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1. 再颁专利

USRE29003E (R)-1-(2-furoyloxy)-3-methylbutyl-penicillin 失效
标题翻译：（R）-1-（2-呋喃氧基）-3-甲基丁基 - 青霉素
公开(公告)号：USRE29003E
公开(公告)日：1976-10-12
申请号：US619128
申请日：1975-10-02
申请人： Andre Furlenmeier , Paul Lanz , Peter Quitt , Karl Vogler, deceased , by Heinrich Vogler, heir at Law , by Niklaus Eduard Vogler, heir at Law , by Franziska Elisabeth Vogler, heir at Law
发明人： Andre Furlenmeier , Paul Lanz , Peter Quitt , Karl Vogler, deceased , by Heinrich Vogler, heir at Law , by Niklaus Eduard Vogler, heir at Law , by Franziska Elisabeth Vogler, heir at Law
IPC分类号： C07D307/24 , C07D307/68 , C07D307/84 , C07D499/00
CPC分类号： C07D499/00 , C07D307/24 , C07D307/68 , C07D307/84
摘要： Compounds represented by the following formula ##EQU1## wherein A is a substituted or unsubstituted heterocyclic radical and T is a C.sub.2 -C.sub.5 alkyl, alkenyl, cyclopropylmethyl, cyclobutylmethyl or cyclopentyl groupA process for their preparation and novel intermediates therefor are disclosed. These compounds are useful antibiotics.

2. 发明授权

US3956323A Furan, benzofuran and tetrahydrofuran carboxylic acid esters 失效
标题翻译：呋喃，苯并呋喃和四氢呋喃羧酸酯
公开(公告)号：US3956323A
公开(公告)日：1976-05-11
申请号：US494144
申请日：1974-08-02
申请人： Andre Furlenmeier , Peter Quitt , Karl Vogler , Paul Lanz
发明人： Andre Furlenmeier , Peter Quitt , Karl Vogler , Paul Lanz
IPC分类号： C07D213/79 , C07D213/89 , C07D307/24 , C07D307/68 , C07D307/84 , C07D499/60 , C07D307/56 , C07D307/85
CPC分类号： C07D213/79 , C07D213/89 , C07D307/24 , C07D307/68 , C07D307/84
摘要： Compounds represented by the following formula ##EQU1## wherein A is a substituted or unsubstituted heterocyclic radical and T is a C.sub.2 -C.sub.5 alkyl, alkenyl, cyclopropylmethyl, cyclobutylmethyl or cyclopentyl groupA process for their preparation and novel intermediates therefor are disclosed. These compounds are useful antibiotics.
摘要翻译：由下式表示的化合物S ANGLE CH 3 A-COO-CH-CO-NH-CH-CHC ANGLE |||| CH 3 TC-N-CH并行性| OCOOH其中A是取代或未取代的杂环基，T是 C 2 -C 5烷基，烯基，环丙基甲基，环丁基甲基或环戊基。其制备和新颖中间体的方法被公开。这些化合物是有用的抗生素。

3. 发明专利

AU5027172A PENICILLINS 未知
公开(公告)号：AU5027172A
公开(公告)日：1974-06-20
申请号：AU5027172
申请日：1972-12-19
申请人： ANDRE FURLENMEIER , PAUL LANZ , PETER QUITT , KARL VOGLER
发明人： FURLENMEIER ANDRE , LANZ PAUL , QUITT PETER , VOGLER KARL
IPC分类号： C07D207/32 , C07D207/327 , C07D209/18 , C07D213/55 , C07D257/04 , C07D307/54 , C07D333/24 , C07D499/00 , C07D499/60 , C07D99/16 , A61K21/00
摘要： 1353578 Penicillins F HOFFMANN-LA ROCHE & CO AG 11 Jan 1973 [12 Jan 1972] 1605/73 Headings C2A and C2C Novel penicillins having the general Formula (I) and salts thereof, wherein T is a C 2-5 alkyl group and R is a furyl, pyrrolyl, thienyl, oxazolyl, isoxazolyl, thiazolyl, pyridyl, pyrimidinyl, tetrazolyl or indolyl group, which groups R can be substituted by halogen, C 1-3 alkyl, C 1-3 alkoxy or C 1-3 alkylthio, are prepared by N-acylating 6- aminopenicillanic acid (having the carboxyl group protected) with an acid of Formula (II) wherein T and R have the aforesaid meanings, or with an N-acylating functional derivative thereof, and cleaving off the carboxyl-protecting group. The carboxyl group may be protected by saltformation or esterification. Functional derivatives of the acid (II) are, e.g. halides, azides, anhydrides, reactive esters and active amides. When the acid itself is used, a condensing agent such as dicyclohexylcarbodiimide is preferably present. The reaction is usually performed in an inert solvent. The acids of Formula (II) above, which are said to be novel, are prepared by reacting an acid of Formula (V) with the benzyl or tert. butyl ester of a compound of Formula IV in the presence of benzenesulphonyl chloride or phosgene, R and T having the aforesaid meanings, to give an ester of Formula (III) wherein B is a benzyl- or tert.butyl-protected carboxyl group and then cleaving off the protecting group, e.g. by hydrogenation or treatment with a strong acid respectively, to give the desired acid (II). The latter may be converted to the corresponding acid chloride with thionyl chloride. Examples are given for preparing the following acids (II): (R)-2-[(2-isopropyl-2H- tetrazol - 5 - yl)acetoxy] - isocaproic acid; (R)-2- [(2-thienyl)acetoxy]isocaproic acid; and (R)-2-[(3- indolyl)acetoxy]isocaproic acid. Pharmaceutical compositions having antibiotic activity against Gram-positive and -negative bacteria comprise a penicillin of Formula (I) hereinbefore or a salt or hydrate thereof, in association with a compatible pharmaceutical carrier.

4. 发明授权

US3957758A 6-Acyl derivatives of aminopenicillanic acid 失效
标题翻译：氨基苯甲酸的6-ACY衍生物
公开(公告)号：US3957758A
公开(公告)日：1976-05-18
申请号：US492947
申请日：1974-07-30
申请人： Andre Furlenmeier , Peter Quitt , Karl Vogler , Paul Lanz
发明人： Andre Furlenmeier , Peter Quitt , Karl Vogler , Paul Lanz
IPC分类号： C07D307/24 , C07D307/68 , C07D307/84 , C07D499/60 , C07D499/44
CPC分类号： C07D307/84 , C07D307/24 , C07D307/68
摘要： Compounds represented by the following formula ##EQU1## wherein A is a substituted or unsubstituted heterocyclic radical and T is a C.sub.2 -C.sub.5 alkyl, alkenyl, cyclopropylmethyl, cyclobutylmethyl or cyclopentyl groupA process for their preparation and novel intermediates therefor are disclosed. These compounds are useful antibiotics.

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