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1. 发明申请

US20090081308A1 ANHDYROUS LACTOSE AGGLOMERATES AND THE PREPARATION THEREOF 有权
标题翻译：高分子乳糖聚合物及其制备方法
公开(公告)号：US20090081308A1
公开(公告)日：2009-03-26
申请号：US11722968
申请日：2005-12-21
申请人： Klaas Daniel Kussendrager , Bouwe Walsma
发明人： Klaas Daniel Kussendrager , Bouwe Walsma
IPC分类号： A61K47/30 , B29C67/02 , A61P43/00 , A61K9/14
CPC分类号： C13K5/00 , A61K9/2018 , C13B50/004
摘要： The invention relates to a process for the preparation of anhydrous lactose agglomerates, said process comprising (i) subjecting essentially anhydrous lactose primary particles comprising at least 60 wt % crystalline-lactose in a granulator to a wet granulation step at a temperature in the range of 30-100° C. using a binder solution, wherein the granulation mass is subjected to drying for at least part of the granulation step, and (ii) after-drying the granulation mass. The anhydrous lactose agglomerates thus produced comprise at least 50 wt %-lactose crystallites and have a total water content in the range of 0-1.0 wt %, which is required according to the standards laid down by the Pharmacopoeia for anhydrous lactose excipients. These agglomerates combine have excellent compactibility and flowability properties and are particularly useful as excipient in moisture-sensitive applications.
摘要翻译：本发明涉及一种制备无水乳糖附聚物的方法，所述方法包括（i）在造粒机中将基本上含有至少60重量％结晶乳糖的无水乳糖一次粒子在湿法制粒步骤中在 30-100℃，使用粘合剂溶液，其中造粒物质至少部分造粒步骤进行干燥，和（ii）将造粒物料干燥。如此生产的无水乳糖附聚物包含至少50重量％的乳糖微晶，并且具有0-1.0重量％的总含水量，根据“药典”为无水乳糖赋形剂制定的标准是必需的。这些团聚体组合具有优异的紧密性和流动性，并且在湿度敏感应用中特别可用作赋形剂。

2. 发明授权

US08501236B2 Method for producing a crystalline tableting additive, additive thus obtained and use thereof 有权
标题翻译：制造结晶压片添加剂的方法，由此获得的添加剂及其用途
公开(公告)号：US08501236B2
公开(公告)日：2013-08-06
申请号：US13408359
申请日：2012-02-29
申请人： Klaas Daniel Kussendrager , Henricus Alphonsus Maria Van Den Biggelaar
发明人： Klaas Daniel Kussendrager , Henricus Alphonsus Maria Van Den Biggelaar
IPC分类号： A61K9/14
CPC分类号： C13B30/028 , A61K9/2018 , A61K47/26 , C13K5/00
摘要： A method for producing a tableting additive, which method comprises providing a spray dried tableting additive in particulate form which particles at leas partially consist of amorphous additive material and at least partially of crystalline additive material; and crystallising the amorphous additive material by subjecting the particles for a short time and under agitation to a temperature between 30 and 100° C. at a relative humidity between 60 and 25%. More in particular, the relationship between relative humidity and temperature is defined by the formula: % relative humidity=218-47*Ln(T(° C.)), wherein T(° C.) is the temperature to which the particles are subjected.
摘要翻译：一种压片添加剂的制造方法，该方法包括提供颗粒形式的喷雾干燥的压片添加剂，其中所述颗粒部分由无定形添加剂材料和至少部分结晶添加剂材料组成; 并通过在短时间和搅拌下使颗粒在相对湿度为60至25％的温度下在30至100℃之间的温度下使无定形添加剂材料结晶。更特别地，相对湿度和温度之间的关系由下式定义：％相对湿度= 218-47 * Ln（T（℃）），其中T（℃）是颗粒的温度遭受。

3. 发明申请

US20120220764A1 METHOD FOR PRODUCING A CRYSTALLINE TABLETING ADDITIVE, ADDITIVE THUS OBTAINED AND USE THEREOF 有权
标题翻译：生产结晶添加剂的方法，获得的添加剂及其用途
公开(公告)号：US20120220764A1
公开(公告)日：2012-08-30
申请号：US13408359
申请日：2012-02-29
申请人： Klaas Daniel KUSSENDRAGER , Henricus Alphonsus Maria Van Den Biggelaar
发明人： Klaas Daniel KUSSENDRAGER , Henricus Alphonsus Maria Van Den Biggelaar
IPC分类号： C07H3/04
CPC分类号： C13B30/028 , A61K9/2018 , A61K47/26 , C13K5/00
摘要： A method for producing a tableting additive, which method comprises providing a spray dried tableting additive in particulate form which particles at leas partially consist of amorphous additive material and at least partially of crystalline additive material; and crystallising the amorphous additive material by subjecting the particles for a short time and under agitation to a temperature between 30 and 100° C. at a relative humidity between 60 and 25%. More in particular, the relationship between relative humidity and temperature is defined by the formula: % relative humidity=218-47*Ln(T(° C.)), wherein T(° C.) is the temperature to which the particles are subjected.
摘要翻译：一种压片添加剂的制造方法，该方法包括提供颗粒形式的喷雾干燥的压片添加剂，其中所述颗粒部分由无定形添加剂材料和至少部分结晶添加剂材料组成; 并通过在短时间和搅拌下使颗粒在相对湿度为60至25％的温度下在30至100℃之间的温度下使无定形添加剂材料结晶。更特别地，相对湿度和温度之间的关系由下式定义：％相对湿度= 218-47 * Ln（T（℃）），其中T（℃）是颗粒的温度遭受。

4. 发明授权

US06447811B1 Pesticide against plant-pathogenic microorganisms 失效
标题翻译：农药抗植物致病微生物
公开(公告)号：US06447811B1
公开(公告)日：2002-09-10
申请号：US09530728
申请日：2000-06-30
申请人： Willem Jacobus Ravensberg , Richard Karel Van der Pas , Klaas Daniel Kussendrager , Johannes Antonius Maria Maas
发明人： Willem Jacobus Ravensberg , Richard Karel Van der Pas , Klaas Daniel Kussendrager , Johannes Antonius Maria Maas
IPC分类号： A01N6300
CPC分类号： A01N63/00 , A01N43/08 , A01N59/12 , A01N59/24 , A01N65/08 , A01N65/18 , A01N65/20 , A01N65/44
摘要： A formulation comprising lactoperoxidase, thiocyanate and/or iodide and a hydrogen peroxide donor system, in particular glucose oxidase and glucose, is useful for controlling plant-pathogenic microorganisms such as fungi and bacteria. Preferably the formulation also contains an oil.
摘要翻译：包含乳过氧化物酶，硫氰酸盐和/或碘化物和过氧化氢供体系统，特别是葡萄糖氧化酶和葡萄糖的制剂可用于控制植物病原微生物如真菌和细菌。优选地，制剂还含有油。

5. 发明授权

US6010698A Process for recovering growth factors, or a composition containing one or more growth factors, from milk or a milk derivative 失效
标题翻译：用于从乳或乳衍生物回收生长因子或含有一种或多种生长因子的组合物的方法
公开(公告)号：US6010698A
公开(公告)日：2000-01-04
申请号：US46821
申请日：1998-03-24
申请人： Klaas Daniel Kussendrager , Marinus Gerardus Cornelis Kivits , Hubert Karel Lemmen , Theodorus Johannes Antonia Maria van Kessel
发明人： Klaas Daniel Kussendrager , Marinus Gerardus Cornelis Kivits , Hubert Karel Lemmen , Theodorus Johannes Antonia Maria van Kessel
IPC分类号： C07K1/18 , C07K1/34 , C07K14/47 , C07K14/475 , C07K14/515 , C07K14/65 , C07K14/79 , C12N9/08 , A61K38/43 , A61K38/00 , C07K5/00 , C07K7/00
CPC分类号： C12N9/0065 , C07K14/475 , C07K14/515 , C07K14/79
摘要： The invention relates to a process for recovering one or more growth factors from milk or a milk derivative, comprising adsorbing at least one growth factor from the milk or the milk derivative to a cation exchanger, followed by fractionated elution of the cation exchanger, whereby at least one fraction is obtained which is enriched in growth factors, followed by the further treatment of this fraction at a pH of at least 3.5 and not more than 4.5.
摘要翻译：本发明涉及从乳或乳衍生物中回收一种或多种生长因子的方法，包括将至少一种生长因子从乳或乳衍生物吸附到阳离子交换剂中，然后分离洗脱阳离子交换剂，由此在获得富含生长因子的至少一个级分，然后在至少3.5且不大于4.5的pH下进一步处理该级分。

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