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2. 发明申请

US20080255182A1 Certain chemical entities, compositions, and methods 审中-公开
标题翻译：某些化学实体，组合物和方法
公开(公告)号：US20080255182A1
公开(公告)日：2008-10-16
申请号：US12007143
申请日：2008-01-07
申请人： Xiangping Qian , Andrew I. McDonald , Han-Jie Zhou , Luke W. Ashcraft , Bing Yao , Hong Jiang , Jennifer Kuo Chen Huang , Jianchao Wang , David J. Morgans , Bradley P. Morgan , Gustave Bergnes , Dashyant Dhanak , Steven D. Knight , Nicholas D. Adams , Cynthia A. Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
发明人： Xiangping Qian , Andrew I. McDonald , Han-Jie Zhou , Luke W. Ashcraft , Bing Yao , Hong Jiang , Jennifer Kuo Chen Huang , Jianchao Wang , David J. Morgans , Bradley P. Morgan , Gustave Bergnes , Dashyant Dhanak , Steven D. Knight , Nicholas D. Adams , Cynthia A. Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
IPC分类号： A61K31/437 , A61P35/00
CPC分类号： C07D233/64 , C07C235/48 , C07C235/50 , C07C235/52 , C07C237/22 , C07C255/57 , C07C255/59 , C07C255/60 , C07C257/08 , C07C257/18 , C07C259/18 , C07C271/20 , C07C271/24 , C07C271/28 , C07C275/26 , C07C275/40 , C07C275/42 , C07C281/06 , C07C307/10 , C07C311/37 , C07C311/46 , C07C2601/02 , C07C2601/14 , C07D207/273 , C07D211/34 , C07D211/76 , C07D213/30 , C07D231/12 , C07D231/14 , C07D233/61 , C07D233/70 , C07D235/06 , C07D235/16 , C07D235/18 , C07D235/26 , C07D239/36 , C07D249/08 , C07D257/04 , C07D261/08 , C07D263/10 , C07D263/12 , C07D263/32 , C07D271/06 , C07D271/07 , C07D271/10 , C07D271/113 , C07D277/30 , C07D277/42 , C07D277/56 , C07D285/02 , C07D285/125 , C07D295/145 , C07D295/155 , C07D333/38 , C07D403/10 , C07D403/12 , C07D413/06 , C07D471/04 , C07D498/04 , C07F9/6506 , C07F9/6561
摘要： Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
摘要翻译：公开了通过调节一种或多种有丝分裂驱动蛋白的活性来治疗细胞增殖性疾病和病症的化合物。

4. 发明申请

US20070079805A1 Air and fuel supply system for combustion engine operating at optimum engine speed 审中-公开
标题翻译：内燃机的空气和燃料供应系统以最佳发动机转速运转
公开(公告)号：US20070079805A1
公开(公告)日：2007-04-12
申请号：US11519227
申请日：2006-09-12
申请人： James Weber , Scott Leman , Gerald Coleman , Kevin Duffy , Eric Fluga , Jonathan Kilkenny
发明人： James Weber , Scott Leman , Gerald Coleman , Kevin Duffy , Eric Fluga , Jonathan Kilkenny
IPC分类号： F02D13/00
CPC分类号： F02B33/00 , F01L1/181 , F01L9/02 , F01L9/026 , F01L9/04 , F01L13/0015 , F01L2001/0535 , F01L2820/01 , F01N3/103 , F01N3/2073 , F01N13/009 , F01N13/011 , F01N13/10 , F01N13/107 , F01N2240/25 , F01N2570/18 , F02B3/06 , F02B29/0406 , F02B29/0412 , F02B37/00 , F02B37/004 , F02B37/013 , F02B37/025 , F02B2075/1824 , F02B2275/14 , F02B2275/32 , F02D13/0203 , F02D13/0226 , F02D13/023 , F02D13/0269 , F02D15/04 , F02D31/001 , F02D41/0007 , F02D41/0235 , F02D41/403 , F02D2041/001 , F02M21/02 , F02M26/01 , F02M26/08 , F02M26/15 , F02M26/19 , F02M26/21 , F02M26/23 , Y02A50/2325 , Y02T10/123 , Y02T10/142 , Y02T10/144 , Y02T10/146 , Y02T10/44
摘要： An engine and method of operating an internal combustion engine with either a continuously variable speed transmission or electric drive is provided. The engine and method comprises operating the engine at its optimum engine speed throughout a range of vehicle speeds through, supplying pressurized air from an intake manifold to an air intake port of a combustion chamber in the cylinder, and operating an air intake valve to open the air intake port to allow the pressurized air to flow between the combustion chamber and the intake manifold during a portion of a compression stroke of the piston. In at least one embodiment, the engine and method further comprises using a mixture of pressurized air and recirculated exhaust gas.
摘要翻译：提供了一种使用无级变速传动装置或电动驱动装置来操作内燃机的发动机和方法。发动机和方法包括通过将加压空气从进气歧管供应到气缸中的燃烧室的进气口，在整个车速范围内以最佳发动机转速操作发动机，并且操作进气阀以打开空气进入口，以在活塞的压缩冲程的一部分期间允许加压空气在燃烧室和进气歧管之间流动。在至少一个实施例中，发动机和方法还包括使用加压空气和再循环废气的混合物。

5. 发明申请

US20070006842A1 Method of transitioning between operating modes in an internal combustion engine 有权
标题翻译：内燃机运行模式之间的转换方法
公开(公告)号：US20070006842A1
公开(公告)日：2007-01-11
申请号：US11178928
申请日：2005-07-11
申请人： Mary Kesse , Kevin Duffy , Cory Brown , Roger Urven
发明人： Mary Kesse , Kevin Duffy , Cory Brown , Roger Urven
IPC分类号： F02B3/12
CPC分类号： F02M45/086 , F02D35/023 , F02D41/1446 , F02D41/3035 , F02D41/3076 , F02D41/405 , F02M61/1813 , F02M61/182 , F02M2200/46 , Y02T10/44
摘要： A method of operating an internal combustion engine is provided. The method includes injecting a first fuel charge into at least one cylinder of the engine. The method further includes determining a value indicative of at least one of a cylinder pressure and a rate of change in cylinder pressure. The method further includes injecting a second fuel charge into the at least one cylinder, upon the occurrence of a predetermined contingency, which may be a determined cylinder pressure or rate in change thereof exceeding a predetermined threshold. An internal combustion engine is further provided, including an electronic controller having a control algorithm. The control algorithm includes software for determining a value indicative of at least one of a cylinder pressure and a rate of change in cylinder pressure of at least one cylinder of the engine. The control algorithm further includes logic for transitioning a fuel injector of the engine between modes, based upon the occurrence of a predetermined contingency, which may be the determined value.
摘要翻译：提供了一种操作内燃机的方法。该方法包括将第一燃料装料喷射到发动机的至少一个气缸中。该方法还包括确定指示气缸压力和气缸压力变化率中的至少一个的值。该方法还包括在发生预定的偶然事件时将第二燃料电荷注入到所述至少一个气缸中，其可以是确定的气缸压力或其变化的速率超过预定阈值。还提供一种内燃机，包括具有控制算法的电子控制器。控制算法包括用于确定指示发动机的至少一个气缸的气缸压力和气缸压力变化率中的至少一个的值的软件。控制算法还包括用于基于预定意外事件的发生（其可以是确定的值）在模式之间转换发动机的燃料喷射器的逻辑。

6. 发明申请

US20050235950A1 Air and fuel supply system for combustion engine 审中-公开
标题翻译：内燃机空气和燃料供应系统
公开(公告)号：US20050235950A1
公开(公告)日：2005-10-27
申请号：US10992897
申请日：2004-11-19
申请人： James Weber , Scott Leman , Gerald Coleman , Kevin Duffy , Eric Fluga , Jonathan Kilkenny , Steven Tien
发明人： James Weber , Scott Leman , Gerald Coleman , Kevin Duffy , Eric Fluga , Jonathan Kilkenny , Steven Tien
IPC分类号： F01L1/34 , F01N3/023 , F01N3/035 , F01N9/00 , F01N13/02 , F01N13/10 , F02B3/00 , F02B29/04 , F02B37/013 , F02B37/02 , F02B37/18 , F02B37/22 , F02B75/02 , F02D13/02 , F02D15/04 , F02M25/07 , F02M45/04 , F02M45/08 , F02M59/46 , F02M61/20 , F02M63/00 , F02M63/02
CPC分类号： F02D13/0226 , F01L1/34 , F01L2800/11 , F01N3/0231 , F01N3/035 , F01N9/002 , F01N13/009 , F01N13/0097 , F01N13/10 , F02B29/0406 , F02B29/0418 , F02B29/0425 , F02B29/0437 , F02B37/004 , F02B37/013 , F02B37/02 , F02B37/025 , F02B37/18 , F02B37/22 , F02B2275/14 , F02D13/0203 , F02D13/0253 , F02D13/0269 , F02D15/04 , F02M26/08 , F02M26/15 , F02M26/19 , F02M26/21 , F02M26/23 , F02M26/27 , F02M26/28 , F02M45/04 , F02M45/086 , F02M47/027 , F02M59/466 , F02M61/205 , F02M63/0007 , F02M63/001 , F02M63/0015 , F02M63/0017 , F02M63/004 , F02M63/0045 , F02M63/0225 , Y02T10/123 , Y02T10/142 , Y02T10/144 , Y02T10/47
摘要： A method of operating an internal combustion engine including at least one cylinder and a piston slidable in the cylinder is provided. In at least one embodiment, the method includes: supplying a mixture of pressurized air and recirculated exhaust gas from an intake manifold to an air intake port of a combustion chamber in the cylinder; operating an air intake valve to open the air intake port to allow the pressurized air and exhaust gas mixture to flow between the combustion chamber and the intake manifold during a portion of a compression stroke of the piston; and operably controlling a fuel supply system to inject fuel into the combustion chamber via a common rail fuel injector.
摘要翻译：提供了一种操作内燃机的方法，所述内燃机包括至少一个汽缸和可在气缸中滑动的活塞。在至少一个实施例中，该方法包括：将来自进气歧管的加压空气和再循环废气的混合物供应到气缸中的燃烧室的进气口; 操作进气阀以打开进气口，以允许加压空气和废气混合物在活塞的压缩冲程的一部分期间在燃烧室和进气歧管之间流动; 以及可操作地控制燃料供应系统，以经由共轨燃料喷射器将燃料喷射到所述燃烧室中。

7. 发明申请

US20050039654A1 Selective oxygen enrichment in slagging cyclone combustors 失效
标题翻译：排渣旋风燃烧器中选择性富氧
公开(公告)号：US20050039654A1
公开(公告)日：2005-02-24
申请号：US10645101
申请日：2003-08-21
申请人： Mark D'Agostini , William Welliver , Craig Cain-Borgman , Kevin Fogash , Kevin Duffy , Francis Milcetich
发明人： Mark D'Agostini , William Welliver , Craig Cain-Borgman , Kevin Fogash , Kevin Duffy , Francis Milcetich
IPC分类号： F23C3/00 , F23D1/02 , F23J9/00 , F23L7/00 , F23D1/00
CPC分类号： F23L7/007 , F23C3/008 , F23D1/02 , F23J9/00 , F23L2900/07007 , Y02E20/344
摘要： A method for combusting a fuel in a cyclone combustor having a burner and a barrel includes: feeding a stream of the fuel into the barrel at the burner end of the barrel; feeding a stream(s) of a first oxidant (e.g., air) having a first oxygen concentration into the barrel at a first flowrate, the stream(s) of the first oxidant including a predominant stream; feeding a stream(s) of a second oxidant (e.g., oxygen) having a second oxygen concentration into the barrel at a second flowrate and in a selective manner, whereby a portion of the first oxidant combines with a portion of the second oxidant, thereby forming a combined oxidant having a combined oxygen concentration, and a portion of the first oxidant from the predominant stream continues having the first oxygen concentration; and combusting a portion of the fuel with a portion of the combined oxidant in the barrel.
摘要翻译：一种用于在具有燃烧器和桶的旋风燃烧器中燃烧燃料的方法包括：在燃烧器端部的燃烧器端部将燃料流进料到筒体中; 将具有第一氧浓度的第一氧化剂（例如空气）的流以第一流速进料到所述桶中，所述第一氧化剂的流包括主流; 将具有第二氧浓度的第二氧化剂（例如氧）的流以第二流量和选择性方式进料到筒中，由此一部分第一氧化剂与第二氧化剂的一部分组合，由此形成具有组合氧浓度的组合氧化剂，并且来自主流的第一氧化剂的一部分继续具有第一氧浓度; 并且将一部分燃料与筒中组合的氧化剂的一部分一起燃烧。

8. 发明申请

US20120283287A1 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS 审中-公开
标题翻译：某些化学实验，组合物和方法
公开(公告)号：US20120283287A1
公开(公告)日：2012-11-08
申请号：US13442688
申请日：2012-04-09
申请人： Xiangping Qian , Andrew I. McDonald , Han-Jie Zhou , Luke W. Ashcraft , Bing Yao , Hong Jiang , Jennifer Kuo Chen Huang , Jianchao Wang , David J. Morgans, JR. , Bradley P. Morgan , Gustave Bergnes , Dashyant Dhanak , Steven D. Knight , Nicholas D. Adams , Cynthia A. Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
发明人： Xiangping Qian , Andrew I. McDonald , Han-Jie Zhou , Luke W. Ashcraft , Bing Yao , Hong Jiang , Jennifer Kuo Chen Huang , Jianchao Wang , David J. Morgans, JR. , Bradley P. Morgan , Gustave Bergnes , Dashyant Dhanak , Steven D. Knight , Nicholas D. Adams , Cynthia A. Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
IPC分类号： A61K31/437 , A61P35/00
CPC分类号： C07D233/64 , C07C235/48 , C07C235/50 , C07C235/52 , C07C237/22 , C07C255/57 , C07C255/59 , C07C255/60 , C07C257/08 , C07C257/18 , C07C259/18 , C07C271/20 , C07C271/24 , C07C271/28 , C07C275/26 , C07C275/40 , C07C275/42 , C07C281/06 , C07C307/10 , C07C311/37 , C07C311/46 , C07C2601/02 , C07C2601/14 , C07D207/273 , C07D211/34 , C07D211/76 , C07D213/30 , C07D231/12 , C07D231/14 , C07D233/61 , C07D233/70 , C07D235/06 , C07D235/16 , C07D235/18 , C07D235/26 , C07D239/36 , C07D249/08 , C07D257/04 , C07D261/08 , C07D263/10 , C07D263/12 , C07D263/32 , C07D271/06 , C07D271/07 , C07D271/10 , C07D271/113 , C07D277/30 , C07D277/42 , C07D277/56 , C07D285/02 , C07D285/125 , C07D295/145 , C07D295/155 , C07D333/38 , C07D403/10 , C07D403/12 , C07D413/06 , C07D471/04 , C07D498/04 , C07F9/6506 , C07F9/6561
摘要： Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
摘要翻译：公开了通过调节一种或多种有丝分裂驱动蛋白的活性来治疗细胞增殖性疾病和病症的化合物。

9. 发明授权

US08207340B2 Imidazopyridinyl benzamide mitotic kinesin inhibitors 有权
标题翻译：咪唑并吡啶基苯甲酰胺有丝分裂驱动蛋白抑制剂
公开(公告)号：US08207340B2
公开(公告)日：2012-06-26
申请号：US12350094
申请日：2009-01-07
申请人： Xiangping Qian , Andrew I. McDonald , Han-Jie Zhou , Luke W. Ashcraft , Bing Yao , Hong Jiang , Jennifer Kuo Chen Huang , Jianchao Wang , David J. Morgans, Jr. , Bradley P. Morgan , Gustave Bergnes , Dashyant Dhanak , Steven D. Knight , Nicholas D. Adams , Cynthia A. Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
发明人： Xiangping Qian , Andrew I. McDonald , Han-Jie Zhou , Luke W. Ashcraft , Bing Yao , Hong Jiang , Jennifer Kuo Chen Huang , Jianchao Wang , David J. Morgans, Jr. , Bradley P. Morgan , Gustave Bergnes , Dashyant Dhanak , Steven D. Knight , Nicholas D. Adams , Cynthia A. Parrish , Kevin Duffy , Duke Fitch , Rosanna Tedesco
IPC分类号： C07D471/02 , A61K31/47
CPC分类号： C07D233/64 , C07C235/48 , C07C235/50 , C07C235/52 , C07C237/22 , C07C255/57 , C07C255/59 , C07C255/60 , C07C257/08 , C07C257/18 , C07C259/18 , C07C271/20 , C07C271/24 , C07C271/28 , C07C275/26 , C07C275/40 , C07C275/42 , C07C281/06 , C07C307/10 , C07C311/37 , C07C311/46 , C07C2601/02 , C07C2601/14 , C07D207/273 , C07D211/34 , C07D211/76 , C07D213/30 , C07D231/12 , C07D231/14 , C07D233/61 , C07D233/70 , C07D235/06 , C07D235/16 , C07D235/18 , C07D235/26 , C07D239/36 , C07D249/08 , C07D257/04 , C07D261/08 , C07D263/10 , C07D263/12 , C07D263/32 , C07D271/06 , C07D271/07 , C07D271/10 , C07D271/113 , C07D277/30 , C07D277/42 , C07D277/56 , C07D285/02 , C07D285/125 , C07D295/145 , C07D295/155 , C07D333/38 , C07D403/10 , C07D403/12 , C07D413/06 , C07D471/04 , C07D498/04 , C07F9/6506 , C07F9/6561
摘要： Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
摘要翻译：公开了通过调节一种或多种有丝分裂驱动蛋白的活性来治疗细胞增殖性疾病和病症的化合物。

10. 发明授权

US07661263B2 Method of operating an internal combustion engine 有权
标题翻译：操作内燃机的方法
公开(公告)号：US07661263B2
公开(公告)日：2010-02-16
申请号：US10928425
申请日：2004-08-27
申请人： Gerald N. Coleman , James J Driscoll , Kevin Duffy , Dennis L Endicott , Stephen A Faulkner , Jonathan Kilkenny , Maarten Verkiel
发明人： Gerald N. Coleman , James J Driscoll , Kevin Duffy , Dennis L Endicott , Stephen A Faulkner , Jonathan Kilkenny , Maarten Verkiel
IPC分类号： F01N3/00
CPC分类号： F02D41/3017 , F01N3/0842 , F01N3/0878 , F01N2430/06 , Y02T10/128
摘要： A method of operating an internal combustion engine includes operating the engine in a first combustion mode. The method also includes switching operation of the engine to a second combustion mode. The method includes directing an exhaust stream of the engine into contact with a NOx adsorber substantially only during the operation in the second combustion mode.
摘要翻译：一种操作内燃机的方法包括以第一燃烧模式操作发动机。该方法还包括将发动机切换到第二燃烧模式。该方法包括引导发动机的废气流基本上仅在第二燃烧模式下的操作期间与NOx吸附器接触。

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