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1. 发明申请

WO2007054208A1 EDIBLE PRODUCT CONTAINING GINSENG POLYSACCHARIDES AND BENEFICIAL BACTERIA 审中-公开
标题翻译：含有金属多糖和有益细菌的食用产品
公开(公告)号：WO2007054208A1
公开(公告)日：2007-05-18
申请号：PCT/EP2006/010324
申请日：2006-10-26
申请人： UNILEVER N.V. , UNILEVER PLC , HINDUSTAN LEVER LIMITED , ALBERS, Ruud , BLOM, Wilhelmina, Martina , LEDEBOER, Adrianus, Marinus , MOHEDE, Ingrid, Celestina, Maria , SANDERS, Jan, Willem
发明人： ALBERS, Ruud , BLOM, Wilhelmina, Martina , LEDEBOER, Adrianus, Marinus , MOHEDE, Ingrid, Celestina, Maria , SANDERS, Jan, Willem
IPC分类号： A23L1/30
CPC分类号： A23L33/135 , A23L33/105 , A23Y2220/73
摘要： One aspect of the present invention relates to an edible product containing: • probiotic bacteria in an amount of at least 10 3 bacteria per gram; and • at least 0.5 mg/g of ginseng polysaccharides containing at least 2 monosaccharide units, preferably at least 4 monosaccharide units. Another aspect of the invention relates to the use of the aforementioned product in therapeutic and prophylactic treatments. The present invention further provides a method of producing a packaged liquid edible product containing probiotic bacteria and ginseng polysaccharides in the aforementioned amounts.
摘要翻译：本发明的一个方面涉及一种食用产品，其含有：每克至少10 3个细菌的量的益生菌; 和至少0.5mg / g的含有至少2个单糖单元，优选至少4个单糖单元的人参多糖。本发明的另一方面涉及上述产品在治疗和预防治疗中的用途。本发明还提供一种以上述量生产含有益生菌和人参多糖的包装液体食用产品的方法。

2. 发明申请

WO2007009568A1 EDIBLE PRODUCT CONTAINING BENEFICIAL BACTERIA 审中-公开
标题翻译：食用含有益菌的产品
公开(公告)号：WO2007009568A1
公开(公告)日：2007-01-25
申请号：PCT/EP2006/006306
申请日：2006-06-29
申请人： UNILEVER N.V. , UNILEVER PLC , HINDUSTAN LEVER LIMITED , ALBERS, Ruud , BRUL, Stanley , LEDEBOER, Adrianus, Marinus , MEIJER, Willem, Maarten
发明人： ALBERS, Ruud , BRUL, Stanley , LEDEBOER, Adrianus, Marinus , MEIJER, Willem, Maarten
IPC分类号： A23L1/30 , A23L1/03 , A23C9/12 , A23D7/005 , A23G9/00 , A23L2/52 , A21D13/00
CPC分类号： A23C9/12 , A23G9/00 , A23G2200/02
摘要： The present invention provides a method of preparing an edible product comprising non-viable bacteria providing a health benefit, the method comprising subjecting viable bacteria to at least two sub-lethal treatments to obtain the non-viable bacteria providing a health benefit, each sub-lethal treatment on its own not being sufficient to render the bacteria non-viable. The method porvides non-viable bacteria providing health benefits but which can conveniently be incorporated into a range of edible products.
摘要翻译：本发明提供一种制备包含提供健康益处的非活细菌的食用产品的方法，所述方法包括将活细菌经受至少两次次致死处理以获得提供健康益处的非存活细菌，致命的治疗本身不足以使细菌不可行。该方法培养提供健康益处的非活细菌，但可方便地并入一系列可食用产品中。

3. 发明申请

WO2007019901A1 FOOD PRODUCTS COMPRISING PROBIOTIC MICRO-ORGANISMS AND ANTIBODIES 审中-公开
标题翻译：包含生物微生物和抗体的食品
公开(公告)号：WO2007019901A1
公开(公告)日：2007-02-22
申请号：PCT/EP2006/005060
申请日：2006-05-24
申请人： UNILEVER N.V. , UNILEVER PLC , HINDUSTAN LEVER LIMITED , FRENKEN, Leo, Gerardus, Joseph , HAMMARSTRÖM, Lars-Göran , LEDEBOER, Adrianus, Marinus
发明人： FRENKEN, Leo, Gerardus, Joseph , HAMMARSTRÖM, Lars-Göran , LEDEBOER, Adrianus, Marinus
IPC分类号： A61K39/395 , C07K16/10 , A61K35/74 , A23L1/03
CPC分类号： C07K16/10 , A23G9/363 , A23G9/38 , A23L33/135 , A23L33/18 , A61K35/745 , A61K35/747 , A61K36/06 , A61K39/395 , A61K2039/505 , C07K2317/22 , C07K2317/622 , C07K2317/76 , A61K2300/00
摘要： The present invention relates to food products or pharmaceutical preparations comprising antibodies or antibody fragments which are active in the gut and probiotic micro-organisms independent from the antibodies or antibody fragments. In particular, the invention relates to a method for preparing food products and pharmaceutical preparations comprising the antibodies or antibody fragments and probiotic micro-organisms and the use of these products to deliver health benefits to humans.
摘要翻译：本发明涉及包含抗体或抗体片段的食品或药物制品，所述抗体或抗体片段与肠道和益生菌微生物在抗体或抗体片段无关。特别地，本发明涉及制备包含抗体或抗体片段和益生菌微生物的食品和药物制剂的方法，以及这些产品用于向人类提供健康益处的方法。

4. 发明申请

WO2006056306A2 HEAVY CHAIN AND DOMAIN ANTIBODIES 审中-公开
标题翻译：重链和域抗体
公开(公告)号：WO2006056306A2
公开(公告)日：2006-06-01
申请号：PCT/EP2005011805
申请日：2005-11-03
申请人： UNILEVER NV , UNILEVER PLC , LEVER HINDUSTAN LTD , FRENKEN LEO GERARDUS JOSEPH , HAMMARSTROEM LENNART , LEDEBOER ADRIANUS MARINUS
发明人： FRENKEN LEO GERARDUS JOSEPH , HAMMARSTROEM LENNART , LEDEBOER ADRIANUS MARINUS
IPC分类号： A61K9/00 , A23L33/10 , A23L33/17 , A61K35/74 , A61K39/395 , C12N1/21 , C12N15/74
CPC分类号： A23L2/39 , A23F3/14 , A23F3/34 , A23G9/363 , A23L2/52 , A23L7/126 , A23L27/60 , A23L33/135 , A23L33/18 , A23L33/195 , A23V2002/00 , A23Y2220/17 , A61K9/0056 , A61K9/1652 , A61K2039/505 , C07K16/10 , C07K2317/22 , C07K2317/569 , C07K2317/622 , A23V2250/5434
摘要： The present invention relates to heavy chain immunoglobulins or fragments thereof of the VHH or VNAR type, or domain antibodies (dAbs) of the heavy or light chains of immunoglobulins or fragments thereof, suitable for use in the management of infections, in particular of the gastrointestinal tract. The present invention also relates to a delivery system comprising these heavy chain immunoglobulins or functional fragments thereof of the VHH or VNAR type, or domain antibodies (dAbs) of the heavy or light chains of immunoglobulins or fragments thereof, and hosts comprising expression vectors encoding for these heavy chain immunoglobulins or functional fragments thereof of the VHH or VNAR type, or domain antibodies (dAbs) of the heavy or light chains of immunoglobulins or fragments thereof. The invention also relates to food products and pharmaceutical preparations comprising the delivery system, and methods for the preparation of food products according to the invention.
摘要翻译：本发明涉及VHH或VNAR型的重链免疫球蛋白或其片段或免疫球蛋白或其片段的重链或轻链的结构域抗体（dAb），其适用于治疗感染，特别是胃肠道道。本发明还涉及包含VHH或VNAR型的这些重链免疫球蛋白或其功能片段或免疫球蛋白或其片段的重链或轻链的结构域抗体（dAb）的递送系统，以及包含编码 VHH或VNAR型的这些重链免疫球蛋白或其功能片段，或免疫球蛋白或其片段的重链或轻链的结构域抗体（dAb）。本发明还涉及包含递送系统的食品和药物制剂以及用于制备根据本发明的食品的方法。

5. 发明申请

WO2004060073A1 FERMENTED MILK PRODUCT COMPRISING TRIPEPTIDE VPP AND/OR IPP 审中-公开
标题翻译：含有TRIPEPTIDE VPP和/或IPP的发酵奶制品
公开(公告)号：WO2004060073A1
公开(公告)日：2004-07-22
申请号：PCT/EP2003/013644
申请日：2003-12-03
申请人： UNILEVER N.V. , UNILEVER PLC , HINDUSTAN LEVER LIMITED , DRAAISMA, René, Bernardus , KONING, Mettina, Maria, G. , LEDEBOER, Adrianus, Marinus , SCHALK, Johannes
发明人： DRAAISMA, René, Bernardus , KONING, Mettina, Maria, G. , LEDEBOER, Adrianus, Marinus , SCHALK, Johannes
IPC分类号： A23C9/123
CPC分类号： A23C9/1234 , A23C9/1322 , A23Y2220/39
摘要： The invention relates to a fermented milk product comprising an amount of tripeptides VPP and/or IPP expressed as equivalent IPP concentration [IPPeq] of 145 ?M or more comprising 40-600 mmol/kg K+ and/or 30-400 mmol/kg Ca2+ and/or 6-50 mmol/kg Mg2+.
摘要翻译：本发明涉及一种发酵乳产品，其包含一定量的三肽VPP和/或IPP，其表示为等同IPP浓度[IPPeq]为145nM或更多，其包含40-600mmol / kg K +和/或30-400mmol / kg Ca2 +，和 /或6-50mmol / kg Mg2 +。

6. 发明申请

WO1994026882A1 PROLINE IMINOPEPTIDASE, PROCESS FOR ITS PREPARATION AND ITS USE IN THE FLAVOURING OF FOOD COMPOSITIONS 审中-公开
标题翻译：精氨酸酶抑制剂，其制备方法及其在食品组合物挥发中的应用
公开(公告)号：WO1994026882A1
公开(公告)日：1994-11-24
申请号：PCT/EP1994001497
申请日：1994-05-09
申请人： QUEST INTERNATIONAL B.V. , BOOT, Jacobus , DEUTZ, Inge, Elisabeth, M. , LEDEBOER, Adrianus, Marinus , LEENHOUTS, Cornelis, Johannes , TOONEN, Maria, Yvonne
发明人： QUEST INTERNATIONAL B.V.
IPC分类号： C12N09/48
CPC分类号： C12Y304/11005 , A21D8/042 , A23C19/063 , A23L5/25 , A23L5/27 , A23L27/24 , C12N9/52
摘要： A novel proline iminopeptidase which is a metal dependent serine peptidase, which is obtainable from Propionibacterium shermanii ATCC 9617 and which has a calculated molecular mass of 45 kDa. The proline iminopeptidase has an amino acid sequence according to the unique sequence of Figure 3. Genetic variants having a homology exceeding 60 % and having the same functionality are comprised by the invention. The proline iminopeptidase can be prepared in large quantities with the use of a genetically modified microorganism. It is used for modifying the flavour of food products, and in particular for rendering the product less bitter.
摘要翻译：作为金属依赖性丝氨酸肽酶的新型脯氨酸亚氨基肽酶，其可从丙酸杆菌ATCC 9617获得，其计算分子量为45kDa。脯氨酸亚氨基肽酶具有根据图3的唯一序列的氨基酸序列。本发明包括具有超过60％的同源性并且具有相同官能度的遗传变体。脯氨酸亚氨基肽酶可以使用遗传修饰的微生物大量制备。它用于改变食品的味道，特别是用于使产品更少的苦味。

7. 发明申请

WO9923221A3 MULTIVALENT ANTIGEN-BINDING PROTEINS 审中-公开
标题翻译：多功能抗体结合蛋白
公开(公告)号：WO9923221A3
公开(公告)日：1999-10-07
申请号：PCT/EP9806991
申请日：1998-10-27
申请人： UNILEVER PLC , UNILEVER NV , FRENKEN LEON GERARDUS JOSEPH , HOWELL STEVEN , LEDEBOER ADRIANUS MARINUS , LOGT CORNELIS PAUL ERI VAN DER
发明人： FRENKEN LEON GERARDUS JOSEPH , HOWELL STEVEN , LEDEBOER ADRIANUS MARINUS , LOGT CORNELIS PAUL ERI VAN DER
IPC分类号： A61K38/00 , A61K39/395 , C07K16/00 , C07K16/12 , C07K16/26 , C07K16/44 , C07K16/46 , C07K19/00 , C12N1/15 , C12N15/13 , C12N15/62 , G01N33/531 , G01N33/577
CPC分类号： G01N33/531 , A61K38/00 , C07K16/00 , C07K16/1275 , C07K16/26 , C07K16/44 , C07K16/468 , C07K2317/22 , C07K2317/34 , C07K2317/569 , C07K2319/00 , Y10S977/927
摘要： A multivalent antigen binding protein comprises a single polypeptide chain comprising, in series, two or more single domain binding units which are preferably heavy chain variable domains derived from an immunoglobulin naturally devoid of light chains. Methods for their production and uses thereof, in particular for diagnosis, immunoassay and purification methods are disclosed.
摘要翻译：多价抗原结合蛋白包含单个多肽链，其包含两个或更多个单结构域结合单元，其优选是衍生自天然缺乏轻链的免疫球蛋白的重链可变结构域。公开了其生产方法及其用途，特别是用于诊断，免疫测定和纯化方法。

8. 发明申请

WO1994012656A1 LACTOBACILLUS SAKE LIKE STRAINS, PRODUCTION AND USE OF THEIR EXOPOLYSACCHARIDES 审中-公开
标题翻译： LACTOBACILLUS KE KE KE STR STR ES ES ES ES ES ES ES ES ES ES ES ES ES ES ES
公开(公告)号：WO1994012656A1
公开(公告)日：1994-06-09
申请号：PCT/EP1993003338
申请日：1993-11-26
申请人： QUEST INTERNATIONAL B.V. , VAN DEN BERG, Dirk, Johannes, Cornelis , LEDEBOER, Adrianus, Marinus , ROBIJN, Gerard, Willem , VREEKER, Robert
发明人： QUEST INTERNATIONAL B.V.
IPC分类号： C12P19/04
CPC分类号： C12R1/225 , A21D2/181 , A23C9/1234 , A23D7/0056 , A23D7/015 , A23L27/60 , A23L29/269 , A23Y2220/77 , C12P19/04
摘要： New Lactobacillus sake like strains are provided obtainable from meat products, which strains are capable of producing an exopolysaccharide having shear-thinning properties, even at low concentrations, and/or thickening and/or emulsion-stabilizing properties.
摘要翻译：新的乳杆菌真菌样菌株提供可从肉制品获得，该菌株能够产生具有剪切稀化性质的外部多糖，甚至在低浓度，和/或增稠和/或乳化稳定性质。

9. 发明申请

WO2006056306A3 HYDROGEL POLYMERIC CONJUGATES OF A PRODRUG 审中-公开
公开(公告)号：WO2006056306A3
公开(公告)日：2006-06-01
申请号：PCT/EP2005/011805
申请日：2005-11-03
申请人： UNILEVER N.V. , UNILEVER PLC , HINDUSTAN LEVER LIMITED , FRENKEN, Leo Gerardus Joseph , HAMMARSTRÖM, Lennart , LEDEBOER, Adrianus Marinus
发明人： FRENKEN, Leo Gerardus Joseph , HAMMARSTRÖM, Lennart , LEDEBOER, Adrianus Marinus
IPC分类号： A61K9/00 , A61K35/74 , C12N15/74 , C12N1/21 , A61K39/395 , A23L1/00 , A61K39/42 , A23L1/24 , A23G7/00 , A23D7/00
摘要： The present invention relates to heavy chain immunoglobulins or fragments thereof of the VHH or VNAR type, or domain antibodies (dAbs) of the heavy or light chains of immunoglobulins or fragments thereof, suitable for use in the management of infections, in particular of the gastrointestinal tract. The present invention also relates to a delivery system comprising these heavy chain immunoglobulins or functional fragments thereof of the VHH or VNAR type, or domain antibodies (dAbs) of the heavy or light chains of immunoglobulins or fragments thereof, and hosts comprising expression vectors encoding for these heavy chain immunoglobulins or functional fragments thereof of the VHH or VNAR type, or domain antibodies (dAbs) of the heavy or light chains of immunoglobulins or fragments thereof. The invention also relates to food products and pharmaceutical preparations comprising the delivery system, and methods for the preparation of food products according to the invention.

10. 发明申请

WO1998010080A1 SALT-INDUCIBLE PROMOTER DERIVABLE FROM A LACTIC ACID BACTERIUM, AND ITS USE IN A LACTIC ACID BACTERIUM FOR PRODUCTION OF A DESIRED PROTEIN 审中-公开
标题翻译：从酸乳杆菌衍生的盐诱导促进剂及其用于生产所需蛋白质的酸性细菌
公开(公告)号：WO1998010080A1
公开(公告)日：1998-03-12
申请号：PCT/EP1997004755
申请日：1997-08-20
申请人： UNILEVER N.V. , UNILEVER PLC , SANDERS, Jan, Willem , KOK, Jan , VENEMA, Gerard , LEDEBOER, Adrianus, Marinus
发明人： UNILEVER N.V. , UNILEVER PLC
IPC分类号： C12N15/74
CPC分类号： C12N15/746 , C07K14/335
摘要： The invention provides a salt-inducible promoter present in SEQ ID NO: 10 and derivable from a lactic acid bacterium in isolation from the coding sequence normally controlled by said promoter in a wild-type lactic acid bacterium, with modifications and important parts thereof. Also provided are a recombinant vector and a transformed lactic acid bacterium comprising such promoter, and the production of a desired protein by such transformed bacterium, whereby the gene encoding said desired protein or a precursor thereof is expressed under control of such promoter. The desired protein can be secreted by the bacterium due to the presence of a signal sequence. The action of the salt-inducible promoter is enhanced at a pH of about 4-4.5 and/or by the presence of glutamic acid. Such process can be used in a fermentation process, in which the desired protein is a lytic protein causing lysis of the cells and release of the cell content. Or the desired protein can be an enzyme involved in flavour formation, e.g. in producing dressings, spreads, sausages and sour dough, or a protein functioning in a cheese production process, such as chymosin or a precursor thereof, or an enzyme involved in cheese flavour formation.
摘要翻译：本发明提供了存在于SEQ ID NO：10中的衍生自乳酸菌的盐诱导型启动子，其与野生型乳酸菌通常由所述启动子控制的编码序列分开，其修饰和重要部分。还提供了包含这种启动子的重组载体和转化的乳酸菌，并且通过这种转化细菌产生所需的蛋白质，由此编码所述所需蛋白质或其前体的基因在这种启动子的控制下表达。由于信号序列的存在，所需的蛋白质可被细菌分泌。在约4-4.5的pH和/或谷氨酸的存在下，盐诱导型启动子的作用增强。这种方法可以用于发酵过程，其中所需蛋白质是引起细胞裂解和释放细胞内容物的裂解蛋白。或者所需的蛋白质可以是涉及风味形成的酶，例如在制作敷料，酱油，香肠和酸面团中，或在奶酪生产过程中起作用的蛋白质，例如凝乳酶或其前体，或涉及奶酪香味形成的酶。

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