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1. 发明专利

GB795951A A device for the preparation of legal and other documents 未知
公开(公告)号：GB795951A
公开(公告)日：1958-06-04
申请号：GB3165253
申请日：1953-11-14
申请人： HERBERT WILSON STACEY , WILLIAM KENNETH DUNCAN TAYLOR
IPC分类号： G03F1/90
摘要： 795,951. Copy-holders; stencils. STACEY. H. W., and TAYLOR, W. K. DUNCAN-. Sept. 16, 1954 [Nov. 14. 1953]. No. 31652/53. Classes 100(2) and 100(3) [Also in Group XX] A device for simplifying the preparation of legal and other documents comprises a number of rigid strips e.g. in the form of cards, slides, stencils, each of which has inscribed thereon by writing, typing, printing &c. a standard clause or clauses, and a holder in which the strips containing the required clauses can be assembled to form the required document, the strips being insertable in and removal from the holder at one end only thereof, and secured therein when assembled. In one construction, Fig. 1, simple strips 21 transparent or opaque and of plastic material are slid into a frame 20 through a slot in the bottom member of the frame and secured therein by a rod 22 and nuts 23. Various securing means are described including pins or bolts passing from back to front through the frame, or hinged bolts. Slots may be provided in the sides of the strips to receive tabs to indicate, for example, the numbers of the clauses, or the frame may have a separate marginal part 20a, Fig. 10, holding a sheet 26 for this purpose. In this construction, the frame has a solid back, and a sponge rubber strip 24 or a leaf spring is provided at the top against which the first strip impinges. A bar 27 sliding in slots 20b, 20c retains the strips. The marginal part may be formed separately and attached to the main frame. The frame may be constructed so as to hold a set of strips on both of its faces, and the strips may be formed as pockets, Fig. 11 (not shown), into which cards with the clauses thereon can be inserted. Each pocket may be divided so as to have a marginal portion. The strips may have interengaging means at their upper and lower edges. In one form, Fig. 13, (not shown), these means are constituted by a tongue on one edge and a groove on the other. A similar construction is employed for mounting the strips in the frame. Another form of tongue and groove interconnection 21d, 21e is shown in Fig. 16. In this construction each strip which is of pocket form has projections 21f at the ends engaging grooves 20f in the frame. The projections 21f may extend from both faces of the strip, the grooves 20f being suitably modified. The holder may consist of a single member with a stop at one end and locking means at the other. The strips may be blank with surfaces upon which the clauses can be written. Those containing clauses of similar type may have the same colour, the colour being varied for different types of clauses.

2. 发明专利

GB653879A Improvements in or relating to the production of fluoro- and fluorochloro carbons 未知
公开(公告)号：GB653879A
公开(公告)日：1951-05-30
申请号：GB2261848
申请日：1948-08-27
申请人： JOHN HARDIE COLLINS , KENNETH DUNCAN WADSWORTH , HARRY ROWLAND LEECH , ICI LTD
IPC分类号： C07C17/007
摘要： Fluorocarbons and/or fluorochlorocarbons are made by reacting on carbon jointly with fluorine and chlorine at above 350 DEG C. Amongst the products of reaction there are specified tetrafluorochloroethane and tetrafluorodichloroethane together with compounds such as hydrogen fluoride, carbon dioxide and silicon tetrafluoride. The reactive gases may be derived from a mixture of these gases or a compound thereof, e.g. chlorine mono- or tri-fluoride, or from mixtures of such compounds with themselves or with chlorine or fluorine. The carbon may be in the form of graphite or wood charcoal. Reactor temperatures of 500-550 DEG C. are given and the gases may be preheated. Ratios of fluorine to chlorine may be widely varied, e.g. 1 : 3 to 3 : 1 ratios are quoted, and where large proportions of chlorine are used only small amounts of tetrafluoromethane are obtained. The reactor should be made of material such as recrystalline alumina or a metal such as nickel which is resistant to reactants and products. The gases may be passed through a bed of carbon or a fluidized technique may be used. In examples: (1) fluorine and chlorine in mol. ratio of 0.9 : 1 are passed through Acheson graphite at 500 DEG C. in a stream of nitrogen products being collected in a catch-pot at 5-10 DEG C. and then in traps immersed in liquid air, the pot providing a brown resinous material, possibly a polynuclear aromatic fluorocarbon, and the traps yielding on fractionation after scrubbing with caustic soda solution the above specified compounds, mainly trifluorochloromethane and tetrafluorodichloroethane, and some heptafluorochloropropane; (2) fluorine and chlorine in a mol. ratio of 1.8 : 1 are passed through wood charcoal at 500 DEG C. in a stream of nitrogen and products isolated as in (1) save that HF is removed before the traps by NaF treatment, trifluorochloromethane and tetrafluoromethane are the chief products, and in (3) chlorine trifluoride diluted in a ratio of 1 : 3 with nitrogen is passed through artificial graphite at 500 DEG C. and products are isolated as before excess chlorine trifluoride and its derivatives being removed by scrubbing with sodium hydroxide and sulphite, the main products being trifluorochloromethane and carbon tetrafluoride.

3. 发明授权

US5190643A Water treatment device having means to count times used and limit useage 失效
标题翻译：水处理装置具有计数所用时间和限制使用的装置
公开(公告)号：US5190643A
公开(公告)日：1993-03-02
申请号：US818620
申请日：1992-01-10
申请人： J. Kenneth Duncan , Wesley A. Schroeder
发明人： J. Kenneth Duncan , Wesley A. Schroeder
IPC分类号： A47J31/60 , C02F1/00
CPC分类号： C02F1/003 , A47J31/605 , C02F2209/445 , C02F2307/04
摘要： A lid assembly for a portable water treatment device of the type including a vessel with an opened upper end and a replaceable filter cartridge adapted to be contained therein. A lid assembly is adapted to be attached to the opened upper end of the vessel above the replaceable filter cartridge and operable to monitor the number of times the water treatment device is used. The lid assembly includes a housing having a central aperture therethrough communicating with the filter cartridge. A gate member is reciprocally movable between a position closing the aperture in the housing and a position opening the aperture in the housing. In the opened position, water to be treated may be poured into the filter cartridge through the aperture. Indicator means are provided and are movable incrementally in response to movement of the gate member. The indicator means move one increment during a cyclic movement of the gate member from the closed position to the opened position and back to the closed position. Movement of the indicator is limited to a predetermined number of increments, the indicator preventing further movement of the gate member upon reaching a predetermined number of increments.
摘要翻译：一种用于便携式水处理装置的盖组件，其类型包括具有敞开的上端的容器和适于容纳在其中的可替换的滤筒。盖组件适于附接到容纳在可更换过滤器滤芯上方的敞开的上端，并可操作以监测使用水处理装置的次数。盖组件包括具有穿过与滤筒连通的中心孔的壳体。门构件在关闭壳体中的孔的位置和打开壳体中的孔的位置之间可往复移动。在打开位置，待处理的水可以通过孔倒入滤筒中。指示装置被设置并且响应于门构件的运动可以增量地移动。指示器意味着在门构件从关闭位置到打开位置的循环运动期间移动一个增量并且返回到关闭位置。指示器的移动被限制为预定数量的增量，该指示器防止门构件在达到预定数量的增量时进一步移动。

4. 发明申请

US20090215805A1 4-Heteroaryl Pyrimidine Derivatives and use thereof as Protein Kinase Inhibitors 审中-公开
标题翻译： 4-杂芳基嘧啶衍生物及其作为蛋白激酶抑制剂的用途
公开(公告)号：US20090215805A1
公开(公告)日：2009-08-27
申请号：US12083559
申请日：2006-10-09
申请人： Gavin Wood , Christopher Meades , Peter Martin Fischer , Shudong Wang , Kenneth Duncan , Daniella I. Zheleva , Campbell Mcinnes , Mark Thomas
发明人： Gavin Wood , Christopher Meades , Peter Martin Fischer , Shudong Wang , Kenneth Duncan , Daniella I. Zheleva , Campbell Mcinnes , Mark Thomas
IPC分类号： A61K31/506 , C07D239/02 , G01N33/566 , G01N33/53 , A61P25/28 , A61P3/10 , A61P35/00
CPC分类号： C07D401/14 , C07D403/04
摘要： The present invention relates to compounds of formula (I) or formula (II), or pharmaceutically acceptable salts thereof. Further aspects relate to pharmaceutical compositions comprising compounds according to the invention, and the use of said compounds in the preparation of a medicament for treating a variety of disorders, including proliferative disorders, viral disorders, stroke, etc.
摘要翻译：本发明涉及式（I）或式（II）化合物或其药学上可接受的盐。其它方面涉及包含根据本发明的化合物的药物组合物，以及所述化合物在制备用于治疗各种疾病（包括增殖性病症，病毒性疾病，中风等）的药物中的用途。

5. 发明申请

US20100292231A1 Indazole Compounds for Treating Inflammatory Disorders, Demyelinating Disorders and Cancers 审中-公开
标题翻译：用于治疗炎性疾病，脱髓鞘疾病和癌症的吲唑化合物
公开(公告)号：US20100292231A1
公开(公告)日：2010-11-18
申请号：US12698597
申请日：2010-02-02
申请人： Alfred M. Ajami , Kenneth Duncan
发明人： Alfred M. Ajami , Kenneth Duncan
IPC分类号： A61K31/5377 , C07D471/16 , A61K31/4745 , C07D413/14 , C07D401/14 , A61K31/497 , A61P35/00 , A61P29/00 , A61P11/00 , A61P17/06 , A61P31/18
CPC分类号： C07D471/16
摘要： Compounds of formula (I) or formula (Ia) and a method of treating a patient suffering from certain inflammatory disorders, demyelinating disorders, FLT3-mediated disorders, CSF-1R-mediated disorders, cancers and leukemias, comprising administering to said patient a therapeutically effective amount of a compound of formula (I) or formula (Ia) or a pharmaceutically acceptable salt thereof. Definitions for the variables are provided herein.
摘要翻译：式（I）或式（Ia）化合物和治疗患有某些炎性疾病，脱髓鞘疾病，FLT3介导的病症，CSF-1R介导的病症，癌症和白血病的患者的方法，包括向所述患者施用治疗有效量的式（I）或式（Ia）化合物或其药学上可接受的盐。变量的定义在这里提供。

6. 发明申请

US20080318954A1 Compounds 审中-公开
标题翻译：化合物
公开(公告)号：US20080318954A1
公开(公告)日：2008-12-25
申请号：US10588372
申请日：2005-02-07
申请人： Kenneth Duncan , Darren Gibson , Shudong Wang , Daniella I. Zheleva , Peter Martin Fischer
发明人： Kenneth Duncan , Darren Gibson , Shudong Wang , Daniella I. Zheleva , Peter Martin Fischer
IPC分类号： A61K31/505 , A61P19/08 , C07D401/02 , A61K31/5355 , A61K31/444 , C07D413/02 , C07D417/04
CPC分类号： C07D417/04 , C07D417/14
摘要： The present invention relates to compounds of formula (I), or a pharmaceutically acceptable salts thereof, wherein: Z1: 1 is N or CH; Z2 and Z3 are each independently N or CR7; R1, R2, R3, R4, R5, R6, and R7 are each independently H, R8, or R9; each R8 is independently a hydrocarbyl group; and each R9 is independently halo, NO2, alkoxy, CN, CF3, S03H, SO2NR10R11, S02R12, NR13R14(CH2)aCOOR15, (CH2)bCONR16R17, (CH2)cCOR18 or (CH2)dOH; a, b, c and d are each independently 0, 1 2 3 or 4; R10-18 are each independently H or alkyl; provided that when R1 and R2 are both H, Z1 is CH; or Z2 is N; or Z1 is CH and Z2 is N; and wherein the compound is other than 4-(4,5-dimethylthiazol-2-yl)-N-(3,4,5trimethoxyphenyl)-2-pyrimidineamine or 4-(5-(2-hydroxyethyl)-4-methylthiazol-2-yl)N-(3,4,5-trimethoxyphenyl)-2-pyrimidineamine. Further aspects relate to the use of compounds of formula (I) in the preparation of a medicament for treating one or more disorders selected from a proliferative disorder, a viral disorder, a CNS disorder, diabetes, stroke or alopecia.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，其中：Z1：1是N或CH; Z2和Z3各自独立地为N或CR7; R 1，R 2，R 3，R 4，R 5，R 6和R 7各自独立地为H，R 8或R 9; 每个R 8独立地是烃基; 并且每个R 9独立地为卤素，NO 2，烷氧基，CN，CF 3，SO 3 H，SO 2 NR 10 R 11，SO 2 R 12，NR 13 R 14（CH 2）a COOR 15，（CH 2）b CONR 16 R 17，（CH 2）c COR 18或（CH 2） a，b，c和d各自独立地为0，1 2 3或4; R 10-18各自独立地为H或烷基; 条件是当R1和R2都是H时，Z1是CH; 或Z2为N; 或Z 1为CH，Z 2为N; 并且其中所述化合物不是4-（4,5-二甲基噻唑-2-基）-N-（3,4,5-三甲氧基苯基）-2-嘧啶胺或4-（5-（2-羟乙基）-4-甲基噻唑-2-基）吡啶-2-基）N-（3,4,5-三甲氧基苯基）-2-嘧啶胺。其它方面涉及式（I）化合物在制备用于治疗选自增殖性病症，病毒病症，CNS病症，糖尿病，中风或脱发的一种或多种病症的药物中的用途。

7. 发明申请

US20070158083A1 Extended life system to protect a home/structure from burning in a wildfire/forest fire 审中-公开
公开(公告)号：US20070158083A1
公开(公告)日：2007-07-12
申请号：US11352089
申请日：2006-02-10
申请人： Kenneth Duncan
发明人： Kenneth Duncan
IPC分类号： A62C35/00 , A62C37/36 , A62C37/08
CPC分类号： A62C3/0214 , A62C3/0292 , A62C37/36
摘要： The Extended Life System to Protect a Home/Structure from Burning in a Wildfire/Forest Fire consists of a 1700+ gallon water tank (1), a standby generator (2) operating off a fuel supply of natural gas (17) or propane (17) a power transfer (3), a self priming water pump (4), a pressure booster (at least one, more if needed) (5), water lines (6), fixed, directional sprayer heads (7), temperature/smoke sensors (hereafter referred to as sensors) (8), a manual on/off switch (9), and an automatic on switch (10) The system will be a permanent fixture which will allow for the safety of a home/structure (hereafter referred to as structure) at all times, even if the owner of said structure is not available to turn the system on. The system will utilize the existing water supply (12) of any particular structure to keep the water tank full before and during use. It will also use the existing water supply, routed through a solenoid operated valve (20) to protect the landscape (15), and the walls (19) of the structure, if necessary. The water tank will also be kept as full as possible by the use of rain gutters (11) which will return the used water to the water tank. In the case of the stoppage of the existing water supply, this will add many hours to the operation of the unit. If there is an immanent danger of fire, and the owner of the structure is available, they will be able to turn the system on, and evacuate to safety. If the owner is NOT available, the sensors will turn on the system via the automatic switch when the fire gets close enough to trigger the sensors. If there is any loss of existing power (13) at the main service panel (16) the power transfer will automatically transfer power to the system from the generator, which will also start automatically in the event there is a power loss. Once the system is turned on, the water pump pumps the water to the pressure booster. The pressure booster is used to ensure proper pressure is maintained in order to assure proper coverage of the water. The water will cover the roof (14), enter the rain gutter, and return to the water tank.

8. 发明申请

US20050201833A1 METHOD AND APPARATUS FOR LAYING PIPE ON AN INCLINE 失效
标题翻译：方法和装置在线上安装管道
公开(公告)号：US20050201833A1
公开(公告)日：2005-09-15
申请号：US10798644
申请日：2004-03-11
申请人： Kenneth Duncan
发明人： Kenneth Duncan
IPC分类号： E03F3/06 , F16L1/028 , F16L1/12
CPC分类号： F16L1/028
摘要： A pipeline is constructed in steep terrain by digging a ditch on the incline, assembling pipe joints together adjacent a top of the incline and then lowering the assembled pipe joints down the incline through the ditch. A wheeled assembly at the lower end of the pipeline carries much of the load and rolls down the ditch as allowed by winch equipment at the top of the incline. Bearing supports are installed periodically in the ditch to support the pipeline, the supports being of a softer material than coatings on the pipe.
摘要翻译：在陡峭的地形上建造一条管道，通过在斜坡上挖沟，将管接头组装在靠近倾斜顶部的地方，然后通过沟渠将组合的管接头放下倾斜处。在管道下端的一个轮式组件承载了大量的载荷，并且在倾斜顶部的绞车设备允许的情况下将沟槽向下滚动。轴承支架周期性地安装在沟槽中以支撑管道，支撑件比管道上的涂层更柔软。

9. 发明授权

US5368384A Hand-held mixing device with heating element 失效
标题翻译：带加热元件的手持式混合装置
公开(公告)号：US5368384A
公开(公告)日：1994-11-29
申请号：US109641
申请日：1993-08-20
申请人： J. Kenneth Duncan , Mark Cartellone , Dov Glucksman
发明人： J. Kenneth Duncan , Mark Cartellone , Dov Glucksman
IPC分类号： A47J43/044 , A47J43/07 , B01F15/06
CPC分类号： A47J43/0705 , A47J43/044 , A47J2043/04427 , A47J27/004 , Y10S366/601
摘要： A hand-held mixing device comprising an electric motor, an elongated shaft extending from the motor, a housing enclosing the motor and a major portion of the shaft, a blade at the free end of the shaft, a heating element extending from the housing, the heating element formed to have at least one coil surrounding the blade, the coil being dimensioned to be spaced from the outer edge of the blade and to form a generally annular gap thereabout. The motor and heating element are electrically connectable to an electrical power source wherein the electrical power to the motor and to the heating element are independently controllable.
摘要翻译：一种手持混合装置，包括电动机，从电动机延伸的细长轴，包围电动机的壳体和轴的主要部分，在轴的自由端的叶片，从壳体延伸的加热元件，所述加热元件形成为具有围绕所述叶片的至少一个线圈，所述线圈的尺寸设计成与所述叶片的外边缘间隔开并在其周围形成大致环形的间隙。电动机和加热元件可电连接到电源，其中电动机和加热元件的电力是独立可控的。

10. 发明授权

US08404692B2 Pyrimidin-4-yl-3, 4-dihydro-2H-pyrrolo [1,2A] pyrazin-1-one compounds 有权
标题翻译：嘧啶-4-基-3,4-二氢-2H-吡咯并[1,2A]吡嗪-1-酮化合物
公开(公告)号：US08404692B2
公开(公告)日：2013-03-26
申请号：US12083534
申请日：2006-10-09
申请人： Stuart Jones , Robert Westwood , Mark Thomas , Janice McLachlan , Kenneth Duncan , Fred Scaerou , Daniella I. Zheleva
发明人： Stuart Jones , Robert Westwood , Mark Thomas , Janice McLachlan , Kenneth Duncan , Fred Scaerou , Daniella I. Zheleva
IPC分类号： A61K31/4965
CPC分类号： C07D487/04
摘要： The present invention relates to compounds of formula (I), or pharmaceutically acceptable salts thereof, wherein Z is NR11, NHCO, NHSO2, NHCH2, CH2, CH2CH2, or CH═CH; X is a hydrocarbyl group optionally substituted by one or more R12 groups; R10 and R11 are each independently II or alkyl; R1-R4 are each independently II or (CII2)mR12, where m is O, 1, 2, or 3; each R12 is independently (CH2)aR16, where each R16 is independently selected from O(CH2)bR13, R13, COR13, COOR13, CN, CONR13R14, NR13R14, NR13COR14, SR13, SOR13, SO2R13, NR13SO2R14, SO2OR13, SO2NR13R14, halogen, CF3, and NO2, and wherein each a is 0, 1, 2, or 3 and b is 0, 1, 2, or 3; R13 and R14 are each independently H or (CH2)aR15, where n is 0, 1, 2, or 3; and each R15 is independently selected from alkyl, cycloalkyl, heteroaryl, aralkyl, aryl and heterocycloalkyl, each of which may be optionally substituted by one or more substituents selected from halogen, OH, CN, COO-alkyl, aralkyl, SO2-alkyl, SO2-aryl, COOH, CO-alkyl, CO-aryl, NH2, NH-alkyl, N(alkyl)2, CF3, alkyl and alkoxy, wherein said alkyl and alkoxy groups may be further substituted by one or more OH groups. Further aspects of the invention relate to pharmaceutical compositions comprising compounds of formula I, and the use of compounds of formula (I) in the preparation of a medicament for treating a variety of disorders, including proliferative disorders, viral disorders, stroke, etc.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，其中Z为NR11，NHCO，NHSO2，NHCH2，CH2，CH2CH2或CH = CH; X是任选被一个或多个R 12基团取代的烃基; R 10和R 11各自独立地为II或烷基; R1-R4各自独立地为II或（CII2）mR12，其中m为0,1,2或3; 每个R 12独立地为（CH 2）a R 16，其中每个R 16独立地选自O（CH 2）b R 13，R 13，COR 13，COOR 13，CN，CONR 13 R 14，NR 13 R 14，NR 13 COR 14，SR 13，SOR 13，SO 2 R 13，NR 13 SO 2 R 14，SO 2 R 13，SO 2 NR 13 R 14， CF 3和NO 2，并且其中每个a是0,1,2或3，b是0,1,2或3; R 13和R 14各自独立地为H或（CH 2）a R 15，其中n为0,1,2或3; 并且每个R 15独立地选自烷基，环烷基，杂芳基，芳烷基，芳基和杂环烷基，其各自可以任选被一个或多个选自卤素，OH，CN，COO-烷基，芳烷基，SO 2 - 烷基，SO 2 - 芳基，COOH，CO-烷基，CO-芳基，NH 2，NH-烷基，N（烷基）2，CF 3，烷基和烷氧基，其中所述烷基和烷氧基可进一步被一个或多个OH基取代。本发明的其它方面涉及包含式I化合物的药物组合物，以及式（I）化合物在制备用于治疗多种病症（包括增殖性病症，病毒性疾病，中风等）的药物中的用途。

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