia-Fernandez
IPC分类号： B01L99/00
CPC分类号： F16K99/0046 , B01J19/0093 , B01J2219/0081 , B01L3/502715 , B01L2200/027 , B01L2200/0689 , B01L2300/0681 , F16K2099/0084
摘要： A magnetic connector assembly for microfluidic devices comprises a first magnetic connector with at least one orifice extending therethrough and a second magnetic connector. The first and second connectors are configured to magnetically attract each other. In one aspect, the first magnetic connector is configured to sealingly engage a surface of a microfluidic chip with the second magnetic connector disposed on an opposite side of the microfluidic chip. The first magnetic connector is configured to seal with the microfluidic chip about a channel opening in the microfluidic chip and provide flow communication between the channel opening and the orifice in the first magnetic connector. In at least one other aspect, the first magnetic connector and second magnetic connector each have at least one orifice and are configured to change a flow communication therebetween upon a rotation of the first or second magnetic connector with respect to the other magnetic connector.
摘要翻译：用于微流体装置的磁性连接器组件包括具有延伸穿过其中的至少一个孔的第一磁性连接器和第二磁性连接器。第一和第二连接器被配置为磁吸引彼此。在一个方面，第一磁性连接器构造成密封地接合微流体芯片的表面与设置在微流体芯片的相对侧上的第二磁性连接器。第一磁性连接器构造成围绕微流体芯片中的通道开口与微流体芯片密封，并且在第一磁性连接器中提供通道开口和孔口之间的流动连通。在至少另一方面中，第一磁性连接器和第二磁性连接器各自具有至少一个孔口，并且构造成在第一或第二磁性连接器相对于另一个磁性连接器旋转时改变其间的流动连通。

2. 发明授权

US08236480B2 Fabrication method of topographically modulated microstructures using pattern homogenization with UV light 有权
标题翻译：使用紫外光图案均匀化的地形调制微结构的制造方法
公开(公告)号：US08236480B2
公开(公告)日：2012-08-07
申请号：US12127352
申请日：2008-05-27
申请人： Laurie E. Locascio , Francisco Javier Atencia-Fernandez , Susan Barnes , Jack F. Douglas
发明人： Laurie E. Locascio , Francisco Javier Atencia-Fernandez , Susan Barnes , Jack F. Douglas
IPC分类号： G03F7/20
CPC分类号： B01F5/0646 , B01F5/0647 , B01F13/0059 , B01L3/502707 , B01L2300/0874 , B81B2201/058 , B81C99/0085 , B81C99/009 , B81C2201/0157 , B81C2201/019 , G03F1/50
摘要： A method for microfabrication of a microfluidic device having sub-millimeter three dimensional relief structures is disclosed. In this method, homogeneous surfaces, which do not exhibit apparent pixel geometry, emerge from the interaction of the overlapping of diffracted light under opaque pixels and the nonlinear polymerization properties of the photoresist material. The method requires a single photolithographic step and allows for the fabrication of microstructures over large areas (centimeters) with topographic modulation of features smaller than 100 micrometers. The method generates topography that is useful in a broad range of microfluidic applications.
摘要翻译：公开了一种具有亚毫米三维浮雕结构的微流体装置的微细加工方法。在这种方法中，不表现出明显的像素几何形状的均匀表面从不透明像素处的衍射光的重叠与光致抗蚀剂材料的非线性聚合性质的相互作用中出现。该方法需要单个光刻步骤，并且允许在大面积（厘米）上制造具有小于100微米的特征的地形调制的微结构。该方法产生在广泛的微流体应用中有用的形貌。

3. 发明授权

US08216526B2 Method and device for generating diffusive gradients in a microfluidic chamber 有权
标题翻译：用于在微流体室中产生漫射梯度的方法和装置
公开(公告)号：US08216526B2
公开(公告)日：2012-07-10
申请号：US12401900
申请日：2009-03-11
申请人： Laurie E. Locascio , Francisco Javier Atencia-Fernandez
发明人： Laurie E. Locascio , Francisco Javier Atencia-Fernandez
IPC分类号： G01N15/06 , G01N33/00 , G01N33/48
CPC分类号： B01F15/0404 , B01F13/0059 , B01F13/0093 , B01L3/5027 , Y10T436/11 , Y10T436/25
摘要： A microfluidic device is described, capable of generating multiple spatial chemical gradients simultaneously inside a microfluidic chamber. The chemical gradients are generated by diffusion, without convection, and can either be maintained constant over long time periods, or modified dynamically. A representative device is described with a circular chamber in which diffusion occurs, with three access ports for the delivery and removal of solutes. A gradient typically forms in minutes, and can be maintained constant indefinitely. Gradients overlapping with different spatial location, and a controlled rotation of a gradient formed by diffusion are demonstrated. The device can also be used to evaluate chemotactic responses of bacteria or other microorganisms in the absence of convective flow.
摘要翻译：描述了一种微流体装置，其能够在微流体室内同时产生多个空间化学梯度。化学梯度是通过扩散产生的，没有对流，并且可以在长时间段内保持恒定，或者动态地修改。描述了具有扩散发生的圆形室的代表性装置，具有用于输送和去除溶质的三个进入端口。梯度通常在几分钟内形成，并且可以无限期地保持恒定。示出了与不同空间位置重叠的梯度，以及由扩散形成的梯度的受控旋转。该装置还可用于评估在没有对流流动的情况下细菌或其他微生物的趋化反应。

4. 发明授权

US06703189B2 Chemical modification of substrates by photo-ablation under different local atmospheres and chemical environments for the fabrication of microstructures 有权
标题翻译：在不同的局部气氛和化学环境下通过光蚀刻对基底进行化学修饰以制备微结构
公开(公告)号：US06703189B2
公开(公告)日：2004-03-09
申请号：US09905567
申请日：2001-07-13
申请人： Emanuel A. Waddell, Jr. , Timothy J. Johnson , Gary W. Kramer , Laurie E. Locascio
发明人： Emanuel A. Waddell, Jr. , Timothy J. Johnson , Gary W. Kramer , Laurie E. Locascio
IPC分类号： G03C500
CPC分类号： B23K26/123 , B23K26/361 , B23K26/40 , B23K2103/52 , Y10S430/146
摘要： A method for simultaneously forming microstructures in substrates and altering their chemical character. The method involves exposing a surface portion of a substrate to light source, which is strong enough and of the appropriate wavelength to cause ablation of the substrate. The ablation of the substrate is controlled to form microstructures therein, such as channels. The ablation is conducted under a chemical atmosphere, which causes a change in the chemical functionality of the microstructures. The chemical atmosphere can be a gas, liquid or solid that is provided on the substrate surface. The method can be used to fabricate or modify microfluidic systems.
摘要翻译：同时在基材中形成微结构并改变其化学特性的方法。该方法包括将基底的表面部分暴露于足够强并且具有合适波长的光源以引起基底的烧蚀。控制衬底的烧蚀以在其中形成诸如通道的微结构。消融在化学气氛下进行，这导致微结构的化学官能度发生变化。化学气氛可以是设置在基板表面上的气体，液体或固体。该方法可用于制造或修饰微流体系统。

5. 发明授权

US09198645B2 Controlled vesicle self-assembly in continuous two phase flow microfluidic channels 有权
标题翻译：在连续两相流微流体通道中控制囊泡自组装
公开(公告)号：US09198645B2
公开(公告)日：2015-12-01
申请号：US10895366
申请日：2004-07-21
申请人： Andreas Jahn , Wyatt N. Vreeland , Laurie E. Locascio , Michael Gaitan
发明人： Andreas Jahn , Wyatt N. Vreeland , Laurie E. Locascio , Michael Gaitan
IPC分类号： A61K9/127 , A61B17/00
CPC分类号： A61B17/0057 , A61B2017/00654 , A61B2017/00659 , A61B2017/00898 , A61K9/1277
摘要： Methods for the formation of liposomes that encapsulate reagents in a continuous 2-phase flow microfluidic network with precision control of size, for example, from 100 nm to 300 nm, by manipulation of liquid flow rates are described. By creating a solvent-aqueous interfacial region in a microfluidic format that is homogenous and controllable on the length scale of a liposome, fine control of liposome size and polydispersity can be achieved.
摘要翻译：描述了通过操纵液体流速来形成将试剂封装在连续的2相流微流体网络中的脂质体的方法，其精确控制尺寸例如为100nm至300nm。通过在脂质体的长度尺度上产生均匀且可控的微流体形式的溶剂 - 水界面区域，可以实现脂质体大小和多分散性的精细控制。

6. 发明授权

US07658536B2 Microfluidic flow manipulation device 有权
标题翻译：微流控流量装置
公开(公告)号：US07658536B2
公开(公告)日：2010-02-09
申请号：US12106990
申请日：2008-04-21
申请人： Timothy J. Johnson , David J. Ross , Laurie E. Locascio
发明人： Timothy J. Johnson , David J. Ross , Laurie E. Locascio
IPC分类号： B01F5/00
CPC分类号： G05D7/0694 , Y10S366/03 , Y10T137/0318 , Y10T137/2224 , Y10T137/87652
摘要： Disclosed is an apparatus and method for the mixing of two microfluidic channels wherein several wells are oriented diagonally across the width of a mixing channel. The device effectively mixes the confluent streams with electrokinetic flow, and to a lesser degree, with pressure driven flow. The device and method may be further adapted to split a pair of confluent streams into two or more streams of equal or non-equal concentrations of reactants. Further, under electrokinetic flow, the surfaces of said wells may be specially coated so that the differing electroosmotic mobility between the surfaces of the wells and the surfaces of the channel may increase the mixing efficiency. The device and method are applicable to the steady state mixing as well as the dynamic application of mixing a plug of reagent with a confluent stream.
摘要翻译：公开了一种用于混合两个微流体通道的装置和方法，其中若干孔沿着混合通道的宽度倾斜地定向。该装置将汇合流与电动流有效地混合，并且在较小程度上与压力驱动流混合。装置和方法可以进一步适于将一对汇合流分成两个或更多个相等或不相等浓度的反应物流。此外，在电动流动下，可以特别地涂覆所述孔的表面，使得孔的表面和通道表面之间的不同的电渗流动性可以提高混合效率。该装置和方法适用于稳态混合以及将试剂塞与汇合流混合的动态应用。

7. 发明申请

US20090155728A1 Fabrication Method of Topographically Modulated Microstructures Using Pattern Homogenization with UV Light 有权
标题翻译：使用紫外光图案均匀化的地形调制微结构的制造方法
公开(公告)号：US20090155728A1
公开(公告)日：2009-06-18
申请号：US12127352
申请日：2008-05-27
申请人： Laurie E. Locascio , Francisco Javier Atencia-Fernandez , Susan Barnes , Jack F. Douglas
发明人： Laurie E. Locascio , Francisco Javier Atencia-Fernandez , Susan Barnes , Jack F. Douglas
IPC分类号： G03F7/20
CPC分类号： B01F5/0646 , B01F5/0647 , B01F13/0059 , B01L3/502707 , B01L2300/0874 , B81B2201/058 , B81C99/0085 , B81C99/009 , B81C2201/0157 , B81C2201/019 , G03F1/50
摘要： A method for microfabrication of a microfluidic device having sub-millimeter three dimensional relief structures is disclosed. In this method, homogeneous surfaces, which do not exhibit apparent pixel geometry, emerge from the interaction of the overlapping of diffracted light under opaque pixels and the nonlinear polymerization properties of the photoresist material. The method requires a single photolithographic step and allows for the fabrication of microstructures over large areas (centimeters) with topographic modulation of features smaller than 100 micrometers. The method generates topography that is useful in a broad range of microfluidic applications.
摘要翻译：公开了一种具有亚毫米三维浮雕结构的微流体装置的微细加工方法。在这种方法中，不表现出明显的像素几何形状的均匀表面从不透明像素处的衍射光的重叠与光致抗蚀剂材料的非线性聚合性质的相互作用中出现。该方法需要单个光刻步骤，并且允许在大面积（厘米）上制造具有小于100微米的特征的地形调制的微结构。该方法产生在广泛的微流体应用中有用的形貌。

8. 发明申请

US20080190773A1 MICROFLUIDIC FLOW MANIPULATION DEVICE 有权
标题翻译：微流控制装置
公开(公告)号：US20080190773A1
公开(公告)日：2008-08-14
申请号：US12106990
申请日：2008-04-21
申请人： Timothy J. Johnson , David J. Ross , Laurie E. Locascio
发明人： Timothy J. Johnson , David J. Ross , Laurie E. Locascio
IPC分类号： G01N27/447 , B01F13/00
CPC分类号： G05D7/0694 , Y10S366/03 , Y10T137/0318 , Y10T137/2224 , Y10T137/87652
摘要： Disclosed is an apparatus and method for the mixing of two microfluidic channels wherein several wells are oriented diagonally across the width of a mixing channel. The device effectively mixes the confluent streams with electrokinetic flow, and to a lesser degree, with pressure driven flow. The device and method may be further adapted to split a pair of confluent streams into two or more streams of equal or non-equal concentrations of reactants. Further, under electrokinetic flow, the surfaces of said wells may be specially coated so that the differing electroosmotic mobility between the surfaces of the wells and the surfaces of the channel may increase the mixing efficiency. The device and method are applicable to the steady state mixing as well as the dynamic application of mixing a plug of reagent with a confluent stream.
摘要翻译：公开了一种用于混合两个微流体通道的装置和方法，其中若干孔沿着混合通道的宽度倾斜地定向。该装置将汇合流与电动流有效地混合，并且在较小程度上与压力驱动流混合。装置和方法可以进一步适于将一对汇合流分成两个或更多个相等或不相等浓度的反应物流。此外，在电动流动下，可以特别地涂覆所述孔的表面，使得孔的表面和通道表面之间的不同的电渗流动性可以提高混合效率。该装置和方法适用于稳态混合以及将试剂塞与汇合流混合的动态应用。

9. 发明授权

US07029561B2 Fluidic temperature gradient focusing 有权
公开(公告)号：US07029561B2
公开(公告)日：2006-04-18
申请号：US10197331
申请日：2002-07-18
申请人： David Ross , Laurie E. Locascio
发明人： David Ross , Laurie E. Locascio
IPC分类号： G01N27/447 , G01N27/453
CPC分类号： G01N27/44791 , G01N27/44795
摘要： A method and device are provided for concentrating and separating ionic species in solution within a fluidic device having a fluid conduit such as a channel or capillary. The concentration is achieved by balancing the electrophoretic velocity of an analyte against the bulk flow of solution in the presence of a temperature gradient. Using an appropriate buffer, the temperature gradient can generate a corresponding gradient in the electrophoretic velocity so that the electrophoretic and bulk velocities sum to zero at a unique point and the analyte will be focused at that point. The method and device may be adapted for use with a variety of analytes including fluorescent dyes, amino acids, proteins, DNA and to concentrate a dilute analyte.

10. 发明授权

US06907895B2 Method for microfluidic flow manipulation 失效
标题翻译：微流体流动操作方法
公开(公告)号：US06907895B2
公开(公告)日：2005-06-21
申请号：US10188664
申请日：2002-07-01
申请人： Timothy J. Johnson , David J. Ross , Laurie E. Locascio
发明人： Timothy J. Johnson , David J. Ross , Laurie E. Locascio
IPC分类号： G05D7/06 , B01F13/02
CPC分类号： G05D7/0694 , Y10S366/03 , Y10T137/0318 , Y10T137/2224 , Y10T137/87652
摘要： Disclosed is an apparatus and method for the mixing of two microfluidic channels wherein several wells are oriented diagonally across the width of a mixing channel. The device effectively mixes the confluent streams with electrokinetic flow, and to a lesser degree, with pressure driven flow. The device and method may be further adapted to split a pair of confluent streams into two or more streams of equal or non-equal concentrations of reactants. Further, under electrokinetic flow, the surfaces of said wells may be specially coated so that the differing electroosmotic mobility between the surfaces of the wells and the surfaces of the channel may increase the mixing efficiency. The device and method are applicable to the steady state mixing as well as the dynamic application of mixing a plug of reagent with a confluent stream.
摘要翻译：公开了一种用于混合两个微流体通道的装置和方法，其中若干孔沿着混合通道的宽度倾斜地定向。该装置将汇合流与电动流有效地混合，并且在较小程度上与压力驱动流混合。装置和方法可以进一步适于将一对汇合流分成两个或更多个相等或不相等浓度的反应物流。此外，在电动流动下，可以特别地涂覆所述孔的表面，使得孔的表面和通道表面之间的不同的电渗流动性可以提高混合效率。该装置和方法适用于稳态混合以及将试剂塞与汇合流混合的动态应用。

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