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1. 发明申请

WO2005059110A2 METHODS AND MATERIALS FOR CANINE BREED IDENTIFICATION 审中-公开
标题翻译：犬种鉴定方法与材料
公开(公告)号：WO2005059110A2
公开(公告)日：2005-06-30
申请号：PCT/US2004/042267
申请日：2004-12-15
申请人： FRED HUTCHINSON CANCER RESEARCH CENTER , OSTRANDER, Elaine , KRUGLYAK, Leonid , PARKER, Heidi, G. , KIM, Lisa, V. , STEPHENS, Matthew , MALEK, Tiffany, B. , SUTTER, Nathan, B. , CARLSON, Scott
发明人： OSTRANDER, Elaine , KRUGLYAK, Leonid , PARKER, Heidi, G. , KIM, Lisa, V. , STEPHENS, Matthew , MALEK, Tiffany, B. , SUTTER, Nathan, B. , CARLSON, Scott
IPC分类号： C12N
CPC分类号： C12Q1/6888 , C12Q2600/156 , G06F19/18
摘要： In one aspect, the invention provides methods for determining the contributions of canid populations to a canid genome. The methods comprise the steps of: (a) obtaining the identity of one or both alleles in a test canid genome for each of a set of markers; and (b) determining the contributions of canid populations to the test canid genome by comparing the alleles in the test canid genome to a database comprising canid population profiles, wherein each canid population profile comprises genotype information for the set of markers in the canid populations.
摘要翻译：在一个方面，本发明提供了确定犬种群对犬科基因组的贡献的方法。所述方法包括以下步骤：（a）在一组标记物中获得测试犬基因组中的一个或两个等位基因的身份; 和（b）通过将测试犬科基因组中的等位基因与含有犬种种群谱的数据库进行比较来确定犬科群体对测试犬基因组的贡献，其中每个犬种群体谱包括在犬种群中的该组标记的基因型信息。

2. 发明申请

WO2007084433A2 ARRAY-BASED POLYMORPHISM MAPPING AT SINGLE NUCLEOTIDE RESOLUTION 审中-公开
标题翻译：单核苷酸多态性分析中基于阵列的多态性定位
公开(公告)号：WO2007084433A2
公开(公告)日：2007-07-26
申请号：PCT/US2007000987
申请日：2007-01-12
申请人： UNIV PRINCETON , KRUGLYAK LEONID , BOTSTEIN DAVID , GRESHAM DAVID , RUDERFER DOUGLAS , PRATT STEPHEN
发明人： KRUGLYAK LEONID , BOTSTEIN DAVID , GRESHAM DAVID , RUDERFER DOUGLAS , PRATT STEPHEN
IPC分类号： C12Q1/68
CPC分类号： G06F19/20 , G06F19/18
摘要： Disclosed herein is a system useful for detecting sequence differences (e.g., single- nucleotide polymorphisms) between genomes using data from a single hybridization with a genomic DNA microarray, such as a whole-genome array. The methods described herein can be used to detect, simply and inexpensively, differences in sequence among the genomes of individual members of a species, for example. In examples described herein, the system and methods were used to detect a variety of spontaneous single base-pair substitutions, insertions and deletions, and most (>90%) of the approximately 30,000 known single-nucleotide polymorphisms between two Saccharomyces cerevisiae strains. The system and methods were also used to elucidate the genetic basis of phenotypic variants and identify the small number of single base-pair changes accumulated during experimental evolution of yeast.
摘要翻译：本文公开的是使用来自与基因组DNA微阵列（例如全基因组阵列）的单一杂交的数据来检测基因组之间的序列差异（例如，单核苷酸多态性）的系统。本文描述的方法可用于例如简单且廉价地检测物种的各个成员的基因组之间的序列差异。在本文描述的实施例中，系统和方法用于检测多种自发单碱基对取代，插入和缺失，并且大多数（> 90％）大约30,000个已知的两个酿酒酵母菌株之间的单核苷酸多态性。系统和方法也用于阐明表型变体的遗传基础，并确定在酵母实验进化过程中累积的单碱基对变化的数量少。

3. 发明申请

WO2007084433A3 ARRAY-BASED POLYMORPHISM MAPPING AT SINGLE NUCLEOTIDE RESOLUTION 审中-公开
公开(公告)号：WO2007084433A3
公开(公告)日：2007-07-26
申请号：PCT/US2007/000987
申请日：2007-01-12
申请人： THE TRUSTEES OF PRINCETON UNIVERSITY , KRUGLYAK, Leonid , BOTSTEIN, David , GRESHAM, David , RUDERFER, Douglas , PRATT, Stephen
发明人： KRUGLYAK, Leonid , BOTSTEIN, David , GRESHAM, David , RUDERFER, Douglas , PRATT, Stephen
IPC分类号： C12Q1/68
摘要： Disclosed herein is a system useful for detecting sequence differences (e.g., single- nucleotide polymorphisms) between genomes using data from a single hybridization with a genomic DNA microarray, such as a whole-genome array. The methods described herein can be used to detect, simply and inexpensively, differences in sequence among the genomes of individual members of a species, for example. In examples described herein, the system and methods were used to detect a variety of spontaneous single base-pair substitutions, insertions and deletions, and most (>90%) of the approximately 30,000 known single-nucleotide polymorphisms between two Saccharomyces cerevisiae strains. The system and methods were also used to elucidate the genetic basis of phenotypic variants and identify the small number of single base-pair changes accumulated during experimental evolution of yeast.

4. 发明申请

WO2005059110A3 METHODS AND MATERIALS FOR CANINE BREED IDENTIFICATION 审中-公开
标题翻译：犬种鉴定方法与材料
公开(公告)号：WO2005059110A3
公开(公告)日：2006-04-27
申请号：PCT/US2004042267
申请日：2004-12-15
申请人： HUTCHINSON FRED CANCER RES , OSTRANDER ELAINE , KRUGLYAK LEONID , PARKER HEIDI G , KIM LISA V , STEPHENS MATTHEW , MALEK TIFFANY B , SUTTER NATHAN B , CARLSON SCOTT
发明人： OSTRANDER ELAINE , KRUGLYAK LEONID , PARKER HEIDI G , KIM LISA V , STEPHENS MATTHEW , MALEK TIFFANY B , SUTTER NATHAN B , CARLSON SCOTT
IPC分类号： G01N33/48 , C12N20060101 , C12Q1/68
CPC分类号： C12Q1/6888 , C12Q2600/156 , G06F19/18
摘要： In one aspect, the invention provides methods for determining the contributions of canid populations to a canid genome. The methods comprise the steps of: (a) obtaining the identity of one or both alleles in a test canid genome for each of a set of markers; and (b) determining the contributions of canid populations to the test canid genome by comparing the alleles in the test canid genome to a database comprising canid population profiles, wherein each canid population profile comprises genotype information for the set of markers in the canid populations.
摘要翻译：在一个方面，本发明提供了确定犬种群对犬科基因组的贡献的方法。所述方法包括以下步骤：（a）在一组标记物中获得测试犬基因组中的一个或两个等位基因的身份; 和（b）通过将测试犬科基因组中的等位基因与含有犬种种群谱的数据库进行比较来确定犬科群体对测试犬基因组的贡献，其中每个犬种群体谱包括在犬种群中的该组标记的基因型信息。

5. 发明专利

SU1227230A1 TILTING DOLL 未知
公开(公告)号：SU1227230A1
公开(公告)日：1986-04-30
申请号：SU3417029
申请日：1982-04-05
申请人： KRUGLYAK LEONID
发明人： KRUGLYAK LEONID I
IPC分类号： A63H15/06

6. 发明专利

SU1680177A1 NEEDLE FOR ACUPUNCTURE 未知
公开(公告)号：SU1680177A1
公开(公告)日：1991-09-30
申请号：SU4704635
申请日：1989-06-14
申请人： KRUGLYAK LEONID
发明人： KRUGLYAK LEONID I
IPC分类号： A61H39/08

7. 发明专利

SU1344380A1 GAME 未知
公开(公告)号：SU1344380A1
公开(公告)日：1987-10-15
申请号：SU3881558
申请日：1985-04-08
申请人： KRUGLYAK LEONID
发明人： KRUGLYAK LEONID I
IPC分类号： A63H13/15

8. 发明专利

SU1630875A1 SHACKLE BRACING TOOL 未知
公开(公告)号：SU1630875A1
公开(公告)日：1991-02-28
申请号：SU4282559
申请日：1987-07-10
申请人： KRUGLYAK LEONID
发明人： KRUGLYAK LEONID I
IPC分类号： B25B27/12

9. 发明专利

SU1485347A1 DEVICE FOR SECURING WIRES 未知
公开(公告)号：SU1485347A1
公开(公告)日：1989-06-07
申请号：SU4252511
申请日：1987-04-07
申请人： KRUGLYAK LEONID
发明人： KRUGLYAK LEONID I

10. 发明专利

SU1431791A1 GAME 未知
公开(公告)号：SU1431791A1
公开(公告)日：1988-10-23
申请号：SU4055575
申请日：1986-04-14
申请人： KRUGLYAK LEONID , RABINOVICH LEONID
发明人： KRUGLYAK LEONID I , RABINOVICH LEONID I
IPC分类号： A63H33/26

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