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1. 发明申请

US20140026683A1 METHODS, APPARATUSES AND SYSTEMS FOR COLLECTION OF TISSUE SECTIONS 有权
标题翻译：方法，收集组织部分的装置和系统
公开(公告)号：US20140026683A1
公开(公告)日：2014-01-30
申请号：US13821028
申请日：2011-09-07
申请人： Kenneth Jeffrey Hayworth , Richard Schalek , Juan Carlos Tapia , Narayanan Kasthuri , Jeff Lichtman
发明人： Kenneth Jeffrey Hayworth , Richard Schalek , Juan Carlos Tapia , Narayanan Kasthuri , Jeff Lichtman
IPC分类号： A61B16/00
CPC分类号： G01N1/06 , A61B16/00 , G01N35/00009 , G01N2001/065 , G01N2001/066
摘要： Methods, apparatuses and systems for facilitating automated or semi-automated collection of tissue samples cut by a microtome. In one example, a collection apparatus may be moved back and forth between respective positions at which the collection apparatus is operatively coupled to a microtome so as to collect cut tissue samples, or routine access to the microtome is provided. Relatively easy movement and positioning of the collection apparatus is facilitated, while at the same time ensuring structural stability and appropriate alignment and/or isolation between the collection apparatus and the microtome. A fluid reservoir receives samples cut by the microtome, and the collection apparatus may collect samples via a conveyor-like substrate disposed near/in the reservoir. A linear movement of the substrate may be controlled based on a cutting rate of the microtome, and the fluid level in the reservoir may be automatically maintained to facilitate effective sample collection.
摘要翻译：用于促进由切片机切割的组织样品的自动或半自动收集的方法，装置和系统。在一个示例中，收集装置可以在收集装置可操作地耦合到切片机的各个位置之间来回移动，以便收集切割的组织样本，或者提供对切片机的常规访问。促进收集装置的相对容易的移动和定位，同时确保收集装置和切片机之间的结构稳定性和适当的对准和/或隔离。流体储存器接收由切片机切割的样品，并且收集装置可以经由设置在储存器附近的输送器状基板收集样品。可以基于切片机的切割速度来控制基底的线性运动，并且可以自动维持储存器中的液体水平以促进有效的样品收集。

2. 发明申请

US20100323445A1 METHODS, APPARATUS AND SYSTEMS FOR PRODUCTION, COLLECTION, HANDLING, AND IMAGING OF TISSUE SECTIONS 有权
标题翻译：方法，组织部分的生产，收集，处理和成像的装置和系统
公开(公告)号：US20100323445A1
公开(公告)日：2010-12-23
申请号：US12695297
申请日：2010-01-28
申请人： Kenneth Jeffrey Hayworth , Amy Au Hayworth
发明人： Kenneth Jeffrey Hayworth , Amy Au Hayworth
IPC分类号： C12N5/071
CPC分类号： G01N1/06 , G01N1/286 , G01N1/312 , G01N2001/066 , G01N2001/362 , H01J2237/201 , H01J2237/202 , H01J2237/26 , Y10T156/1052 , Y10T156/1056 , Y10T156/1057 , Y10T156/1059 , Y10T156/1062 , Y10T156/12 , Y10T156/1322 , Y10T156/1712
摘要： Methods, apparatus and systems for collecting thin tissue samples for imaging. Thin tissue sections may be cut from tissue samples using a microtome-quality knife. In one example, tissue samples are mounted to a substrate that is rotated such that thin tissue sections are acquired via lathing. Collection of thin tissue sections may be facilitated by a conveyor belt. Thin tissue sections may be mounted to a thin substrate (e.g., by adhering thin tissue sections to a thin substrate via a roller mechanism) that may be imaged, for example, by an electron beam (e.g., in an electron microscope). This tissue sections may be strengthened before cutting via a blockface thinfilm deposition technique and/or a blockface taping technique. An automated reel-to-reel imaging technique may be employed for collected/mounted tissue sections to facilitate random-access imaging of tissue sections and maintaining a comprehensive library including a large volume of samples.
摘要翻译：用于收集用于成像的薄组织样本的方法，装置和系统。可以使用切片机质量刀从组织样品切割薄组织切片。在一个实例中，将组织样品安装到旋转的基底上，使得通过车床获得薄的组织切片。通过传送带可以促进薄组织切片的收集。薄组织切片可以例如通过电子束（例如，在电子显微镜中）被安装到薄基底（例如，通过将薄组织切片通过辊机构粘附到薄基底上）。在经由块状薄膜沉积技术和/或块状胶带技术切割之前，可以加强该组织切片。可以采用自动卷线对卷成像技术来收集/安装的组织切片，以促进组织切片的随机取景成像并维持包括大量样品的综合库。

3. 发明授权

US09784648B2 Methods, apparatuses and systems for collection of tissue sections 有权
公开(公告)号：US09784648B2
公开(公告)日：2017-10-10
申请号：US13821028
申请日：2011-09-07
申请人： Kenneth Jeffrey Hayworth , Richard Schalek , Juan Carlos Tapia , Narayanan Kasthuri , Jeff Lichtman
发明人： Kenneth Jeffrey Hayworth , Richard Schalek , Juan Carlos Tapia , Narayanan Kasthuri , Jeff Lichtman
IPC分类号： G01N1/06 , A61B16/00 , G01N35/00
CPC分类号： G01N1/06 , A61B16/00 , G01N35/00009 , G01N2001/065 , G01N2001/066
摘要： Methods, apparatuses and systems for facilitating automated or semi-automated collection of tissue samples cut by a microtome. In one example, a collection apparatus may be moved back and forth between respective positions at which the collection apparatus is operatively coupled to a microtome so as to collect cut tissue samples, or routine access to the microtome is provided. Relatively easy movement and positioning of the collection apparatus is facilitated, while at the same time ensuring structural stability and appropriate alignment and/or isolation between the collection apparatus and the microtome. A fluid reservoir receives samples cut by the microtome, and the collection apparatus may collect samples via a conveyor-like substrate disposed near/in the reservoir. A linear movement of the substrate may be controlled based on a cutting rate of the microtome, and the fluid level in the reservoir may be automatically maintained to facilitate effective sample collection.

4. 发明授权

US09304067B2 Methods, apparatus and systems for production, collection, handling, and imaging of tissue sections 有权
标题翻译：组织切片的生产，收集，处理和成像的方法，装置和系统
公开(公告)号：US09304067B2
公开(公告)日：2016-04-05
申请号：US13734121
申请日：2013-01-04
申请人： Kenneth Jeffrey Hayworth , Amy Au Hayworth
发明人： Kenneth Jeffrey Hayworth , Amy Au Hayworth
IPC分类号： G01N1/06 , G01N1/28 , G01N1/36 , G01N1/31
CPC分类号： G01N1/06 , G01N1/286 , G01N1/312 , G01N2001/066 , G01N2001/362 , H01J2237/201 , H01J2237/202 , H01J2237/26 , Y10T156/1052 , Y10T156/1056 , Y10T156/1057 , Y10T156/1059 , Y10T156/1062 , Y10T156/12 , Y10T156/1322 , Y10T156/1712
摘要： Methods, apparatus and systems for collecting thin tissue samples for imaging. Thin tissue sections may be cut from tissue samples using a microtome-quality knife. In one example, tissue samples are mounted to a substrate that is rotated such that thin tissue sections are acquired via lathing. Collection of thin tissue sections may be facilitated by a conveyor belt. Thin tissue sections may be mounted to a thin substrate (e.g., by adhering thin tissue sections to a thin substrate via a roller mechanism) that may be imaged, for example, by an electron beam (e.g., in an electron microscope). Thin tissue sections may be strengthened before cutting via a blockface thinfilm deposition technique and/or a blockface taping technique. An automated reel-to-reel imaging technique may be employed for collected/mounted tissue sections to facilitate random-access imaging of tissue sections and maintaining a comprehensive library including a large volume of samples.
摘要翻译：用于收集用于成像的薄组织样本的方法，装置和系统。可以使用切片机质量刀从组织样品切割薄组织切片。在一个实例中，将组织样品安装到旋转的基底上，使得通过车床获得薄的组织切片。通过传送带可以促进薄组织切片的收集。薄组织切片可以例如通过电子束（例如，在电子显微镜中）被安装到薄基底（例如，通过将薄组织切片通过辊机构粘附到薄基底上）。在通过块状薄膜沉积技术和/或块状胶带技术切割之前可以加强薄组织切片。可以采用自动卷线对卷成像技术来收集/安装的组织切片，以促进组织切片的随机取景成像并维持包括大量样品的综合库。

5. 发明授权

US07677289B2 Methods and apparatuses for the automated production, collection, handling, and imaging of large numbers of serial tissue sections 有权
标题翻译：用于自动化生产，收集，处理和成像大量连续组织切片的方法和装置
公开(公告)号：US07677289B2
公开(公告)日：2010-03-16
申请号：US10886799
申请日：2004-07-08
申请人： Kenneth Jeffrey Hayworth , Amy Au Hayworth
发明人： Kenneth Jeffrey Hayworth , Amy Au Hayworth
IPC分类号： B65C9/04 , B65C9/06 , B65H75/00 , B32B38/04 , B32B38/10 , G01N1/06 , B65H81/02 , B65H75/04 , B32B38/18
CPC分类号： G01N1/06 , G01N1/286 , G01N1/312 , G01N2001/066 , G01N2001/362 , H01J2237/201 , H01J2237/202 , H01J2237/26 , Y10T156/1052 , Y10T156/1056 , Y10T156/1057 , Y10T156/1059 , Y10T156/1062 , Y10T156/12 , Y10T156/1322 , Y10T156/1712
摘要： An automatic taping lathe-microtome that produces a continuous ribbon of tissue by lathing an extremely thin strip off the surface of a cylindrical block containing a multitude of embedded tissue samples. Mechanisms are included for sandwiching this fragile ribbon of tissue between a pair of support tapes. Viewing holes are cut in the support tapes above and below each tissue slice such that the tapes act as slot grids allowing for direct viewing of each tissue slice in a transmission electron microscope (TEM). The resulting tissue-tape is placed on a spooling mechanism and fed into the beam of a TEM much like the film in a movie projector. This allows for random-access imaging of any section on the tape without requiring the TEM's vacuum be broken. This system is intended to give neuroscientists a tool to ultrastructure image large volumes of neural tissue and to trace multi-scale synaptic circuits.
摘要翻译：一种自动贴片车床切片机，通过从包含大量嵌入的组织样本的圆柱形块体的表面上铺下极薄的条带，产生连续的组织带。包括将这种脆弱的组织带夹在一对支撑带之间的机制。在每个组织切片上方和下方的支撑带上切割观察孔，使得带作为狭槽网格，允许在透射电子显微镜（TEM）中直接观察每个组织切片。所得到的纸巾带放置在卷绕机构上，并与电影放映机中的胶片一样进给到TEM的束中。这允许对磁带上任何部分进行随机访问成像，而不需要断开TEM的真空。该系统旨在给予神经科学家超微结构图像大量的神经组织和跟踪多尺度突触电路的工具。

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