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1. 发明授权

US06727348B2 Compositions and methods for the diagnosis and treatment of body weight disorders, including obesity 失效
标题翻译：用于诊断和治疗体重紊乱（包括肥胖）的组合物和方法
公开(公告)号：US06727348B2
公开(公告)日：2004-04-27
申请号：US09893238
申请日：2001-06-27
申请人： Karen Moore , Deborah Lynn Nagle
发明人： Karen Moore , Deborah Lynn Nagle
IPC分类号： C07K100
CPC分类号： C07K14/47 , C07K2319/00 , C07K2319/02
摘要： The present invention relates to mammalian mahogany genes, including the human mahogany gene, which are novel genes involved in the control of mammalian body weight. The invention encompasses nucleotide sequences of the mahogany gene, host cell expression systems of the mahogany gene, and hosts which have been transformed by these expression systems, including transgenic animals. The invention also encompasses novel mahogany gene products, including mahogany proteins, polypeptides and peptides containing amino acid sequences mahogany proteins, fusion proteins of mahogany proteins polypeptides and peptides, and antibodies directed against such mahogany gene products. The present invention also relates to methods and compositions for the diagnosis and treatment of mammalian body weight disorders, including obesity, cachexia, and anorexia, and for the identification of subjects susceptible to such disorders. Further, the invention relates to methods of using the mahogany gene and gene products of the invention for the identification of compounds which modulate the expression of the mahogany gene and/or the activity of the mahogany gene product. Such compounds can be useful as therapeutic agents in the treatment of mammalian body weight disorders, including obesity, cachexia, and anorexia.
摘要翻译：本发明涉及哺乳动物红木基因，包括人类桃花心木基因，它们是参与控制哺乳动物体重的新基因。本发明包括桃花心木基因的核苷酸序列，桃花心木基因的宿主细胞表达系统以及由这些表达系统转化的宿主，包括转基因动物。本发明还包括新颖的桃花心木基因产物，包括桃花心木蛋白，多肽和含有氨基酸序列桃花心木蛋白的肽，桃花心木蛋白多肽和肽的融合蛋白，以及针对这种桃花心木基因产物的抗体。本发明还涉及用于诊断和治疗哺乳动物体重障碍（包括肥胖症，恶病质和厌食症）的方法和组合物，以及用于鉴定易受此类疾病影响的受试者。此外，本发明涉及使用本发明的桃花心木基因和基因产物来鉴定调节桃花心木基因表达的化合物和/或桃花心木基因产物的活性的方法。这些化合物可用作治疗哺乳动物体重障碍（包括肥胖症，恶病质和厌食）的治疗剂。

2. 发明授权

US5192756A Aminosterol antibiotic 失效
标题翻译：氨基甾醇抗生素
公开(公告)号：US5192756A
公开(公告)日：1993-03-09
申请号：US853634
申请日：1992-03-18
申请人： Michael Zasloff , Karen Moore , Suzanne Wehrli
发明人： Michael Zasloff , Karen Moore , Suzanne Wehrli
IPC分类号： A61K31/575 , A61K31/56 , A61P31/00 , A61P31/04 , C07J41/00
CPC分类号： C07J41/0005
摘要： An aminosterol antibiotic, (3.beta.(N-[3-aminopropyl]-1,4-butanediamine)-7.alpha.,24.zeta.-dihydroxy-5.alpha.-cholestane 24-sulfate), which can be isolated from the stomach of the common dogfish shark, Squalus acanthias, is disclosed.
摘要翻译：氨基甾醇抗生素（3β（N- [3-氨基丙基] -1,4-丁二胺）-7α，24ζ-二羟基-5α-胆甾烷24-硫酸盐），其可以从共同的胃中分离鳕鱼，Squ鱼，披露。

3. 发明授权

US08927214B2 Methods and compositions for dual extraction of protein and nucleic acid 有权
标题翻译：双重提取蛋白质和核酸的方法和组合物
公开(公告)号：US08927214B2
公开(公告)日：2015-01-06
申请号：US13450039
申请日：2012-04-18
申请人： Michele Susan Yarnall , Wenling Wang , Karen Moore , Mary Fielder
发明人： Michele Susan Yarnall , Wenling Wang , Karen Moore , Mary Fielder
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： C07K1/145 , C12N15/1003 , C12Q1/6895
摘要： The present invention provides a method of isolating nucleic acid and protein from the same biological sample, comprising, in the following order: a) disrupting the biological sample; b) contacting the disrupted biological sample of (a) with a protein lysis buffer that lacks any component that denatures or reduces protein to produce a first lysate; c) centrifuging the first lysate of (b) to produce a first supernatant containing protein and a pellet containing nucleic acid; d) removing the first supernatant of (c), thereby isolating protein from the biological sample; e) contacting the pellet of (d) with nucleic acid lysis buffer to produce a second lysate; f) centrifuging the second lysate of (e) to produce a second supernatant containing nucleic acid; and g) removing the second supernatant of (f), thereby isolating nucleic acid from the same biological sample.
摘要翻译：本发明提供了从同一生物样品中分离核酸和蛋白质的方法，其包括以下顺序：a）破坏生物样品; b）使破坏的（a）生物样品与蛋白质裂解缓冲液接触，所述蛋白质裂解缓冲液缺乏任何成分变性或降低蛋白质以产生第一裂解物的成分; c）离心（b）的第一裂解物以产生含有蛋白质的第一上清液和含有核酸的沉淀物; d）除去（c）的第一上清液，从而从生物样品中分离蛋白质; e）使（d）的沉淀与核酸裂解缓冲液接触以产生第二裂解物; f）离心（e）的第二裂解物以产生含有核酸的第二上清液; 和g）除去（f）的第二上清液，从而分离来自相同生物样品的核酸。

4. 发明申请

US20050092098A1 Pipeline including network and topology for identifying, locating and quantifying physical phenomena 失效
标题翻译：管道包括用于识别，定位和量化物理现象的网络和拓扑
公开(公告)号：US20050092098A1
公开(公告)日：2005-05-05
申请号：US10991767
申请日：2004-11-17
申请人： John Richardson , Karen Moore , Robert Carrington
发明人： John Richardson , Karen Moore , Robert Carrington
IPC分类号： G01M3/18 , G01N27/20 , G01N3/32
CPC分类号： G01N27/205 , G01M3/18
摘要： A method and system for detecting, locating and quantifying a physical phenomena such as strain or a deformation in a structure. A plurality of laterally adjacent conductors may each include a plurality of segments. Each segment is constructed to exhibit a unit value representative of a defined energy transmission characteristic. A plurality of identity groups are defined with each identity group comprising a plurality of segments including at least one segment from each of the plurality of conductors. The segments contained within an identity group are configured and arranged such that each of their associated unit values may be represented by a concatenated digit string which is a unique number relative to the other identity groups. Additionally, the unit values of the segments within an identity group maintain unique ratios with respect to the other unit values in the identity group.
摘要翻译：用于检测，定位和量化结构中的应变或变形的物理现象的方法和系统。多个横向相邻的导体可以各自包括多个段。每个段被构造为表现出代表定义的能量传输特性的单位值。多个身份组被定义为每个身份组包括多个段，其包括来自多个导体中的每一个的至少一个段。包含在身份组内的段被配置和排列成使得它们的相关单位值中的每一个可以由连接的数字串表示，该数字串是相对于其他身份组的唯一编号。另外，身份组中段的单位值相对于身份组中的其他单位值保持唯一的比率。

5. 发明申请

US20090254398A1 Computer system for managing orders for and deliveries of goods 有权
标题翻译：用于管理货物订单和运送的计算机系统
公开(公告)号：US20090254398A1
公开(公告)日：2009-10-08
申请号：US12143620
申请日：2008-06-20
申请人： Bruce Smith , Chuck Hamilton , Stephen D. Osborne , Tony E. Gomes , Kathy Howell , Steven M. Bailey , Anthony Rivalsky , Don Edwards , Eric Wehrley , Al Ortlepp , Nina Bryson , Mark Seraydarian , Sammy Tom , Jim Dromey , Karen Moore , Kathy Kamiya , Sandy Bustillos , Sue Trainoff , Karen Patterson , Yukio Sato , Renee Neighbours , Suzanne Li , Adrian Reilly , Daniel Tan , Ping Kao , Cathy Brady , Grace Tachibana , Homs Lee , Amit Bagade , Nagesh Tavarageri , Simin Mofidi
发明人： Bruce Smith , Chuck Hamilton , Stephen D. Osborne , Tony E. Gomes , Kathy Howell , Steven M. Bailey , Anthony Rivalsky , Don Edwards , Eric Wehrley , Al Ortlepp , Nina Bryson , Mark Seraydarian , Sammy Tom , Jim Dromey , Karen Moore , Kathy Kamiya , Sandy Bustillos , Sue Trainoff , Karen Patterson , Yukio Sato , Renee Neighbours , Suzanne Li , Adrian Reilly , Daniel Tan , Ping Kao , Cathy Brady , Grace Tachibana , Homs Lee , Amit Bagade , Nagesh Tavarageri , Simin Mofidi
IPC分类号： G06Q10/00 , G06Q30/00 , G06Q50/00 , G06N5/02
CPC分类号： G06Q10/087 , G06Q10/083 , G06Q30/0601
摘要： A computer system may manage orders for goods from a plurality of purchasers. The computer system may receive the orders, calculate an approximate volume that the goods which are the subject of each order would collectively occupy during shipment, and compare each calculated approximate volume to a pre-determine maximum allowed volume that the purchaser of the order is permitted. The computer system may accept each order whose approximate volume does not exceed the maximum allowed volume for the purchaser of the order, or reject each order whose approximate volume exceeds this maximum allowed volume.
摘要翻译：计算机系统可以管理来自多个购买者的商品的订单。计算机系统可以接收订单，计算作为每个订单的主体的商品在装运期间将共同占据的大致量，并且将每个计算出的大约体积与允许购买者允许的预定最大允许体积进行比较。计算机系统可以接受大致音量不超过订单购买者的最大允许音量的每个订单，或拒绝大约音量超过此最大允许音量的每个订单。

6. 发明申请

US20050097965A1 Structures including network and topology for identifying, locating and quantifying physical phenomena 失效
标题翻译：包括用于识别，定位和量化物理现象的网络和拓扑结构
公开(公告)号：US20050097965A1
公开(公告)日：2005-05-12
申请号：US10992440
申请日：2004-11-17
申请人： John Richardson , Karen Moore , Robert Carrington
发明人： John Richardson , Karen Moore , Robert Carrington
IPC分类号： G01M3/18 , G01N27/20 , G01N3/32
CPC分类号： G01N27/205 , G01M3/18
摘要： A method and system for detecting, locating and quantifying a physical phenomena such as strain or a deformation in a structure. A plurality of laterally adjacent conductors may each include a plurality of segments. Each segment is constructed to exhibit a unit value representative of a defined energy transmission characteristic. A plurality of identity groups are defined with each identity group comprising a plurality of segments including at least one segment from each of the plurality of conductors. The segments contained within an identity group are configured and arranged such that each of their associated unit values may be represented by a concatenated digit string which is a unique number relative to the other identity groups. Additionally, the unit values of the segments within an identity group maintain unique ratios with respect to the other unit values in the identity group.
摘要翻译：用于检测，定位和量化结构中的应变或变形的物理现象的方法和系统。多个横向相邻的导体可以各自包括多个段。每个段被构造为表现出代表定义的能量传输特性的单位值。多个身份组被定义为每个身份组包括多个段，其包括来自多个导体中的每一个的至少一个段。包含在身份组内的段被配置和排列成使得它们的相关单位值中的每一个可以由连接的数字串表示，该数字串是相对于其他身份组的唯一编号。另外，身份组中段的单位值相对于身份组中的其他单位值保持唯一的比率。

7. 发明授权

US06274339B1 Methods and compositions for the diagnosis and treatment of body weight disorders, including obesity 失效
标题翻译：用于诊断和治疗体重障碍的方法和组合物，包括肥胖症
公开(公告)号：US06274339B1
公开(公告)日：2001-08-14
申请号：US09245041
申请日：1999-02-05
申请人： Karen Moore , Deborah Lynn Nagle
发明人： Karen Moore , Deborah Lynn Nagle
IPC分类号： A01K67027
CPC分类号： C07K14/47 , C07K2319/00 , C07K2319/02
摘要： The present invention relates to mammalian mahogany genes, including the human mahogany gene, which are novel genes involved in the control of mammalian body weight. The invention encompasses nucleotide sequences of the mahogany gene, host cell expression systems of the mahogany gene, and hosts which have been transformed by these expression systems, including transgenic animals. The invention also encompasses novel mahogany gene products, including mahogany proteins, polypeptides and peptides containing amino acid sequences mahogany proteins, fusion proteins of mahogany proteins polypeptides and peptides, and antibodies directed against such mahogany gene products. The present invention also relates to methods and compositions for the diagnosis and treatment of mammalian body weight disorders, including obesity, cachexia, and anorexia, and for the identification of subjects susceptible to such disorders. Further, the invention relates to methods of using the mahogany gene and gene products of the invention for the identification of compounds which modulate the expression of the mahogany gene and/or the activity of the mahogany gene product. Such compounds can be useful as therapeutic agents in the treatment of mammalian body weight disorders, including obesity, cachexia, and anorexia.
摘要翻译：本发明涉及哺乳动物红木基因，包括人类桃花心木基因，它们是参与控制哺乳动物体重的新基因。本发明包括桃花心木基因的核苷酸序列，桃花心木基因的宿主细胞表达系统以及由这些表达系统转化的宿主，包括转基因动物。本发明还包括新颖的桃花心木基因产物，包括桃花心木蛋白，多肽和含有氨基酸序列桃花心木蛋白的肽，桃花心木蛋白多肽和肽的融合蛋白，以及针对这种桃花心木基因产物的抗体。本发明还涉及用于诊断和治疗哺乳动物体重障碍（包括肥胖症，恶病质和厌食症）的方法和组合物，以及用于鉴定易受此类疾病影响的受试者。此外，本发明涉及使用本发明的桃花心木基因和基因产物来鉴定调节桃花心木基因表达的化合物和/或桃花心木基因产物的活性的方法。这些化合物可用作治疗哺乳动物体重障碍（包括肥胖症，恶病质和厌食）的治疗剂。

8. 发明授权

US08341091B2 Computer system for managing orders for and deliveries of goods 有权
标题翻译：用于管理货物订单和运送的计算机系统
公开(公告)号：US08341091B2
公开(公告)日：2012-12-25
申请号：US12143620
申请日：2008-06-20
申请人： Bruce Smith , Chuck Hamilton , Stephen D. Osborne , Tony E. Gomes , Kathy Howell , Steven M. Bailey , Anthony Rivalsky , Don Edwards , Eric Wehrley , Al Ortlepp , Nina Bryson , Mark Seraydarian , Sammy Tom , Jim Dromey , Karen Moore , Kathy Kamiya , Sandy Bustillos , Sue Trainoff , Karen Patterson , Yukio Sato , Renee Neighbours , Suzanne Li , Adrian Reilly , Daniel Tan , Ping Kao , Cathy Brady , Grace Tachibana , Homs Lee , Amit Bagade , Nagesh Tavarageri , Simin Mofidi
发明人： Bruce Smith , Chuck Hamilton , Stephen D. Osborne , Tony E. Gomes , Kathy Howell , Steven M. Bailey , Anthony Rivalsky , Don Edwards , Eric Wehrley , Al Ortlepp , Nina Bryson , Mark Seraydarian , Sammy Tom , Jim Dromey , Karen Moore , Kathy Kamiya , Sandy Bustillos , Sue Trainoff , Karen Patterson , Yukio Sato , Renee Neighbours , Suzanne Li , Adrian Reilly , Daniel Tan , Ping Kao , Cathy Brady , Grace Tachibana , Homs Lee , Amit Bagade , Nagesh Tavarageri , Simin Mofidi
IPC分类号： G06Q30/00 , G06Q10/00 , G06G1/14 , G06F17/00
CPC分类号： G06Q10/087 , G06Q10/083 , G06Q30/0601
摘要： A computer system may manage orders for goods from a plurality of purchasers. The computer system may receive the orders, calculate an approximate volume that the goods which are the subject of each order would collectively occupy during shipment, and compare each calculated approximate volume to a pre-determine maximum allowed volume that the purchaser of the order is permitted. The computer system may accept each order whose approximate volume does not exceed the maximum allowed volume for the purchaser of the order, or reject each order whose approximate volume exceeds this maximum allowed volume.
摘要翻译：计算机系统可以管理来自多个购买者的商品的订单。计算机系统可以接收订单，计算作为每个订单的主体的商品在装运期间将共同占据的大致量，并且将每个计算出的大约体积与允许购买者允许的预定最大允许体积进行比较。计算机系统可以接受大致音量不超过订单购买者的最大允许音量的每个订单，或拒绝大约音量超过此最大允许音量的每个订单。

9. 发明申请

US20070218198A1 METHODS FOR COATING CONDUIT INTERIOR SURFACES UTILIZING A THERMAL SPRAY GUN WITH EXTENSION ARM 失效
标题翻译：使用扩展臂涂覆热喷枪的管道内部表面的方法
公开(公告)号：US20070218198A1
公开(公告)日：2007-09-20
申请号：US11122164
申请日：2005-05-03
申请人： Karen Moore , Raymond Zatorski
发明人： Karen Moore , Raymond Zatorski
IPC分类号： B05D7/22 , B05D1/08
CPC分类号： C23C4/14 , C23C4/12 , C23C4/16 , F16L58/1027 , Y02T50/67
摘要： Systems and methods for applying a coating to an interior surface of a conduit. In one embodiment, a spray gun configured to apply a coating is attached to an extension arm which may be inserted into the bore of a pipe. The spray gun may be a thermal spray gun adapted to apply a powder coating. An evacuation system may be used to provide a volume area of reduced air pressure for drawing overspray out of the pipe interior during coating. The extension arm as well as the spray gun may be cooled to maintain a consistent temperature in the system, allowing for more consistent coating.
摘要翻译：将涂层施加到导管的内表面的系统和方法。在一个实施例中，构造成施加涂层的喷枪附接到可插入管的孔中的延伸臂上。喷枪可以是适用于施加粉末涂层的热喷枪。排气系统可以用于提供减小的空气压力的体积面积，以便在涂覆期间将过量喷射出管道内部。延伸臂和喷枪可以被冷却以保持系统中一致的温度，从而允许更一致的涂层。

10. 发明授权

US06713277B1 Methods and composition for the diagnosis and treatment of body weight disorders, including obesity 失效
标题翻译：用于诊断和治疗体重紊乱（包括肥胖）的方法和组成
公开(公告)号：US06713277B1
公开(公告)日：2004-03-30
申请号：US09358055
申请日：1999-07-21
申请人： Karen Moore , Deborah Lynn Nagle
发明人： Karen Moore , Deborah Lynn Nagle
IPC分类号： C12P2106
CPC分类号： C07K14/47 , C07K2319/00 , C07K2319/02
摘要： The present invention relates to mammalian mahogany genes, including the human mahogany gene, which are novel genes involved in the control of mammalian body weight. The invention encompasses nucleotide sequences of the mahogany gene, host cell expression systems of the mahogany gene, and hosts which have been transformed by these expression systems, including transgenic animals. The invention also encompasses novel mahogany gene products, including mahogany proteins, polypeptides and peptides containing amino acid sequences mahogany proteins, fusion proteins of mahogany proteins polypeptides and peptides, and antibodies directed against such mahogany gene products. The present invention also relates to methods and compositions for the diagnosis and treatment of mammalian body weight disorders, including obesity, cachexia, and anorexia, and for the identification of subjects susceptible to such disorders. Further, the invention relates to methods of using the mahogany gene and gene products of the invention for the identification of compounds which modulate the expression of the mahogany gene and/or the activity of the mahogany gene product. Such compounds can be useful as therapeutic agents in the treatment of mammalian body weight disorders, including obesity, cachexia, and anorexia.
摘要翻译：本发明涉及哺乳动物红木基因，包括人类桃花心木基因，它们是参与控制哺乳动物体重的新基因。本发明包括桃花心木基因的核苷酸序列，桃花心木基因的宿主细胞表达系统以及由这些表达系统转化的宿主，包括转基因动物。本发明还包括新颖的桃花心木基因产物，包括桃花心木蛋白，多肽和含有氨基酸序列桃花心木蛋白的肽，桃花心木蛋白多肽和肽的融合蛋白，以及针对这种桃花心木基因产物的抗体。本发明还涉及用于诊断和治疗哺乳动物体重障碍（包括肥胖症，恶病质和厌食症）的方法和组合物，以及用于鉴定易受此类疾病影响的受试者。此外，本发明涉及使用本发明的桃花心木基因和基因产物来鉴定调节桃花心木基因表达的化合物和/或桃花心木基因产物的活性的方法。这些化合物可用作治疗哺乳动物体重障碍（包括肥胖症，恶病质和厌食）的治疗剂。

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