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1. 发明专利

JP2019533635A 新規なジヒドロポルフィンe6誘導体及びその薬学的に許容される塩、その調製方法並びに使用审中-公开
公开(公告)号：JP2019533635A
公开(公告)日：2019-11-21
申请号：JP2017563115
申请日：2016-12-28
申请人：リウ,フゥイ , LIU,Hui
发明人：シャン,フア
IPC分类号： A61P35/00 , A61P9/00 , A61P31/20 , A61K31/409 , C07D487/22
摘要：本発明は、医薬技術分野に属し、新規なジヒドロポルフィンe6誘導体及びその薬学的に許容される塩、その調製方法並び使用に関する。ジヒドロポルフィンe6エーテル系アミノ酸誘導体は、構成一般式I及びこの構成一般式Iの光学異性体を含み、その調製方法は、ジヒドロポルフィンe6における3−ビニル基をエーテル化させ、15−エチルカルボキシル基とアミノ酸とを反応させてペプチドを形成する。当該ジヒドロポルフィンe6エーテル系アミノ酸誘導体及びその薬学的に許容される塩は、光線力学抗腫瘍薬として適用できる。本発明のジヒドロポルフィンe6エーテル系アミノ酸誘導体は、従来から臨床に使用されてきた同種の感光剤であるタラポルフィンに比べると、光線力学抗腫瘍活性が強くて潜在毒性/光毒性比が高いなどのメリットを有し、光線力学がん治療薬、光線力学によって加齢黄斑変性及び火焔状母斑のような良性血管疾患を治療する薬、及び光線力学によって尖圭コンジロームを治療する薬を含む光線力学抗腫瘍薬の調製に適用できる。【化1】

2. 发明专利

JP2011256642A Water shielding device for building 有权
标题翻译：防水屏蔽装置
公开(公告)号：JP2011256642A
公开(公告)日：2011-12-22
申请号：JP2010133195
申请日：2010-06-10
申请人： Liu hui hong , 劉揮▲ホン▼
发明人： RYU HWI-HON
IPC分类号： E04H9/14
摘要： PROBLEM TO BE SOLVED: To provide a water shielding device for building, which can be easily assembled and is capable of effectively preventing intrusion of water.SOLUTION: A water shielding device is composed of two lateral columns and a plurality of impervious plates. A coupling groove is provided on one side of the lateral column, a waterproof rod member and a pressing member are provided in the coupling groove, a plurality of screw holes extending up to the coupling groove are provided on the inside end surface of the lateral column, and bolts shanks are screwed into the screw holes. The impervious plate is fitted into the coupling groove of the lateral column and arranged between the waterproof rod member and the pressing member, a protruding fitting part is provided above the impervious plate, and a recessed groove is provided in the lower bottom part of the impervious plate. Thus, the plurality of impervious plates form an impervious wall of a predetermined height by fitting the fitting parts and the recessed grooves with each other respectively, and the pressing member and the waterproof rod member are brought into close contact with the impervious plates by turning each of the bolt shanks.
摘要翻译：要解决的问题：提供一种易于组装并能够有效防止水侵入的建筑用防水装置。解决方案：水屏蔽装置由两个侧柱和多个不透水板组成。在侧柱的一侧设置有联接槽，在联接槽中设置有防水杆构件和按压构件，在侧柱的内侧端面上设置有多个螺纹孔，螺栓杆被拧入螺丝孔中。不透水板安装在侧柱的联接槽中，布置在防水杆构件和按压构件之间，在不透水板的上方设置有突出的配合部分，在不透水板的下底部设有凹槽盘子。因此，通过将配合部和凹槽分别配合，使多个不透水板形成规定高度的不透水壁，通过将各个不透水板与防渗板紧密接触，的螺栓柄。版权所有（C）2012，JPO＆INPIT

3. 发明公开

EP3526827A1 BATTERY PACK 有权转让
公开(公告)号：EP3526827A1
公开(公告)日：2019-08-21
申请号：EP16918594.9
申请日：2016-10-14
申请人： Milwaukee Electric Tool Corporation , Sommerfeld, Steven T. , Gall, Benjamin D. , Liu, Hui Shu Beldon
发明人： SOMMERFELD, Steven T. , GALL, Benjamin D. , SHU, Beldon Liu Hui
IPC分类号： H01M2/02

4. 发明授权

EP3269881B1 GATE BOARD TIGHTENING DEVICE 有权
公开(公告)号：EP3269881B1
公开(公告)日：2019-03-13
申请号：EP17167480.7
申请日：2017-04-21
申请人： Liu, Hui-Hung
发明人： Liu, Hui-Hung
IPC分类号： E02B7/22 , E02B7/54

5. 发明公开

EP3683221A1 NOVEL CHLORIN E6 DERIVATIVE AND PHARMACEUTICALLY-ACCEPTABLE SALTS THEREOF, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF 有权转让
公开(公告)号：EP3683221A1
公开(公告)日：2020-07-22
申请号：EP16904241.3
申请日：2016-12-28
申请人： Liu, Hui
发明人： SHANG, Hua
IPC分类号： C07D487/04 , A61K31/409 , A61P35/00 , A61P17/00 , A61P27/02 , A61P31/20 , A61K41/00
摘要： The present application relates to a new chlorin e6 derivatives and pharmaceutically acceptable salt thereof, as well as preparation and use thereof, which belongs to the medicine field. The chlorin e6 ether amino acid derivative comprises general structural formula I and optical isomers thereof. The preparation process comprises etherification of 3-vinyl in chlorin e6, A peptide is produced from 15-carboxylethyl and amino acid. The chlorin e6 ether amino acid derivative and pharmaceutically acceptable salt thereof can be used as a photodynamic anti-tumor drug. Compared with the prior similar photosensitizer Talaporfin used in clinic, the chlorin e6 ether amino acid derivative of the present application possess improved photodynamic anti-tumor activities and a high ratio of darktoxicity-phototoxicity. The prepared new photodynamic anti-tumor drugs comprises photodynamic anti-cancer drugs, drugs for photodynamic treatment of benign vascular diseases, such as age-related macular degeneration and naevus flammeus, and drugs for photodynamic treatment of condyloma acuminata.

6. 发明公开

EP3630294A1 COMPOSITION FOR CONDITIONING HAIR 有权转让
公开(公告)号：EP3630294A1
公开(公告)日：2020-04-08
申请号：EP17911526.6
申请日：2017-05-31
申请人： L'OREAL , Liu, Hui , Chia, Wi-Soon , De Boni, Maxime
发明人： LIU, Hui , CHIA, Wi-Soon , DE BONI, Maxime
IPC分类号： A61Q5/00 , A61K8/891 , A61K8/898 , A61K8/06

7. 发明公开

EP3269881A1 GATE BOARD TIGHTENING DEVICE 有权
标题翻译：闸板紧固装置
公开(公告)号：EP3269881A1
公开(公告)日：2018-01-17
申请号：EP17167480.7
申请日：2017-04-21
申请人： Liu, Hui-Hung
发明人： Liu, Hui-Hung
IPC分类号： E02B7/22 , E02B7/54
CPC分类号： E02B7/22 , E02B7/54
摘要： A gate board tightening device (2) is mountable in a main rail (81) of floodgate device (8) and includes a drive bar (3), a retention plate (4), and a first coupling seat (5) and a second coupling seat (6). The drive bar (3) has two ends respectively provided with a first connection terminal (31) and a second connection terminal (32). The first connection terminal (31) is coupled with the first coupling seat (5) and the second connection terminal (32) is coupled with the second coupling seat (6). The retention plate (4) is inserted into a tubular member (814) formed in the main rail (81) of the floodgate device (8) with the first coupling seat (5) mounted at one end of the main rail (81) of the floodgate device (8) and the second coupling seat (6) mounted at an opposite end of the main rail (81) of the floodgate device (8). When gate boards (82) of the floodgate device (8) are sequentially disposed in the coupling channel (811) of the main rail (81), an operation member (A) is inserted into a hole (312) formed in the first connection terminal (31) of the drive bar (3) and the operation member (A) is wrenched to cause the drive bar (3) to rotate in site for driving the retention plate (4) to horizontally push the gate boards (82) so that a powerful tight engagement is established between the gate boards (82) and a water-resistant strip (817) arranged in the main rail (81) of the floodgate device (8).
摘要翻译：一种门板紧固装置（2）可安装在闸门装置（8）的主轨道（81）中并包括驱动杆（3），保持板（4）和第一联接座（5）以及第二联接座联接座（6）。驱动杆（3）的两端分别设置有第一连接端子（31）和第二连接端子（32）。第一连接端子（31）与第一连接座（5）连接，第二连接端子（32）与第二连接座（6）连接。在第一连接座（5）安装在主轨道（81）的一端处时，保持板（4）插入形成在水闸装置（8）的主轨道（81）中的管状构件（814）所述闸门装置（8）和所述第二联接座（6）安装在所述闸门装置（8）的主轨道（81）的相对端处。当闸门装置（8）的闸板（82）依次设置在主轨道（81）的联接通道（811）中时，操作构件（A）插入形成于第一连接部（3）的端子（31）和操作构件（A）被扳动以使驱动杆（3）在现场旋转以驱动保持板（4）以水平地推动门板（82）在门板（82）和布置在水闸装置（8）的主轨道（81）中的防水条（817）之间建立强有力的紧密接合。

8. 发明专利

CA3041382A1 NEW CHLORIN E6 DERIVATIVE AND PHARMACEUTICALLY ACCEPTABLE SALT THEREOF AND PROCESS FOR PREPARING AND USE OF THE SAME 未知
公开(公告)号：CA3041382A1
公开(公告)日：2018-05-03
申请号：CA3041382
申请日：2016-12-28
申请人： LIU HUI
发明人： SHANG HUA
IPC分类号： C07D487/04 , A61K31/409 , A61K41/00 , A61P17/00 , A61P27/02 , A61P31/20 , A61P35/00
摘要： Provided are a novel chlorin e6 derivative and pharmaceutically-acceptable salts thereof, a preparation method therefor, and an application thereof, relating to the technical field of pharmacy. The chlorin e6 derivative ether-based amino acid derivative comprises structural general formula I and an optical isomer of the structural general formula I. The preparation method is: etherifying 3-vinyl in chlorin e6, and producing peptide from 15-acetate carboxyl and amino acid. The chlorin e6 derivative ether-based amino acid derivative and pharmaceutically-acceptable salts thereof can be used as anti-tumor drugs of photodynamic therapy. As compared with Talaporfin which is the existing clinically-used photosensitizer, the novel chlorin e6 derivative has advantages of stronger anti-tumor activity and higher dark toxicity-phototoxicity ratio, and can be used for preparing novel anti-tumor drugs of the photodynamic therapy, including caner-treating drugs of photodynamic therapy, drugs for treating benign vascular diseases by the photodynamic therapy such as macular degeneration and nevus flammeus, as well as drugs for treating condyloma acuminate by the photodynamic therapy.

9. 发明专利

GB202104257D0 Flood-protective ventilation louver 未知
公开(公告)号：GB202104257D0
公开(公告)日：2021-05-12
申请号：GB202104257
申请日：2021-03-26
申请人： LIU HUI HUNG

10. 发明专利

CA2127596C MULTICOLOUR VOLTAGE TUNABLE QUANTUM WELL INTERSUBBAND INFRARED PHOTODETECTOR AND ASSOCIATED METHOD 未知
公开(公告)号：CA2127596C
公开(公告)日：2003-12-02
申请号：CA2127596
申请日：1994-07-07
申请人： LIU HUI CHUN
发明人： LIU HUI CHUN
IPC分类号： G01J1/16 , H01L31/0304 , H01L31/0352 , H01L31/101 , H01L31/108
摘要： A quantum well intersubband infrared (IR) photodetector has a spectral response tunable by an external voltage. The photodetector consists of multiple doped quantum wells with different well widths and barrier heights. The preferred embodiment is made by repeating the whole structure of the active region of a multiple quantum well intersubband IR photodetector. Differences between repeats or groups of well widths and barrier heights result in differences in the spectral IR response of the different repeats. The device resistance of a given group is designed to be very different from those for all the other groups. As a function of an applied voltage, the repeat with the highest resistance will be turned on to detect IR with the response peak at a wavelength .lambda.1. Subsequently, the next highest resistance repeat will turn on when increasing voltage with its response peaked at .lambda.2, and so on. Since .lambda.1, .lambda.2 are different from each other, a voltage tunable multicolour photodetector is realized.

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