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1. 发明公开

EP1254177A1 RUMINANT MHC CLASS I-LIKE Fc RECEPTORS 审中-公开
标题翻译：反刍动物MHC I类相似Fc受体
公开(公告)号：EP1254177A1
公开(公告)日：2002-11-06
申请号：EP01904699.4
申请日：2001-02-02
申请人： Hammarström, Lennart , Kacskovics, Imre
发明人： Hammarström, Lennart , Kacskovics, Imre
IPC分类号： C07K14/755 , C07K16/04
CPC分类号： C07K16/283 , A01K2217/05 , A01K2227/101 , A01K2227/103 , A01K2267/01 , C07K14/70535 , C07K14/70539 , C07K16/00 , C07K2317/34 , C07K2317/52 , C12N15/8509
摘要： Immunoglobulin G (IgG) transporting ruminant Fc receptor (FcRn) α-chain DNA molecules, especially those of cow, dromedary and sheep (SEQ ID NO: 1, SEQ ID NO:2, SEQ ID NO:3) are disclosed. Protein expressed by said FcRn α-chain DNA molecules are disclosed and include SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6. Vectors containing the ruminant IgG transporting FcRn α-chain DNA molecules, and hosts transformed with such vectors are also included. Further, a method of producing colostrums or milk with enhanced levels of immunoglobulins or proteins fused to immunoglobulin η-chains of FcRn interacting parts thereof is also disclosed.

2. 发明申请

WO2006056306A3 HYDROGEL POLYMERIC CONJUGATES OF A PRODRUG 审中-公开
公开(公告)号：WO2006056306A3
公开(公告)日：2006-06-01
申请号：PCT/EP2005/011805
申请日：2005-11-03
申请人： UNILEVER N.V. , UNILEVER PLC , HINDUSTAN LEVER LIMITED , FRENKEN, Leo Gerardus Joseph , HAMMARSTRÖM, Lennart , LEDEBOER, Adrianus Marinus
发明人： FRENKEN, Leo Gerardus Joseph , HAMMARSTRÖM, Lennart , LEDEBOER, Adrianus Marinus
IPC分类号： A61K9/00 , A61K35/74 , C12N15/74 , C12N1/21 , A61K39/395 , A23L1/00 , A61K39/42 , A23L1/24 , A23G7/00 , A23D7/00
摘要： The present invention relates to heavy chain immunoglobulins or fragments thereof of the VHH or VNAR type, or domain antibodies (dAbs) of the heavy or light chains of immunoglobulins or fragments thereof, suitable for use in the management of infections, in particular of the gastrointestinal tract. The present invention also relates to a delivery system comprising these heavy chain immunoglobulins or functional fragments thereof of the VHH or VNAR type, or domain antibodies (dAbs) of the heavy or light chains of immunoglobulins or fragments thereof, and hosts comprising expression vectors encoding for these heavy chain immunoglobulins or functional fragments thereof of the VHH or VNAR type, or domain antibodies (dAbs) of the heavy or light chains of immunoglobulins or fragments thereof. The invention also relates to food products and pharmaceutical preparations comprising the delivery system, and methods for the preparation of food products according to the invention.

3. 发明申请

WO2012019058A9 EXPRESSION OF ANTIBODY OR A FRAGMENT THEREOF IN LACTOBACILLUS 审中-公开
公开(公告)号：WO2012019058A9
公开(公告)日：2012-02-09
申请号：PCT/US2011/046670
申请日：2011-08-04
申请人： HERA PHARMACEUTICALS, INC. , HAMMARSTRÖM, Lennart , MARCOTTE, Harold , ALVAREZ, Miguel, Angel , MARTIN, Maria Cruz
发明人： HAMMARSTRÖM, Lennart , MARCOTTE, Harold , ALVAREZ, Miguel, Angel , MARTIN, Maria Cruz
IPC分类号： C12N1/21 , A01N63/02
摘要： Described herein are methods and compositions for expressing an antibody or a fragment thereof in a microorganism and use of the microorganism to treat or prevent a pathogenic infection in a mammal.

4. 发明申请

WO2008105740A1 A NEW IMMUNOGLOBULIN AGAINST HELICOBACTER PYLORI 审中-公开
标题翻译：一种新的免疫抑制剂，用于治疗HELICOBACTER PYLORI
公开(公告)号：WO2008105740A1
公开(公告)日：2008-09-04
申请号：PCT/SE2008/050236
申请日：2008-03-03
申请人： HELICURE AB , BORÉN, Thomas , HAMMARSTRÖM, Lennart
发明人： BORÉN, Thomas , HAMMARSTRÖM, Lennart
IPC分类号： A61K39/40 , C07K16/12 , C12N15/10 , G01N33/569
CPC分类号： G01N33/56922 , C07K16/121 , C07K2317/21 , C07K2317/622
摘要： The present invention relates to materials and methods for prevention, treatment and diagnosing of infections caused by Helicobacter pylori (H. pylori). More specifically the present invention relates to new specific variable antibody regions, derivatives thereof and the fully human immunoglobulin, Abba3, which exhibit specific activity to the BabA antigen, expressed by H. pylori, and that competes for the binding of BabA to fucosylated ABO/Lewis b blood group antigens (Leb). The invention further relates to methods for the production of said immunoglobulins, their isolation and use, for example in detection of disease causing H. pylori. The present invention also relates to immunization therapies, i.e. passive vaccination for the treatment and prevention of pathologic infections caused by H. pylori strains.
摘要翻译：本发明涉及由幽门螺杆菌（幽门螺杆菌）引起的感染的预防，治疗和诊断的材料和方法。更具体地，本发明涉及新的具体可变抗体区域，其衍生物和完全人免疫球蛋白Abba3，其表现出由幽门螺杆菌表达的BabA抗原的比活性，并且竞争BabA与岩藻糖基化ABO / Lewis B血型抗原（Leb）。本发明还涉及生产所述免疫球蛋白的方法，其分离和用途，例如在检测导致幽门螺杆菌的疾病中。本发明还涉及免疫疗法，即用于治疗和预防由幽门螺杆菌菌株引起的病理感染的被动接种。

5. 发明申请

WO1997047646A1 HELICOBACTER PYLORI ADHESIN BINDING GROUP ANTIGEN 审中-公开
标题翻译： HELICOBACTER PYLORI ADHESIN绑定组抗原
公开(公告)号：WO1997047646A1
公开(公告)日：1997-12-18
申请号：PCT/SE1997001009
申请日：1997-06-10
申请人： BORÉN, Thomas , ARNQVIST, Anna , NORMARK, Staffan , ILVER, Dag , HAMMARSTRÖM, Lennart
IPC分类号： C07K14/205
CPC分类号： C07K14/205 , A61K39/00 , A61K2039/51
摘要： A novel Helicobacter pylori blood group antigen binding (BAB) adhesin protein was isolated and purified, whereby said protein or fractions thereof bind specifically to fucosylated blood group antigens. The protein sequence of said adhesin is disclosed in this application. Simultaneously the DNA sequences for two genes, babA and babB, producing highly similar proteins, are disclosed. Said adhesin and/or DNA is useful for diagnose and therapy and/or prophylaxis directed against H. pylori induced infections, e.g. gastritis and acid peptic disease, i.e. active vaccination. A new immunoglobulin composition, which exhibits specific activity to a Lewis antigen binding Helicobacter pylori adhesin, or preferably, monoclonal and/or polyclonal antibodies to said adhesin offer a new and more efficient method of treatment and/or prevention of gastrointestinal diseases, caused by Helicobacter pylori or other Helicobacter species, i.e. passive vaccination.
摘要翻译：分离和纯化了一种新型幽门螺杆菌血型抗原结合（BAB）粘附素蛋白，由此所述蛋白质或其部分特异性结合岩藻糖化血型抗原。所述粘附素的蛋白质序列在本申请中公开。同时公开了两种基因的DNA序列，即产生高度相似蛋白质的babA和babB。所述粘附素和/或DNA可用于针对幽门螺杆菌诱导的感染的诊断和治疗和/或预防，例如。胃炎和酸性消化性疾病，即主动接种疫苗。对Lewis结合幽门螺杆菌粘附素的Lewis抗原结合，或者优选地，对所述粘附素的单克隆和/或多克隆抗体具有比活性的新的免疫球蛋白组合物提供了一种新的更有效的治疗和/或预防胃肠道疾病的方法，由幽门螺杆菌或其他幽门螺杆菌物种引起，即被动接种疫苗。

6. 发明申请

WO2012019058A1 EXPRESSION OF ANTIBODY OR A FRAGMENT THEREOF IN LACTOBACILLUS 审中-公开
标题翻译：在乳杆菌中表达抗体或其片段
公开(公告)号：WO2012019058A1
公开(公告)日：2012-02-09
申请号：PCT/US2011/046670
申请日：2011-08-04
申请人： HERA PHARMACEUTICALS, INC. , HAMMARSTRÖM, Lennart , MARCOTTE, Harold , ALVAREZ, Miguel, Angel , MARTIN, Maria Cruz
发明人： HAMMARSTRÖM, Lennart , MARCOTTE, Harold , ALVAREZ, Miguel, Angel , MARTIN, Maria Cruz
IPC分类号： C12N1/21 , A01N63/02
CPC分类号： C12N15/746 , A61K35/747 , A61K2035/115 , A61K2039/505 , C07K16/2821 , C07K16/2845 , C07K2317/14 , C07K2317/20 , C07K2317/569 , C07K2317/622 , Y02A50/386 , Y02A50/388 , Y02A50/401 , Y02A50/403 , Y02A50/407 , Y02A50/41 , Y02A50/412 , Y02A50/423 , Y02A50/466 , Y02A50/471 , Y02A50/48 , Y02A50/484
摘要： Described herein are methods and compositions for expressing an antibody or a fragment thereof in a microorganism and use of the microorganism to treat or prevent a pathogenic infection in a mammal.
摘要翻译：本文描述了用于在微生物中表达抗体或其片段的方法和组合物，并且使用该微生物来治疗或预防哺乳动物的病原体感染。

7. 发明申请

WO2012019054A2 EXPRESSION OF ANTIBODY OR A FRAGMENT THEREOF IN LACTOBACILLUS 审中-公开
标题翻译：抗体或其片段在乳杆菌中的表达
公开(公告)号：WO2012019054A2
公开(公告)日：2012-02-09
申请号：PCT/US2011/046665
申请日：2011-08-04
申请人： HERA PHARMACEUTICALS, INC. , HAMMARSTRÖM, Lennart , MARCOTTE, Harold
发明人： HAMMARSTRÖM, Lennart , MARCOTTE, Harold
IPC分类号： H01L21/50
CPC分类号： A61K35/747 , A61K2039/505 , C07K16/2821 , C07K16/2845 , C07K2317/14 , C07K2317/20 , C07K2317/569 , C07K2317/622 , C12N1/20 , Y02A50/386 , Y02A50/388 , Y02A50/401 , Y02A50/403 , Y02A50/407 , Y02A50/41 , Y02A50/412 , Y02A50/423 , Y02A50/466 , Y02A50/471 , Y02A50/48 , Y02A50/484
摘要： Described herein are methods and compositions for expressing an antibody or a fragment thereof in a microorganism and use of the microorganism to treat or prevent a pathogenic infection in a mammal.
摘要翻译：本文描述了用于在微生物中表达抗体或其片段的方法和组合物，以及该微生物用于治疗或预防哺乳动物中的致病性感染的用途。

8. 发明申请

WO2010076339A1 MEANS AND METHOD FOR THE TREATMENT OF ANTIBODY DEFICIENCY DISEASES BASED ON IL-21 AND IL-21 VARIANTS 审中-公开
标题翻译：基于IL-21和IL-21变体治疗抗体缺陷性疾病的手段和方法
公开(公告)号：WO2010076339A1
公开(公告)日：2010-07-08
申请号：PCT/EP2010/050040
申请日：2010-01-05
申请人： FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V. , BORTE, Stephan , HAMMARSTRÖM, Lennart , SACK, Ulrich
发明人： BORTE, Stephan , HAMMARSTRÖM, Lennart , SACK, Ulrich
IPC分类号： C07K14/54 , A61K38/20
CPC分类号： A61K38/20 , A61K38/00 , C07K14/54
摘要： The present invention relates to an lnterleukin-21 (IL-21 ) variant which is capable of increasing the secretion of IgG and/or IgA antibodies in B cells and/or is capable of binding the IL-2 receptor complex and/or the IL-4 receptor complex, comprising stretches of amino acids of lnterleukin-4 (IL-4) or lnterleukin-2 (IL-2) in substitution of amino acids of IL-21. The present invention also relates to a pharmaceutical composition comprising IL-21 and/or an IL-21 variant and at least one compound selected from IgA inducing protein (IGIP), Syntenin-1, Galectin-1 and Galectin-3. The present invention further relates to a pharmaceutical composition for the treatment of a primary humoral immunodeficiency disease comprising IL-21 and/or an IL-21 variant and IL-4 and/or IL-2 and/or IGIP and/or Syntenin-1 and/or Galectin-1 and/or Galectin-3. Furthermore the present invention relates to a kit for the treatment of a primary humoral immunodeficiency disease, comprising IL-21 and/or an IL-21 variant and IL-4 and/or IL-2 and/or IGIP and/or Syntenin-1 and/or Galectin-1 and/or Galectin-3 and optionally at least one element selected from a stimulator of CD40 molecules, a ligand of the tumor necrosis superfamily, a polypeptide with human leukocyte interferon activity, a vaccine protein antigen; and a vaccine polysaccharide antigen.
摘要翻译：本发明涉及能够增加B细胞中IgG和/或IgA抗体分泌和/或能够结合IL-2受体复合物和/或IL的白细胞介素-21（IL-21）变体 -4受体复合物，其包含白介素-4（IL-4）或白细胞介素-2（IL-2）的氨基酸的延伸，以取代IL-21的氨基酸。本发明还涉及包含IL-21和/或IL-21变体和至少一种选自IgA诱导蛋白（IGIP），合成素-1，半乳凝素-1和半乳凝素-3的化合物的药物组合物。本发明还涉及用于治疗包含IL-21和/或IL-21变体和IL-4和/或IL-2和/或IGIP和/或合成素-1的初级体液免疫缺陷病的药物组合物和/或半乳凝素-1和/或半乳凝素-3。此外，本发明涉及用于治疗初级体液免疫缺陷病的试剂盒，其包含IL-21和/或IL-21变体和IL-4和/或IL-2和/或IGIP和/或合成素-1 和/或半乳凝素-1和/或半乳凝素-3和任选的至少一种选自CD40分子的刺激物，肿瘤坏死超家族的配体，具有人白细胞干扰素活性的多肽，疫苗蛋白抗原的元件; 和疫苗多糖抗原。

9. 发明申请

WO2002066502A1 HELICOBACTER PYLORI SIALIC ACID BINDING ADHESIN, SABA AND SABA - GENE 审中-公开
标题翻译： HELICOBACTER PYLORI SIALIC ACID BINDING ADHESIN，SABA AND SABA - GENE
公开(公告)号：WO2002066502A1
公开(公告)日：2002-08-29
申请号：PCT/SE2002/000301
申请日：2002-02-21
申请人： BORÉN, Thomas , HAMMARSTRÖM, Lennart
发明人： BORÉN, Thomas , HAMMARSTRÖM, Lennart
IPC分类号： C07K14/205
CPC分类号： C07K14/205 , A61K38/00
摘要： An isolated Helicobacter pylori protein binding to sialyl-Lewis x antigen and having an approximate molecular weight of 66kDa and comprising the amino acid sequences SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, and sialyl-Lewis x antigen-binding H.pylori alleles of the protein, recombinant forms of the protein, such as a protein having the amino acid sequence SEQ ID NO: 5, or the protein alleles, and sialyl-Lewis x antigen binding portions of the proteins, are disclosed. The protein or portion of protein maybe used as a medicament or diagnostic antigen, and can be used in a method of determining the presence of sialyl-Lewis x antigen-binding H.pylori bacteria in a biological sample. Further, a DNA molecule encoding the protein or portion of protein, a vector comprising the DNA molecule, and a host transformed with the vector are comprised by the disclosure. Additionally, a method of determining the presence of sialyl-Lewis x or related carbohydrate structures in a sample, is described. This method has a wide range of different applications.
摘要翻译：分离的幽门螺杆菌蛋白质与唾液酸 - 路易斯x抗原结合并且具有66kDa的近似分子量并且包含氨基酸序列SEQ ID NO：1，SEQ ID NO：2，SEQ ID NO：3，SEQ ID NO：4，和唾液酸 - 路易斯×抗原结合幽门螺杆菌等位基因，蛋白质的重组形式，例如具有氨基酸序列SEQ ID NO：5的蛋白质，或蛋白质等位基因，以及唾液酸 - 路易斯×抗原结合部分的蛋白质。蛋白质或蛋白质部分可以用作药物或诊断抗原，并且可以用于确定生物样品中唾液酸 - 路易斯×抗原结合幽门螺杆菌细菌的存在的方法。此外，本公开内容包括编码蛋白质或蛋白质部分的DNA分子，包含DNA分子的载体和用载体转化的宿主。另外，描述了确定样品中唾液酸 - 路易斯x或相关碳水化合物结构的存在的方法。该方法具有广泛的不同应用。

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