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1. 发明申请

WO2004104586A1 ALLERGEN TEST DEVICES AND METHODS FOR THEIR USE 审中-公开
标题翻译：过敏试验装置及其使用方法
公开(公告)号：WO2004104586A1
公开(公告)日：2004-12-02
申请号：PCT/US2004/015097
申请日：2004-05-14
申请人： CIPHERGEN BIOSYSTEMS, INC. , BOSCHETTI, Egisto , LOMAS, Lee, O.
发明人： BOSCHETTI, Egisto , LOMAS, Lee, O.
IPC分类号： G01N33/53
CPC分类号： G01N33/6854
摘要： The present invention provides apparatus and methods for detecting the presence of antibodies associated with allergic reactions in a subject sample. By providing a one step analysis for determining potential subject hypersensitivity to a number of allergens, the present invention minimizes both the labor required to determine a subject's hypersensitivity profile and the discomfort that has routinely been suffered by the subject.
摘要翻译：本发明提供用于检测与受试样品中的过敏反应相关的抗体的存在的装置和方法。通过提供用于确定对许多过敏原的潜在受试者超敏反应的一步分析，本发明使确定受试者的超敏反应特征所需的劳动和受试者常规遭受的不适最小化。

2. 发明申请

WO2004031724A2 APPARATUS AND METHOD FOR EXPRESSION AND CAPTURE OF BIOMOLECULES AND COMPLEXES ON ADSORBENT SURFACES 审中-公开
标题翻译：生物分子和复合物在吸附表面上的表达和捕获的装置和方法
公开(公告)号：WO2004031724A2
公开(公告)日：2004-04-15
申请号：PCT/US2003/030760
申请日：2003-09-29
申请人： CIPHERGEN BIOSYSTEMS, INC. , LOMAS, Lee, O. , BOSCHETTI, Egisto , YIP, Tai-Tung
发明人： LOMAS, Lee, O. , BOSCHETTI, Egisto , YIP, Tai-Tung
IPC分类号： G01N
CPC分类号： G01N33/54366 , B01J2219/00283 , B01J2219/00317 , B01J2219/00423 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00637 , B01J2219/00639 , B01J2219/00641 , B01J2219/00659 , B01J2219/00695 , B01J2219/007 , B01J2219/00725 , G01N33/54353
摘要： The present invention relates to the fields of molecular biology, combinatorial chemistry and biochemistry. Particularly, the present invention describes apparatus and methods for the detection and isolation of binding partners and activity modulators for biomolecules. The apparatus described allows for expression, capture and analysis of one or more biomolecules in a single step.
摘要翻译：本发明涉及分子生物学，组合化学和生物化学领域。特别地，本发明描述了用于检测和分离用于生物分子的结合配偶体和活性调节剂的装置和方法。所描述的装置允许在单个步骤中表达，捕获和分析一种或多种生物分子。

3. 发明申请

WO2004009798A2 PROTEIN INTERACTION DIFFERENCE MAPPING 审中-公开
标题翻译：蛋白质相互作用差异图
公开(公告)号：WO2004009798A2
公开(公告)日：2004-01-29
申请号：PCT/US0323320
申请日：2003-07-23
申请人： CIPHERGEN BIOSYSTEMS INC , RICH WILLIAM , BOSCHETTI EGISTO , LOMAS LEE O , YIP TAI-TUNG
发明人： RICH WILLIAM , BOSCHETTI EGISTO , LOMAS LEE O , YIP TAI-TUNG
IPC分类号： G01N27/62 , B01J20/281 , B01J20/285 , C40B30/04 , G01N30/02 , G01N30/08 , G01N30/34 , G01N30/72 , G01N30/88 , G01N33/53 , G01N33/543 , G01N33/68 , C12N
CPC分类号： C40B30/04 , G01N33/54306 , G01N33/6803
摘要： This invention provides methods and materials for mapping interaction characteristics between components of a multicomponent biological complex. The methods involve capturing a multicomponent complex on a solid support and washing the support with a series of elution washes forming a gradient of solute concentrations, and determining whether a particular elution wash eluted a particular component.
摘要翻译：本发明提供了用于映射多组分生物复合物组分之间相互作用特征的方法和材料。该方法涉及在固体支持物上捕获多组分复合物，并用一系列洗脱洗液洗涤载体，形成溶质浓度梯度，并确定特定洗脱洗液是否洗脱了特定组分。

4. 发明申请

WO2007120999A2 CHELATING MONOMERS AND POLYMERS 审中-公开
标题翻译：吸引单体和聚合物
公开(公告)号：WO2007120999A2
公开(公告)日：2007-10-25
申请号：PCT/US2007/063388
申请日：2007-03-06
申请人： BIO-RAD LABORATORIES, INC. , ZHANG, Hongmin , BOSCHETTI, Egisto , LOMAS, Lee, O. , UM, Pil-je
发明人： ZHANG, Hongmin , BOSCHETTI, Egisto , LOMAS, Lee, O. , UM, Pil-je
IPC分类号： B01D3/00 , B01D59/44 , C08F30/04 , G01N24/00
CPC分类号： C08F220/36 , B01D71/28 , C02F1/683 , C02F2101/20 , C08F220/30 , C08F222/1006 , Y10T436/24
摘要： This invention provides chelating moieties that comprise an aryl group. Monomers that include the chelating moieties can be polymerized into chelating polymers. Chelating polymers are useful to chelate metals. Chelating polymers in the form of metal chelates are useful for binding analytes, such as polypeptides that comprise histidine residues. Chelating polymers can be includes in articles such as chips and chromatographic materials.
摘要翻译：本发明提供了包含芳基的螯合部分。包含螯合部分的单体可以聚合成螯合聚合物。螯合聚合物可用于螯合金属。金属螯合物形式的螯合聚合物可用于结合分析物，例如包含组氨酸残基的多肽。螯合聚合物可以包括在诸如芯片和色谱材料的制品中。

5. 发明申请

WO2007061643A3 POLYMER PROBE DOPED WITH CONDUCTIVE MATERIAL FOR MASS SPECTROMETRY 审中-公开
公开(公告)号：WO2007061643A3
公开(公告)日：2007-05-31
申请号：PCT/US2006/043695
申请日：2006-11-09
申请人： BIO-RAD LABORATORIES, INC. , BOSCHETTI, Egisto , LOMAS, Lee, O.
发明人： BOSCHETTI, Egisto , LOMAS, Lee, O.
IPC分类号： H01J49/40
摘要： A mass spectrometer probe is formed of a nonconductive polymer that is doped with conductive material. The probe may be used as, or as part of, a repeller plate in a parallel laser ion desorption/ionization time-of-flight mass spectrometer. Transparent locations on the probe enable a sample placed thereon to be visualized before or during mass spectrometry. The conductive nature of the probe maintains the consistency of the electromagnetic field applied to the sample. The probe also displays low outgassing and high mechanical and chemical stability, thereby enabling it to be used repetitively.

6. 发明申请

WO2007061643A2 POLYMER PROBE DOPED WITH CONDUCTIVE MATERIAL FOR MASS SPECTROMETRY 审中-公开
标题翻译：聚合物探针与导电材料进行质谱分析
公开(公告)号：WO2007061643A2
公开(公告)日：2007-05-31
申请号：PCT/US2006043695
申请日：2006-11-09
申请人： BIO RAD LABORATORIES , BOSCHETTI EGISTO , LOMAS LEE O
发明人： BOSCHETTI EGISTO , LOMAS LEE O
IPC分类号： B01D59/44
CPC分类号： H01J49/0418
摘要： A mass spectrometer probe is formed of a nonconductive polymer that is doped with conductive material. The probe may be used as, or as part of, a repeller plate in a parallel laser ion desorption/ionization time-of-flight mass spectrometer. Transparent locations on the probe enable a sample placed thereon to be visualized before or during mass spectrometry. The conductive nature of the probe maintains the consistency of the electromagnetic field applied to the sample. The probe also displays low outgassing and high mechanical and chemical stability, thereby enabling it to be used repetitively.
摘要翻译：质谱仪探针由掺杂有导电材料的非导电聚合物形成。探针可以用作平行激光离子解吸/电离飞行时间质谱仪中的或作为排斥板的一部分。在探针之前或期间，探针上的透明位置使其上放置的样品可视化。探头的导电性质保持了施加到样品的电磁场的一致性。该探头还显示出低的除气和高的机械和化学稳定性，从而使其能够重复使用。

7. 发明申请

WO2007120999A3 CHELATING MONOMERS AND POLYMERS 审中-公开
标题翻译：吸引单体和聚合物
公开(公告)号：WO2007120999A3
公开(公告)日：2008-02-21
申请号：PCT/US2007063388
申请日：2007-03-06
申请人： BIO RAD LABORATORIES , ZHANG HONGMIN , BOSCHETTI EGISTO , LOMAS LEE O , UM PIL-JE
发明人： ZHANG HONGMIN , BOSCHETTI EGISTO , LOMAS LEE O , UM PIL-JE
IPC分类号： A61K39/00
CPC分类号： C08F220/36 , B01D71/28 , C02F1/683 , C02F2101/20 , C08F220/30 , C08F222/1006 , Y10T436/24
摘要： This invention provides chelating moieties that comprise an aryl group. Monomers that include the chelating moieties can be polymerized into chelating polymers. Chelating polymers are useful to chelate metals. Chelating polymers in the form of metal chelates are useful for binding analytes, such as polypeptides that comprise histidine residues. Chelating polymers can be includes in articles such as chips and chromatographic materials.
摘要翻译：本发明提供了包含芳基的螯合部分。包含螯合部分的单体可以聚合成螯合聚合物。螯合聚合物可用于螯合金属。金属螯合物形式的螯合聚合物可用于结合分析物，例如包含组氨酸残基的多肽。螯合聚合物可以包括在诸如芯片和色谱材料的制品中。

8. 发明申请

WO2005089910A1 MULTI-COMPARTMENT FILTER AND METHOD OF FILTERING USING SAME 审中-公开
标题翻译：多层过滤器和使用该过滤器的过滤方法
公开(公告)号：WO2005089910A1
公开(公告)日：2005-09-29
申请号：PCT/US2005/007054
申请日：2005-03-08
申请人： CIPHERGEN BIOSYSTEMS, INC. , BOSCHETTI, Egisto , LOMAS, Lee, O. , GIROT, Pierre
发明人： BOSCHETTI, Egisto , LOMAS, Lee, O. , GIROT, Pierre
IPC分类号： B01D57/02
CPC分类号： G01N27/44704 , B01D57/02 , B01J20/3204 , B01J20/327 , B01J20/3272 , B01J20/3274 , B01J2220/54 , C07K1/24 , C07K1/34 , G01N27/44795
摘要： Each embodiment includes a central sample reservoir (110) and a plurality of satellite reservoirs (120 A-H). In a first embodiment, a first electrode (140) in electrical contact with the central reservoir is charged and second electrodes (150 A-H) in electrical contact with the satellite reservoirs are sequentially charged, thereby pI filtering molecules in the central reservoir into the satellite reservoirs. In a second embodiment, the central reservoir is configured to rotate so that molecules in a sample in the central reservoir are centrifugally pI-filtered into the satellite reservoirs. In a third embodiment, first and second electrodes proximate opposite first and second satellite reservoirs, respectively, are charged. Some molecules in a sample are pI filtered into the first and second satellite reservoirs. Third and fourth electrodes proximate opposite third and fourth satellite reservoirs, respectively, are then charged. Some molecules in a sample are pI filtered into the third and fourth satellite reservoirs.
摘要翻译：每个实施例包括中央样品储存器（110）和多个卫星储存器（120A-H）。在第一实施例中，与中央储存器电接触的第一电极（140）被充电，并且与卫星储存器电接触的第二电极（150AH）被顺序地充电，从而将中央储存器中的分子过滤到卫星储存器。在第二实施例中，中央储存器被配置为旋转，使得中央储存器中的样品中的分子被离心地pI过滤到卫星储存器中。在第三实施例中，分别与第一和第二卫星储存器相邻的第一和第二电极被充电。样品中的一些分子被pI过滤到第一和第二卫星储层中。然后分别靠近相对的第三和第四卫星储存器的第三和第四电极被充电。样品中的一些分子被pI过滤到第三和第四卫星储层中。

9. 发明申请

WO2004031724A3 APPARATUS AND METHOD FOR EXPRESSION AND CAPTURE OF BIOMOLECULES AND COMPLEXES ON ADSORBENT SURFACES 审中-公开
标题翻译：生物分子和复合物在吸附表面上的表达和捕获的装置和方法
公开(公告)号：WO2004031724A3
公开(公告)日：2005-04-14
申请号：PCT/US0330760
申请日：2003-09-29
申请人： CIPHERGEN BIOSYSTEMS INC , LOMAS LEE O , BOSCHETTI EGISTO , YIP TAI-TUNG
发明人： LOMAS LEE O , BOSCHETTI EGISTO , YIP TAI-TUNG
IPC分类号： C12M1/34 , G01N20060101 , G01N33/543
CPC分类号： G01N33/54366 , B01J2219/00283 , B01J2219/00317 , B01J2219/00423 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00637 , B01J2219/00639 , B01J2219/00641 , B01J2219/00659 , B01J2219/00695 , B01J2219/007 , B01J2219/00725 , G01N33/54353
摘要： The present invention relates to the fields of molecular biology, combinatorial chemistry and biochemistry. Particularly, the present invention describes apparatus and methods for the detection and isolation of binding partners and activity modulators for biomolecules. The apparatus described allows for expression, capture and analysis of one or more biomolecules in a single step.
摘要翻译：本发明涉及分子生物学，组合化学和生物化学领域。特别地，本发明描述了用于检测和分离用于生物分子的结合配偶体和活性调节剂的装置和方法。所描述的装置允许在单个步骤中表达，捕获和分析一种或多种生物分子。

10. 发明申请

WO2004009798A3 PROTEIN INTERACTION DIFFERENCE MAPPING 审中-公开
公开(公告)号：WO2004009798A3
公开(公告)日：2004-01-29
申请号：PCT/US2003/023320
申请日：2003-07-23
申请人： CIPHERGEN BIOSYSTEMS, INC. , RICH, William , BOSCHETTI, Egisto , LOMAS, Lee, O. , YIP, Tai-Tung
发明人： RICH, William , BOSCHETTI, Egisto , LOMAS, Lee, O. , YIP, Tai-Tung
IPC分类号： G01N33/543
摘要： This invention provides methods and materials for mapping interaction characteristics between components of a multicomponent biological complex. The methods involve capturing a multicomponent complex on a solid support and washing the support with a series of elution washes forming a gradient of solute concentrations, and determining whether a particular elution wash eluted a particular component.

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