专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

WO2011006354A1 POLYMERIC BASED AND SURFACE TREATED METALLIC HYBRID MATERIALS AND FABRICATION METHODS THEREOF 审中-公开
标题翻译：聚合物和表面处理金属杂化材料及其制备方法
公开(公告)号：WO2011006354A1
公开(公告)日：2011-01-20
申请号：PCT/CN2010/001053
申请日：2010-07-14
申请人： VERSITECH LIMITED , THE CITY UNIVERSITY OF HONG KONG , WONG, Hoiman, Karen , YEUNG, Waikwok, Kelvin , CHEUNG, Manchee , LUK, Dipkei, Keith , LAM, Kimho, Paul
发明人： WONG, Hoiman, Karen , YEUNG, Waikwok, Kelvin , CHEUNG, Manchee , LUK, Dipkei, Keith , LAM, Kimho, Paul
IPC分类号： A61L27/36 , A61L27/24 , A61L27/20 , A61L27/18 , A61L27/34 , A61L27/60
CPC分类号： A61L27/58 , A61L27/446 , A61L2400/18 , C08L67/04
摘要： Novel hybrid materials and fabrication methods thereof are provided. The novel hybrid materials can include a biodegradable polymer and a biodegradable metallic material. The hybrid material can also include a coupling agent between the biodegradable metallic material and the biodegradable polymer. A method of fabricating a hybrid material can include performing a surface treatment process on the biodegradable metallic material, and then either performing a solvent formation method or a thermal formation method.
摘要翻译：提供了新颖的混合材料及其制造方法。新型混合材料可以包括可生物降解的聚合物和可生物降解的金属材料。混合材料还可以包括可生物降解的金属材料和可生物降解的聚合物之间的偶联剂。制造混合材料的方法可以包括对可生物降解的金属材料进行表面处理，然后进行溶剂形成法或热成形法。

2. 发明申请

WO2010094212A2 ANTIBACTERIAL SURFACE AND METHOD OF FABRICATION 审中-公开
标题翻译：抗菌表面和制造方法
公开(公告)号：WO2010094212A2
公开(公告)日：2010-08-26
申请号：PCT/CN2010000216
申请日：2010-02-18
申请人： VERSITECH LTD , UNIV CITY HONG KONG , YEUNG WAIKWOK KELVIN , CHEUNG MANCHEE , LUK DIPKEI KEITH , YEUNG CHEYAN , KAO YITSUN RICHARD , CHU KIMHO PAUL
发明人： YEUNG WAIKWOK KELVIN , CHEUNG MANCHEE , LUK DIPKEI KEITH , YEUNG CHEYAN , KAO YITSUN RICHARD , CHU KIMHO PAUL
IPC分类号： A61L27/34
CPC分类号： A61L27/06 , A61L27/34 , A61L27/54 , A61L2300/25 , A61L2300/404 , A61L2300/602 , A61L2300/606 , C08L89/00
摘要： This invention involves a plasma treated and controllable release antimicrobial peptide coated titanium alloy for surgical implantation, where the alloy with antimicrobial properties is fabricated using surface techniques without adversely compromising its biocompatibility and original mechanical properties. The surface techniques form antimicrobial layers on the alloy capable of resisting microbial adhesion and proliferation, while allowing mammalian cell adhesion and proliferation when the alloy is implanted to human body. In one embodiment, PIII&D is applied to incorporate ions, electrons, free radicals, atoms or molecules on a titanium alloy substrate. A pressurized hydrothermal treatment can be carried out to establish reactive functional groups for antimicrobial purpose or for connecting the substrate and external antimicrobial molecules. An outermost layer of the titanium alloy includes antibacterial peptides possessing a controllable release mechanism, and is fabricated alone or in an assembly of the aforementioned basal surface layers. The controllable release mechanism is able to withstand long-term deep tissue infection after surgery, and in an embodiment comprises APTES as a linker molecule.
摘要翻译：本发明涉及用于手术植入的等离子体处理和可控释放的抗微生物肽包被的钛合金，其中具有抗微生物性质的合金使用表面技术制造而不会不利地损害其生物相容性和原始机械性能。表面技术在能够抵抗微生物粘附和增殖的合金上形成抗微生物层，同时当将合金植入人体时允许哺乳动物细胞粘附和增殖。在一个实施方案中，应用PIII和D将离子，电子，自由基，原子或分子结合到钛合金基底上。可以进行加压水热处理以建立用于抗微生物目的的反应性官能团或用于连接底物和外部抗微生物分子。钛合金的最外层包括具有可控释放机构的抗菌肽，并且单独制造或在上述基础表面层的组装中制造。可释放机制能够经受手术后的长期深部组织感染，并且在一个实施方案中包含作为连接分子的APTES。

3. 发明申请

WO2009000158A1 STRONTIUM FORTIFIED CALCIUM NANO- AND MICROPARTICLE COMPOSITIONS AND METHODS OF MAKING AND USING THEREOF 审中-公开
标题翻译：高分子量的纳米和微晶组合物及其制备和使用方法
公开(公告)号：WO2009000158A1
公开(公告)日：2008-12-31
申请号：PCT/CN2008/001211
申请日：2008-06-23
申请人： THE UNIVERSITY OF HONG KONG , LU, Weijia, William , LI, Zhaoyang , LAM, Wingmoon, Raymond , LUK, Dipkei, Keith
发明人： LU, Weijia, William , LI, Zhaoyang , LAM, Wingmoon, Raymond , LUK, Dipkei, Keith
IPC分类号： A61L27/12 , A61L27/32 , A61L31/02 , A61K6/033 , C01B25/32 , C25D13/02
CPC分类号： A61K9/1611 , A61K9/141 , A61K9/143 , A61K33/24 , A61L24/0068 , A61L27/306 , A61L27/50 , A61L2400/12
摘要： Compositions containing strontium fortified calcium nanoparticles and/or microparticles, and methods of making and using thereof are described herein. The strontium fortified calcium compounds contain calcium ions, calcium atoms, strontium ions, strontium atoms, and combinations thereof and one or more anions. Exemplary anions include, but are not limited to, citrate, phosphate, carbonate, and combinations thereof. The particles can be formulated for enteral or parenteral administration by incorporating the particles into a pharmaceutically carrier. The compositions can further contain one or more active agents useful for bone diseases or disorders, such as vitamin D, growth factors, and combinations thereof. The compositions can be used to treat or prevent one or more bone diseases or disorders of the bone, such as osteoporosis. Alternatively, the particles can be coated onto a substrate, such as the surface of an implant. The coatings can be used to improved biocompatibility of the implant, prevent loosening of the implant, reducing leaching of metal ions from metallic implants, and reduce corrosion. The coatings can be applied to the substrate using a variety of techniques well known in the art. In one embodiment, the coating is applied using electrophoretic deposition. The use of nano- and/or microparticles that provide high surface area helps to improve interfacial strength between the coating and the implant, which allows for the use of lower sintering temperatures. Lowering sintering temperatures minimizes or prevents thermal decomposition of the coating material and/or degradation of the implant material.
摘要翻译：包含锶强化钙纳米颗粒和/或微粒的组合物及其制备和使用方法在本文中描述。锶强化钙化合物含有钙离子，钙原子，锶离子，锶原子及其组合以及一种或多种阴离子。示例性的阴离子包括但不限于柠檬酸盐，磷酸盐，碳酸盐及其组合。可以通过将颗粒并入药物载体中来将颗粒配制成肠或肠胃外给药。所述组合物还可含有一种或多种用于骨疾病或病症的活性剂，例如维生素D，生长因子及其组合。组合物可用于治疗或预防骨骼的一种或多种骨骼疾病或病症，例如骨质疏松症。或者，可以将颗粒涂覆到基底上，例如植入物的表面。涂层可用于改善植入物的生物相容性，防止植入物松动，减少金属离子从金属植入物中浸出，并减少腐蚀。可以使用本领域众所周知的各种技术将涂层施加到基底上。在一个实施方案中，使用电泳沉积施加涂层。提供高表面积的纳米和/或微粒的使用有助于提高涂层和植入物之间的界面强度，这允许使用较低的烧结温度。降低烧结温度可以最小化或防止涂层材料的热分解和/或植入材料的退化。

4. 发明申请

WO2008014665A1 INTERVERTEBRAL DISK TRANSPLANT AND IMPLANTATION METHOD 审中-公开
标题翻译：椎间盘移植和植入方法
公开(公告)号：WO2008014665A1
公开(公告)日：2008-02-07
申请号：PCT/CN2007/002024
申请日：2007-06-28
申请人： THE UNIVERSITY OF HONG KONG , LUK, Dipkei, Keith , RUAN, Dike
发明人： LUK, Dipkei, Keith , RUAN, Dike
IPC分类号： A61F2/44 , A61L27/54
CPC分类号： A61F2/442 , A61F2002/445 , A61L27/3612 , A61L27/3654 , A61L27/3658 , A61L27/3817 , A61L27/3834 , A61L27/3852 , A61L27/3856 , A61L2430/38
摘要： A natural spinal disk including adjacent vertebral structures is removed from a deceased donor, rinsed in normal saline, preserved in a cryopreservative solution, and then frozen by gradually decreasing the temperature using liquid nitrogen or similar method. The implant may be thawed in normal saline solution and then implanted in a patient in need of a vertebral disk replacement.
摘要翻译：包括相邻椎骨结构的天然脊椎盘从死亡供体中移除，用生理盐水冲洗，保存在冷冻保存溶液中，然后通过使用液氮或类似方法逐渐降低温度冷冻。植入物可以在生理盐水溶液中解冻，然后植入需要椎间盘置换的患者。

5. 发明申请

WO2011157057A1 METHODS FOR COMPLEX TISSUE ENGINEERING 审中-公开
标题翻译：复杂组织工程方法
公开(公告)号：WO2011157057A1
公开(公告)日：2011-12-22
申请号：PCT/CN2011/000988
申请日：2011-06-15
申请人： THE UNIVERSITY OF HONG KONG , CHAN, Pui, Barbara , CHENG, Hiuwa , CHIK, Tszkit, Daniel , CHEUNG, Manchee, Kenneth , LUK, Dipkei, Keith
发明人： CHAN, Pui, Barbara , CHENG, Hiuwa , CHIK, Tszkit, Daniel , CHEUNG, Manchee, Kenneth , LUK, Dipkei, Keith
IPC分类号： A61L27/40 , A61L27/38 , C12N5/07 , C12N5/0735 , C12N5/0775 , C12N5/0789
CPC分类号： A61L27/3891 , A61K35/28 , A61K35/51 , A61K35/545 , A61L27/3834 , C12N5/0012 , C12N5/0654 , C12N5/0655 , C12N5/0697 , C12N2502/1311 , C12N2502/1317 , C12N2502/1358 , C12N2527/00 , C12N2533/54
摘要： A simple, highly flexible and scalable platform for making functional complex tissue with heterogeneity and irregularity is provided. The method includes combining undifferentiated cells, such as pluripotent or multipotent stem cells, with a biomaterial to make multiple undifferentiated or naive subunits, exposing the undifferentiated or naive subunits to different cell culture environments for induction of differentiation towards different lineages as required by said complex tissue, and combining the then functional subunits solely or with the undifferentiated subunits. The differentiated subunits thus combined can be cultured under biological, chemical, and/or physical culture conditions suitable to fine-tune the structural and functional properties of the bioengineered complex tissue to form a bioengineered tissue graft that mimics the structural and functional characteristics of native complex tissue. Said bioengineered tissue graft can be used to replace dysfunctional tissue.
摘要翻译：提供了一个简单，高度灵活和可扩展的平台，用于制作具有异质性和不规则性的功能性复合组织。所述方法包括将未分化细胞（例如多能干细胞或多能干细胞）与生物材料组合以制备多个未分化或天真的亚单位，将未分化或幼稚亚基暴露于不同的细胞培养环境，以诱导针对所述复合组织所要求的不同谱系的分化，然后单独或与未分化亚基组合当时的功能亚单位。如此组合的分化亚基可以在适于微调生物工程化复合组织的结构和功能特性的生物，化学和/或物理培养条件下进行培养以形成模拟天然复合物的结构和功能特征的生物工程化组织移植物组织。所述生物工程组织移植物可用于替代功能障碍组织。

6. 发明申请

WO2010094212A3 ANTIBACTERIAL SURFACE AND METHOD OF FABRICATION 审中-公开
公开(公告)号：WO2010094212A3
公开(公告)日：2010-08-26
申请号：PCT/CN2010/000216
申请日：2010-02-18
申请人： VERSITECH LIMITED , THE CITY UNIVERSITY OF HONG KONG , YEUNG, Waikwok, Kelvin , CHEUNG, Manchee , LUK, Dipkei, Keith , YEUNG, Cheyan , KAO, Yitsun, Richard , CHU, Kimho, Paul
发明人： YEUNG, Waikwok, Kelvin , CHEUNG, Manchee , LUK, Dipkei, Keith , YEUNG, Cheyan , KAO, Yitsun, Richard , CHU, Kimho, Paul
IPC分类号： A61L27/22 , A61L27/06 , C23C14/48
摘要： This invention involves a plasma treated and controllable release antimicrobial peptide coated titanium alloy for surgical implantation, where the alloy with antimicrobial properties is fabricated using surface techniques without adversely compromising its biocompatibility and original mechanical properties. The surface techniques form antimicrobial layers on the alloy capable of resisting microbial adhesion and proliferation, while allowing mammalian cell adhesion and proliferation when the alloy is implanted to human body. In one embodiment, PIII&D is applied to incorporate ions, electrons, free radicals, atoms or molecules on a titanium alloy substrate. A pressurized hydrothermal treatment can be carried out to establish reactive functional groups for antimicrobial purpose or for connecting the substrate and external antimicrobial molecules. An outermost layer of the titanium alloy includes antibacterial peptides possessing a controllable release mechanism, and is fabricated alone or in an assembly of the aforementioned basal surface layers. The controllable release mechanism is able to withstand long-term deep tissue infection after surgery, and in an embodiment comprises APTES as a linker molecule.

7. 发明申请

WO2008043254A1 SHAPE MEMORY LOCKING DEVICE FOR ORTHOPEDIC IMPLANTS 审中-公开
标题翻译：用于正交植入物的形状记忆锁定装置
公开(公告)号：WO2008043254A1
公开(公告)日：2008-04-17
申请号：PCT/CN2007/002710
申请日：2007-09-13
申请人： THE UNIVERSITY OF HONG KONG , YEUNG WAIKWOK, Kelvin , LU, Weijia, William , LUK, Dipkei, Keith , CHEUNG, Manchee
发明人： YEUNG WAIKWOK, Kelvin , LU, Weijia, William , LUK, Dipkei, Keith , CHEUNG, Manchee
IPC分类号： A61B17/70 , A61B17/78 , C22C19/03 , C22F1/10
CPC分类号： A61B17/7032 , A61B17/7034 , A61B2017/00867
摘要： A locking mechanism to connect the supporting portions of orthopaedic implants such as in the head, spine, upper limb and lower limb and thereby prevent loosening and fretting at the implant interface of an orthopaedic implant construct has been developed based on shape memory effect and super-elasticity of shape memory materials having at least two shapes in memory selected from the group consisting of metal alloys and polymers.
摘要翻译：已经基于形状记忆效应和超声波处理，开发了用于连接诸如头部，脊柱，上肢和下肢之类的矫形植入物的支撑部分的锁定机构，从而防止在矫形植入物构造的植入物界面处的松动和微动，存储器中具有至少两种形状的形状记忆材料的弹性，其选自金属合金和聚合物。

8. 发明申请

WO2011050582A8 CLASSIFICATION OF SEMATOSENSORY EVOKED POTENTIAL WAVEFORMS 审中-公开
标题翻译：扫描电镜可视波形分类
公开(公告)号：WO2011050582A8
公开(公告)日：2012-03-15
申请号：PCT/CN2010001719
申请日：2010-10-29
申请人： UNIV HONG KONG , HU YONG , LUK DIPKEI KEITH
发明人： HU YONG , LUK DIPKEI KEITH
IPC分类号： A61B5/04
CPC分类号： A61B5/0484 , A61B5/04001 , A61B5/4041 , A61B5/7264
摘要： Embodiments are disclosed relating to classification of sematosensory evoked potential waveforms.
摘要翻译：公开了关于感觉诱发电位波形分类的实施例。

9. 发明申请

WO2011006354A8 POLYMERIC BASED AND SURFACE TREATED METALLIC HYBRID MATERIALS AND FABRICATION METHODS THEREOF 审中-公开
标题翻译：聚合物和表面处理金属杂化材料及其制备方法
公开(公告)号：WO2011006354A8
公开(公告)日：2012-02-02
申请号：PCT/CN2010001053
申请日：2010-07-14
申请人： VERSITECH LTD , UNIV CITY HONG KONG , WONG HOIMAN KAREN , YEUNG WAIKWOK KELVIN , CHEUNG MANCHEE , LUK DIPKEI KEITH , LAM KINON JOHN , CHU KIMHO PAUL
发明人： WONG HOIMAN KAREN , YEUNG WAIKWOK KELVIN , CHEUNG MANCHEE , LUK DIPKEI KEITH , LAM KINON JOHN , CHU KIMHO PAUL
IPC分类号： A61L27/36 , A61L27/18 , A61L27/20 , A61L27/24 , A61L27/34 , A61L27/60
CPC分类号： A61L27/58 , A61L27/446 , A61L2400/18 , C08L67/04
摘要： Novel hybrid materials and fabrication methods thereof are provided. The novel hybrid materials can include a biodegradable polymer and a biodegradable metallic material. The hybrid material can also include a coupling agent between the biodegradable metallic material and the biodegradable polymer. A method of fabricating a hybrid material can include performing a surface treatment process on the biodegradable metallic material, and then either performing a solvent formation method or a thermal formation method.
摘要翻译：提供了新颖的混合材料及其制造方法。新型混合材料可以包括可生物降解的聚合物和可生物降解的金属材料。混合材料还可以包括可生物降解的金属材料和可生物降解的聚合物之间的偶联剂。制造混合材料的方法可以包括对可生物降解的金属材料进行表面处理，然后进行溶剂形成法或热成形法。

10. 发明申请

WO2011050582A1 CLASSIFICATION OF SEMATOSENSORY EVOKED POTENTIAL WAVEFORMS 审中-公开
标题翻译：扫描电镜可视波形分类
公开(公告)号：WO2011050582A1
公开(公告)日：2011-05-05
申请号：PCT/CN2010/001719
申请日：2010-10-29
申请人： THE UNIVERSITY OF HONG KONG , HU, Yong , LUK, Dipkei, Keith
发明人： HU, Yong , LUK, Dipkei, Keith
IPC分类号： A61B5/04
CPC分类号： A61B5/0484 , A61B5/04001 , A61B5/4041 , A61B5/7264
摘要： Embodiments are disclosed relating to classification of sematosensory evoked potential waveforms.
摘要翻译：公开了关于感觉诱发电位波形分类的实施例。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式