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1. 发明申请

US20060094735A1 Compounds, compositions, and methods 有权
公开(公告)号：US20060094735A1
公开(公告)日：2006-05-04
申请号：US11262506
申请日：2005-10-27
申请人： Bainian Feng , Gustave Bergnes , David Morgans , Dashyant Dhanak , Steven Knight , Michael Darcy
发明人： Bainian Feng , Gustave Bergnes , David Morgans , Dashyant Dhanak , Steven Knight , Michael Darcy
IPC分类号： A61K31/517 , C07D403/02
CPC分类号： C07D403/06
摘要： Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.

2. 发明申请

US20050197345A1 Pyrrolidine sulfonamides 失效
标题翻译：吡咯烷磺酰胺
公开(公告)号：US20050197345A1
公开(公告)日：2005-09-08
申请号：US11119026
申请日：2005-04-29
申请人： Dashyant Dhanak , Steven Knight , Jian Jin , Ralph Rivero , Anthony Sapienza
发明人： Dashyant Dhanak , Steven Knight , Jian Jin , Ralph Rivero , Anthony Sapienza
IPC分类号： C07D409/12 , A61K31/496 , C07D49/14
CPC分类号： C07D409/12
摘要： The present invention relates to pyrrolidine sulfonamides, pharmaceutical compositions containing them and their use as urotensin II antagonists.
摘要翻译：本发明涉及吡咯烷磺酰胺，含有它们的药物组合物及其作为尿素转运蛋白II拮抗剂的用途。

3. 发明申请

US20150015028A1 DRAG MITIGATION SYSTEM FOR TRACTOR-TRAILER 审中-公开
标题翻译：拖拉机拖拉机拖拉机减速系统
公开(公告)号：US20150015028A1
公开(公告)日：2015-01-15
申请号：US14327477
申请日：2014-07-09
申请人： Steven Knight Clark
发明人： Steven Knight Clark
IPC分类号： B62D35/00
CPC分类号： B62D35/001
摘要： Disclosed herein is a vortex-generating system for a moving object that has a trailing edge. The system includes a first blade coupled to the object and positioned proximate the trailing edge, a second blade coupled to the object, positioned proximate the trailing edge, and spaced apart from the first blade. The first and second blade cooperate to induce an outwardly directed vortical flow of air away from the trailing edge of the object.
摘要翻译：本文公开了一种用于具有后缘的移动物体的涡流生成系统。该系统包括联接到物体并且靠近后缘定位的第一叶片，联接到物体的第二叶片，定位成靠近后缘并且与第一叶片间隔开。第一和第二叶片配合以引导远离物体的后缘的向外指向的空气流。

4. 发明申请

US20080053530A1 VALVE WITH FREEZE-PROOF HEATED VALVE SEAT 有权
标题翻译：阀门带防冻加热阀座
公开(公告)号：US20080053530A1
公开(公告)日：2008-03-06
申请号：US11777603
申请日：2007-07-13
申请人： Steven Knight , Timothy Neal
发明人： Steven Knight , Timothy Neal
IPC分类号： F16K49/00 , F24J3/00
CPC分类号： F16K49/002 , H01M8/04156 , H01M8/04253 , Y10T137/0318 , Y10T137/6606
摘要： A valve comprises a valve body having a fluid inlet and fluid outlet, a valve seat located in the valve body between the fluid inlet and a fluid outlet, a valve member movable towards and away from the valve seat for controlling the flow of fluid from the fluid inlet to the fluid outlet, and a PTC heater in thermal contact with the valve seat for heating the valve seat. The heater is integrated in the valve in a manner where the valve seat is used as an electrical conductor to facilitate operation and assembly of the valve, and a unique valve construction is provided for enabling self-draining to avoid accumulation of water or other liquid in the valve that might negatively impact performance of the valve.
摘要翻译：阀包括具有流体入口和流体出口的阀体，位于流体入口和流体出口之间的阀体中的阀座，可朝向和远离阀座移动的阀构件，用于控制来自流体出口的流体流动流体出口的流体入口以及与阀座热接触以加热阀座的PTC加热器。加热器集成在阀中，阀座用作电导体以便于阀的操作和组装，并且提供了独特的阀结构，用于实现自排水以避免水或其它液体的积聚阀可能会对阀门的性能产生负面影响。

5. 发明申请

US20070163947A1 Extension and Locking Assembly for Dripless Element and Container Therefore 有权
标题翻译：因此，用于无刷元件和容器的扩展和锁定组件
公开(公告)号：US20070163947A1
公开(公告)日：2007-07-19
申请号：US11668528
申请日：2007-01-30
申请人： Michael Clausen , Steven Knight , Martin Maxwell
发明人： Michael Clausen , Steven Knight , Martin Maxwell
IPC分类号： B01D27/00
CPC分类号： B01D29/21 , B01D29/96 , B01D35/147 , B01D35/30 , B01D35/31 , B01D2201/0415 , B01D2201/162 , B01D2201/301 , B01D2201/4046 , B01D2201/4084
摘要： A filter assembly includes housing enclosing a replaceable filter element. A support core is provided in the housing, and includes an extension and locking assembly. The element includes a ring of filtration media with a pair of end caps. The first end cap includes a central opening to receive the support core. The extension and locking assembly prevents the cover of the housing from being attached to the housing body without a proper filter element installed. The extension and locking assembly includes a bypass member and a locking member, which are in locking engagement when an element is absent in the housing. The second end cap includes internal protrusions which engage the locking member when the filter element is installed to disengage the bypass member from the support core, and allow the element to be inserted and the cover to be installed.
摘要翻译：过滤器组件包括包围可更换过滤元件的壳体。支撑芯设置在壳体中，并且包括延伸和锁定组件。该元件包括具有一对端盖的过滤介质环。第一端盖包括用于接收支撑芯的中心开口。延伸和锁定组件防止外壳的盖子安装到壳体上，而没有安装适当的过滤元件。延伸和锁定组件包括旁路构件和锁定构件，当外壳中不存在元件时，其处于锁定接合。第二端盖包括当安装过滤元件以使旁路构件与支撑芯脱离并允许元件被插入并且盖被安装的内部突起，其接合锁定构件。

7. 发明申请

US20070135432A1 Compounds, methods and compositions 失效
标题翻译：化合物，方法和组合物
公开(公告)号：US20070135432A1
公开(公告)日：2007-06-14
申请号：US11600683
申请日：2006-11-15
申请人： Han-Jie Zhou , David Morgans , Gustave Bergnes , Steven Knight , Kenneth Newlander , Dashyant Dhanak , Nicholas Adams
发明人： Han-Jie Zhou , David Morgans , Gustave Bergnes , Steven Knight , Kenneth Newlander , Dashyant Dhanak , Nicholas Adams
IPC分类号： C07D413/02 , C07D403/02 , A61K31/5377 , A61K31/513
CPC分类号： C07D239/36 , C07D231/12 , C07D233/56 , C07D239/47 , C07D239/91 , C07D249/08 , C07D403/06
摘要： Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.
摘要翻译：公开了通过调节KSP的活性来治疗细胞增殖性疾病和病症的化合物。

8. 发明申请

US20060094708A1 Certain chemical entities, compositions, and methods 有权
标题翻译：某些化学实体，组合物和方法
公开(公告)号：US20060094708A1
公开(公告)日：2006-05-04
申请号：US11121709
申请日：2005-05-03
申请人： Xiangping Qian , Andrew McDonald , Han-Jie Zhou , Luke Ashcraft , Bing Yao , Hong Jiang , Jennifer Chen Huang , Jianchao Wang , David Morgans , Bradley Morgan , Gustave Bergnes , Dashyant Dhanak , Steven Knight , Nicholas Adams , Cynthia Parrish
发明人： Xiangping Qian , Andrew McDonald , Han-Jie Zhou , Luke Ashcraft , Bing Yao , Hong Jiang , Jennifer Chen Huang , Jianchao Wang , David Morgans , Bradley Morgan , Gustave Bergnes , Dashyant Dhanak , Steven Knight , Nicholas Adams , Cynthia Parrish
IPC分类号： A61K31/55 , A61K31/4745 , A61K31/424 , A61K31/421 , A61K31/4196 , A61K31/4184 , C07D491/02 , C07D487/02
CPC分类号： C07D403/12 , C07C235/48 , C07C235/50 , C07C235/52 , C07C237/22 , C07C255/57 , C07C257/18 , C07C259/18 , C07C271/20 , C07C271/28 , C07C275/40 , C07C281/06 , C07C311/37 , C07C2601/14 , C07D207/273 , C07D211/76 , C07D213/30 , C07D231/12 , C07D233/62 , C07D235/18 , C07D235/26 , C07D261/08 , C07D263/10 , C07D271/06 , C07D277/56 , C07D285/02 , C07D295/155 , C07D333/38 , C07D403/10 , C07D471/04 , C07F9/6506 , C07F9/6561
摘要： Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of one or more mitotic kinesins are disclosed.
摘要翻译：公开了通过调节一种或多种有丝分裂驱动蛋白的活性来治疗细胞增殖性疾病和病症的化合物。

9. 发明申请

US20060086652A1 Filter element for keyed latch valve 有权
标题翻译：钥匙锁阀滤芯
公开(公告)号：US20060086652A1
公开(公告)日：2006-04-27
申请号：US11299137
申请日：2005-12-07
申请人： Steven Knight
发明人： Steven Knight
IPC分类号： B01D27/10
CPC分类号： F02M37/22 , B01D29/15 , B01D29/21 , B01D29/902 , B01D29/925 , B01D29/96 , B01D35/153 , B01D35/157 , B01D35/1573 , B01D35/1576 , B01D35/18 , B01D35/26 , B01D36/003 , B01D2201/162 , B01D2201/34 , B01D2201/4046 , B01D2201/4084 , F02M2037/225
摘要： A filter element removably located in a housing having a central valve structure. The element has an end cap with a valve actuating portion. The valve actuating portion includes a cylindrical portion and an annular base projecting radially inward from the cylindrical portion. The valve actuating portion includes a plurality of thin, flat keys spaced around the annular base and projecting radially inward from the cylindrical portion and axially outward from the base. The keys engage the valve structure in the housing when the element is installed, and open up a flow passage through the housing.
摘要翻译：可移除地位于具有中心阀结构的壳体中的过滤元件。该元件具有带有阀致动部分的端盖。阀致动部分包括圆柱形部分和从圆柱形部分径向向内突出的环形基部。阀致动部分包括多个薄的扁平键，其围绕环形基座间隔开并从圆柱形部分径向向内突出并且从基部轴向向外突出。当元件安装时，钥匙接合壳体中的阀结构，并且打开通过壳体的流动通道。

10. 发明申请

US20060052360A1 Compounds, compositions and methods 失效
公开(公告)号：US20060052360A1
公开(公告)日：2006-03-09
申请号：US10538228
申请日：2003-12-12
申请人： Gustave Bergnes , Dashyant Dhanak , Steven Knight , Pu Lu , David Morgans , Kenneth Newlander
发明人： Gustave Bergnes , Dashyant Dhanak , Steven Knight , Pu Lu , David Morgans , Kenneth Newlander
IPC分类号： A61K31/554 , A61K31/55 , A61K31/553 , C07D403/02 , C07D413/02 , C07D417/02
CPC分类号： C07D403/06
摘要： Compounds useful for treating cellular proliferative diseases and disorders by modulating the activity of KSP are disclosed.

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