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    • 8. 发明授权
    • Disaccharide derivatives used in the treatment of hepatic diseases
    • 用于治疗肝脏疾病的二糖衍生物
    • US4080442A
    • 1978-03-21
    • US623049
    • 1975-10-16
    • Akihiro MizutaniKyoji KitoHideki MiyajiTaketoshi KomoriTakao OgawaHideo NagaeHiromi Hanai
    • Akihiro MizutaniKyoji KitoHideki MiyajiTaketoshi KomoriTakao OgawaHideo NagaeHiromi Hanai
    • A61K31/70C07H13/12C07G3/00
    • A61K31/70C07H13/12Y10S514/838
    • A pharmaceutical composition containing as its active ingredient a disaccharide derivative having a derivative group of the following formula (1) bonded to a carbon atom of a disaccharide: ##STR1## wherein Y is a member of the group consisting of NH and O; and when Y is NH, Z is a member of the class consisting of --O-- (disaccharide residue) and --O--, with the proviso that one of the two bonds is attached to the other carbon atom of the same disaccharide to which the formula (1) group is bonded, and when Y is O, Z is a member of the class consisting of --NH.sub.2 and --O--, with the proviso that one of the two bonds is attached to a carbon atom of a disaccharide different from that to which the formula (1) group is bonded. The disaccharide derivative can be prepared by reacting a disaccharide with an activating agent selected from the group consisting of the cyanogen halides, organic cyanic acid esters and halogenocarbonic acid alkyl esters. Said pharmaceutical composition is useful for treating hepatic diseases.
    • 含有与二糖的碳原子键合的具有下式(1)的衍生基团的二糖衍生物作为其活性成分的药物组合物:其中Y是由NH和O组成的组的成员 ; 并且当Y是NH时,Z是由-O-(二糖残基)和-O-构成的类别的成员,条件是两个键之一连接到相同二糖的另一个碳原子上, 式(1)基团键合,并且当Y为O时,Z为由-NH 2和-O-构成的类别的成员,条件是两个键中的一个键连接于不同于 式(1)基团所键合的化合物。 二糖衍生物可以通过使二糖与选自氰基卤化物,有机氰酸酯和卤代碳酸烷基酯的活化剂反应来制备。 所述药物组合物可用于治疗肝脏疾病。