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1. 发明申请

WO2005070490A3 COMPOSITE OPHTHALMIC MICROCANNULA 审中-公开
标题翻译：复合光学微孔
公开(公告)号：WO2005070490A3
公开(公告)日：2005-10-13
申请号：PCT/US2005002603
申请日：2005-01-24
申请人： ISCIENCE SURGICAL CORP , CHRISTIAN JEFFREY , CONSTON STANLEY R , KUPIECKI DAVID J , MCKENZIE JOHN
发明人： CHRISTIAN JEFFREY , CONSTON STANLEY R , KUPIECKI DAVID J , MCKENZIE JOHN
IPC分类号： A61B3/00 , A61B17/34 , A61F9/007 , A61M25/00 , A61M27/00
CPC分类号： A61F9/00781 , A61B3/0008 , A61B17/3421 , A61F9/007 , A61M25/005 , A61M2025/0042
摘要： Microcannulae are constructed with multiple components in a composite design, allowing the microcannulae to have varying mechanical and delivery properties that will enable ophthalmic treatments by minimally invasive means. The microcannula includes at least one flexible, tubular communicating element (9) with an outer diameter of 350 microns or less, a proximal connector for introduction of materials, energy or tools. It may also include a reinforcing member attached to the communicating element, which may be designed to create variable stiffness along the length of the microcannula. The microcannula may also include other features such as a signal beacon near the distal tip.
摘要翻译：微复合体以复合设计的多个组分构成，允许微囊具有不同的机械和递送特性，其将通过微创手段实现眼科治疗。微型插管包括至少一个具有350微米或更小外径的柔性管状连通元件（9），用于引入材料，能量或工具的近端连接件。其还可以包括附接到连通元件的加强构件，该加强构件可被设计成沿着微型插管的长度产生可变的刚度。微型插管还可以包括其他特征，例如靠近远端的信号信标。

2. 发明申请

WO2011082287A1 IMPLANT SYSTEMS WITH TENSIONING FEEDBACK 审中-公开
标题翻译：具有张紧反馈的植入系统
公开(公告)号：WO2011082287A1
公开(公告)日：2011-07-07
申请号：PCT/US2010/062477
申请日：2010-12-30
申请人： AMS RESEARCH CORPORATION , KHAMIS, Chaouki, A. , WIGNALL, Shawn, M. , KUPIECKI, David, J.
发明人： KHAMIS, Chaouki, A. , WIGNALL, Shawn, M. , KUPIECKI, David, J.
IPC分类号： A61F2/00
CPC分类号： A61F2/0045 , A61F2250/0097
摘要： Pelvic or other types of implants are provided that can include tensioning feedback components or portions, such as color changing polymer materials, such as polyacetylene. The color changing polymer can be included with, coated on or otherwise provided with a portion of slings or implant devices to provide targeted feedback to the user or physician of the tension applied to a particular device. A first color can be used to indicate a first (initial) tension or compression stage, and a second color can be used to indicate tensioning of the device beyond a predefined threshold.
摘要翻译：提供骨盆或其他类型的植入物，其可以包括张紧反馈组分或部分，例如变色聚合物材料，例如聚乙炔。变色聚合物可以包括在其中，涂覆或以其他方式设置有一部分吊索或植入装置，以向用户或医师提供施加到特定装置的张力的目标反馈。第一颜色可用于指示第一（初始）张力或压缩级，并且第二颜色可用于指示装置的张紧超出预定义的阈值。

3. 发明申请

WO2006066103B1 OPHTHALMIC IMPLANT FOR TREATMENT OF GLAUCOMA 审中-公开
标题翻译：用于治疗玻璃体的OPHTHALMIC植入物
公开(公告)号：WO2006066103B1
公开(公告)日：2006-10-26
申请号：PCT/US2005045675
申请日：2005-12-16
申请人： ISCIENCE SURGICAL CORP , STEGMANN ROBERT , CONSTON STANLEY R , KUPIECKI DAVID J , MCKENZIE JOHN , PINSON CANDICE D , YAMAMOTO RONALD
发明人： STEGMANN ROBERT , CONSTON STANLEY R , KUPIECKI DAVID J , MCKENZIE JOHN , PINSON CANDICE D , YAMAMOTO RONALD
IPC分类号： A61F9/007
CPC分类号： A61F9/00781
摘要： An implant (11) is placed within Schlemm's canal of the eye and provides tension to the trabecular meshwork. The tension (12) is continuous and increases the aqueous outflow without the necessity of administering cholinergic drugs to treat glaucoma.
摘要翻译：植入物（11）放置在眼睛的施莱姆（Schlemm）运河内，为小梁网提供张力。张力（12）是连续的，并且增加水流出物，而不需要施用胆碱能药物治疗青光眼。

4. 发明申请

WO2002074380A1 CATHETER SHAFT 审中-公开
标题翻译：导管轴
公开(公告)号：WO2002074380A1
公开(公告)日：2002-09-26
申请号：PCT/US2002/008311
申请日：2002-03-18
申请人： LUMEND, INC. , SPARKS, Kurt, D. , KUPIECKI, David, J. , DELL, Kent, D.
发明人： SPARKS, Kurt, D. , KUPIECKI, David, J. , DELL, Kent, D.
IPC分类号： A61M25/00
CPC分类号： A61M25/0043 , A61M25/0009 , A61M25/0045 , A61M2025/006
摘要： A catheter instrument having a shaft for use in small openings where enhanced longitudinal dimensional stability and compressive loading characteristics are desirable. Various embodiments may be shafts of catheters used to treat peripheral vasculatures or coronary vasculatures. Embodiment of the catheter shaft provide enhanced longitudinal dimensional stability and compressive loading characteristics, while maintaining flexibility under loading conditions. In one embodiment, a catheter shaft (100) includes an outer catheter shaft (102) with a lumen therethrough, and an annular compression spring (106) inside the outer catheter shaft (102). Also included is an actuation member (110) inside the annular compression spring (106), wherein the actuation member (110) actuates a working element at a distal end of the catheter.
摘要翻译：具有用于小开口的轴的导管器械，其中需要增强的纵向尺寸稳定性和压缩载荷特性。各种实施例可以是用于治疗外周脉管系统或冠状动脉脉管系统的导管的轴。导管轴的实施例提供增强的纵向尺寸稳定性和压缩载荷特性，同时在加载条件下保持柔性。在一个实施例中，导管轴（100）包括具有穿过其中的内腔的外导管轴（102）和在外导管轴（102）内部的环形压缩弹簧（106）。还包括在环形压缩弹簧（106）内部的致动构件（110），其中致动构件（110）致动导管远端处的工作元件。

5. 发明申请

WO2009038781A4 PELVIC FLOOR TREATMENTS AND RELATED TOOLS AND IMPLANTS 审中-公开
公开(公告)号：WO2009038781A4
公开(公告)日：2009-03-26
申请号：PCT/US2008/010926
申请日：2008-09-19
申请人： AMS RESEARCH CORPORATION , KHAMIS, Chaouki Ahmad , KUPIECKI, David J. , O'HERN, Jeffrey M. , WIGNALL, Sean Michael
发明人： KHAMIS, Chaouki Ahmad , KUPIECKI, David J. , O'HERN, Jeffrey M. , WIGNALL, Sean Michael
IPC分类号： A61F2/00
摘要： Described are implants, tools, and methods useful for treating pelvic conditions such as prolapse, by placing an implant to support pelvic tissue, the implants, tools, and methods involving one or more of an insertion tool that works in coordination with a sheath, adjusting engagements, specific implants and pieces of implants, placement of implants at locations within the pelvic region, and insertion, adjusting, and grommet management tools.

6. 发明申请

WO2009038781A1 PELVIC FLOOR TREATMENTS AND RELATED TOOLS AND IMPLANTS 审中-公开
标题翻译：皮肤地板处理及相关工具和植入物
公开(公告)号：WO2009038781A1
公开(公告)日：2009-03-26
申请号：PCT/US2008010926
申请日：2008-09-19
申请人： AMS RES CORP , KHAMIS CHAOUKI AHMAD , KUPIECKI DAVID J , O'HERN JEFFREY M , WIGNALL SEAN MICHAEL
发明人： KHAMIS CHAOUKI AHMAD , KUPIECKI DAVID J , O'HERN JEFFREY M , WIGNALL SEAN MICHAEL
IPC分类号： A61F2/00
CPC分类号： A61F2/0063 , A61B17/00234 , A61B17/0401 , A61B17/3468 , A61B2017/00805 , A61B2017/0409 , A61B2017/0412 , A61B2017/0427 , A61B2017/0464 , A61B2090/0801 , A61B2090/08021 , A61F2/0045 , A61F2002/0072
摘要： Described are implants, tools, and methods useful for treating pelvic conditions such as prolapse, by placing an implant to support pelvic tissue, the implants, tools, and methods involving one or more of an insertion tool that works in coordination with a sheath, adjusting engagements, specific implants and pieces of implants, placement of implants at locations within the pelvic region, and insertion, adjusting, and grommet management tools.
摘要翻译：描述了可用于治疗盆腔状况的植入物，工具和方法，例如通过放置植入物来支撑骨盆组织，植入物，工具和涉及一种或多种与护套配合工作的插入工具的方法来调节接合，特定植入物和植入物，植入物在骨盆区域内的位置，以及插入，调整和护环管理工具。

7. 发明申请

WO2005069831A2 INJECTOR FOR VISCOUS MATERIALS 审中-公开
标题翻译：注射器粘胶材料
公开(公告)号：WO2005069831A2
公开(公告)日：2005-08-04
申请号：PCT/US2005/001123
申请日：2005-01-12
申请人： ISCIENCE SURGICAL CORPORATION , MCKENZIE, John, R. , CONSTON, Stanley, R. , KUPIECKI, David, J.
发明人： MCKENZIE, John, R. , CONSTON, Stanley, R. , KUPIECKI, David, J.
IPC分类号： A61F9/00 , A61M5/145 , A61M5/168 , A61M5/315 , A61M37/00
CPC分类号： A61M5/1456 , A61F9/0017 , A61M5/16854 , A61M5/31511 , A61M5/31586 , A61M5/486
摘要： An injector is provided to deliver microquantities of viscous materials into the body, such as the eye, for surgical purposes. The injector comprises a syringe body with a plunger disposed therein coupled to a positive displacement mechanism capable of progressively advancing the plunger to precisely deliver microquantities of materials at a constant or predetermined delivery rate.
摘要翻译：提供注射器用于将粘性物质的微量量输送到体内，例如眼睛，用于外科用途。注射器包括注射器本体，其中设置有柱塞，其联接到能够逐渐前进柱塞的正位移机构，以以恒定或预定的输送速率精确地输送材料的微量。

8. 发明申请

WO0245598A3 CATHETER SYSTEM FOR VASCULAR RE-ENTRY FROM A SUB-INTIMAL SPACE 审中-公开
标题翻译：用于从次生空间进行血管再通的导管系统
公开(公告)号：WO0245598A3
公开(公告)日：2003-01-16
申请号：PCT/US0146871
申请日：2001-12-05
申请人： LUMEND INC , SPARKS KURT D , EMERY JEFFREY L , SEYBOLD BRENT D , KUPIECKI DAVID J , PINSON C DANIELLE , MADSEN ALLEN W , KELEHER MICHAEL D , SALINAS SERGIO , CLARK BENJAMIN J , SELMON MATTHEW R
发明人： SPARKS KURT D , EMERY JEFFREY L , SEYBOLD BRENT D , KUPIECKI DAVID J , PINSON C DANIELLE , MADSEN ALLEN W , KELEHER MICHAEL D , SALINAS SERGIO , CLARK BENJAMIN J , SELMON MATTHEW R
IPC分类号： A61B17/00 , A61B17/22 , A61B19/00
CPC分类号： A61B17/320783 , A61B17/3207 , A61B90/37 , A61B2017/00252 , A61B2017/22077 , A61B2017/22094 , A61B2017/22095 , A61B2090/378 , A61B2090/3782
摘要： A catheter system and corresponding methods are provided for accessing a blood vessel true lumen from a suub-intimal plane of the vessel. The catheter system includes visualiation elements for determining the orientation of the true lumen with respect to the sub-intimal plane at an identified entry site from a position in the sub-intimal plane. The entry site is distal to a chronic total occlusion (CTO). The catheter system also includes a system for physically securing tissue of the sub-intimal plane at the entry site to the catheter system. The attaching system reduces or eliminates catheter float within the sub-intimal space. The catheter system further includes re-entry devices to establish and maintain a path from the sub-intimal plane back into the vessel true lumen.
摘要翻译：提供了一种导管系统和相应的方法，用于从血管的内膜面进入血管真腔。导管系统包括可视化元件，用于确定在从内 - 内平面中的位置确定的进入位置处的真腔与相对于内 - 内平面的取向。进入部位远端是慢性全闭塞（CTO）。该导管系统还包括用于物理地将导管系统入口处的亚 - 内膜平面的组织固定的系统。附着系统减少或消除了内膜内空间内的导管浮子。导管系统还包括重建装置，用于建立和维持从内 - 内膜平面返回血管真腔的路径。

9. 发明申请

WO2011053512A1 APPARATUS AND METHOD FOR OCULAR TREATMENT 审中-公开
标题翻译：用于眼科治疗的装置和方法
公开(公告)号：WO2011053512A1
公开(公告)日：2011-05-05
申请号：PCT/US2010/053599
申请日：2010-10-21
申请人： ISCIENCE INTERVENTIONAL CORPORATION , HEE, Michael , CONSTON, Stanley, R. , KUPIECKI, David, J. , MCKENZIE, John, R. , YAMAMOTO, Ronald , NASH, Michael
发明人： HEE, Michael , CONSTON, Stanley, R. , KUPIECKI, David, J. , MCKENZIE, John, R. , YAMAMOTO, Ronald , NASH, Michael
IPC分类号： A61B3/00
CPC分类号： A61F9/0017 , A61B90/39 , A61B2090/3614 , A61B2090/3925 , A61B2090/3945 , A61F9/00736 , A61F9/00781 , A61F9/008 , A61F2009/00851
摘要： The invention provides tools, materials and related methods to surgically access the suprachoroidal space of an eye for the purpose of performing minimally invasive surgery or to deliver drugs to the eye. The invention provides a flexible microcannula or microcatheter device (11, 13) that may be placed into the suprachoroidal space (12, 14) through a small incision (12A) of the overlying tissues, maneuvered into the appropriate region of the space, and then activated to treat tissues adjacent to the distal tip of the device.
摘要翻译：本发明提供了用于手术进入眼睛的脉管外空间以进行微创手术或将药物递送至眼睛的工具，材料和相关方法。本发明提供了一种柔性微插管或微导管装置（11,13），其可以通过上层组织的小切口（12A）放置在脉管外空间（12,14）中，操纵到空间的适当区域，然后被激活以处理邻近该装置的远端的组织。

10. 发明申请

WO2006066103A3 OPHTHALMIC IMPLANT FOR TREATMENT OF GLAUCOMA 审中-公开
标题翻译：眼科植入治疗青光眼
公开(公告)号：WO2006066103A3
公开(公告)日：2006-09-08
申请号：PCT/US2005045675
申请日：2005-12-16
申请人： ISCIENCE SURGICAL CORP , STEGMANN ROBERT , CONSTON STANLEY R , KUPIECKI DAVID J , MCKENZIE JOHN , PINSON CANDICE D , YAMAMOTO RONALD
发明人： STEGMANN ROBERT , CONSTON STANLEY R , KUPIECKI DAVID J , MCKENZIE JOHN , PINSON CANDICE D , YAMAMOTO RONALD
IPC分类号： A61F9/007
CPC分类号： A61F9/00781
摘要： An implant (11) is placed within Schlemm's canal of the eye and provides tension to the trabecular meshwork. The tension (12) is continuous and increases the aqueous outflow without the necessity of administering cholinergic drugs to treat glaucoma.
摘要翻译：植入物（11）被放置在眼睛的施累姆氏管内并为小梁网提供张力。张力（12）是连续的并增加水流出，而不需要施用胆碱能药物来治疗青光眼。

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