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1. 发明申请

US20080293830A1 Method For Activating Efferent Sympathetic Nerves Innervating Adipose Tissues To Improve Obesity And Symptoms Associated Therewith 有权
标题翻译：用于激活感染性交感神经的方法用于改善肥胖症和与之相关的症状
公开(公告)号：US20080293830A1
公开(公告)日：2008-11-27
申请号：US11751144
申请日：2007-05-21
申请人： Hideki KATAGIRI , Yoshitomo OKA , Tetsuya YAMADA , Kenji UNO
发明人： Hideki KATAGIRI , Yoshitomo OKA , Tetsuya YAMADA , Kenji UNO
IPC分类号： A61K45/00 , C12Q1/68 , A61P3/04
CPC分类号： C12N15/8509 , A01K2207/05 , A01K2267/0362 , C07K14/70567 , C12N2799/022 , C12N2799/04 , G01N2500/00 , G01N2800/042 , G01N2800/044
摘要： A method for activating an efferent sympathetic nerve innervating an adipose tissue and improving obesity-associated symptoms is provided, comprising stimulating an afferent vagal nerve from the liver without directly enhancing peroxisome proliferator-activated receptor (PPAR)-γ2 function in the liver.
摘要翻译：提供了激活支配脂肪组织并改善肥胖相关症状的传出交感神经的方法，其包括从肝脏刺激传入迷走神经，而不直接增强肝脏中的过氧化物酶体增殖物激活受体（PPAR） - 功能。

2. 发明申请

US20060187410A1 Ophthalmic lenses capable of sustained drug release and preservative solutions therefor 有权
标题翻译：能够持续释放药物的眼科镜片及其防腐溶液
公开(公告)号：US20060187410A1
公开(公告)日：2006-08-24
申请号：US10549590
申请日：2004-03-25
申请人： Takao Sato , Rei Uchida , Kenji Uno
发明人： Takao Sato , Rei Uchida , Kenji Uno
IPC分类号： G02C7/04
CPC分类号： G02B1/041 , A61F2/16 , A61F9/0017 , A61F2250/0067 , C08F230/02 , C08L43/02 , G02B1/043 , C08L33/00 , C08L2666/02
摘要： An object of the present invention is to provide a practical ophthalmic lens which has an effect of effectively retaining and sustainedly releasing a drug and has form stability before and after release of the drug, wherein the ionic polymer gel having sustained drug releasability can regulate the amount of the drug included therein, depending on the efficacy of the drug used, and storing solution for a practical ophthalmic lens. The present invention relates to a drug delivery ophthalmic lens comprising a cationic group-containing drug in the inside of a copolymer consisting of a hydrophilic monomer having a hydroxyl group in its molecule, at least one member selected from specific phosphate group-containing methacrylates a monomer having a nitrogen atom in its side chain, and a monomer copolymerizable with these components, and also relates to a drug delivery ophthalmic lens comprising an anionic group-containing drug in the inside of a copolymer consisting of a hydrophilic monomer, cationic and anionic monomers, and a monomer copolymerizable with these components, wherein the copolymer contains the anionic monomer in a ratio of 30 to 90 mol % to the cationic monomer, and also relates to storing solution for a practical ophthalmic lens.
摘要翻译：本发明的目的是提供一种实用的眼用透镜，其具有有效地保持和持续释放药物的效果，并且在药物释放之前和之后具有形式稳定性，其中具有持续药物释放性的离子聚合物凝胶可调节量包括在内的药物，取决于所用药物的功效，以及用于实际眼科镜片的储存溶液。本发明涉及一种药物输送眼用透镜，其在由分子中具有羟基的亲水性单体组成的共聚物的内部含有含阳离子基团的药物，至少一种选自特定的含磷酸酯基的甲基丙烯酸酯，单体在其侧链中具有氮原子，以及可与这些组分共聚的单体，还涉及在由亲水性单体，阳离子和阴离子单体构成的共聚物的内部含有含阴离子基团的药物的药物输送眼用透镜，和可与这些组分共聚的单体，其中共聚物含有与阳离子单体的比率为30至90mol％的阴离子单体，并且还涉及用于实际眼用透镜的溶液。

3. 发明授权

US07815895B2 Method for activating efferent sympathetic nerves innervating adipose tissues to improve obesity and symptoms associated therewith 有权
标题翻译：激活支配脂肪组织的传出交感神经以改善与之相关的肥胖和症状的方法
公开(公告)号：US07815895B2
公开(公告)日：2010-10-19
申请号：US11751144
申请日：2007-05-21
申请人： Hideki Katagiri , Yoshitomo Oka , Tetsuya Yamada , Kenji Uno
发明人： Hideki Katagiri , Yoshitomo Oka , Tetsuya Yamada , Kenji Uno
IPC分类号： A61K49/00 , G01N33/567 , C12N5/10 , C12N5/02
CPC分类号： C12N15/8509 , A01K2207/05 , A01K2267/0362 , C07K14/70567 , C12N2799/022 , C12N2799/04 , G01N2500/00 , G01N2800/042 , G01N2800/044
摘要： A method for activating an efferent sympathetic nerve innervating an adipose tissue and improving obesity-associated symptoms is provided, comprising stimulating an afferent vagal nerve from the liver without directly enhancing peroxisome proliferator-activated receptor (PPAR)-γ2 function in the liver.
摘要翻译：提供一种激活支配脂肪组织并改善肥胖相关症状的传出交感神经的方法，包括刺激来自肝脏的传入迷走神经，而不直接增强肝脏中过氧化物酶体增殖物激活受体（PPAR）-γ2功能。

4. 发明授权

US07811601B2 Ophthalmic lenses capable of sustained drug release and preservative solutions therefor 有权
标题翻译：能够持续释放药物的眼科镜片及其防腐溶液
公开(公告)号：US07811601B2
公开(公告)日：2010-10-12
申请号：US10549590
申请日：2004-03-25
申请人： Takao Sato , Rei Uchida , Kenji Uno
发明人： Takao Sato , Rei Uchida , Kenji Uno
IPC分类号： A61K9/00 , A61K9/14 , G02B1/04 , C08F30/02 , C08F130/02 , C08F230/02 , C08F12/28 , C08F20/52 , C08F20/70 , C08F22/40 , C08F120/52 , C08F120/70 , C08F122/40 , C08F220/52 , C08F222/40
CPC分类号： G02B1/041 , A61F2/16 , A61F9/0017 , A61F2250/0067 , C08F230/02 , C08L43/02 , G02B1/043 , C08L33/00 , C08L2666/02
摘要： An object of the present invention is to provide a practical ophthalmic lens which has an effect of effectively retaining and sustainedly releasing a drug and has form stability before and after release of the drug, wherein the ionic polymer gel having sustained drug releasability can regulate the amount of the drug included therein, depending on the efficacy of the drug used, and storing solution for a practical ophthalmic lens.The present invention relates to a drug delivery ophthalmic lens comprising a cationic group-containing drug in the inside of a copolymer consisting of a hydrophilic monomer having a hydroxyl group in its molecule, at least one member selected from specific phosphate group-containing methacrylates a monomer having a nitrogen atom in its side chain, and a monomer copolymerizable with these components, and also relates to a drug delivery ophthalmic lens comprising an anionic group-containing drug in the inside of a copolymer consisting of a hydrophilic monomer, cationic and anionic monomers, and a monomer copolymerizable with these components, wherein the copolymer contains the anionic monomer in a ratio of 30 to 90 mol % to the cationic monomer, and also relates to storing solution for a practical ophthalmic lens.
摘要翻译：本发明的目的是提供一种实用的眼用透镜，其具有有效地保持和持续释放药物的效果，并且在药物释放之前和之后具有形式稳定性，其中具有持续药物释放性的离子聚合物凝胶可调节量包括在内的药物，取决于所用药物的功效，以及用于实际眼科镜片的储存溶液。本发明涉及一种药物输送眼用透镜，其在由分子中具有羟基的亲水性单体组成的共聚物的内部含有含阳离子基团的药物，至少一种选自特定的含磷酸酯基的甲基丙烯酸酯，单体在其侧链中具有氮原子，以及可与这些组分共聚的单体，还涉及在由亲水性单体，阳离子和阴离子单体构成的共聚物的内部含有含阴离子基团的药物的药物输送眼用透镜，和可与这些组分共聚的单体，其中共聚物含有与阳离子单体的比率为30至90mol％的阴离子单体，并且还涉及用于实际眼用透镜的溶液。

5. 发明授权

US06699953B2 Lens made of synthetic resin and process for producing the same 失效
标题翻译：由合成树脂制成的镜片及其制造方法
公开(公告)号：US06699953B2
公开(公告)日：2004-03-02
申请号：US10296796
申请日：2002-11-26
申请人： Tatsuya Oshikiri , Yasushi Oyaizu , Kenji Uno
发明人： Tatsuya Oshikiri , Yasushi Oyaizu , Kenji Uno
IPC分类号： C08F1230
CPC分类号： C08F222/1006 , G02B1/041 , C08L33/14
摘要： The present invention provides a material for optical lenses which not only sufficiently has properties such as impact resistance and dye-affinity essential for the optical lenses but also simultaneously attains a high refractive index, a high Abbe's number and a low specific gravity, and which is photopolymerizable. The present invention further provides a lens made of a synthetic resin which is a copolymer obtained by copolymerizing a composition comprising 20 to 80% by weight of bis-2-methacryloylthioethyl sulfide represented by the following structural formula (1), 5 to 50% by weight of a bifunctional or multifunctional thiol and 0 to 75% by weight of a monomer copolymerizable with these compounds, and which has a refractive index of 1.58 or more, an Abbe's number of 35 or more and a specific gravity of 1.35 or less: CH2═C(CH3)COSCH2CH2SCH2CH2SCOC(CH3)═CH2 Structural formula (1).
摘要翻译：本发明提供了一种光学透镜的材料，其不仅具有充分地具有光学透镜所必需的抗冲击性和染料亲和性等特性，而且同时具有高的折射率，高的阿贝数和低的比重，本发明还提供一种由合成树脂制成的透镜，该透镜是通过将由以下结构式（1）表示的双-2-甲基丙烯酰硫基乙基硫醚为20〜80重量％的组合物共聚合得到的共聚物，其为5〜50 重量％的双官能或多官能硫醇和0至75重量％的可与这些化合物共聚的单体，其折射率为1.58以上，阿贝数为35以上，比重为1.35以下：

6. 发明授权

US07781536B2 Highly oxygen-permeable hydrated ocular lens 有权
标题翻译：高透氧水合眼镜
公开(公告)号：US07781536B2
公开(公告)日：2010-08-24
申请号：US11663525
申请日：2005-09-15
申请人： Takehisa Kamiya , Kazunori Kobayashi , Kenji Uno
发明人： Takehisa Kamiya , Kazunori Kobayashi , Kenji Uno
IPC分类号： C08C19/42
CPC分类号： A61L27/18 , C08F8/12 , C08F290/068 , G02B1/043 , C08L51/085 , C08L83/04 , C08F218/08 , C08F220/56 , C08F2220/1891 , C08F226/06
摘要： It is an object of the present invention to provide an ocular lens superior in the wettability of the surface thereof, hydrating properties, oxygen permeability, flexibility, elasticity, transparency and shape recoverability though it has a composition using a silicone-containing monomer. The present invention relates to a highly oxygen-permeable hydrated ocular lens obtained by saponifying a copolymer prepared from a specific both-terminal (meth)acryl polydimethylsiloxane, a vinyl carboxylate, a (meth)acrylamide type monomer, a vinyl type crosslinking agent, one or both of a (meth)acrylate having a tertiary structure and a (meth)acrylate having a cyclic structure as (meth)acrylates each having a bulky structure at its side chain and a monomer copolymerizable with these compounds.
摘要翻译：本发明的目的是提供一种眼部透镜，其表面的润湿性，水合性，透氧性，柔韧性，弹性，透明性和形状回复性优异，尽管其具有使用含硅氧烷的单体的组合物。本发明涉及通过皂化由特定的两末端（甲基）丙烯酸聚二甲基硅氧烷，羧酸乙烯酯，（甲基）丙烯酰胺型单体，乙烯基型交联剂，一种（甲基）丙烯酸酯）单体制备的共聚物而获得的高透氧性水合眼晶状体或具有三级结构的（甲基）丙烯酸酯和具有环状结构的（甲基）丙烯酸酯作为侧链具有大体积结构的（甲基）丙烯酸酯和可与这些化合物共聚的单体两者。

7. 发明授权

US06402995B1 Process for preparing polyvinyl alcohol contact lenses 失效
标题翻译：制备聚乙烯醇隐形眼镜的方法
公开(公告)号：US06402995B1
公开(公告)日：2002-06-11
申请号：US09463835
申请日：2000-01-28
申请人： Hiroki Degawa , Yuki Ikeda , Kenji Uno
发明人： Hiroki Degawa , Yuki Ikeda , Kenji Uno
IPC分类号： B29D1100
CPC分类号： C08F218/08 , B29C39/006 , B29C2035/0827 , C08F8/12 , C08F216/06 , C08F2810/20 , G02B1/043 , C08L29/04 , C08F226/06 , C08F218/10
摘要： A process for preparing crosslinked polyvinyl alcohol contact lenses through hydrolysis of a copolymer of a vinyl ester with triallyl isocyanurate, which includes preparing a mixture of 100 parts by weight of the vinyl ester with 0.05 to 5 parts by weight of the triallyl isocyanurate, filling a mold composed of a male mold and a female mold with the mixture, applying ultraviolet ray to form a lens-shaped polymer, and hydrolyzing the resultant polymer. Since this process has a lens-shaped polymer formed without machinery processings, the lens surface is not roughened and the shape stability of the completed lens in a swollen state is so good that the handleability thereof is good and the lens can be mass-prepared with equalized quality.
摘要翻译：通过乙烯基酯与三烯丙基异氰脲酸酯的共聚物的水解制备交联聚乙烯醇隐形眼镜的方法，其包括制备100重量份乙烯基酯与0.05-5重量份的三烯丙基异氰脲酸酯的混合物，填充模具由阳模和阴模与混合物组成，施加紫外线以形成透镜状聚合物，并水解所得聚合物。由于该方法具有没有机械加工形成的透镜状聚合物，所以透镜表面不会变粗糙，并且完整的透镜在溶胀状态下的形状稳定性如此良好，使得其可操作性良好并且透镜可以用质量均衡

8. 发明申请

US20080094570A1 Highly Oxygen-Permeable Hydrated Ocular Lens 有权
标题翻译：高透氧性水晶眼镜
公开(公告)号：US20080094570A1
公开(公告)日：2008-04-24
申请号：US11663525
申请日：2005-09-15
申请人： Takehisa Kamiya , Kazunori Kobayashi , Kenji Uno
发明人： Takehisa Kamiya , Kazunori Kobayashi , Kenji Uno
IPC分类号： G02C7/04
CPC分类号： A61L27/18 , C08F8/12 , C08F290/068 , G02B1/043 , C08L51/085 , C08L83/04 , C08F218/08 , C08F220/56 , C08F2220/1891 , C08F226/06
摘要： It is an object of the present invention to provide an ocular lens superior in the wettability of the surface thereof, hydrating properties, oxygen permeability, flexibility, elasticity, transparency and shape recoverability though it has a composition using a silicone-containing monomer. The present invention relates to a highly oxygen-permeable hydrated ocular lens obtained by saponifying a copolymer prepared from a specific both-terminal (meth)acryl polydimethylsiloxane, a vinyl carboxylate, a (meth)acrylamide type monomer, a vinyl type crosslinking agent, one or both of a (meth)acrylate having a tertiary structure and a (meth)acrylate having a cyclic structure as (meth)acrylates each having a bulky structure at its side chain and a monomer copolymerizable with these compounds.
摘要翻译：本发明的目的是提供一种眼部透镜，其表面的润湿性，水合性，透氧性，柔韧性，弹性，透明性和形状回复性优异，尽管其具有使用含硅氧烷的单体的组合物。本发明涉及通过皂化由特定的两末端（甲基）丙烯酸聚二甲基硅氧烷，羧酸乙烯酯，（甲基）丙烯酰胺型单体，乙烯基型交联剂，一种（甲基）丙烯酸酯）单体制备的共聚物而获得的高透氧性水合眼晶状体或具有三级结构的（甲基）丙烯酸酯和具有环状结构的（甲基）丙烯酸酯作为侧链具有大体积结构的（甲基）丙烯酸酯和可与这些化合物共聚的单体两者。

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