专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

3. 发明申请

WO2009000158A1 STRONTIUM FORTIFIED CALCIUM NANO- AND MICROPARTICLE COMPOSITIONS AND METHODS OF MAKING AND USING THEREOF 审中-公开
标题翻译：高分子量的纳米和微晶组合物及其制备和使用方法
公开(公告)号：WO2009000158A1
公开(公告)日：2008-12-31
申请号：PCT/CN2008/001211
申请日：2008-06-23
申请人： THE UNIVERSITY OF HONG KONG , LU, Weijia, William , LI, Zhaoyang , LAM, Wingmoon, Raymond , LUK, Dipkei, Keith
发明人： LU, Weijia, William , LI, Zhaoyang , LAM, Wingmoon, Raymond , LUK, Dipkei, Keith
IPC分类号： A61L27/12 , A61L27/32 , A61L31/02 , A61K6/033 , C01B25/32 , C25D13/02
CPC分类号： A61K9/1611 , A61K9/141 , A61K9/143 , A61K33/24 , A61L24/0068 , A61L27/306 , A61L27/50 , A61L2400/12
摘要： Compositions containing strontium fortified calcium nanoparticles and/or microparticles, and methods of making and using thereof are described herein. The strontium fortified calcium compounds contain calcium ions, calcium atoms, strontium ions, strontium atoms, and combinations thereof and one or more anions. Exemplary anions include, but are not limited to, citrate, phosphate, carbonate, and combinations thereof. The particles can be formulated for enteral or parenteral administration by incorporating the particles into a pharmaceutically carrier. The compositions can further contain one or more active agents useful for bone diseases or disorders, such as vitamin D, growth factors, and combinations thereof. The compositions can be used to treat or prevent one or more bone diseases or disorders of the bone, such as osteoporosis. Alternatively, the particles can be coated onto a substrate, such as the surface of an implant. The coatings can be used to improved biocompatibility of the implant, prevent loosening of the implant, reducing leaching of metal ions from metallic implants, and reduce corrosion. The coatings can be applied to the substrate using a variety of techniques well known in the art. In one embodiment, the coating is applied using electrophoretic deposition. The use of nano- and/or microparticles that provide high surface area helps to improve interfacial strength between the coating and the implant, which allows for the use of lower sintering temperatures. Lowering sintering temperatures minimizes or prevents thermal decomposition of the coating material and/or degradation of the implant material.
摘要翻译：包含锶强化钙纳米颗粒和/或微粒的组合物及其制备和使用方法在本文中描述。锶强化钙化合物含有钙离子，钙原子，锶离子，锶原子及其组合以及一种或多种阴离子。示例性的阴离子包括但不限于柠檬酸盐，磷酸盐，碳酸盐及其组合。可以通过将颗粒并入药物载体中来将颗粒配制成肠或肠胃外给药。所述组合物还可含有一种或多种用于骨疾病或病症的活性剂，例如维生素D，生长因子及其组合。组合物可用于治疗或预防骨骼的一种或多种骨骼疾病或病症，例如骨质疏松症。或者，可以将颗粒涂覆到基底上，例如植入物的表面。涂层可用于改善植入物的生物相容性，防止植入物松动，减少金属离子从金属植入物中浸出，并减少腐蚀。可以使用本领域众所周知的各种技术将涂层施加到基底上。在一个实施方案中，使用电泳沉积施加涂层。提供高表面积的纳米和/或微粒的使用有助于提高涂层和植入物之间的界面强度，这允许使用较低的烧结温度。降低烧结温度可以最小化或防止涂层材料的热分解和/或植入材料的退化。

IPRDB

热门服务

关于我们

友情链接

联系方式