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1. 发明专利

SG11201900677SA COMBINATION THERAPIES OF CHIMERIC ANTIGEN RECEPTORS ADN PD-1 INHIBITORS 未知
公开(公告)号：SG11201900677SA
公开(公告)日：2019-02-27
申请号：SG11201900677S
申请日：2017-07-28
申请人： NOVARTIS AG , UNIV PENNSYLVANIA , ANAK OEZLEM , BILIC SANELA , BROGDON JENNIFER , CAMERON JOHN , CHOU WILLIAM , HOWARD DANNY , ISAACS RANDI , JUNE CARL , LACEY SIMON , MAUDE SHANNON , MELENHORST JAN , SHUSTER STEPHEN , QUINTAS CARDAMA ALFONSO
发明人： GRUPP STEPHAN , ANAK OEZLEM , BILIC SANELA , BROGDON JENNIFER , CAMERON JOHN , CHOU WILLIAM , HOWARD DANNY , ISAACS RANDI , JUNE CARL , LACEY SIMON , MAUDE SHANNON , MELENHORST JAN , SHUSTER STEPHEN , QUINTAS-CARDAMA ALFONSO
IPC分类号： C07K14/725 , A61K35/17 , A61K39/00 , A61K39/395 , C12N5/0783
摘要： Provided are compositions and methods for treating diseases, e.g., cancers, e.g., diseases associated with expression of an antigen, e.g., CD 19, comprising administering a cell that expresses a chimeric antigen receptor (CAR) specific to the antigen, e.g., CD19, in combination with a PD-1 inhibitor.

2. 发明专利

SG10201912978PA METHODS FOR IMPROVING THE EFFICACY AND EXPANSION OF IMMUNE CELLS 未知
公开(公告)号：SG10201912978PA
公开(公告)日：2020-02-27
申请号：SG10201912978P
申请日：2016-07-21
申请人： NOVARTIS AG , UNIV PENNSYLVANIA
发明人： BEDOYA FELIPE , GHASSEMI SABA , JUNE CARL , KAWALEKAR OMKAR , LEVINE BRUCE , MELENHORST JAN , MILONE MICHAEL , POWELL DANIEL , ZHENG ZOE
摘要： The invention provides methods of making immune effector cells (e.g., T cells, NK cells) that can be engineered to express a chimeric antigen receptor (CAR), compositions and reaction mixtures comprising the same, and methods of treatment using the same.

3. 发明专利

SG11201908719QA BIOMARKERS AND CAR T CELL THERAPIES WITH ENHANCED EFFICACY 未知
公开(公告)号：SG11201908719QA
公开(公告)日：2019-10-30
申请号：SG11201908719Q
申请日：2018-03-22
申请人： NOVARTIS AG , UNIV PENNSYLVANIA
发明人： FRAIETTA JOSEPH , MELENHORST JAN
IPC分类号： A61K39/00 , C07K16/28
摘要： INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 27 September 2018 (27.09.2018) WIPO I PCT onion °nolo oloinomll n ono oimIE (10) International Publication Number WO 2018/175733 Al (51) International Patent Classification: A61K 39/00 (2006.01) C07K 16/28 (2006.01) (21) International Application Number: PCT/US2018/023785 (22) International Filing Date: 22 March 2018 (22.03.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/474,991 22 March 2017 (22.03.2017) US 62/621,356 24 January 2018 (24.01.2018) US (71) Applicants: NOVARTIS AG [CH/CH]; Lichtstrasse 35, 4056 Basel (CH). THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA [US/US]; 3160 Chestnut Street, Suite 200, Philadelphia, PA 19104 (US). (72) Inventors: FRAIETTA, Joseph, A.; 18 Saddle Lane, Cherry Hill, NJ 08002 (US). MELENHORST, Jan, J.; 11 Exton Circle, Cherry Hill, NJ 08003 (US). (74) Agent: COLLAZO, Diana M. et al.; Lando & Anastasi, LLP, Riverfront Office Park, One Main Street, Suite 1100, Cambridge, MA 02142 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.17(ii)) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: with international search report (Art. 21(3)) before the expiration of the time limit for amending the claims and to be republished in the event of receipt of amendments (Rule 48.2(h)) with sequence listing part of description (Rule 5.2(a)) 1-1 (54) Title: BIOMARKERS AND CAR T CELL THERAPIES WITH ENHANCED EFFICACY (57) : The invention provides compositions and methods improved CART cell therapies. Specifically, the invention provides 0 cells with altered expression and/or function of one or more genes, e.g., associated with Tet2, and methods of use therefore. The \" invention further provides inhibitors of the one or more genes and methods of use therefore in connection with CART cells.

4. 发明专利

SG11202005005YA BCMA-TARGETING CHIMERIC ANTIGEN RECEPTOR, AND USES THEREOF 未知
公开(公告)号：SG11202005005YA
公开(公告)日：2020-06-29
申请号：SG11202005005Y
申请日：2018-11-30
申请人： NOVARTIS AG , UNIV PENNSYLVANIA
发明人： PRUTEANU-MALINICI IULIAN , MANSFIELD KEITH , ENGELS BORIS , MELENHORST JAN , COHEN ADAM , STADTMAUER EDWARD , GARFALL ALFRED , MILONE MICHAEL , FRAIETTA JOSEPH
IPC分类号： G01N33/574 , G01N33/50
摘要： The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to a method of administering a BCMA-targeting chimeric antigen receptor (CAR) therapy and an additional therapeutic agent.

5. 发明专利

AU2022203932A1 Biomarkers predictive of therapeutic responsiveness to chimeric antigen receptor therapy and uses thereof 未知
公开(公告)号：AU2022203932A1
公开(公告)日：2022-06-23
申请号：AU2022203932
申请日：2022-06-07
申请人： NOVARTIS AG , UNIV PENNSYLVANIA
发明人： BEDOYA FELIPE , BITTER HANS , BROGDON JENNIFER , DORFMEIER CORIN , GARG ABHISHEK , GLASS DAVID , MANNICK JOAN , MELENHORST JAN , MILONE MICHAEL , MURPHY LEON , ORLANDO ELENA , WILCOX NICHOLAS
IPC分类号： G01N33/574 , C12N5/0783
摘要： Cancer biomarkers and methods of using them are disclosed

6. 发明专利

SG10202110257UA CAR T CELL THERAPIES WITH ENHANCED EFFICACY 未知
公开(公告)号：SG10202110257UA
公开(公告)日：2021-10-28
申请号：SG10202110257U
申请日：2016-09-16
申请人： NOVARTIS AG , UNIV PENNSYLVANIA
发明人： MOTZ GREGORY , BUSHMAN FREDERIC , FRAIETTA JOSEPH , JUNE CARL , MELENHORST JAN , NOBLES CHRISTOPHER , YOUNG REGINA
摘要： The invention provides compositions and methods improved CAR T cell therapies. Specifically, the invention provides cells with reduced Tet, e.g., Tet2 function or expression, and methods of use therefore. The invention further provides Tet2 inhibitors and methods of use therefore in connection with CAR T cells.

7. 发明专利

SG11202003177RA METHODS OF MAKING CHIMERIC ANTIGEN RECEPTOR-EXPRESSING CELLS 未知
公开(公告)号：SG11202003177RA
公开(公告)日：2020-05-28
申请号：SG11202003177R
申请日：2018-10-25
申请人： NOVARTIS AG , UNIV PENNSYLVANIA
发明人： FRAIETTA JOSEPH , MELENHORST JAN , ORLANDO ELENA , O'CONNOR RODERICK , JUNE CARL
IPC分类号： C07K14/725 , C12N5/0783
摘要： The disclosure provides methods of making CAR-expressing immune effector cells (e.g., T cells, or NK cells), and compositions and reaction mixtures comprising the same. The disclosure further provides methods of using said CAR-expressing immune effector cells.

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