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2. 发明公开

EP3344996A2 BIOMARKERS PREDICTIVE OF CYTOKINE RELEASE SYNDROME 审中-实审转让
公开(公告)号：EP3344996A2
公开(公告)日：2018-07-11
申请号：EP16775012.4
申请日：2016-09-02
申请人： The Trustees of The University of Pennsylvania , Garfall, Alfred , Ganetsky, Alex , Gill, Saar , Lacey, Simon , Melenhorst, Jan J. , Teachey, David
发明人： GARFALL, Alfred , GANETSKY, Alex , GILL, Saar , LACEY, Simon , MELENHORST, Jan, J. , TEACHEY, David
IPC分类号： G01N33/50 , G01N33/68
CPC分类号： G01N33/6863 , A61K31/675 , A61K35/17 , A61K39/3955 , A61K45/06 , A61P29/00 , A61P37/00 , C07K14/7051 , C07K14/70578 , C07K16/2803 , C07K2317/622 , C07K2317/76 , C07K2319/02 , C07K2319/03 , C12Q1/6876 , C12Q2600/106 , C12Q2600/158 , G01N33/5047 , G01N33/6866 , G01N33/6869 , G01N33/6893 , G01N2800/24 , G01N2800/50 , G01N2800/52 , G01N2800/7095
摘要： The present disclosure relates to the identification and use of biomarkers (e.g., analytes, analyte profiles, or markers (e.g., gene expression and/or protein expression profiles)) with clinical relevance to cytokine release syndrome (CRS).

3. 发明申请

WO2018023025A8 COMBINATION THERAPIES OF CHIMERIC ANTIGEN RECEPTORS AND PD-1 INHIBITORS 审中-公开
公开(公告)号：WO2018023025A8
公开(公告)日：2018-02-01
申请号：PCT/US2017/044425
申请日：2017-07-28
申请人： NOVARTIS AG , THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , ANAK, Oezlem , BILIC, Sanela , BROGDON, Jennifer , CAMERON, John, Scott , CHOU, William , HOWARD, Danny, Roland, Jr. , ISAACS, Randi , JUNE, Carl, H. , LACEY, Simon , MAUDE, Shannon , MELENHORST, Jan, J. , SHUSTER, Stephen , QUINTAS-CARDAMA, Alfonso
发明人： BROGDON, Jennifer , CAMERON, John, Scott , CHOU, William , HOWARD, Danny, Roland, Jr. , ISAACS, Randi , JUNE, Carl, H. , LACEY, Simon , MAUDE, Shannon , MELENHORST, Jan, J. , SHUSTER, Stephen , QUINTAS-CARDAMA, Alfonso , GRUPP, Stephan
IPC分类号： C07K14/725 , A61K39/00 , A61K39/395 , A61K35/17 , C12N5/0783
摘要： Provided are compositions and methods for treating diseases, e.g., cancers, e.g., diseases associated with expression of an antigen, e.g., CD 19, comprising administering a cell that expresses a chimeric antigen receptor (CAR) specific to the antigen, e.g., CD19, in combination with a PD-1 inhibitor.

4. 发明专利

CA3032054A1 COMBINATION THERAPIES OF CHIMERIC ANTIGEN RECEPTORS AND PD-1 INHIBITORS 未知
公开(公告)号：CA3032054A1
公开(公告)日：2018-02-01
申请号：CA3032054
申请日：2017-07-28
申请人： NOVARTIS AG , ANAK OEZLEM , BILIC SANELA , BROGDON JENNIFER , CAMERON JOHN SCOTT , CHOU WILLIAM , HOWARD DANNY ROLAND JR , ISAACS RANDI , JUNE CARL H , LACEY SIMON , MAUDE SHANNON , MELENHORST JAN J , SHUSTER STEPHEN , QUINTAS CARDAMA ALFONSO , UNIV PENNSYLVANIA
发明人： ANAK OEZLEM , BILIC SANELA , BROGDON JENNIFER , CAMERON JOHN SCOTT , CHOU WILLIAM , HOWARD DANNY ROLAND , ISAACS RANDI , JUNE CARL H , LACEY SIMON , MAUDE SHANNON , MELENHORST JAN J , SHUSTER STEPHEN , QUINTAS-CARDAMA ALFONSO , GRUPP STEPHAN
IPC分类号： C07K14/725 , A61K35/17 , A61K39/00 , A61K39/395 , C12N5/0783
摘要： Provided are compositions and methods for treating diseases, e.g., cancers, e.g., diseases associated with expression of an antigen, e.g., CD 19, comprising administering a cell that expresses a chimeric antigen receptor (CAR) specific to the antigen, e.g., CD19, in combination with a PD-1 inhibitor.

5. 发明申请

WO2017210617A2 THERAPEUTIC REGIMENS FOR CHIMERIC ANTIGEN RECEPTOR (CAR)- EXPRESSING CELLS 审中-公开
标题翻译：用于嵌合抗原受体（CAR）的治疗方案 - 表达细胞
公开(公告)号：WO2017210617A2
公开(公告)日：2017-12-07
申请号：PCT/US2017/035778
申请日：2017-06-02
申请人： PORTER, David, L. , FREY, Noelle , JUNE, Carl, H. , LACEY, Simon , CHEN, Fang , MELENHORST, Jan, J. , NOVARTIS AG , THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , MUELLER, Karen Thudium , WOOD, Patricia , ZHANG, Yiyun (Michael) , TARAN, Tetiana
发明人： MUELLER, Karen Thudium , WOOD, Patricia , ZHANG, Yiyun (Michael) , TARAN, Tetiana
IPC分类号： C07K16/28
CPC分类号： C07K16/2803 , A61K2039/545 , C07K2317/24 , C07K2317/53 , C07K2317/622 , C07K2319/03 , C07K2319/33 , C12N5/0636 , C12N2510/00
摘要： The invention provides a method of treating an adult subject having a hematological cancer, comprising administering to the subject selected dosage regimens comprising a plurality of immune effector cells expressing a CAR molecule.
摘要翻译：本发明提供了治疗患有血液癌症的成年受试者的方法，包括向受试者施用包含多种表达CAR分子的免疫效应细胞的选定给药方案。

6. 发明专利

SG11201900677SA COMBINATION THERAPIES OF CHIMERIC ANTIGEN RECEPTORS ADN PD-1 INHIBITORS 未知
公开(公告)号：SG11201900677SA
公开(公告)日：2019-02-27
申请号：SG11201900677S
申请日：2017-07-28
申请人： NOVARTIS AG , UNIV PENNSYLVANIA , ANAK OEZLEM , BILIC SANELA , BROGDON JENNIFER , CAMERON JOHN , CHOU WILLIAM , HOWARD DANNY , ISAACS RANDI , JUNE CARL , LACEY SIMON , MAUDE SHANNON , MELENHORST JAN , SHUSTER STEPHEN , QUINTAS CARDAMA ALFONSO
发明人： GRUPP STEPHAN , ANAK OEZLEM , BILIC SANELA , BROGDON JENNIFER , CAMERON JOHN , CHOU WILLIAM , HOWARD DANNY , ISAACS RANDI , JUNE CARL , LACEY SIMON , MAUDE SHANNON , MELENHORST JAN , SHUSTER STEPHEN , QUINTAS-CARDAMA ALFONSO
IPC分类号： C07K14/725 , A61K35/17 , A61K39/00 , A61K39/395 , C12N5/0783
摘要： Provided are compositions and methods for treating diseases, e.g., cancers, e.g., diseases associated with expression of an antigen, e.g., CD 19, comprising administering a cell that expresses a chimeric antigen receptor (CAR) specific to the antigen, e.g., CD19, in combination with a PD-1 inhibitor.

7. 发明申请

WO2018023025A1 COMBINATION THERAPIES OF CHIMERIC ANTIGEN RECEPTORS ADN PD-1 INHIBITORS 审中-公开
标题翻译：嵌合抗原受体ADN PD-1抑制剂联合治疗
公开(公告)号：WO2018023025A1
公开(公告)日：2018-02-01
申请号：PCT/US2017/044425
申请日：2017-07-28
申请人： NOVARTIS AG , THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , ANAK, Oezlem , BILIC, Sanela , BROGDON, Jennifer , CAMERON, John, Scott , CHOU, William , HOWARD, Danny, Roland, Jr. , ISAACS, Randi , JUNE, Carl, H. , LACEY, Simon , MAUDE, Shannon , MELENHORST, Jan, J. , SHUSTER, Stephen , QUINTAS-CARDAMA, Alfonso
发明人： ANAK, Oezlem , BILIC, Sanela , BROGDON, Jennifer , CAMERON, John, Scott , CHOU, William , HOWARD, Danny, Roland, Jr. , ISAACS, Randi , JUNE, Carl, H. , LACEY, Simon , MAUDE, Shannon , MELENHORST, Jan, J. , SHUSTER, Stephen , QUINTAS-CARDAMA, Alfonso
IPC分类号： C07K14/725 , A61K39/00 , A61K39/395 , A61K35/17 , C12N5/0783
摘要： Provided are compositions and methods for treating diseases, e.g., cancers, e.g., diseases associated with expression of an antigen, e.g., CD 19, comprising administering a cell that expresses a chimeric antigen receptor (CAR) specific to the antigen, e.g., CD19, in combination with a PD-1 inhibitor.
摘要翻译：提供用于治疗疾病例如癌症例如与抗原表达相关的疾病例如CD19的组合物和方法，其包括施用表达嵌合抗原受体（CAR）特异性的细胞到抗原，例如CD19，与PD-1抑制剂组合。

8. 发明申请

WO2017040930A3 BIOMARKERS PREDICTIVE OF CYTOKINE RELEASE SYNDROME 审中-公开
标题翻译：生物标志物预测细胞因子释放综合征
公开(公告)号：WO2017040930A3
公开(公告)日：2017-04-20
申请号：PCT/US2016050112
申请日：2016-09-02
申请人： UNIV PENNSYLVANIA , GARFALL ALFRED , GANETSKY ALEX , GILL SAAR , LACEY SIMON , MELENHORST JAN J , TEACHEY DAVID
发明人： GARFALL ALFRED , GANETSKY ALEX , GILL SAAR , LACEY SIMON , MELENHORST JAN J , TEACHEY DAVID
IPC分类号： G01N33/50 , G01N33/68
CPC分类号： G01N33/5047 , G01N33/6863 , G01N33/6893 , G01N2800/24
摘要： The present disclosure relates to the identification and use of biomarkers (e.g., analytes, analyte profiles, or markers (e.g., gene expression and/or protein expression profiles)) with clinical relevance to cytokine release syndrome (CRS).
摘要翻译：本公开涉及与细胞因子释放综合征（CRS）临床相关的生物标志物（例如，分析物，分析物概况或标志物（例如，基因表达和/或蛋白质表达谱））的鉴定和用途。

9. 发明申请

WO2017040930A2 BIOMARKERS PREDICTIVE OF CYTOKINE RELEASE SYNDROME 审中-公开
标题翻译：生物标志物预测细胞因子释放综合征
公开(公告)号：WO2017040930A2
公开(公告)日：2017-03-09
申请号：PCT/US2016/050112
申请日：2016-09-02
申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA , GARFALL, Alfred , GANETSKY, Alex , GILL, Saar , LACEY, Simon , MELENHORST, Jan, J. , TEACHEY, David
发明人： GARFALL, Alfred , GANETSKY, Alex , GILL, Saar , LACEY, Simon , MELENHORST, Jan, J. , TEACHEY, David
IPC分类号： G01N33/50 , G01N33/68
CPC分类号： G01N33/5047 , G01N33/6863 , G01N33/6893 , G01N2800/24
摘要： The present disclosure relates to the identification and use of biomarkers (e.g., analytes, analyte profiles, or markers (e.g., gene expression and/or protein expression profiles)) with clinical relevance to cytokine release syndrome (CRS).
摘要翻译：本公开涉及与细胞因子释放综合征（CRS）临床相关的生物标志物（例如，分析物，分析物谱或标记物（例如，基因表达和/或蛋白质表达谱））的鉴定和使用。

10. 发明申请

WO0117327A9 LOW COST CONFORMAL EMI/RFI SHIELD 审中-公开
标题翻译：低成本EMI / RFI屏蔽
公开(公告)号：WO0117327A9
公开(公告)日：2002-09-12
申请号：PCT/US0023764
申请日：2000-08-29
申请人： NOKIA MOBILE PHONES LTD , LACEY SIMON
发明人： LACEY SIMON
IPC分类号： H05K3/32 , H05K9/00
CPC分类号： H05K9/003 , H05K3/321 , H05K9/0022 , H05K9/0037
摘要： An EMI/RFI shield includes a shell made from a metalized polymeric material with a shape that is predetermined to form within at least one shielded cavity. The shell has sidewalls that terminate in a flange extending at an angle to the sidewalls. The flange has a lower surface for electrically coupling the shell to a predetermined electrical potential and an upper surface for engaging a structure, preferably a protruding rib from a cover, that exerts a compressive force on the top surface for urging the lower surface into an electrical coupling arrangement with an underlying planar conductor carrying the predetermined electrical potential (e.g., ground). The lower surface can include or be placed upon a layer of electrically conductive compliant material, such as a conductive adhesive. At least one of the sidewalls can include a projecting fluted structure having a size and location that is predetermined to engage a side of the structure that exerts the compressive force.
摘要翻译： EMI / RFI屏蔽包括由金属化的聚合物材料制成的壳体，其具有预定的形状以形成在至少一个屏蔽空腔内。壳体具有终止于与侧壁成一定角度延伸的凸缘的侧壁。凸缘具有用于将壳体电耦合到预定电位的下表面和用于接合结构的上表面，优选地，来自盖的突出肋，其在顶表面上施加压缩力，以将下表面推入电耦合布置与承载预定电位（例如，接地）的底层平面导体。下表面可以包括或放置在导电柔性材料层上，例如导电粘合剂。侧壁中的至少一个可以包括突出的凹槽结构，其具有预定的尺寸和位置，以接合施加压缩力的结构的一侧。

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