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1. 发明授权

US5409709A Antipyretic analgesic preparation containing ibuprofen 失效
标题翻译：含有布洛芬的解热止痛剂
公开(公告)号：US5409709A
公开(公告)日：1995-04-25
申请号：US981340
申请日：1992-11-25
申请人： Kiyotaka Ozawa , Ryoko Sugita , Kiyo Adachi , Tomiyuki Yanase , Syuichi Ueda , Aya Yamane
发明人： Kiyotaka Ozawa , Ryoko Sugita , Kiyo Adachi , Tomiyuki Yanase , Syuichi Ueda , Aya Yamane
IPC分类号： A61K9/24 , A61K33/08 , A61K33/10 , A61K33/12 , A61K9/28
CPC分类号： A61K33/08 , A61K33/10 , A61K33/12 , A61K9/209 , Y10S514/819 , Y10S514/825 , Y10S514/923
摘要： An ibuprofen-containing antipyretic analgesic preparation blending 0.01-30 parts by weight of acetaminophen based on 1 part by weight of ibuprofen, 0.05-100 parts by weight of magnesium-based antacids based on 1 part by weight of the total amount of ibuprofen and acetaminophen, and/or 0.01-30 parts by weight of at least one sedative selected from bromovalerylurea and allylisopropylacetylurea based on 1 part by weight of ibuprofen.
摘要翻译：含有布洛芬的解热镇痛制剂，混合基于1重量份布洛芬的0.01-30重量份对乙酰氨基酚，基于1重量份布洛芬和对乙酰氨基酚的总量为0.05-100重量份的镁基抗酸剂，和/或0.01-30重量份的至少一种选自溴戊烯脲和烯丙基异丙基乙酰脲的镇静剂，基于1重量份的布洛芬。

2. 发明授权

US5225587A Method of producing .alpha.-L-aspartyl-L-phenylalanine methyl ester hydrochloride 失效
标题翻译：生产α-L-天冬氨酰-L-苯丙氨酸甲酯盐酸盐的方法
公开(公告)号：US5225587A
公开(公告)日：1993-07-06
申请号：US864133
申请日：1992-04-06
申请人： Katsumi Sugiyama , Kiyo Adachi , Toshihide Yukawa
发明人： Katsumi Sugiyama , Kiyo Adachi , Toshihide Yukawa
IPC分类号： C07K5/072 , C07K5/075
CPC分类号： C07K5/0613
摘要： A method of purifying .alpha.-L-aspartyl-L-phenylalanine methyl ester as a hydrochloride salt thereof which comprises:i) contacting a mixture of .alpha.-L-aspartyl-L-phenylanaline methyl ester and .beta.-L-aspartyl-L-phenylalanine methyl ester with an aqueous medium containing (a) hydrogen chloride in an amount not more than ca. 2 mol., per liter of said aqueous medium, but not less than 1 mol., per mole of said of said mixture of .alpha.-L-aspartyl-L-phenylalanine methyl ester and .beta.-L-aspartyl-L-phenylalanine methyl ester, and (b) an inorganic chloride selected from the group consisting of NaCl, KCl, NH.sub.4 Cl, CaCl.sub.2, and ZnCl.sub.2 in an amount of at least ca. 50 g., per liter of said aqueous medium, to form crystals of .alpha.-L-aspartyl-L-phenylalanine methyl ester hydrochloride, andii) recovering the .alpha.-L-aspartyl-L-phenylalanine methyl ester hydrochloride crystals therefrom.
摘要翻译：纯化α-L-天冬氨酰基-L-苯丙氨酸甲酯盐酸盐的方法，其包括：i）使α-L-天冬氨酰基-L-苯亚胺甲酯与β-L-天冬氨酰基-L-苯丙氨酸的混合物甲酯与含有（a）氯化氢的含水介质的量不大于约每摩尔所述所述α-L-天冬氨酰基-L-苯丙氨酸甲酯和β-L-天冬氨酰-L-苯丙氨酸甲酯的混合物每升所述水性介质2摩尔，但不小于1摩尔，和（b）选自NaCl，KCl，NH 4 Cl，CaCl 2和ZnCl 2的无机氯化物，其量至少约为。 50升，每升所述水性介质中，形成α-L-天冬氨酰基-L-苯丙氨酸甲酯盐酸盐的晶体，和ii）从其中回收α-L-天冬氨酰基-L-苯丙氨酸甲酯盐酸盐晶体。

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