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1. 发明申请

WO2004074506A3 POLYNUCLEOTIDE SEQUENCES AND CORRESPONDING ENCODED POLYPEPTIDES OF PARTICULAR SECRETED AND MEMBRANE-BOUND PROTEINS OVEREXPRESSED IN CERTAIN CANCERS 审中-公开
标题翻译：特异性分泌和膜结合蛋白的多核苷酸序列和相关编码多肽在某些癌症中的表达
公开(公告)号：WO2004074506A3
公开(公告)日：2005-04-14
申请号：PCT/US2004003030
申请日：2004-01-30
申请人： MERGEN LTD , HU QIANJIN , PENG ALLAN , LIU BIN , LOVE JAMES ROBERT , HAO XIAOFENG , REN MIN , SHENG ZHUMEI
发明人： HU QIANJIN , PENG ALLAN , LIU BIN , LOVE JAMES ROBERT , HAO XIAOFENG , REN MIN , SHENG ZHUMEI
IPC分类号： C12Q20060101 , C12Q1/68 , G01N33/53 , G01N33/574
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/57415
摘要： The present invention relates to the identification of the over expression of certain genes encoding certain secreted and membrane-bound proteins in breast, lung, colon and kidney cancers. Knowledge that these genes are over expressed in the cancers is useful for the detection, diagnosis, prevention and treatment of the specific cancers.
摘要翻译：本发明涉及鉴定乳腺癌，肺癌，结肠癌和肾癌中某些分泌和膜结合蛋白的某些基因的过度表达。这些基因在癌症中过表达的知识对于特异性癌症的检测，诊断，预防和治疗是有用的。

2. 发明申请

WO2004087323A1 MULTI-ARRAY SYSTEMS AND METHODS OF USE THEREOF 审中-公开
标题翻译：多阵列系统及其使用方法
公开(公告)号：WO2004087323A1
公开(公告)日：2004-10-14
申请号：PCT/US2004/009304
申请日：2004-03-26
申请人： MERGEN LTD. , HU, Qianjin , PENG, Allan , LOVE, James, Robert, Jr.
发明人： HU, Qianjin , PENG, Allan , LOVE, James, Robert, Jr.
IPC分类号： B01L3/00
CPC分类号： B01L3/508 , B01L3/502 , B01L7/02 , B01L7/52 , B01L7/525 , B01L9/52 , B01L9/54 , B01L2200/027 , B01L2300/0636 , B01L2300/0822 , B01L2300/0877 , B01L2300/1838 , G01N33/54366
摘要： Multi-array systems useful for performing assays on multiple biomolecule arrays simultaneously while minimizing sample volume are provided. Apparatuses and kits comprising the multi-array systems also provided. Methods of using the multi-array systems in assays such as hybridization arrays are also provided, as well as methods of producing the multi-array systems. In one aspect, the invention provides a multi-array system comprising the following: (a) a first solid substrate having a first surface; (b) a second solid substrate having a second surface, wherein the first and second solid substrates are positioned so that the first surface faces the second surface; (c) a spacer contacting and separating the first and second solid substrates, so as to form at least one reaction chamber comprising a fluid-receiving space between the first and second surfaces; (d) a first biomolecule array immobilized on the first surface; and (e) a second biomolecule array immobilized on the second surface, wherein the first and second biomolecule arrays are exposed to the fluid-receiving space.
摘要翻译：提供了可用于在多个生物分子阵列上同时进行测定同时最小化样品体积的多阵列系统。还提供了包括多阵列系统的装置和套件。还提供了在诸如杂交阵列的测定中使用多阵列系统的方法，以及生产多阵列系统的方法。一方面，本发明提供一种多阵列系统，其包括以下步骤：（a）具有第一表面的第一固体基底; （b）具有第二表面的第二固体基底，其中所述第一和第二固体基底被定位成使得所述第一表面面向所述第二表面; （c）接触和分离第一和第二固体基底的间隔件，以便形成至少一个反应室，该反应室包括第一和第二表面之间的流体接收空间; （d）固定在第一表面上的第一生物分子阵列; 和（e）固定在第二表面上的第二生物分子阵列，其中第一和第二生物分子阵列暴露于流体接收空间。

3. 发明申请

WO2004074506A2 POLYNUCLEOTIDE SEQUENCES AND CORRESPONDING ENCODED POLYPEPTIDES OF PARTICULAR SECRETED AND MEMBRANE-BOUND PROTEINS OVEREXPRESSED IN CERTAIN CANCERS 审中-公开
标题翻译：特异性分泌和膜结合蛋白的多核苷酸序列和相关编码多肽在某些癌症中的表达
公开(公告)号：WO2004074506A2
公开(公告)日：2004-09-02
申请号：PCT/US2004/003030
申请日：2004-01-30
申请人： MERGEN LTD , HU, Qianjin , PENG, Allan , LIU, Bin , LOVE, James, Robert , HAO, Xiaofeng , REN, Min , SHENG, Zhumei
发明人： HU, Qianjin , PENG, Allan , LIU, Bin , LOVE, James, Robert , HAO, Xiaofeng , REN, Min , SHENG, Zhumei
IPC分类号： C12Q
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N33/57415
摘要： The present invention relates to the identification of the over expression of certain genes encoding certain secreted and membrane-bound proteins in breast, lung, colon and kidney cancers. Knowledge that these genes are over expressed in the cancers is useful for the detection, diagnosis, prevention and treatment of the specific cancers.
摘要翻译：本发明涉及鉴定乳腺癌，肺癌，结肠癌和肾癌中某些分泌和膜结合蛋白的某些基因的过度表达。这些基因在癌症中过表达的知识对于特异性癌症的检测，诊断，预防和治疗是有用的。

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