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1. 发明专利

CA2031714A1 R-ENANTIOMERS OF N-PROPARGYL-1-AMINOINDAN COMPOUNDS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 未知
公开(公告)号：CA2031714A1
公开(公告)日：1991-07-04
申请号：CA2031714
申请日：1990-12-06
申请人： YOUDIM MOUSSA B H , FINBERG JOHN P M , LEVY RUTH , STERLING JEFFREY , LERNER DAVID , BERGER PASKIN TIRTSAH , YELLIN HAIM
发明人： YOUDIM MOUSSA B H , FINBERG JOHN P M , LEVY RUTH , STERLING JEFFREY , LERNER DAVID , BERGER-PASKIN TIRTSAH , YELLIN HAIM
IPC分类号： C07C211/38 , A61K31/00 , A61K31/13 , A61K31/135 , A61K31/195 , A61K31/215 , A61K45/06 , A61P25/00 , A61P25/16 , A61P25/24 , A61P25/28 , C07C209/88 , C07C211/30 , C07C211/42 , C12N9/99
摘要： R-(+)-N-propargyl-1-aminoindane of formula (I) and its pharmaceutically acceptable acid addn. salts are new. (I) is prepd. by reacting R(-)-1-aminoindane with propargyl bromide or chloride in the presence of base (and opt. of solvent), then (I) is isolated by e.g. chromatography, distn. or selective extraction. The racemic starting material can be used instead and (I) then recovered by fractional crystallisation of salts formed with an optically active acid.

2. 发明专利

SU880820A1 APPARATUS FOR SECURING PIECE CARGOES ON VEHICLE 未知
公开(公告)号：SU880820A1
公开(公告)日：1981-11-15
申请号：SU2835046
申请日：1979-09-20
申请人： KAZANTSEV ARKADIJ , BALEZIN MIKHAIL , LERNER DAVID A , STRUIN LEV N
发明人： KAZANTSEV ARKADIJ I , BALEZIN MIKHAIL I , LERNER DAVID A , STRUIN LEV N
IPC分类号： B60P7/08

3. 发明专利

SU725085A1 DEVICE FOR MEASURING TAPE-DRIVING MECHANISM STARTING TIME 未知
公开(公告)号：SU725085A1
公开(公告)日：1980-03-30
申请号：SU2660477
申请日：1978-08-31
申请人： EFIMOV YURIJ T , LERNER DAVID M , FEDULOV SERGEJ P
发明人： EFIMOV YURIJ T , LERNER DAVID M , FEDULOV SERGEJ P
IPC分类号： G11B27/10

4. 发明申请

WO2023023583A1 BLOOD FILTRATION SYSTEM WITH INFUSION PUMP STATE DETECTOR 审中-公开
公开(公告)号：WO2023023583A1
公开(公告)日：2023-02-23
申请号：PCT/US2022/075121
申请日：2022-08-18
申请人： NUWELLIS, INC. , LERNER, David , HASKVITZ, David, J. , BERG, Kalley, Francis , SANDOVAL, Steven, Daniel
发明人： LERNER, David , HASKVITZ, David, J. , BERG, Kalley, Francis , SANDOVAL, Steven, Daniel
IPC分类号： A61M1/34 , A61M1/36
摘要： A blood filtration system can be used with an external infusion pump and can include, among other things, a withdrawal line, an infusion (return) line, a filter coupled between the withdrawal line and the infusion line, a controller, and a withdrawal pressure sensor and/or an infusion pressure sensor. The withdrawal pressure sensor can sense a withdrawal pressure signal indicative of a pressure in the withdrawal line. The infusion pressure sensor can be coupled to the infusion line to sense an infusion pressure signal indicative of a pressure in the infusion line. In various embodiments, the controller can detect an operational state of the external infusion pump by analyzing at least the withdrawal pressure signal and/or the infusion pressure signal.

5. 发明申请

WO2022147476A1 DUAL LUMEN CATHETER 审中-公开
公开(公告)号：WO2022147476A1
公开(公告)日：2022-07-07
申请号：PCT/US2021/073199
申请日：2021-12-30
申请人： NUWELLIS, INC. , LERNER, David
发明人： LERNER, David
IPC分类号： A61M1/14 , A61M1/16 , A61M1/34 , A61M5/165
摘要： A catheter may include a withdrawal lumen wall extending around a withdrawal lumen. The withdrawal lumen may have a withdrawal lumen profile. The catheter may include an infusion lumen wall coupled with the withdrawal lumen wall. The infusion lumen wall may extend around an infusion lumen. The infusion lumen may have an infusion lumen profile smaller than the withdrawal lumen profile. A flexible septum may extend between the withdrawal lumen and the infusion lumen. The flexible septum may isolate the withdrawal lumen from the infusion lumen. In another example, a blood filtration system may monitor blood flow velocity within vasculature. The blood filtration system may guide operation of a blood pump or a filtrate bump based on the blood flow velocity within the vasculature.

6. 发明申请

WO2017040218A1 RESTORING AUTONOMIC BALANCE 审中-公开
标题翻译：恢复自动平衡
公开(公告)号：WO2017040218A1
公开(公告)日：2017-03-09
申请号：PCT/US2016/048766
申请日：2016-08-25
申请人： SUNSHINE HEART COMPANY PTY LTD. , OLSON, David , KNUTTILA, Aaron , TAS, Tolga , LERNER, David
发明人： OLSON, David , KNUTTILA, Aaron , TAS, Tolga , LERNER, David
IPC分类号： A61N1/36 , A61B5/0205 , A61N1/05 , A61N1/362 , A61N1/372 , A61M1/10 , A61M1/12
CPC分类号： A61N1/36114 , A61B5/0205 , A61M1/1055 , A61M1/1067 , A61M1/122 , A61N1/0556 , A61N1/36117 , A61N1/36139 , A61N1/3627 , A61N1/37288
摘要： An example electrical stimulation system for use in combination with a non-pulsatile or low-pulsatile ventricular assist device and for restoration of autonomic balance by stimulating at least one nerve. The system includes a stimulation source including a controller configured to control delivery of electrical stimulation at a stimulation rate modeled to simulate a baroreceptor discharge related to an intrinsic heart rate, a lead operably coupled to the stimulation source, and at least one electrode operably coupled to the lead, wherein the at least one electrode is positionable in contact with or adjacent to the at least one nerve.
摘要翻译：用于与非脉动或低搏动心室辅助装置组合使用的示例性电刺激系统，以及通过刺激至少一个神经来恢复自主平衡。所述系统包括刺激源，所述刺激源包括控制器，所述控制器被配置成以刺激速率控制电刺激的传递，所述刺激速率被建模为模拟与内在心率相关的压力感受器放电，可操作地耦合到所述刺激源的引线，以及至少一个电极，所述引线，其中所述至少一个电极可定位成与所述至少一个神经接触或相邻。

7. 发明申请

WO2003039602A3 ABSORBENT MATERIALS WITH COVALENTLY-BONDED, NONLEACHABLE, POLYMERIC ANTIMICROBIAL SURFACES, AND METHODS FOR PREPARATION 审中-公开
公开(公告)号：WO2003039602A3
公开(公告)日：2003-05-15
申请号：PCT/US2002/030998
申请日：2002-09-30
申请人： QUICK MED TECHNOLOGIES, INC. , UNIVERSITY OF FLORIDA , BATICH, Christopher, D. , SCHULTZ, Gregory , MAST, Bruce, A. , OLDERMAN, Gerald, M. , LERNER, David, S. , TOREKI, William , GRANITO, Michael, R.
发明人： BATICH, Christopher, D. , SCHULTZ, Gregory , MAST, Bruce, A. , OLDERMAN, Gerald, M. , LERNER, David, S. , TOREKI, William , GRANITO, Michael, R.
IPC分类号： B05D3/00
摘要： This invention relates to methods and compositions for materials having a non-leaching coating that has antimicrobial properties. The coating is applied to substrates such as gauze-type wound dressings, powders and other substrates. Covalent, non-leaching, non-hydrolyzable bonds are formed between the substrate and the polymer molecules that form the coating. A high concentration of anti-microbial groups on multi-length polymer chains and relatively long average chain lengths, contribute to an absorbent or superabsorbent surface with a high level antimicrobial efficacy.

8. 发明申请

WO0033778A9 INTRINSICALLY BACTERICIDAL ABSORBENT DRESSING AND METHOD OF FABRICATION 审中-公开
标题翻译：特异性杀菌剂吸收剂和制造方法
公开(公告)号：WO0033778A9
公开(公告)日：2001-11-15
申请号：PCT/US9929091
申请日：1999-12-08
申请人： QUICK MED TECHNOLOGIES INC , UNIV FLORIDA , BATICH CHRISTOPHER D , SCHULTZ GREGORY S , MAST BRUCE A , OLDERMAN GERALD M , LERNER DAVID
发明人： BATICH CHRISTOPHER D , SCHULTZ GREGORY S , MAST BRUCE A , OLDERMAN GERALD M , LERNER DAVID
IPC分类号： A61F13/49 , A61F5/441 , A61F13/00 , A61F13/15 , A61F13/20 , A61F13/472 , A61F13/53 , A61L2/16
CPC分类号： A61F13/8405
摘要： A superabsorbent polymer dressing having antimicrobial properties for use in fabricating wound dressings, sanitary napkins, tampons and the like, includes a synthetic polymer matrix fabricated to have an enhanced surface area. Antimicrobial compounds are coupled to the surface of the polymer matrix by non-siloxane bonds.
摘要翻译：具有用于制造伤口敷料，卫生巾，卫生棉条等的抗微生物性能的超吸收性聚合物敷料包括制造成具有增强的表面积的合成聚合物基质。抗微生物化合物通过非硅氧烷键与聚合物基质的表面偶联。

9. 发明申请

WO0222773A3 BIOREACTOR 审中-公开
标题翻译：生物反应器
公开(公告)号：WO0222773A3
公开(公告)日：2003-10-09
申请号：PCT/EP0110668
申请日：2001-09-14
申请人： SHELL INT RESEARCH , CORCHO-SANCHEZ DIEGO , LERNER DAVID NICHOLAS , STEPHENSON RICHARD JOHN , WATKINSON ROBERT JAMES
发明人： CORCHO-SANCHEZ DIEGO , LERNER DAVID NICHOLAS , STEPHENSON RICHARD JOHN , WATKINSON ROBERT JAMES
IPC分类号： C02F3/10 , C12M1/12
CPC分类号： C12M29/04
摘要： A bioreactor for microbial conversion of at least one conversion substrate, which comprises a treatment zone to accommodate when in use a solution of said at least one conversion substrate, a culture holding zone to accommodate when in use a microbial culture capable of metabolising said at least one conversion substrate, a source of primary growth substrate for the microbial culture, a first permeable membrane forming an interface between the treatment zone and the culture holding zone, and a second permeable membrane forming an interface between the source of primary growth substrate and the culture holding zone, the first permeable membrane being of a material which will allow passage of the at least one conversion substrate from the treatment zone to the culture holding zone whilst being impermeable to the microbial culture, the second permeable membrane being of a material permeable to the primary growth substrate but substantially impermeable to water; and a process of operating said bioreactor.
摘要翻译：一种用于至少一种转化底物的微生物转化的生物反应器，其包含处理区，以在使用时适应所述至少一种转化底物的溶液，培养保持区，以在使用时适应能够代谢至少所述至少一种转化底物的微生物培养物一个转化底物，用于微生物培养的一次生长底物源，形成处理区和培养保持区之间的界面的第一渗透膜，以及形成初级生长底物源和培养物之间的界面的第二渗透膜所述第一渗透膜是允许所述至少一个转化基质从所述处理区通过所述培养保持区同时对所述微生物培养物不可渗透的材料，所述第二渗透膜是可透过的初级生长基质，但基本上不透水; 以及操作所述生物反应器的过程。

10. 发明申请

WO1997002027A1 POLYAMINE DERIVATIVES OF 1-AMINOINDAN 审中-公开
标题翻译： 1-氨基茚的聚胺衍生物
公开(公告)号：WO1997002027A1
公开(公告)日：1997-01-23
申请号：PCT/US1996011318
申请日：1996-07-05
申请人： TEVA PHARMACEUTICAL INDUSTRIES, LTD. , GILAD, Gad , GILAD, Varda , STERLING, Jeffrey , HERZIG, Yaacov , LERNER, David , VEINBERG, Alex , MILMAN, Isaac , FINKELSTEIN, Nina
发明人： TEVA PHARMACEUTICAL INDUSTRIES, LTD.
IPC分类号： A61K31/15
CPC分类号： C07C279/12 , A61K31/135 , A61K31/155 , C07C211/42 , C07C233/41 , C07C2602/24
摘要： A compound of general formula (I), wherein n is 1 or 2; R1 and R2 are each independently hydrogen, hydroxy, substituted or unsubstituted C1-4 alkyl, substituted or unsubstituted C1-4 alkoxy or halogeno; R5 is hydrogen, substituted or unsubstituted C1-4 alkyl, amino or NR6R7; R3, R4, R6 and R7 are each independently hydrogen or (CH2)m-[NH(CH2)x]y-NHR11 wherein m is from 0-5, y is from 0-5 and each x is independently from 1-5 and R11 is hydrogen or C(NH)NH2; provided that when R3 and R4 are both hydrogen, R5 is amino or NR6R7; pharmaceutically acceptable salts and optically active isomers thereof.
摘要翻译：通式（I）的化合物，其中n为1或2; R 1和R 2各自独立地为氢，羟基，取代或未取代的C 1-4烷基，取代或未取代的C 1-4烷氧基或卤素; R5是氢，取代或未取代的C1-4烷基，氨基或NR6R7; R3，R4，R6和R7各自独立地为氢或（CH2）m- [NH（CH2）x] y-NHR11，其中m为0-5，y为0-5，并且各x独立地为1-5 和R 11是氢或C（NH）NH 2; 条件是当R3和R4都是氢时，R5是氨基或NR6R7; 其药学上可接受的盐和旋光异构体。

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