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1. 发明授权

US07537680B2 Mixing reactions by temperature gradient focusing 有权
标题翻译：通过温度梯度聚焦进行混合反应
公开(公告)号：US07537680B2
公开(公告)日：2009-05-26
申请号：US11039904
申请日：2005-01-24
申请人： David J. Ross , Michael J. Tarlov , Karin M. Balss
发明人： David J. Ross , Michael J. Tarlov , Karin M. Balss
IPC分类号： G01N27/447
CPC分类号： G01N27/44795
摘要： A method is provided for observing mixing interactions and reactions of two materials in a fluid. The method in one form provides for concentrating by balancing electrophoretic velocities of a material against the bulk flow of fluid in the presence of a temperature gradient. Using an appropriate fluid, the temperature gradient can generate a corresponding gradient in the electrophoretic velocity of the material so that the electrophoretic and bulk velocities sum to zero at a unique position and the material will be focused at that position. A second material can then be introduced into the fluid and allowed to move through and interact with the focused band of the first material. Products of the interaction can then be detected as they are focused at a different position along the gradient. The method can be adapted to study the temperature dependence of the molecular interaction.
摘要翻译：提供了一种用于观察流体中两种材料的混合相互作用和反应的方法。一种形式的方法通过在存在温度梯度的情况下将材料的电泳速度与流体的体积流平衡来提供浓缩。使用适当的流体，温度梯度可以在材料的电泳速度上产生相应的梯度，使得电泳和体积速度在独特的位置处为零，并且材料将聚焦在该位置。然后可以将第二材料引入流体并允许其移动通过并与第一材料的聚焦带相互作用。然后可以检测相互作用的产物，因为它们沿着梯度聚焦在不同的位置。该方法可用于研究分子相互作用的温度依赖性。

2. 发明授权

US07572357B2 Chiral temperature gradient focusing 失效
标题翻译：手性温度梯度聚焦
公开(公告)号：US07572357B2
公开(公告)日：2009-08-11
申请号：US11039955
申请日：2005-01-24
申请人： David J. Ross , Wyatt N. Vreeland , Karin M. Balss
发明人： David J. Ross , Wyatt N. Vreeland , Karin M. Balss
IPC分类号： G01N27/447
CPC分类号： G01N27/44795 , G01N27/44734
摘要： A method and device are provided for concentrating and separating materials in fluids within a fluidic device having a fluid conduit such as a channel or capillary. The concentration is achieved by balancing the electrophoretic velocity of a material against the bulk flow of fluid in the presence of a temperature gradient. An additive is added to the fluid which interacts with the material and which modifies the normal electrophoretic mobility of the material. Using an appropriate fluid, the temperature gradient can generate a corresponding gradient in the electrophoretic velocity so that the electrophoretic and bulk velocities sum to zero at a unique position along the conduit and the material will be focused at that position. The method and device may be adapted for use with a variety of materials including fluorescent dyes, amino acids, proteins, DNA and to concentrate a dilute material.
摘要翻译：提供了一种方法和装置，用于在具有诸如通道或毛细管的流体导管的流体装置内的流体中浓缩和分离材料。通过在存在温度梯度的情况下平衡材料的电泳速度与流体的体积流动来实现浓度。将添加剂添加到与材料相互作用并且改变材料的正常电泳迁移率的流体中。使用适当的流体，温度梯度可以产生相应的电泳速度梯度，使得电泳和体积速度在沿着导管的独特位置处总和为零，并且材料将聚焦在该位置。该方法和装置可适用于各种材料，包括荧光染料，氨基酸，蛋白质，DNA和浓缩稀释材料。

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